An efficient,chromium-catalyzed highly enantioselective preparation of protected 1,3-diols has been achieved.In the presence of a chiral chromium catalyst using the carbazole-based bisoxazoline as the chiral ligand,a ...An efficient,chromium-catalyzed highly enantioselective preparation of protected 1,3-diols has been achieved.In the presence of a chiral chromium catalyst using the carbazole-based bisoxazoline as the chiral ligand,a variety of optically pure 1,3-diols were synthesized in 34%-87%yields with up to 98%ee.The benzyl as well as silyl ethers were suitable substitutions for the hydroxyl group.Meanwhile,aromatic,aliphatic and α,β-unsaturated aldehydes are well tolerated under the mild reaction conditions.展开更多
ObjectiveTo investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) degranulation....ObjectiveTo investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) degranulation.MethodsThe investigation was performed in vitro by administering each compound into rat peritoneal MCs and rat basophilic leukemia-2H3 cells followed by activation with 50 μg/mL of compound 48/80 or 1 μM of ionomycin. The concentration of histamine released from each group was measured by a high-performance liquid chromatography-fluorometry system with post-column derivatization using o-phthalaldehyde.Results8-Hydroxyisocapnolactone-2-3-diol inhibited degranulation of compound 48/80 activated-rat peritoneal MCs with the histamine release percentages of 74.57%, 72.21% and 51.79% when the 10 μM, 30 μM and 100 μM concentrations were used, respectively. Where as about 81% histamine was released by the control group. Degranulation inhibition ability was also observed in ionomycin-activated rat basophilic leukemia-2H3 cells. In contrast, friedelin failed to inhibit degranulation in either cell type. The inhibition of 8-hydroxyisocapnolactone-2-3-diol was not related to the depletion of histamine synthesis as implied by the total histamine measurement.ConclusionsThese results exhibit the promising of 8-hydroxyisocapnolactone-2-3-diol is a potential parent structure for developing a MCs stabilizer.展开更多
Two chiral building blocks 1 and 2 for anti-and syn-1, 3-diols has been achieved in 8 steps and 7 steps respectively, starting from the readily available and inexpensive D (+)-xylose 3.
In this study, we used a mixture of organic liquid propane-1,3-diol and ionic liquid 1-ethyl-3-methylimidazolium chloride([emim]Cl) as the entrainer to separate tert-butyl alcohol(TBA) + water. We measured the isobari...In this study, we used a mixture of organic liquid propane-1,3-diol and ionic liquid 1-ethyl-3-methylimidazolium chloride([emim]Cl) as the entrainer to separate tert-butyl alcohol(TBA) + water. We measured the isobaric vapor–liquid equilibrium(VLE) for the quaternary system TBA + water + propane-1,3-diol + [emim]Cl at 101.3 kPa, and found the VLE data to be well correlated with the nonrandom two-liquid model. These results show that the mixed solvent of propane-1,3-diol + [emim]Cl can increase the relative volatility of TBA to water and break the azeotropic point. We found no notable synergetic effect between them, and observed that the liquid mixed solvent of propane-1,3-diol and [emim]Cl had lower viscosity than [emim]Cl, which makes it a promising entrainer for separating the TBA + water azeotrope in industrial applications.展开更多
A new 3-（3,4-methylenedioxyphenyl）-propane-1,2-diol glycoside,named cinnamomdiol A（1）,together with two known compounds,3-（3,4-methylenedioxyphenyl）-propane-1,2-diol（2） and taxifolin（3）,was isolated from the...A new 3-（3,4-methylenedioxyphenyl）-propane-1,2-diol glycoside,named cinnamomdiol A（1）,together with two known compounds,3-（3,4-methylenedioxyphenyl）-propane-1,2-diol（2） and taxifolin（3）,was isolated from the roots of Cinnamomum camphora.Their structures were determined on the basis of spectroscopic evidences.Compounds 2 and 3 were isolated from the title plant for the first time.展开更多
A facile ndxture of the C-11 isomeric 3 - oxo-7αH-eudes ma-4-en- 9β, 1 2-diol has been achieved ffom oxycarvone. The C-11 configuration of natural product is established through comparison of IHNMR spectra between ...A facile ndxture of the C-11 isomeric 3 - oxo-7αH-eudes ma-4-en- 9β, 1 2-diol has been achieved ffom oxycarvone. The C-11 configuration of natural product is established through comparison of IHNMR spectra between synthatic 1b, or the mixture of 1a and 1b, and natural diol.展开更多
Background:In today’s context,vegetable oils,commonly used in culinary practices such as frying and baking,are integral to numerous daily dietary choices.Palm oil,a frequently employed vegetable oil,raises concerns s...Background:In today’s context,vegetable oils,commonly used in culinary practices such as frying and baking,are integral to numerous daily dietary choices.Palm oil,a frequently employed vegetable oil,raises concerns surrounding food safety,thus presenting a significant challenge.Methods:This research aims to enhance consumer awareness regarding the potential health risks associated with 3-monochloropropane-1,2-diol(3-MCPD)and glycidyl fatty acid esters(GEs)commonly found in food and edible oil products.The study endeavours to apprise consumers of these health risks through a comprehensive survey.The survey enlisted the participation of 120 respondents within the age bracket of 18 years to those above 36 years(capped at 50 years).Results:Strikingly,a significant proportion,ranging from 88%to 89%,demonstrated a lack of awareness concerning the potential risks associated with 3-MCPD and GEs in food products.Conclusion:This study underscores the urgency of augmenting consumer's awareness levels regarding 3-MCPD and GEs.Furthermore,it promotes a more detailed examination of Malaysian edible oils and food products available in the market to establish an appropriate Tolerable Daily Intake for the Malaysian population.This research contributes to the broader discourse on food safety and public health by highlighting these crucial facets.展开更多
目的建立气相色谱-串联质谱法(gas chromatography-tandem mass spectrometry,GC-MS/MS)快速测定婴幼儿配方奶粉、冷冻饮品及食用油中2-氯-1,3-丙二醇(2-monochloropropane-1,3-diol,2-MCPD)和3-氯-1,2-丙二醇(3-monochloropropane-1,2-...目的建立气相色谱-串联质谱法(gas chromatography-tandem mass spectrometry,GC-MS/MS)快速测定婴幼儿配方奶粉、冷冻饮品及食用油中2-氯-1,3-丙二醇(2-monochloropropane-1,3-diol,2-MCPD)和3-氯-1,2-丙二醇(3-monochloropropane-1,2-diol,3-MCPD)的分析方法。方法本研究基于苯基硼酸作为衍生试剂,样品经氯化钠水溶液提取,玻璃硅藻土小柱净化,高速冷冻离心,加入一定量水去除过量苯基硼酸进行测定。以5%苯基-甲基聚硅氧烷毛细管色谱柱(30 m×0.25 mm,0.25μm)进行分离,质谱采用电子轰击源(electron bombardment ion source,EI)电离,选择反应监测(selected reaction monitoring,SRM)模式对婴幼儿配方奶粉、冷冻饮品及食用油中2-MCPD和3-MCPD进行定性和定量分析。结果该方法在婴幼儿配方奶粉、冷冻饮品及食用油3种基质中,方法线性范围为10~400 ng/mL,相关系数均在0.99以上,平均回收率在84.0%~107.8%之间,相对标准偏差(relative standard deviations,RSDs)在1.1%~9.3%之间。婴幼儿配方奶粉和冷冻饮品中2-MCPD和3-MCPD检出限均为10μg/kg;食用油中2-MCPD和3-MCPD检出限为30μg/kg;婴幼儿配方奶粉和冷冻饮品中2-MCPD和3-MCPD定量限均为25μg/kg;食用油中2-MCPD和3-MCPD定量限为100μg/kg。结论本方法样品前处理快速、简单,净化效果好,结果准确性高,适用于婴幼儿配方奶粉、冷冻饮品及食用油中2-MCPD和3-MCPD快速检测分析。展开更多
A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characteriz...A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.展开更多
基金NSFC(Nos.21421091,XDB20000000)the "Thousand Plan" Youth program for financial support
文摘An efficient,chromium-catalyzed highly enantioselective preparation of protected 1,3-diols has been achieved.In the presence of a chiral chromium catalyst using the carbazole-based bisoxazoline as the chiral ligand,a variety of optically pure 1,3-diols were synthesized in 34%-87%yields with up to 98%ee.The benzyl as well as silyl ethers were suitable substitutions for the hydroxyl group.Meanwhile,aromatic,aliphatic and α,β-unsaturated aldehydes are well tolerated under the mild reaction conditions.
文摘ObjectiveTo investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) degranulation.MethodsThe investigation was performed in vitro by administering each compound into rat peritoneal MCs and rat basophilic leukemia-2H3 cells followed by activation with 50 μg/mL of compound 48/80 or 1 μM of ionomycin. The concentration of histamine released from each group was measured by a high-performance liquid chromatography-fluorometry system with post-column derivatization using o-phthalaldehyde.Results8-Hydroxyisocapnolactone-2-3-diol inhibited degranulation of compound 48/80 activated-rat peritoneal MCs with the histamine release percentages of 74.57%, 72.21% and 51.79% when the 10 μM, 30 μM and 100 μM concentrations were used, respectively. Where as about 81% histamine was released by the control group. Degranulation inhibition ability was also observed in ionomycin-activated rat basophilic leukemia-2H3 cells. In contrast, friedelin failed to inhibit degranulation in either cell type. The inhibition of 8-hydroxyisocapnolactone-2-3-diol was not related to the depletion of histamine synthesis as implied by the total histamine measurement.ConclusionsThese results exhibit the promising of 8-hydroxyisocapnolactone-2-3-diol is a potential parent structure for developing a MCs stabilizer.
文摘Two chiral building blocks 1 and 2 for anti-and syn-1, 3-diols has been achieved in 8 steps and 7 steps respectively, starting from the readily available and inexpensive D (+)-xylose 3.
基金supported by the Innovation Fund of Tianjin University (No. 2010XJ-0022)
文摘In this study, we used a mixture of organic liquid propane-1,3-diol and ionic liquid 1-ethyl-3-methylimidazolium chloride([emim]Cl) as the entrainer to separate tert-butyl alcohol(TBA) + water. We measured the isobaric vapor–liquid equilibrium(VLE) for the quaternary system TBA + water + propane-1,3-diol + [emim]Cl at 101.3 kPa, and found the VLE data to be well correlated with the nonrandom two-liquid model. These results show that the mixed solvent of propane-1,3-diol + [emim]Cl can increase the relative volatility of TBA to water and break the azeotropic point. We found no notable synergetic effect between them, and observed that the liquid mixed solvent of propane-1,3-diol and [emim]Cl had lower viscosity than [emim]Cl, which makes it a promising entrainer for separating the TBA + water azeotrope in industrial applications.
文摘A new 3-（3,4-methylenedioxyphenyl）-propane-1,2-diol glycoside,named cinnamomdiol A（1）,together with two known compounds,3-（3,4-methylenedioxyphenyl）-propane-1,2-diol（2） and taxifolin（3）,was isolated from the roots of Cinnamomum camphora.Their structures were determined on the basis of spectroscopic evidences.Compounds 2 and 3 were isolated from the title plant for the first time.
文摘A facile ndxture of the C-11 isomeric 3 - oxo-7αH-eudes ma-4-en- 9β, 1 2-diol has been achieved ffom oxycarvone. The C-11 configuration of natural product is established through comparison of IHNMR spectra between synthatic 1b, or the mixture of 1a and 1b, and natural diol.
文摘Background:In today’s context,vegetable oils,commonly used in culinary practices such as frying and baking,are integral to numerous daily dietary choices.Palm oil,a frequently employed vegetable oil,raises concerns surrounding food safety,thus presenting a significant challenge.Methods:This research aims to enhance consumer awareness regarding the potential health risks associated with 3-monochloropropane-1,2-diol(3-MCPD)and glycidyl fatty acid esters(GEs)commonly found in food and edible oil products.The study endeavours to apprise consumers of these health risks through a comprehensive survey.The survey enlisted the participation of 120 respondents within the age bracket of 18 years to those above 36 years(capped at 50 years).Results:Strikingly,a significant proportion,ranging from 88%to 89%,demonstrated a lack of awareness concerning the potential risks associated with 3-MCPD and GEs in food products.Conclusion:This study underscores the urgency of augmenting consumer's awareness levels regarding 3-MCPD and GEs.Furthermore,it promotes a more detailed examination of Malaysian edible oils and food products available in the market to establish an appropriate Tolerable Daily Intake for the Malaysian population.This research contributes to the broader discourse on food safety and public health by highlighting these crucial facets.
文摘目的建立气相色谱-串联质谱法(gas chromatography-tandem mass spectrometry,GC-MS/MS)快速测定婴幼儿配方奶粉、冷冻饮品及食用油中2-氯-1,3-丙二醇(2-monochloropropane-1,3-diol,2-MCPD)和3-氯-1,2-丙二醇(3-monochloropropane-1,2-diol,3-MCPD)的分析方法。方法本研究基于苯基硼酸作为衍生试剂,样品经氯化钠水溶液提取,玻璃硅藻土小柱净化,高速冷冻离心,加入一定量水去除过量苯基硼酸进行测定。以5%苯基-甲基聚硅氧烷毛细管色谱柱(30 m×0.25 mm,0.25μm)进行分离,质谱采用电子轰击源(electron bombardment ion source,EI)电离,选择反应监测(selected reaction monitoring,SRM)模式对婴幼儿配方奶粉、冷冻饮品及食用油中2-MCPD和3-MCPD进行定性和定量分析。结果该方法在婴幼儿配方奶粉、冷冻饮品及食用油3种基质中,方法线性范围为10~400 ng/mL,相关系数均在0.99以上,平均回收率在84.0%~107.8%之间,相对标准偏差(relative standard deviations,RSDs)在1.1%~9.3%之间。婴幼儿配方奶粉和冷冻饮品中2-MCPD和3-MCPD检出限均为10μg/kg;食用油中2-MCPD和3-MCPD检出限为30μg/kg;婴幼儿配方奶粉和冷冻饮品中2-MCPD和3-MCPD定量限均为25μg/kg;食用油中2-MCPD和3-MCPD定量限为100μg/kg。结论本方法样品前处理快速、简单,净化效果好,结果准确性高,适用于婴幼儿配方奶粉、冷冻饮品及食用油中2-MCPD和3-MCPD快速检测分析。
文摘A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.
