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Three-dimensional visualization helps surgoens to make surgical decision:The 3D-ViDru trial-a randomized trial
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作者 Esther Giehl-Brown Frederic Konrad +5 位作者 Steffen Löck Johannes Schweipert Felix Schön Jens-Peter Kühn Jürgen Weitz Carina Riediger 《Hepatobiliary & Pancreatic Diseases International》 2026年第1期52-61,共10页
Background:Successful liver resection in oncologic surgery depends on safety,precision,and efficacy,all of which require a thorough understanding of liver anatomy.Contrast-enhanced computed tomography(CT)-generated th... Background:Successful liver resection in oncologic surgery depends on safety,precision,and efficacy,all of which require a thorough understanding of liver anatomy.Contrast-enhanced computed tomography(CT)-generated three-dimensional(3D)models have been proposed as a valuable tool to enhance this understanding.However,a systematic comparison of different display modalities across professional groups has not yet been performed.Methods:In this prospective,monocentric randomized trial,we compared high-resolution twodimensional(2D)CT images of liver malignancies with their corresponding standardized,non-colored 3D virtual and printed models in facilitating anatomical and spatial understanding as well as surgical decision-making.A total of 91 participants,including 40 surgeons,10 radiologists,and 41 students,evaluated six clinical cases(three centrally and three peripherally located liver malignancies).Each participant assessed one central and one peripheral case per display modality,presented in a random order.Results:Compared to 2D CT images,both 3D virtual and printed models significantly improved the identification of tumor location(P<0.001),enhanced the comprehension of spatial relationships with adjacent liver and portal veins(P<0.001 and P=0.019,respectively),and facilitated clinical decisionmaking(P<0.001).No significant difference was observed between virtual and printed models in terms of effectiveness.Within the different groups,surgeons and students,but not radiologists,more accurately identified tumor location and spatial relationships with adjacent liver and portal veins using 3D models.Subjectively,most surgeons and students preferred 3D printed models over virtual models and 2D CT images.Conclusions:This study demonstrated that standardized,non-colored 3D virtual and printed models equally help preoperative anatomical understanding and decision-making,particularly for surgeons and students.By isolating the influence of display modality,our findings clarify prior inconsistent results and support the integration of cost-effective 3D visualization by applying virtual models into surgical planning and education.Preference for printed models despite comparable efficacy highlights the importance of user-centered implementation strategies. 展开更多
关键词 High-resolution 2D CT images 3D virtual models 3D printed models Surgical oncology Liver surgery Surgical decision-making
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Characterization of rockfalls in Cappadocia region(Türkiye)by empirical and 3-Dimensional methods
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作者 Ogün Ozan VAROL Mutluhan AKIN +1 位作者 İsmail DINÇER Ahmet ORHAN 《Journal of Mountain Science》 2026年第1期203-220,共18页
Rockfall hazards pose significant risks to both cultural heritage and populated areas,necessitating comprehensive assessment methodologies.Despite extensive research on rockfalls,only a small number of studies have di... Rockfall hazards pose significant risks to both cultural heritage and populated areas,necessitating comprehensive assessment methodologies.Despite extensive research on rockfalls,only a small number of studies have directly compared empirical methods with modelling approaches.This study investigated rockfalls in five settlements within the Cappadocia region of Türkiye,employing both empirical methods and advanced three-dimensional(3D)probabilistic modeling.The energy line angle approach was applied to identify rockfall propagation zones,while high-resolution digital surface models derived from unmanned aerial vehicle(UAV)imagery facilitated detailed 3D rockfall simulations.Cappadocia’s unique geological setting—comprising alternating layers of ignimbrites and weaker fluviolacustrine deposits—renders it highly susceptible to rockfalls intensified by wetting-drying and freeze-thaw cycles.Results indicate that rockfall propagation characteristics vary markedly between settlements:Göre and Tatlarin exhibit shorter runout distances due to basalt-dominated slopes,whereas Akköy,SoğanlıandŞahinefendi display longer trajectories associated with welded ignimbrites.Empirical cone propagation analyses correspond broadly with field observations,but variations in energy line angles(23°-33°)highlight the necessity for site-specific calibration.Comparative evaluations demonstrate that 3D probabilistic modeling better captures local-scale block dynamics and identifies high-risk areas affected by topographic and structural features such as rockfall ditches.These findings emphasize the importance of integrating empirical and 3D approaches to improve hazard zoning,optimize mitigation structures and guide the protection of Cappadocia’s unique cultural heritage landscape. 展开更多
关键词 ROCKFALL 3D probabilistic modeling Empirical analysis Energy line angle Cultural heritage
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Delaminated lower slab thermal regime before slab break-off in the Pamirs:Implications from 3D kinematic modeling
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作者 Haris Faheem YingFeng Ji +6 位作者 Waqar Ahmed Rui Qu Ye Zhu Fitriani Fitriani Jun Yang Shoichi Yoshioka Nobuaki Suenaga 《Earth and Planetary Physics》 2026年第1期13-21,共9页
The intracontinental subduction of a>200-km-long section of the Tajik-Tarim lithosphere beneath the Pamir Mountains is proposed to explain nearly 30 km of shortening in the Tajik fold-thrust belt and the Pamir upli... The intracontinental subduction of a>200-km-long section of the Tajik-Tarim lithosphere beneath the Pamir Mountains is proposed to explain nearly 30 km of shortening in the Tajik fold-thrust belt and the Pamir uplift.Seismic imaging revealed that the upper slab was scraped and that the lower slab had subducted to a depth of>150 km.These features constitute the tectonic complexity of the Pamirs,as well as the thermal subduction mechanism involved,which remains poorly understood.Hence,in this study,high-resolution three-dimensional(3D)kinematic modeling is applied to investigate the thermal structure and geometry of the subducting slab beneath the Pamirs.The modeled slab configuration reveals distinct along-strike variations,with a steeply dipping slab beneath the southern Pamirs,a more gently inclined slab beneath the northern Pamirs,and apparent upper slab termination at shallow depths beneath the Pamirs.The thermal field reveals a cold slab core after delamination,with temperatures ranging from 400℃to 800℃,enveloped by a hotter mantle reaching~1400℃.The occurrence of intermediate-depth earthquakes aligns primarily with colder slab regions,particularly near the slab tear-off below the southwestern Pamirs,indicating a strong correlation between slab temperature and seismicity.In contrast,the northern Pamirs exhibit reduced seismicity at depth,which is likely associated with thermal weakening and delamination.The central Pamirs show a significant thermal anomaly caused by a concave slab,where the coldest crust does not descend deeply,further suggesting crustal detachment or mechanical failure.The lateral asymmetry in slab temperature possibly explains the mechanism of lateral tearing and differential slab-mantle coupling. 展开更多
关键词 PAMIRS SUBDUCTION 3D kinematic modeling slab geometry intermediate-depth earthquake crustal delamination seismicity distribution
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Automatic gating and riser system design and defect control for K4169 superalloy guide blade casting based on parametric 3D modeling-simulation integrated system
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作者 Le-chuan Li Ya-jun Yin +4 位作者 Bing-zheng Fan Guo-yan Shui Xiao-yuan Ji Jian-xin Zhou Lei Jin 《China Foundry》 2026年第1期20-30,共11页
Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical si... Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical simulation plays a significant role in quantitatively evaluating current processes and making targeted improvements,but its limitations lie in the inability to dynamically reflect the formation outcomes of castings under varying process conditions,making real-time adjustments to gating and riser designs challenging.In this study,an automated design model for gating and riser systems based on integrated parametric 3D modeling-simulation framework is proposed,which enhances the flexibility and usability of evaluating the casting process by simulation.Firstly,geometric feature extraction technology is employed to obtain the geometric information of the target casting.Based on this information,an automated design framework for gating and riser systems is established,incorporating multiple structural parameters for real-time process control.Subsequently,the simulation results for various structural parameters are analyzed,and the influence of these parameters on casting formation is thoroughly investigated.Finally,the optimal design scheme is generated and validated through experimental verification.Simulation analysis and experimental results show that using a larger gate neck(24 mm in side length) and external risers promotes a more uniform temperature distribution and a more stable flow state,effectively eliminating shrinkage cavities and enhancing process yield by 15%. 展开更多
关键词 numerical simulation automatic design investment casting parametric 3D modeling gating and riser system
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Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions 被引量:1
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作者 Chentong GAO Huiyu SUN +1 位作者 Jianping GU W.M.HUANG 《Applied Mathematics and Mechanics(English Edition)》 2025年第1期123-138,共16页
Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade compone... Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade components.In this paper,a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established.Based on Kirchhoff's plate assumptions,the displacement variables of the plate are expressed.By incorporating the braiding directions into the constitutive equation of the braided composites,the dynamic model of the plate considering braiding directions is obtained.The effects of the speeds,braiding directions,and braided angles on the responses of the plate with fixed-axis rotation and translational motion,respectively,are investigated.This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions.It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications. 展开更多
关键词 three-dimensional(3D)braided composite braiding direction composite thin plate large overall motion dynamic model
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Implementation of the Actuator Disc Approach in Modeling Three-Dimensional Full-Sized Tidal Turbines and Flow Interactions in an Idealized Channel
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作者 Anas Abdul RAHMAN Vengatesan VENUGOPAL 《China Ocean Engineering》 2025年第3期504-517,共14页
A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for... A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for the implementation of the source term to represent an array of 20 m rotor diameter turbines deployed in an idealized channel is reviewed and discussed in detail. Flow interactions between multiple turbines are investigated for a single row arrangement with only two turbines and a two row arrangement containing three turbines. The results demonstrate that the non-hydrostatic solver shows better agreement when validated against published experimental data. Notably,the mesh density at the device location can strongly influence the simulated thrust from the disc. Although the actuator disc model can generally replicate the wake interactions well, the results indicate that it cannot accurately characterize the flow for regions with high turbulences. While a model setup with the largest lateral spacing(1.5D) demonstrates excellent agreement with the experimental data, the 0.5D model(smallest gap) deviates by up to 25%. These findings demonstrate the effectiveness of the applied source term in reproducing the wake profile, which is comparable with the published data, and highlight the inherent nature of the RANS and actuator disc models. 展开更多
关键词 velocity deficit wake characteristics device spacing non-hydrostatic model Telemac3D tidal turbine
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Dynamic Modeling of the Three-Dimensional Seated Human Body for High-Speed Train Ride Comfort Analysis
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作者 Hanwen Xu Xinbiao Xiao +4 位作者 Xiaoqing Dong Jian Han Peng Chen Qin Hu Xuesong Jin 《Chinese Journal of Mechanical Engineering》 2025年第5期478-507,共30页
Typically,seat or floor acceleration is used to evaluate the ride comfort of a high-speed train.However,the dynamic performance of the human body significantly differs from that of the floor.Therefore,using the car bo... Typically,seat or floor acceleration is used to evaluate the ride comfort of a high-speed train.However,the dynamic performance of the human body significantly differs from that of the floor.Therefore,using the car body floor and seat accelerations to calculate the ride comfort index of a high-speed train may not reflect the true feelings of passengers.In this study,a 3D human-seat-vehicle-track coupling model was established to investigate the ride comfort of highspeed train passengers.The seated human model,which considers the longitudinal,lateral,vertical,pitching,yawing,and rolling motions,comprises the head,upper torso,lower torso,pelvis,thighs,and shanks.The model parameters were determined using multi-axis excitation measurement data based on a genetic algorithm.Subsequently,the applicability of the small-angle assumption and natural modes of the human model is analyzed.Using the coupling system model,the vibration characteristics of the human-seat interaction surface were analyzed.The ride comfort of the high-speed train and human body dynamic performance were analyzed under normal conditions,track geometric irregularities and train meeting conditions.The results showed that the passenger seats in the front and rear rows adjacent to the window had a higher acceleration value than the others.The human backrest and seat pad connection points have higher vibration amplitudes than the car body floor in the human-sensitive frequency range,indicating that using the acceleration values on the floor may underestimate the discomfort of passengers.The ride comfort of high-speed trains diminishes in the presence of track geometric irregularities and when trains pass each other.When the excitation frequency of track geometry irregularities approached the natural frequency of the human-seat-vehicle system,ride comfort in high-speed trains decreased significantly.Moreover,using seat acceleration to evaluate passenger ride comfort overlooks the vibration characteristics of the human body.The transient aerodynamic force generated when the train meets can cause a larger car body roll and lateral motion at 2 Hz,which,in turn,decreases the passenger ride comfort.This study presents a detailed human-seat-vehicle-track coupling system that can reflect a passenger’s dynamic performance under complex operating conditions. 展开更多
关键词 Seated human body High-speed train Ride comfort 3D Human body-seat-vehicle-track coupling coupled model
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Three-dimensional forward modeling of DC resistivity using the aggregation-based algebraic multigrid method 被引量:5
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作者 陈辉 邓居智 +2 位作者 尹敏 殷长春 汤文武 《Applied Geophysics》 SCIE CSCD 2017年第1期154-164,192,共12页
To speed up three-dimensional (3D) DC resistivity modeling, we present a new multigrid method, the aggregation-based algebraic multigrid method (AGMG). We first discretize the differential equation of the secondar... To speed up three-dimensional (3D) DC resistivity modeling, we present a new multigrid method, the aggregation-based algebraic multigrid method (AGMG). We first discretize the differential equation of the secondary potential field with mixed boundary conditions by using a seven-point finite-difference method to obtain a large sparse system of linear equations. Then, we introduce the theory behind the pairwise aggregation algorithms for AGMG and use the conjugate-gradient method with the V-cycle AGMG preconditioner (AGMG-CG) to solve the linear equations. We use typical geoelectrical models to test the proposed AGMG-CG method and compare the results with analytical solutions and the 3DDCXH algorithm for 3D DC modeling (3DDCXH). In addition, we apply the AGMG-CG method to different grid sizes and geoelectrical models and compare it to different iterative methods, such as ILU-BICGSTAB, ILU-GCR, and SSOR-CG. The AGMG-CG method yields nearly linearly decreasing errors, whereas the number of iterations increases slowly with increasing grid size. The AGMG-CG method is precise and converges fast, and thus can improve the computational efficiency in forward modeling of three-dimensional DC resistivity. 展开更多
关键词 AGMG DC resistivity method 3D modeling finite difference method
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Research on the Three-dimensional Modeling and Optimization of a Virtual Tower Crane Based on 3DS Max, Solidworks and EON Professional 被引量:2
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作者 HOU Xiao-ting LI Chang-hua 《International Journal of Plant Engineering and Management》 2013年第1期15-19,共5页
Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enha... Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enhancing the requests of image quality and stability of the virtual construction scene, taking a tower crane for example. We studied the technology of three-dimensional modeling and optimization of a virtual tower crane, and a method named two-stage model optimization was put forward. This depended on the modeling stage using Solidworks and 3DS Max and the performance optimization stage in EON. The practice of software development indicates that the proposed methods of three-dimensional modeling and optimization could satisfy the performance request of virtual construction system and be popularized to other virtual system. 展开更多
关键词 3DS Max SOLIDWORKS EON Professional virtual tower crane three-dimensional modeling andoptimization virtual construction
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Three-dimensional acoustic wave equation modeling based on the optimal finite-difference scheme 被引量:4
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作者 蔡晓慧 刘洋 +4 位作者 任志明 王建民 陈志德 陈可洋 王成 《Applied Geophysics》 SCIE CSCD 2015年第3期409-420,469,共13页
Generally, FD coefficients can be obtained by using Taylor series expansion (TE) or optimization methods to minimize the dispersion error. However, the TE-based FD method only achieves high modeling precision over a... Generally, FD coefficients can be obtained by using Taylor series expansion (TE) or optimization methods to minimize the dispersion error. However, the TE-based FD method only achieves high modeling precision over a limited range of wavenumbers, and produces large numerical dispersion beyond this range. The optimal FD scheme based on least squares (LS) can guarantee high precision over a larger range of wavenumbers and obtain the best optimization solution at small computational cost. We extend the LS-based optimal FD scheme from two-dimensional (2D) forward modeling to three-dimensional (3D) and develop a 3D acoustic optimal FD method with high efficiency, wide range of high accuracy and adaptability to parallel computing. Dispersion analysis and forward modeling demonstrate that the developed FD method suppresses numerical dispersion. Finally, we use the developed FD method to source wavefield extrapolation and receiver wavefield extrapolation in 3D RTM. To decrease the computation time and storage requirements, the 3D RTM is implemented by combining the efficient boundary storage with checkpointing strategies on GPU. 3D RTM imaging results suggest that the 3D optimal FD method has higher precision than conventional methods. 展开更多
关键词 3D acoustic wave equation optimal finite-difference forward modeling reversetime migration
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Three-dimensional modeling of effect of surface intermetallic phase on surface defects of Al-Fe-Si aluminum foils during twin-roll casting
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作者 朱远志 万强 +2 位作者 李丙亮 周峰 张雅峰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第2期477-483,共7页
Scanning electron microscopy and X-ray energy dispersive spectrum analysis show that the clusters of intermetallic AlFeSi particle are distributed on or near the aluminum foil stock surfaces heterogeneously. 3D finite... Scanning electron microscopy and X-ray energy dispersive spectrum analysis show that the clusters of intermetallic AlFeSi particle are distributed on or near the aluminum foil stock surfaces heterogeneously. 3D finite element modeling shows that these clusters of hard particles induce the fracture of the nano-scale lubricant oil film at first and further lead to severe deformation in the nearby aluminum foil substrate along the rolling direction. Consequently, the optical property in this region differs from that in the surroundings, resulting in surface defects. 展开更多
关键词 Al-Fe-Si alloy precipitated phase aluminum foils lubricant oil film twin-roll cast 3D modeling
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Solubility and Thermodynamic Modeling of 3⁃Nitro⁃1,2,4⁃triazole⁃5⁃one(NTO)in Different Binary Solvents 被引量:1
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作者 GUO Hao-qi YANG Yu-lin 《含能材料》 北大核心 2025年第3期295-303,共9页
Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging f... Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging from 278.15 K to 318.15 K.The solubility in each system was found to be positively correlated with temperature.Furthermore,solubility data were analyzed using four equations:the modified Apelblat equation,Van’t Hoff equation,λh equation and CNIBS/R-K equations,and they provided satisfactory results for both two systems.The average root-mean-square deviation(105RMSD)values for these models were less than 13.93.Calculations utilizing the Van’t Hoff equation and Gibbs equations facilitated the derivation of apparent thermodynamic properties of NTO dissolution in the two systems,including values for Gibbs free energy,enthalpy and entropy.The%ζ_(H)is larger than%ζ_(TS),and all the%ζ_(H)data are≥58.63%,indicating that the enthalpy make a greater contribution than entropy to theΔG_(soln)^(Θ). 展开更多
关键词 3-nitro-l 2 4-triazole-5-one(NTO) SOLUBILITY thermodynamic models apparent thermodynamic analysis
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Development of Patient-Derived Conditionally Reprogrammed 3D Breast Cancer Culture Models for Drug Sensitivity Evaluation
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作者 Jing Cai Haoyun Zhu +4 位作者 Weiling Guo Ting Huang Pangzhou Chen Wen Zhou Ziyun Guan 《Oncology Research》 2026年第1期500-520,共21页
Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual pat... Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual patient responses towards different drugs.This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations.Methods:Tumor and adjacent tissues from female breast cancer patients were collected during surgery.Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models.The obtained patient-derived conditional reprogramming breast cancer(CRBC)cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres to form 3D culture models.Comparisons between 2D and 3D models were made using immunohistochemistry(tumor markers),MTS assays(cell viability),flow cytometry(apoptosis),transwell assays(migration),and Western blotting(protein expression).Drug sensitivity tests were conducted to evaluate patient-specific responses to anti-cancer agents.Results:2D and 3D culture models were successfully established using samples from eight patients.The 3D models retained histological and marker characteristics of the original tumors.Compared to 2D cultures,3D models exhibited increased apoptosis,enhanced drug resistance,elevated stem cell marker expression,and greater migration ability—features more reflective of in vivo tumor behavior.Conclusion:Patient-derived 3D CRBC models effectively mimic the in vivo tumor microenvironment and demonstrate stronger resistance to anti-cancer drugs than 2D models.These hydrogel-based models offer a cost-effective and clinically relevant platform for drug screening and personalized breast cancer treatment. 展开更多
关键词 Patient-derived breast cancer cells conditional reprogramming hydrogel microsphere 3D culture model drug screening
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DNASE1L3 Mediates Hepatocellular Carcinoma Tumor Growth and Organoid Models via the Wnt/β-Catenin Signaling Pathway
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作者 Shulong Zhang Yijun Zhao +5 位作者 Li Geng Feihong Song Li Feng Jun Jiang Qianqian Cai Fei Fan 《Oncology Research》 2026年第3期691-724,共34页
Background:Hepatocellular carcinoma(HCC)is a highly lethal malignancy driven by both intrinsic oncogenic pathways and immune microenvironmental regulation.Emerging evidence suggests that DNASE1L3 may influence tumor b... Background:Hepatocellular carcinoma(HCC)is a highly lethal malignancy driven by both intrinsic oncogenic pathways and immune microenvironmental regulation.Emerging evidence suggests that DNASE1L3 may influence tumor biology and immune responses;however,its specific roles in HCC progression and macrophage-mediated regulation remain unclear.This study aimed to elucidate the biological functions of DNASE1L3 in HCC and to determine how it modulates tumor behavior and immune interactions.Methods:Bioinformatics analyses of the GSE41804 and Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC)datasets were used to identify hub genes.Functional assays assessed the impact of DNASE1L3 on HCC cell proliferation,migration,invasion,and cell cycle progression.The effects of DNASE1L3 on macrophage polarization and the Wnt/β-catenin signaling pathway were examined using a co-culture system.An HCC organoid model was established to further validate its regulatory function.Results:Eight prognostic signature genes were identified,with deoxyribonuclease I-like 3(DNase I-like 3)selected as the hub gene.DNASE1L3 overexpression suppressed HCC cell growth,inhibited migration and invasion,induced G1 arrest,and modulated epithelial-mesenchymal transition(EMT)markers.DNASE1L3 knockdown promoted M2-like macrophage polarization.Mechanistically,DNASE1L3 interacted withβ-catenin to enhance its ubiquitination and degradation,thereby inhibiting Wnt/β-catenin signaling and reducing PD-L1 expression.DNASE1L3 overexpression similarly restricted organoid growth and suppressed pathway activity.Conclusion:DNASE1L3 acts as a negative regulator of HCC progression by targeting the Wnt/β-catenin pathway and reducing PD-L1 expression,thereby influencing both tumor cell behavior and macrophage-mediated immune responses. 展开更多
关键词 Hepatocellular carcinoma DNASE1L3 Wnt/β-catenin signaling pathway organoid models tumor growth
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In an Ocean or a River:Bilinear Auto-Backlund Transformations and Similarity Reductions on an Extended Time-Dependent(3+1)-Dimensional Shallow Water Wave Equation 被引量:1
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作者 GAO Xin-yi 《China Ocean Engineering》 2025年第1期160-165,共6页
With respect to oceanic fluid dynamics,certain models have appeared,e.g.,an extended time-dependent(3+1)-dimensional shallow water wave equation in an ocean or a river,which we investigate in this paper.Using symbolic... With respect to oceanic fluid dynamics,certain models have appeared,e.g.,an extended time-dependent(3+1)-dimensional shallow water wave equation in an ocean or a river,which we investigate in this paper.Using symbolic computation,we find out,on one hand,a set of bilinear auto-Backlund transformations,which could connect certain solutions of that equation with other solutions of that equation itself,and on the other hand,a set of similarity reductions,which could go from that equation to a known ordinary differential equation.The results in this paper depend on all the oceanic variable coefficients in that equation. 展开更多
关键词 OCEAN RIVER extended time-dependent(3+1)-dimensional shallow water wave equation bilinear auto-Bäcklund transformation similarity reduction symbolic computation
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Automatic identification of discontinuities and refined modeling of rock blocks from 3D point cloud data of rock surfaces 被引量:1
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作者 Yaopeng Ji Shengyuan Song +5 位作者 Jianping Chen Jingyu Xue Jianhua Yan Yansong Zhang Di Sun Qing Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第5期3093-3106,共14页
The spatial distribution of discontinuities and the size of rock blocks are the key indicators for rock mass quality evaluation and rockfall risk assessment.Traditional manual measurement is often dangerous or unreach... The spatial distribution of discontinuities and the size of rock blocks are the key indicators for rock mass quality evaluation and rockfall risk assessment.Traditional manual measurement is often dangerous or unreachable at some high-steep rock slopes.In contrast,unmanned aerial vehicle(UAV)photogrammetry is not limited by terrain conditions,and can efficiently collect high-precision three-dimensional(3D)point clouds of rock masses through all-round and multiangle photography for rock mass characterization.In this paper,a new method based on a 3D point cloud is proposed for discontinuity identification and refined rock block modeling.The method is based on four steps:(1)Establish a point cloud spatial topology,and calculate the point cloud normal vector and average point spacing based on several machine learning algorithms;(2)Extract discontinuities using the density-based spatial clustering of applications with noise(DBSCAN)algorithm and fit the discontinuity plane by combining principal component analysis(PCA)with the natural breaks(NB)method;(3)Propose a method of inserting points in the line segment to generate an embedded discontinuity point cloud;and(4)Adopt a Poisson reconstruction method for refined rock block modeling.The proposed method was applied to an outcrop of an ultrahigh steep rock slope and compared with the results of previous studies and manual surveys.The results show that the method can eliminate the influence of discontinuity undulations on the orientation measurement and describe the local concave-convex characteristics on the modeling of rock blocks.The calculation results are accurate and reliable,which can meet the practical requirements of engineering. 展开更多
关键词 Three-dimensional(3D)point cloud Rock mass Automatic identification Refined modeling Unmanned aerial vehicle(UAV)
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Integrating geographic information system and 3D virtual reality for optimized modeling of large-scale photovoltaic wind hybrid system:A case study in Dakhla City,Morocco 被引量:1
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作者 Elmostafa Achbab Rachid Lambarki +1 位作者 Hassan Rhinane Dennoun Saifaoui 《Energy Geoscience》 2025年第2期174-193,共20页
This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)syste... This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)system connected to the local grid.The study focuses on Dakhla,Morocco,a region with vast untapped renewable energy potential.By leveraging GIS,we are innovatively analyzing geographical and environmental factors that influence optimal site selection and system design.The incorporation of VR technologies offers an unprecedented level of realism and immersion,allowing stakeholders to virtually experience the project's impact and design in a dynamic,interactive environment.This novel methodology includes extensive data collection,advanced modeling,and simulations,ensuring that the hybrid system is precisely tailored to the unique climatic and environmental conditions of Dakhla.Our analysis reveals that the region possesses a photovoltaic solar potential of approximately2400 k Wh/m^(2) per year,with an average annual wind power density of about 434 W/m^(2) at an 80-meter hub height.Productivity simulations indicate that the 20 MW hybrid system could generate approximately 60 GWh of energy per year and 1369 GWh over its 25-year lifespan.To validate these findings,we employed the System Advisor Model(SAM)software and the Global Solar Photovoltaic Atlas platform.This comprehensive and interdisciplinary approach not only provides a robust assessment of the system's feasibility but also offers valuable insights into its potential socio-economic and environmental impact. 展开更多
关键词 Geographic information systems 3D virtual reality(VR)modeling Wind energy Solar photovoltaic(PV)energy Hybrid renewable energy system assessment
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A 3-DIMENSIONAL DATA MODEL FOR VISUALIZING CLOVERLEAF JUNCTION IN A CITY MODEL 被引量:6
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作者 Chen Jun Sun Min Zhou Qiming 《Geo-Spatial Information Science》 1999年第1期9-15,共7页
The research work has been seldom done about cloverleaf junction expression in a 3-dimensional city model (3DCM). The main reason is that the cloverleaf junction is often in a complex and enormous construction. Its ma... The research work has been seldom done about cloverleaf junction expression in a 3-dimensional city model (3DCM). The main reason is that the cloverleaf junction is often in a complex and enormous construction. Its main body is bestraddle in air,and has aerial intersections between its parts. This complex feature made cloverleaf junction quite different from buildings and terrain, therefore, it is difficult to express this kind of spatial objects in the same way as for buildings and terrain. In this paper,authors analyze spatial characteristics of cloverleaf junction, propose an all-constraint points TIN algorithm to partition cloverleaf junction road surface, and develop a method to visualize cloverleaf junction road surface using TIN. In order to manage cloverleaf junction data efficiently, the authors also analyzed the mechanism of 3DCM data management, extended BLOB type in relational database, and combined R-tree index to manage 3D spatial data. Based on this extension, an appropriate data 展开更多
关键词 3-dimensional CITY model (3DCM) GIS cloverleaf JUNCTION DATA STRUCTURE DATABASE
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Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures
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作者 Muhammad Qasim Khan Fazal Malik +1 位作者 Fahad Alturise Noor Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期123-153,共31页
Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important a... Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject. 展开更多
关键词 Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication
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A 3-Dimensional Cargo Loading Algorithm for the Conveyor-Type Loading System
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作者 Hyeonbin Jeong Young Tae Ryu +1 位作者 Byung Duk Song Sang-Duck Lee 《Computer Modeling in Engineering & Sciences》 2025年第3期2739-2769,共31页
This paper proposes a novel cargo loading algorithm applicable to automated conveyor-type loading systems.The algorithm offers improvements in computational efficiency and robustness by utilizing the concept of discre... This paper proposes a novel cargo loading algorithm applicable to automated conveyor-type loading systems.The algorithm offers improvements in computational efficiency and robustness by utilizing the concept of discrete derivatives and introducing logistics-related constraints.Optional consideration of the rotation of the cargoes was made to further enhance the optimality of the solutions,if possible to be physically implemented.Evaluation metrics were developed for accurate evaluation and enhancement of the algorithm’s ability to efficiently utilize the loading space and provide a high level of dynamic stability.Experimental results demonstrate the extensive robustness of the proposed algorithm to the diversity of cargoes present in Business-to-Consumer environments.This study contributes practical advancements in both cargo loading optimization and automation of the logistics industry,with potential applications in last-mile delivery services,warehousing,and supply chain management. 展开更多
关键词 3-dimensional loading automated loading system B2C logistics cargo loading algorithm conveyortype loading
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