Purpose: Adenosine stress CMR is commonly used to assess myocardial ischaemia. Obtaining high quality images requires maximising signal to noise ratio (SNR) over a large double-oblique field of view (FOV) whilst minim...Purpose: Adenosine stress CMR is commonly used to assess myocardial ischaemia. Obtaining high quality images requires maximising signal to noise ratio (SNR) over a large double-oblique field of view (FOV) whilst minimising artefacts. A 32-channel surface coil may provide a higher SNR over a larger FOV compared to standard coils, possibly leading to improved image quality. Materials and Methods: 50 adenosine perfusion CMR scans were performed on a Philips Achieva CV 1.5T, with either a 5 or 32-channel coil (25 patients each) using standardised acquisition protocols. 3 short axis slices were acquired per cardiac cycle and the resulting cine images were scored by two blinded CMR specialists on a quality scale of 1 to 5. Phantom studies were performed using similar acquisition parameters and the SNR was calculated and compared across a range of acceleration factors. Results: The mean patient age was 62 ± 11 years and 50% of patients were male. The image quality scores were higher using the 32-channel coil (mean 3.8 ± 0.7 vs 3.2 ± 0.9 p = 0.002). The average phantom SNR was greater for the 32-element coil across the range of acceleration factors measured (103 vs 86 p = <0.001). Conclusions: The 32-channel coil produces significantly higher quality images and a higher SNR than the 5-channel coil in routine perfusion CMR.展开更多
目的:探讨序贯激光结合^(32)P同位素敷贴协同治疗烧伤增生性瘢痕的疗效及对瘢痕组织TGF-β_(1)、BMP-7的影响。方法:选择2021年3月-2023年3月在笔者医院收治的124例烧伤增生性瘢痕患者,随机分为对照组和观察组,每组62例。对照组患者均...目的:探讨序贯激光结合^(32)P同位素敷贴协同治疗烧伤增生性瘢痕的疗效及对瘢痕组织TGF-β_(1)、BMP-7的影响。方法:选择2021年3月-2023年3月在笔者医院收治的124例烧伤增生性瘢痕患者,随机分为对照组和观察组,每组62例。对照组患者均予以序贯激光治疗,观察组在接受激光治疗后给予^(32)P同位素敷贴。比较两组患者的总有效率、瘙痒视觉模拟评分(VAS)、温哥华瘢痕量表(Vancouver scar scale,VSS)评分、简明健康状况调查量表(Short form 36 health survey,SF-36)评分、监测瘢痕组织中TGF-β_(1)、BMP-7水平及不良反应发生情况。随访6个月,观察两组患者的复发率。结果:末次治疗后,观察组患者的总有效率、SF-36评分均高于对照组(P<0.05);观察组患者的VAS评分、VSS评分均低于对照组(P<0.05);观察组患者的TGF-β_(1)水平低于对照组,BMP-7水平高于对照组(P<0.05)。两组患者在不良反应发生率方面差异无统计学意义(P>0.05)。随访6个月后,观察组患者的复发率低于对照组(P<0.05)。结论:序贯激光结合^(32)P同位素敷贴协同治疗烧伤后增生性瘢痕能够有效改善患者的临床症状和生活质量,降低复发风险,同时能够调节TGF-β_(1)和BMP-7在瘢痕形成过程中的平衡,抑制成纤维细胞增殖和胶原沉积。展开更多
文摘Purpose: Adenosine stress CMR is commonly used to assess myocardial ischaemia. Obtaining high quality images requires maximising signal to noise ratio (SNR) over a large double-oblique field of view (FOV) whilst minimising artefacts. A 32-channel surface coil may provide a higher SNR over a larger FOV compared to standard coils, possibly leading to improved image quality. Materials and Methods: 50 adenosine perfusion CMR scans were performed on a Philips Achieva CV 1.5T, with either a 5 or 32-channel coil (25 patients each) using standardised acquisition protocols. 3 short axis slices were acquired per cardiac cycle and the resulting cine images were scored by two blinded CMR specialists on a quality scale of 1 to 5. Phantom studies were performed using similar acquisition parameters and the SNR was calculated and compared across a range of acceleration factors. Results: The mean patient age was 62 ± 11 years and 50% of patients were male. The image quality scores were higher using the 32-channel coil (mean 3.8 ± 0.7 vs 3.2 ± 0.9 p = 0.002). The average phantom SNR was greater for the 32-element coil across the range of acceleration factors measured (103 vs 86 p = <0.001). Conclusions: The 32-channel coil produces significantly higher quality images and a higher SNR than the 5-channel coil in routine perfusion CMR.
文摘目的:探讨序贯激光结合^(32)P同位素敷贴协同治疗烧伤增生性瘢痕的疗效及对瘢痕组织TGF-β_(1)、BMP-7的影响。方法:选择2021年3月-2023年3月在笔者医院收治的124例烧伤增生性瘢痕患者,随机分为对照组和观察组,每组62例。对照组患者均予以序贯激光治疗,观察组在接受激光治疗后给予^(32)P同位素敷贴。比较两组患者的总有效率、瘙痒视觉模拟评分(VAS)、温哥华瘢痕量表(Vancouver scar scale,VSS)评分、简明健康状况调查量表(Short form 36 health survey,SF-36)评分、监测瘢痕组织中TGF-β_(1)、BMP-7水平及不良反应发生情况。随访6个月,观察两组患者的复发率。结果:末次治疗后,观察组患者的总有效率、SF-36评分均高于对照组(P<0.05);观察组患者的VAS评分、VSS评分均低于对照组(P<0.05);观察组患者的TGF-β_(1)水平低于对照组,BMP-7水平高于对照组(P<0.05)。两组患者在不良反应发生率方面差异无统计学意义(P>0.05)。随访6个月后,观察组患者的复发率低于对照组(P<0.05)。结论:序贯激光结合^(32)P同位素敷贴协同治疗烧伤后增生性瘢痕能够有效改善患者的临床症状和生活质量,降低复发风险,同时能够调节TGF-β_(1)和BMP-7在瘢痕形成过程中的平衡,抑制成纤维细胞增殖和胶原沉积。
