高浓度酒精饮料如白酒、伏特加和白兰地,其辛辣口感的强弱直接影响酒的品质。酒入口引发的辛辣感大多是酒精和乙醛引起的,是一种痛觉。我们之前的研究表明平均分子量35 kDa透明质酸片段HA35可有效治疗炎症性和神经性疼痛。通过探究透明...高浓度酒精饮料如白酒、伏特加和白兰地,其辛辣口感的强弱直接影响酒的品质。酒入口引发的辛辣感大多是酒精和乙醛引起的,是一种痛觉。我们之前的研究表明平均分子量35 kDa透明质酸片段HA35可有效治疗炎症性和神经性疼痛。通过探究透明质酸片段HA35和平均分子量1800 kDa透明质酸HA1800对高浓度酒精饮料的辛辣口感的影响。使用疼痛定量评估方法(NRS)评价高浓度酒精饮料的辛辣口感,结果表明预先饮用30 mL 0.5%的HA35明显减少46%vol和53%vol中国白酒、40%vol伏特加和40%vol白兰地的酒精辛辣口感(P<0.05),而预先饮用30 mL 0.5%的HA1800减少酒精辛辣口感效果不明显(P>0.05);而直接饮用含终浓度0.5%的HA35和0.5%HA35与0.1%HA1800混合的高浓度酒精饮料,均明显减少辛辣口感和酒精气味(P<0.05)。因此,研究表明终浓度0.5%的HA35是一种减少高浓度酒精饮料辛辣口感和酒精气味的饮料添加剂或解酒辛辣伴侣。展开更多
Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interac...Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interacts with various receptors in the human body, including CD44, LYVE-1, RHAMM, and TLR2, and is well-known for its analgesic effects when used in intra-articular or ultrasound-guided nerve trunk injections. Studies have shown that hyaluronidase cleaves high molecular weight HA to generate HA35, a low molecular weight fragment with enhanced tissue permeability, capable of binding to HA receptors on cell surfaces to produce broad-spectrum analgesic effects. Methods: Ten patients diagnosed with MPS were treated and assessed in this study. HA35 was administered through injection at a dosage of 100 mg daily for 15 days. Patients evaluated their MPS, overall pain levels, and treatment satisfaction using the Numerical Pain Rating Scale (NPRS), the Global Pain Scale (GPS), and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Follow-up evaluations were performed three months post-treatment to assess the duration of therapeutic effects. Results: Significant improvements were observed in NPRS, GPS, and TSQM scores both during and after the treatment period (P Conclusions: HA35 provides effective and sustained relief from pain associated with MPS, demonstrating a prolonged therapeutic benefit.展开更多
文摘高浓度酒精饮料如白酒、伏特加和白兰地,其辛辣口感的强弱直接影响酒的品质。酒入口引发的辛辣感大多是酒精和乙醛引起的,是一种痛觉。我们之前的研究表明平均分子量35 kDa透明质酸片段HA35可有效治疗炎症性和神经性疼痛。通过探究透明质酸片段HA35和平均分子量1800 kDa透明质酸HA1800对高浓度酒精饮料的辛辣口感的影响。使用疼痛定量评估方法(NRS)评价高浓度酒精饮料的辛辣口感,结果表明预先饮用30 mL 0.5%的HA35明显减少46%vol和53%vol中国白酒、40%vol伏特加和40%vol白兰地的酒精辛辣口感(P<0.05),而预先饮用30 mL 0.5%的HA1800减少酒精辛辣口感效果不明显(P>0.05);而直接饮用含终浓度0.5%的HA35和0.5%HA35与0.1%HA1800混合的高浓度酒精饮料,均明显减少辛辣口感和酒精气味(P<0.05)。因此,研究表明终浓度0.5%的HA35是一种减少高浓度酒精饮料辛辣口感和酒精气味的饮料添加剂或解酒辛辣伴侣。
文摘Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interacts with various receptors in the human body, including CD44, LYVE-1, RHAMM, and TLR2, and is well-known for its analgesic effects when used in intra-articular or ultrasound-guided nerve trunk injections. Studies have shown that hyaluronidase cleaves high molecular weight HA to generate HA35, a low molecular weight fragment with enhanced tissue permeability, capable of binding to HA receptors on cell surfaces to produce broad-spectrum analgesic effects. Methods: Ten patients diagnosed with MPS were treated and assessed in this study. HA35 was administered through injection at a dosage of 100 mg daily for 15 days. Patients evaluated their MPS, overall pain levels, and treatment satisfaction using the Numerical Pain Rating Scale (NPRS), the Global Pain Scale (GPS), and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Follow-up evaluations were performed three months post-treatment to assess the duration of therapeutic effects. Results: Significant improvements were observed in NPRS, GPS, and TSQM scores both during and after the treatment period (P Conclusions: HA35 provides effective and sustained relief from pain associated with MPS, demonstrating a prolonged therapeutic benefit.
