We present the preparation and measurement of the radioactive isotope^(37)Ar,which was produced using thermal neutrons from a reactor,as a calibration source for liquid xenon time projection chambers.^(37)Ar is a low-...We present the preparation and measurement of the radioactive isotope^(37)Ar,which was produced using thermal neutrons from a reactor,as a calibration source for liquid xenon time projection chambers.^(37)Ar is a low-energy calibration source with a half-life of 35.01 days,making it suitable for calibration in the low-energy region of liquid xenon dark-matter experiments.Radioactive isotope^(37)Ar was produced by irradiating ^(36)Ar with thermal neutrons.It was subsequently measured in a gaseous xenon time projection chamber(GXe TPC)to validate its radioactivity.Our results demonstrate that^(37)Ar is an effective and viable calibration source that offers precise calibration capabilities in the low-energy domain of xenon-based detectors.展开更多
目的探究蛋白激酶B(Akt)/核转录因子(NF-κB)信号通路、白介素-37(IL-37)对儿童重症肺炎(SP预后的预测价值。方法选取2022年3月至2024年7月郑州大学第一附属医院收治的230例重症肺炎患儿作为研究组,另选同期115例轻症肺炎患儿作为对照...目的探究蛋白激酶B(Akt)/核转录因子(NF-κB)信号通路、白介素-37(IL-37)对儿童重症肺炎(SP预后的预测价值。方法选取2022年3月至2024年7月郑州大学第一附属医院收治的230例重症肺炎患儿作为研究组,另选同期115例轻症肺炎患儿作为对照组。比较研究组和对照组患儿的血清Akt mRNA、NF-κB mRNA、IL-37水平,并比较不同临床特征SP患儿和不同28 d预后SP患儿的血清Akt mRNA、NF-κB mRNA、IL-37水平。应用Spearman分析血清Akt mRNA、NF-κB mRNA、IL-37水平与重症肺炎患儿临床特征、预后的相关性,应用受试者工作特征(ROC)曲线分析血清Akt mRNA、NF-κB mRNA、IL-37水平对重症肺炎患儿预后的预测价值。结果研究组患儿的血清Akt m RNA、NF-κB m RNA、IL-37水平分别为1.09±0.27、1.06±0.25、(98.67±27.56)pg/mL,明显高于对照组的0.82±0.21、0.79±0.23、(65.19±18.91)pg/mL,差异均有统计学意义(P<0.05);伴有肺不张、胸腔积液、肺实变、肺外并发症的SP患儿的血清Akt mRNA、NF-κB m RNA、IL-37水平明显高于无肺不张、无胸腔积液、无肺实变、无肺外并发症的SP患儿,差异均有统计学意义(P<0.05);SP患儿治疗28 d后评估预后,其中71例预后不良,159例预后良好;研究组预后不良患儿血清Akt m RNA、NF-κB m RNA、IL-37水平分别为1.35±0.32、1.31±0.30、(122.68±37.19)pg/mL,明显高于预后良好患儿的0.97±0.20、0.95±0.19、(87.95±20.86)pg/mL,差异有统计学意义(P<0.05);Spearman分析结果显示,血清Akt mRNA、NF-κB m RNA、IL-37水平与SP患儿肺不张、胸腔积液、肺实变、肺外并发症、预后不良均呈正相关(P<0.05);ROC分析结果显示,血清Akt mRNA、NF-κB m RNA、IL-37水平预测SP患儿预后不良的曲线下面积(AUC)分别为0.760、0.761、0.792,三者联合预测预后不良的AUC为0.894,明显大于各指标单独预测的AUC(P<0.05)。结论SP患儿血清Akt mRNA、NF-κB m RNA、IL-37水平明显升高,且与临床特征、预后不良密切相关,三者联合可为临床预测SP患儿预后提供可靠临床依据。展开更多
基金supported by National Key R&D grant from the Ministry of Science and Technology of China(Nos.2021YFA1601600,2023YFA1606200)National Science Foundation of China(Nos.12090062,12105008)the Major State Basic Research Development Program of China.
文摘We present the preparation and measurement of the radioactive isotope^(37)Ar,which was produced using thermal neutrons from a reactor,as a calibration source for liquid xenon time projection chambers.^(37)Ar is a low-energy calibration source with a half-life of 35.01 days,making it suitable for calibration in the low-energy region of liquid xenon dark-matter experiments.Radioactive isotope^(37)Ar was produced by irradiating ^(36)Ar with thermal neutrons.It was subsequently measured in a gaseous xenon time projection chamber(GXe TPC)to validate its radioactivity.Our results demonstrate that^(37)Ar is an effective and viable calibration source that offers precise calibration capabilities in the low-energy domain of xenon-based detectors.
文摘目的探究蛋白激酶B(Akt)/核转录因子(NF-κB)信号通路、白介素-37(IL-37)对儿童重症肺炎(SP预后的预测价值。方法选取2022年3月至2024年7月郑州大学第一附属医院收治的230例重症肺炎患儿作为研究组,另选同期115例轻症肺炎患儿作为对照组。比较研究组和对照组患儿的血清Akt mRNA、NF-κB mRNA、IL-37水平,并比较不同临床特征SP患儿和不同28 d预后SP患儿的血清Akt mRNA、NF-κB mRNA、IL-37水平。应用Spearman分析血清Akt mRNA、NF-κB mRNA、IL-37水平与重症肺炎患儿临床特征、预后的相关性,应用受试者工作特征(ROC)曲线分析血清Akt mRNA、NF-κB mRNA、IL-37水平对重症肺炎患儿预后的预测价值。结果研究组患儿的血清Akt m RNA、NF-κB m RNA、IL-37水平分别为1.09±0.27、1.06±0.25、(98.67±27.56)pg/mL,明显高于对照组的0.82±0.21、0.79±0.23、(65.19±18.91)pg/mL,差异均有统计学意义(P<0.05);伴有肺不张、胸腔积液、肺实变、肺外并发症的SP患儿的血清Akt mRNA、NF-κB m RNA、IL-37水平明显高于无肺不张、无胸腔积液、无肺实变、无肺外并发症的SP患儿,差异均有统计学意义(P<0.05);SP患儿治疗28 d后评估预后,其中71例预后不良,159例预后良好;研究组预后不良患儿血清Akt m RNA、NF-κB m RNA、IL-37水平分别为1.35±0.32、1.31±0.30、(122.68±37.19)pg/mL,明显高于预后良好患儿的0.97±0.20、0.95±0.19、(87.95±20.86)pg/mL,差异有统计学意义(P<0.05);Spearman分析结果显示,血清Akt mRNA、NF-κB m RNA、IL-37水平与SP患儿肺不张、胸腔积液、肺实变、肺外并发症、预后不良均呈正相关(P<0.05);ROC分析结果显示,血清Akt mRNA、NF-κB m RNA、IL-37水平预测SP患儿预后不良的曲线下面积(AUC)分别为0.760、0.761、0.792,三者联合预测预后不良的AUC为0.894,明显大于各指标单独预测的AUC(P<0.05)。结论SP患儿血清Akt mRNA、NF-κB m RNA、IL-37水平明显升高,且与临床特征、预后不良密切相关,三者联合可为临床预测SP患儿预后提供可靠临床依据。
