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面向冶金质检的2D/3D视觉协同检测系统关键算法
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作者 华晋军 王思贤 +1 位作者 唐文明 李树丰 《河北冶金》 2026年第2期65-69,84,共6页
针对热态钢轨质检中高温干扰、缺陷复杂及结构与纹理信息割裂等问题,本文提出并验证了一套面向冶金质检的2D/3D视觉系统检测系统的关键算法。在2D检测方面,提出轻量化DFAM-YOLO-Met(Defect-Focused Attention Module YOLO for Metallur... 针对热态钢轨质检中高温干扰、缺陷复杂及结构与纹理信息割裂等问题,本文提出并验证了一套面向冶金质检的2D/3D视觉系统检测系统的关键算法。在2D检测方面,提出轻量化DFAM-YOLO-Met(Defect-Focused Attention Module YOLO for Metallurgy)模型,通过将特征增强技术与注意力模块与YOLO模型进行耦合,实现对微小缺陷的高效识别。在自建图像集上取得91.6%的mAP和0.89的F1-score,在3D建模方面,设计三阶段点云优化与分段曲率拟合策略,引入热响应补偿机制,实现高温下的在线尺寸精测,误差由±0.28 mm降至±0.12 mm,满足国标≤0.15 mm的要求;在多模态融合方面,构建图-点映射与模块互引机制,实现2D与3D检测结果的联动复核,系统误报率由2.4%降至1.5%,复合缺陷Recall提升11.7%。实测表明,系统可在5 m/s钢轨产线上稳定运行72 h,单帧推理时延11.4 ms,GPU功耗低于15 W,具备良好鲁棒性与部署价值,为冶金行业在高温高速工况下实现智能质检提供了技术路径与实践参考。 展开更多
关键词 热态钢轨 表面检测 MAP 多模态融合 数据增强 2d/3d视觉协同
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Advances and Prospects in Body-Size Measurement of Sheep:From 2D Vision to 3D Reconstruction and 2D-3D Fusion
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作者 DAI Weijiao LIANG Yudongchen +5 位作者 ZHOU Yong YAO Chao ZHANG Cheng SONG Yongjian LI Guoliang TIAN Fang 《智慧农业(中英文)》 2026年第1期120-147,共28页
[Significance]In alignment with the national germplasm security strategy,current research efforts are accelerating the adoption of precision breeding in sheep.Within the whole-genome selection,accurate phenotyping of ... [Significance]In alignment with the national germplasm security strategy,current research efforts are accelerating the adoption of precision breeding in sheep.Within the whole-genome selection,accurate phenotyping of body morphometrics is critical for assessing growth performance and breeding value.Traditional manual measurements are inefficient,prone to human error,and may cause stress to sheep,limiting their suitability for precision sheep management.By summarizing the applications of sheep body size measurement technologies and analyzing their development directions,this paper provides theoretical references and practical guidance for the research and application of non contact sheep body size measurement.[Progress]This review synthesizes progress across three principal methodological paradigms:two-dimensional(2D)image-based techniques,three-dimensional(3D)point cloud-based approaches,and integrated 2D-3D fusion systems.2D methods,employing either handcrafted geometric features or deep learning-based keypoint detector algorithms,are cost-effective and operationally simple but sensitive to variation in imaging conditions and unable to capture critical circumference metrics.3D point-cloud approaches enable precise reconstruction of full animal morphology,supporting comprehensive body-size acquisition with higher accuracy,yet face challenges including high hardware costs,complex data workflows,and sensitivity to posture variability.Hybrid 2D-3D fusion systems combine semantic richness from RGB imagery with geometric completeness from point clouds.Having been effectively validated in other livestock specise,e.g.,cattle and pigs,these fusion systems have demonstrated excellent performance,providing important technical references and practical insights for sheep body size measurement.[Conclusions and Prospects]Firstly,future research should focus on constructing large-scale,high-quality datasets for sheep body size measurement that encompass diverse breeds,growth stages,and environmental conditions,thereby enhancing model robustness and generalization.Secondly,the development of lightweight artificial intelligence models is essential.Techniques such as model compression,quantization,and algorithmic optimization can substantially reduce computational complexity and storage requirements,facilitating deployment in resource-constrained environments.Thirdly,the 3D point cloud processing pipeline should be streamlined to improve the efficiency of data acquisition,filtering,registration,and segmentation,while promoting the integration of low-cost,high-resilience vision systems into practical farming scenarios.Fourthly,specific emphasis should be placed on improving the accuracy of curved-dimensional measurements,such as chest circumference,abdominal circumference,and shank circumference,through advances in pose standardization,refined 3D segmentation strategies,and multimodal data fusion.Finally,the cross-fertilization of sheep body size measurement technologies with analogous methods for other livestock species offers a promising pathway for mutual learning and collaborative innovation,accelerating the industrialization of automated sheep morphometric systems and supporting the development of intelligent,data-driven pasture management practices. 展开更多
关键词 smart breeding computer vision image recognition three-dimensional reconstruction 2d-3d body measurement
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血清Hcy、25-OH-D3、SF水平与2型糖尿病患者胰岛素抵抗的关系
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作者 李利函 王善龙 宋影 《黑龙江医药科学》 2026年第2期76-78,共3页
目的:探讨血清同型半胱氨酸(Hcy)、25-羟基维生素D3(25-OH-D3)、铁蛋白(SF)水平与2型糖尿病患者胰岛素抵抗的关系。方法:选取2023年1月至2024年12月河南科技大学第二附属医院收治的2型糖尿病患者92例纳入2型糖尿病组,另择同期有健康体检... 目的:探讨血清同型半胱氨酸(Hcy)、25-羟基维生素D3(25-OH-D3)、铁蛋白(SF)水平与2型糖尿病患者胰岛素抵抗的关系。方法:选取2023年1月至2024年12月河南科技大学第二附属医院收治的2型糖尿病患者92例纳入2型糖尿病组,另择同期有健康体检者92例纳入对照组。比较2型糖尿病组、对照组血清Hcy、25-OH-D3、SF、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平,通过Pearson相关分析法分析指标间的相关性。结果:相较对照组,2型糖尿病组血清Hcy、SF水平更高,血清25-(OH)D3水平更低(P<0.05)。相较对照组,2型糖尿病组FPG、FINS、HOMA-IR水平更高(P<0.05)。Pearson相关分析法结果显示,血清Hcy、SF水平与FPG、胰岛素、HOMA-IR呈正相关(P<0.05),血清25-OH-D3水平与FPG、胰岛素、HOMA-IR呈负相关(P<0.05)。结论:2型糖尿病患者血清Hcy、SF水平更高,血清25-OH-D3水平更低,且其表达水平与患者胰岛素抵抗水平密切相关。 展开更多
关键词 2型糖尿病 同型半胱氨酸 25-羟基维生素d3 铁蛋白 胰岛素抵抗
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T_(1)-3D BRAVO序列与T_(1)WI、T_(2)WI、FLAIR常规序列在发育性静脉畸形诊断中的应用价值比较
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作者 刘志方 桂国华 徐廉俊 《影像研究与医学应用》 2026年第1期82-85,共4页
目的:比较T_(1)-3D BRAVO序列与T_(1)WI、T_(2)WI、液体衰减反转恢复(FLAIR)常规序列在发育性静脉畸形(DVA)诊断中的应用价值。方法:选取2024年7月—2025年7月韶关市中医院收治的50例DVA患者作为研究对象,所有患者均行MRI常规序列与T_(1... 目的:比较T_(1)-3D BRAVO序列与T_(1)WI、T_(2)WI、液体衰减反转恢复(FLAIR)常规序列在发育性静脉畸形(DVA)诊断中的应用价值。方法:选取2024年7月—2025年7月韶关市中医院收治的50例DVA患者作为研究对象,所有患者均行MRI常规序列与T_(1)-3D BRABO序列检查。比较T_(1)-3D BRAVO序列与常规序列的可见性、病变与周围组织的界限、病变的血流信号、诊断的准确率。结果:T_(1)-3D BRAVO序列诊断的灵敏度、特异度、准确率均高于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。T_(1)-3D BRAVO序列在病变显示效果、病变形态呈现、病变位置准确性、病变大小测量准确性、病变与邻近结构关系等可见性方面均优于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。T_(1)-3D BRAVO序列在病变与正常组织的分界清晰度、病变边缘形态清晰度、病变边缘锐利度、病变与脑血管结构的区分度等方面均优于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。T_(1)-3D BRAVO序列在血流信号的识别能力、静脉回流的显示能力、血流信号诊断辅助作用等方面均优于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。结论:T_(1)-3D BRAVO序列诊断DVA的准确性更高,其可见性更强,能够清晰显示病灶与周围组织的界限及血流信号。 展开更多
关键词 T_(1)-3d BRAVO序列 T_(1)WI T_(2)WI FLAIR序列 发育性静脉畸形
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血清25-(OH)D3、YKL40、NT-proBNP、sST2对川崎病患儿冠状动脉病变的预测
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作者 计晓兰 蒋蕾 《中外医学研究》 2026年第5期5-8,共4页
目的:探究与分析血清25-羟基维生素D3[25-(OH)D3]、甲壳质酶蛋白-40(YKL40)、N末端B型钠尿肽前体(NT-proBNP)、可溶性生长刺激表达基因2蛋白(sST2)对川崎病患儿冠状动脉病变风险的预测价值。方法:回顾性分析2022年10月—2024年9月苏州... 目的:探究与分析血清25-羟基维生素D3[25-(OH)D3]、甲壳质酶蛋白-40(YKL40)、N末端B型钠尿肽前体(NT-proBNP)、可溶性生长刺激表达基因2蛋白(sST2)对川崎病患儿冠状动脉病变风险的预测价值。方法:回顾性分析2022年10月—2024年9月苏州市吴江区儿童医院收治的42例川崎病患儿(将其设为研究组)以及同时期进行常规体检的45名健康儿童(将其设为对照组)的临床资料。根据研究组心脏彩超结果,又分为冠状动脉病变组(18例)及无冠状动脉病变组(24例)。比较研究组和对照组血清指标,预测冠状动脉病变风险的价值。结果:研究组血清25-(OH)D3水平低于对照组,YKL40、NT-proBNP、sST2水平均高于对照组,差异有统计学意(P<0.05)。冠状动脉病变组血清YKL40、NT-proBNP、sST2水平高于无冠状动脉病变组,25-(OH)D3水平低于无冠状动脉病变组,差异有统计学意(P<0.05)。研究组血清25-(OH)D3水平与冠状动脉病变呈负相关,差异有统计学意(P<0.05)。YKL40、NT-proBNP、sST2水平与冠状动脉病变呈正相关(P<0.05)。25-(OH)D3、YKL40、NT-proBNP、sST2预测冠状动脉病变风险的AUC分别为0.921、0.931、0.745、0.963。结论:血清25-(OH)D3、YKL40、NT-proBNP、sST2水平与KD患儿冠状动脉病变密切相关,联合检测有助于临床早期识别KD患儿冠状动脉病变的高危人群。 展开更多
关键词 川崎病 冠状动脉病变 血清25-羟基维生素d3 甲壳质酶蛋白-40 N末端B型钠尿肽前体 可溶性生长刺激表 达基因2蛋白
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3D slope stability analysis considering strength anisotropy by a microstructure tensor enhanced elasto-plastic finite element method 被引量:1
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作者 Wencheng Wei Hongxiang Tang +1 位作者 Xiaoyu Song Xiangji Ye 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1664-1684,共21页
This article presents a micro-structure tensor enhanced elasto-plastic finite element(FE)method to address strength anisotropy in three-dimensional(3D)soil slope stability analysis.The gravity increase method(GIM)is e... This article presents a micro-structure tensor enhanced elasto-plastic finite element(FE)method to address strength anisotropy in three-dimensional(3D)soil slope stability analysis.The gravity increase method(GIM)is employed to analyze the stability of 3D anisotropic soil slopes.The accuracy of the proposed method is first verified against the data in the literature.We then simulate the 3D soil slope with a straight slope surface and the convex and concave slope surfaces with a 90turning corner to study the 3D effect on slope stability and the failure mechanism under anisotropy conditions.Based on our numerical results,the end effect significantly impacts the failure mechanism and safety factor.Anisotropy degree notably affects the safety factor,with higher degrees leading to deeper landslides.For concave slopes,they can be approximated by straight slopes with suitable boundary conditions to assess their stability.Furthermore,a case study of the Saint-Alban test embankment A in Quebec,Canada,is provided to demonstrate the applicability of the proposed FE model. 展开更多
关键词 Strength anisotropy Elasto-plastic finite element method(FEM) Three-dimensional(3d)soil slope Gravity increase method(GIM) Stability analysis Case study
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Genetic Variation Analysis of 3D Gene and Molecular Detection of Porcine Kobuvirus in 2013-2014
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作者 倪艳秀 何孔旺 +10 位作者 茅爱华 俞正玉 李彬 郭容利 吕立新 祝昊丹 周俊明 温立斌 张雪寒 王小敏 汪伟 《Agricultural Science & Technology》 CAS 2015年第3期442-446,共5页
[Objective] This study aimed to investigate the prevalence and variation of porcine kobuvirus (PKV) in suckling piglets in China. [Method] In 2013-2014, 224 feces samples from suckling piglets with diarrhea in 27 pi... [Objective] This study aimed to investigate the prevalence and variation of porcine kobuvirus (PKV) in suckling piglets in China. [Method] In 2013-2014, 224 feces samples from suckling piglets with diarrhea in 27 pig farms of five provinces in China were collected to detect 3D genes of PKV with RT-PCR method; the sequences and genetic variation of 29 PKV 3D genes were analyzed. [Result] Total positive rate of PKV in feces samples from suckling piglets with diarrhea was 65.18% (146/224); total positive rate of PKV in pig farms was 85,2% (23/27); nucleotide sequences and the deduced amino acid sequences of 29 PKV 3D genes shared 87.0%-100% and 92.7%-100% homologies with six PKV-related 3D sequences, respectively. [Conclusion] PKV infection is prevalent in suckling piglets in China; PKV 3D genes exhibit high diversity. 展开更多
关键词 Porcine kobuvirus Molecular detection 3d gene Genetic variation analysis
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Highly efficient contact detection strategy of 3D discontinuous deformation analysis in continuous-discontinuous simulation
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作者 Jingyu Kang Xiaodong Fu +5 位作者 Qian Sheng Xing Wang Haifeng Ding Xuehan Zhao Tian Xi Shangwei Jiang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第11期6977-6992,共16页
Contact detection is the most time-consuming stage in 3D discontinuous deformation analysis(3D-DDA)computation.Improving the efficiency of 3D-DDA is beneficial for its application in large-scale computing.In this stud... Contact detection is the most time-consuming stage in 3D discontinuous deformation analysis(3D-DDA)computation.Improving the efficiency of 3D-DDA is beneficial for its application in large-scale computing.In this study,aiming at the continuous-discontinuous simulation of 3D-DDA,a highly efficient contact detection strategy is proposed.Firstly,the global direct search(GDS)method is integrated into the 3D-DDA framework to address intricate contact scenarios.Subsequently,all geometric elements,including blocks,faces,edges,and vertices are divided into searchable and unsearchable parts.Contacts between unsearchable geometric elements would be directly inherited,while only searchable geometric elements are involved in contact detection.This strategy significantly reduces the number of geometric elements involved in contact detection,thereby markedly enhancing the computation efficiency.Several examples are adopted to demonstrate the accuracy and efficiency of the improved 3D-DDA method.The rock pillars with different mesh sizes are simulated under self-weight.The deformation and stress are consistent with the analytical results,and the smaller the mesh size,the higher the accuracy.The maximum speedup ratio is 38.46 for this case.Furthermore,the Brazilian splitting test on the discs with different flaws is conducted.The results show that the failure pattern of the samples is consistent with the results obtained by other methods and experiments,and the maximum speedup ratio is 266.73.Finally,a large-scale impact test is performed,and approximately 3.2 times enhanced efficiency is obtained.The proposed contact detection strategy significantly improves efficiency when the rock has not completely failed,which is more suitable for continuous-discontinuous simulation. 展开更多
关键词 3d discontinuous deformation analysis Contact detection Computation efficiency Continuous-discontinuous simulation FRACTURE
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KMT2D调控PI3K/AKT信号通路促进食管鳞状细胞癌发展 被引量:1
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作者 周珍 魏娉 +3 位作者 姜琳娜 何鹏 尹峰 安欣 《解剖科学进展》 2025年第1期55-57,61,共4页
目的 研究KMT2D与PI3K/AKT信号通路在食管鳞状细胞癌的发展中的相互作用机制。方法 通过免疫组化实验分析癌组织和癌旁组织KMT2D的表达水平;将KYSE-410细胞分为pcDNA NC组、pcDNA KMT2D和LY294002组。细胞集落形成实验检测KYSE-410细胞... 目的 研究KMT2D与PI3K/AKT信号通路在食管鳞状细胞癌的发展中的相互作用机制。方法 通过免疫组化实验分析癌组织和癌旁组织KMT2D的表达水平;将KYSE-410细胞分为pcDNA NC组、pcDNA KMT2D和LY294002组。细胞集落形成实验检测KYSE-410细胞生长能力;Transwell实验分析KYSE-410细胞侵袭能力;流式细胞术分析KYSE-410细胞凋亡率;蛋白免疫印迹实验分析KMT2D对PI3K/AKT通路的调控作用。结果 癌组织中KMT2D表达水平降低。与pcDNA NC组相比,pcDNA KMT2D组和LY294002组的KYSE-410细胞的集落形成数量和侵袭能力降低、凋亡率增加、PI3K和AKT蛋白磷酸化水平下降。结论 KMT2D能够抑制食管鳞状细胞癌KYSE-410细胞的生长和侵袭,促进KYSE-410细胞的凋亡,并且KMT2D这一作用与抑制PI3K/AKT信号通路激活有关。 展开更多
关键词 食管鳞状细胞癌 KMT2d PI3K AKT 侵袭 凋亡
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3D打印多孔TiO_(2)光催化降解筛及光催化性能
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作者 李翠霞 袁博 +1 位作者 王安航 张鑫 《兰州理工大学学报》 北大核心 2025年第3期15-23,共9页
开发了一种使用直写成型(DIW)3D打印方法制备多孔TiO_(2)光催化降解筛的成型技术,厘清了打印浆料中P25粉末、TiO_(2)前驱体溶胶和聚乙烯醇(PVA)含量对其成型性能的影响规律;进一步研究了降解筛的物相组成、微观形貌、能带结构和载流子寿... 开发了一种使用直写成型(DIW)3D打印方法制备多孔TiO_(2)光催化降解筛的成型技术,厘清了打印浆料中P25粉末、TiO_(2)前驱体溶胶和聚乙烯醇(PVA)含量对其成型性能的影响规律;进一步研究了降解筛的物相组成、微观形貌、能带结构和载流子寿命,并在模拟自然光下测定了其对盐酸四环素(TC)的光催化降解性能和循环稳定性.结果表明:TiO_(2)前驱体溶胶起到了分散P25颗粒和稳定浆料的作用,而PVA的加入则进一步改善了浆料的流变性能.当使用9 g P25粉末与10 mL TiO_(2)前驱体溶胶和1 mL质量分数为7%的PVA溶液混合时,得到了具有最佳成型性能的打印浆料,制备的降解筛结构完整,无塌陷和开裂.热处理后TiO_(2)前驱体溶胶转化而来的小粒径TiO_(2)填充在P25颗粒之间,起到了增强机械强度的作用,而PVA作为造孔剂极大地丰富了降解筛的孔隙结构.TiO_(2)光催化降解筛对TC表现出优异的光催化性能和循环稳定性,140 min内的降解率为98.4%,并在5次循环之后保持96.0%的降解率. 展开更多
关键词 3d打印 光催化 TiO_(2) 盐酸四环素
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负载BMP-2基因转染骨髓间充质干细胞的3 D打印nHAC/PLA水凝胶混合支架治疗骨缺损的实验研究
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作者 赵光宗 尹航 李华壮 《实用手外科杂志》 2025年第3期363-366,共4页
目的探究负载BMP-2基因转染骨髓间充质干细胞的3 D打印nHAC/PLA水凝胶混合支架治疗骨缺损的疗效。方法把52只6月龄雌性健康新西兰大白兔按照随机分配原则分为4组,每组13只,构建15.0 mm兔桡骨节段性缺损模型,分组实施不同干预。A组:采用B... 目的探究负载BMP-2基因转染骨髓间充质干细胞的3 D打印nHAC/PLA水凝胶混合支架治疗骨缺损的疗效。方法把52只6月龄雌性健康新西兰大白兔按照随机分配原则分为4组,每组13只,构建15.0 mm兔桡骨节段性缺损模型,分组实施不同干预。A组:采用BMP-2基因修饰的MSCs结合3 D打印nHAC/PLA水凝胶支架植入;B组:植入未经修饰的MSCs/3 D打印nHAC/PLA水凝胶复合体;C组:仅植入3 D打印nHAC/PLA水凝胶支架;D组:空白对照。于术后第6周和第12周分别进行X线检测和组织学观察,以评估各组修复材料在骨缺损修复中的效果。结果X线分析:术后6周、12周A组骨形成明显优于B组、C组、D组。组织学分析:A组6周后骨组织均匀分布在支架孔隙中,12周后骨性愈合,髓腔再通,支架几乎完全降解;B组6周后可见少量支架孔隙内有新骨生成,12周后靠近截骨端的髓腔被骨皮质封闭,结缔组织长入支架孔隙内;C、D组中,即使在术后12周,也未观察到骨形成。结论负载BMP-2基因转染骨髓间充质干细胞的3 D打印nHAC/PLA水凝胶混合支架为创伤性骨缺损治疗提供更加安全、有效、可靠的全新治疗方案,具有临床推广价值。 展开更多
关键词 BMP-2基因 3 d打印 nHAC/PLA 骨缺损 修复
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维生素D3介导TIPE2调控慢性鼻-鼻窦炎伴鼻息肉中巨噬细胞的功能及表型
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作者 黄小荣 谭晖 +3 位作者 陈娟 卡迪丽娅·木拉提 张瑾 陈伦牮 《医学分子生物学杂志》 2025年第3期237-244,共8页
目的探讨维生素D3(vitamin D3,VD3)介导的肿瘤坏死因子α诱导蛋白8样蛋白2(tumor necrosis factor-alpha induced protein 8-like protein,TIPE2)对慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)中巨噬细胞... 目的探讨维生素D3(vitamin D3,VD3)介导的肿瘤坏死因子α诱导蛋白8样蛋白2(tumor necrosis factor-alpha induced protein 8-like protein,TIPE2)对慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)中巨噬细胞功能和表型的调控作用。方法收集新疆维吾尔自治区人民医院CRSwNP患者的外周血标本作为CRSwNP组,收集单纯鼻中隔偏曲需行手术治疗的患者外周血标本作为Control组,RT-qPCR和蛋白质印迹检测外周血中TIPE2和精氨酸酶-1(Arg-1)的表达,化学发光法检测外周血中VD3浓度的分级变化。体外培养J774A.1巨噬细胞,将J774A.1巨噬细胞分为沉默TIPE2组(si-TIPE2#2组)及其阴性对照组(si-NC组)、过表达TIPE2的阴性对照组(oe-NC组)、oe-NC联合VD3治疗组(oe-NC+VD3组)、过表达TIPE2的重组载体(oe-TIPE2)联合VD3治疗组(oe-TIPE2+VD3组)。另外,建立CRSwNP小鼠模型,将CRSwNP小鼠分为空载体(empty vector)治疗组(CRSwNP+empty vector组)、CRSwNP+oe-TIPE2组、CRSwNP+oe-TIPE2+VD3组,收集各组小鼠的外周血并分离血清和巨噬细胞。RT-qPCR和蛋白质印迹检测巨噬细胞中TIPE2和Arg-1的表达。酶联免疫吸附测试(ELISA)法检测各组J774A.1巨噬细胞培养物上清液以及小鼠血清中白细胞介素(IL)-4、IL-13的水平。结果与Control组比较,CRSwNP组中VD3分级降低,而TIPE2和Arg-1的表达水平及IL-4、IL-13的血清浓度上调(P均<0.05)。Arg-1和TIPE2的水平显著性正相关(r=0.994,P<0.01),Arg-1和TIPE2分别与VD3分级呈显著性负相关(r=-0.652,P<0.01;r=-0.745,P<0.01)。与si-NC组比,si-TIPE2#2组的Arg-1的表达水平及IL-4、IL-13的浓度都降低(P均<0.05)。与oe-NC组比,oe-NC+VD3组的TIPE2和Arg-1的表达水平及IL-4、IL-13的浓度都降低(P均<0.05)。而与oe-NC+VD3组比,oe-TIPE2+VD3组的TIPE2和Arg-1的表达水平及IL-4、IL-13的浓度都增加(P均<0.05)。与CRSwNP+empty vector组比,CRSwNP+oe-TIPE2组中TIPE2和Arg-1的表达水平升高,VD3的浓度降低,IL-4、IL-13的血清浓度都增加(P均<0.05)。与CRSwNP+oe-TIPE2组比,CRSwNP+oe-TIPE2+VD3组中TIPE2和Arg-1的表达水平降低,VD3的浓度升高,IL-4、IL-13的血清浓度减少(P均<0.05)。结论VD3通过下调TIPE2的表达抑制CRSwNP中Arg-1、IL-4、IL-13的表达。 展开更多
关键词 慢性鼻-鼻窦炎伴鼻息肉 维生素d3 巨噬细胞极化 肿瘤坏死因子α诱导蛋白8样蛋白2 炎症反应
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3D打印辅助弯角椎体成形术对骨质疏松性椎体压缩骨折患者骨水泥分布、实验室及影像学参数的影响
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作者 赵晨阳 杜娟 +2 位作者 范小波 庞超见 王永彬 《中国临床医生杂志》 2026年第2期231-234,共4页
目的研究3D打印辅助弯角椎体成形术对骨质疏松性椎体压缩骨折(OVCF)患者骨水泥分布、血清超敏C-反应蛋白(hs-CRP)、前列腺素E_(2)(PGE_(2))及Cobb’角的影响。方法将2023年1月至2024年1月河北省邯郸市第一医院收治130例OVCF患者作为研... 目的研究3D打印辅助弯角椎体成形术对骨质疏松性椎体压缩骨折(OVCF)患者骨水泥分布、血清超敏C-反应蛋白(hs-CRP)、前列腺素E_(2)(PGE_(2))及Cobb’角的影响。方法将2023年1月至2024年1月河北省邯郸市第一医院收治130例OVCF患者作为研究对象,采用随机数字表法分为观察组65例(采用3D打印辅助弯角椎体成形术治疗)和对照组65例(采用经皮椎体后凸成形术治疗)。比较两组患者围手术期相关指标、骨水泥分布、实验室及影像学参数、日常生活活动能力的变化。结果观察组患者术中总透视次数、骨水泥灌注量少于对照组,手术时间、术后首次下床时间短于对照组,骨水泥分布良好占比高于对照组(P<0.05)。两组患者术后血清hs-CRP、PGE_(2)水平均高于术前,但观察组低于对照组(P<0.05)。两组术后伤椎前缘高度、伤椎中央高度均高于术前,局部Cobb’角小于术前,且观察组术后上述指标均优于对照组;两组患者术后巴瑟尔指数评分均高于术前,且观察组术后上述评分高于对照组(P<0.05)。结论3D打印辅助弯角椎体成形术能够提高OVCF患者骨水泥分布良好占比,抑制术后血清hs-CRP、PGE_(2)的释放,促进伤椎生理结构和日常生活活动能力的恢复。 展开更多
关键词 骨质疏松性椎体压缩骨折 3d打印辅助弯角椎体成形术 经皮椎体后凸成形术 骨水泥分布 超敏C-反应蛋白 前列腺素E_(2) 局部Cobb’角
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血清25-羟维生素D、壳多糖酶-3-样蛋白1与老年2型糖尿病患者肌少症的相关性 被引量:5
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作者 杨令芝 王焱 +5 位作者 王烤 黄茂 师权 黄文彬 刘琳丰 李杨梅 《河北医药》 2025年第1期55-58,共4页
目的 探讨血清25-羟维生素D[25(OH)D]、壳多糖酶-3-样蛋白1(CHI3L1)对老年2型糖尿病(T2DM)合并肌少症的预测价值。方法 选择2023年1月至2024年4月收治的193例老年T2DM患者,按照肌少症标准分为肌少症组67例和非肌少症126例。化学发光法... 目的 探讨血清25-羟维生素D[25(OH)D]、壳多糖酶-3-样蛋白1(CHI3L1)对老年2型糖尿病(T2DM)合并肌少症的预测价值。方法 选择2023年1月至2024年4月收治的193例老年T2DM患者,按照肌少症标准分为肌少症组67例和非肌少症126例。化学发光法检测患者血清25(OH)D水平,酶联免疫吸附法检测患者血清CHI3L1水平。Logistic回归方程计算患者发生肌少症的独立预测因素。绘制受试者工作曲线(ROC),根据曲线下面积(AUC)评价患者血清25(OH)D、CHI3L1水平预测发生肌少症的诊断效能。结果 患者年龄、血清25(OH)D水平、血清CHI3L1水平为患者发生肌少症的影响因素。相关性分析显示,血清25(OH)D水平与患者ASMI值呈正相关(P<0.05),年龄、患者血清CHI3L1水平呈负相关(P<0.05)。患者血清CHI3L1水平的诊断效能明显高于年龄(Z=4.136,P<0.05),进一步分析显示患者血清25(OH)D水平、CHI3L1水平联合检测的诊断效能明显高于年龄、血清25(OH)D水平、CHI3L1水平(Z=4.989、5.899、2.609,P<0.05)。结论 对于老年T2DM患者,血清25(OH)D水平、CHI3L1水平可有效预测患者是否发生肌少症,可以作为早期肌少症诊断的辅助诊断指标。 展开更多
关键词 2型糖尿病 肌少症 血清25-羟维生素d 壳多糖酶-3-样蛋白1
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Synthesis, Bioactivity, and Crystal Structure Analysis of 2-(3-Oxobenzo[d]isothiazol-2(3H)-yl)ethyl Benzoates 被引量:3
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作者 王向辉 游诚航 林强 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2013年第8期1123-1130,共8页
Fifteen novel 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)ethyl benzoates were synthesi- zed by the condensation of 2-(2-hydroxyethyl)benzo[d]isothiazol-3(2H)-one with substituted benzoic acids in dichloromethane. All... Fifteen novel 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)ethyl benzoates were synthesi- zed by the condensation of 2-(2-hydroxyethyl)benzo[d]isothiazol-3(2H)-one with substituted benzoic acids in dichloromethane. All the compounds were characterized by elemental analysis, IR, ESI-MS and 1H NMR. The crystal structures for 2-(2-hydroxyethyl)benzo[d]isothiazol-3(2H)-one (2) and 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)ethyl 2-methoxybenzoate (30) have been determined by X-ray crystal structure analysis. Compound 2 (C9H9NO2S) crystallizes in the monoclinic system, space group Pn with a = 10.552(3), b = 7.849(2), c = 10.765(4) A, β = 103.128(4)°, V= 868.3(5) A3, Mr = 195.24, Dc = 1.493 Mg.m-3, μ = 0.33 mm-1, F(000) = 408, Z = 4, R= 0.0314 and wR= 0.0628. Compound 30 (C17H15NO4S) crystallizes in the triclinic system, space group P1 with a = 8.028(2), b = 9.300(2), c = 10.430(3)A, V= 752.1(3)A3, Mr = 329.36, D,= 1.454 Mg.m-3, p = 0.24 mm-1, F(000) = 344, Z = 2, R = 0.0377 and wR = 0.0904. The preliminary biological test indicated that the title compounds show better growth inhibitory activity against the gram-positive bacteria than the gram-negative bacteria. 展开更多
关键词 2-(3-oxobenzo[d]isothiazoi-23H)-yl)ethyl benzoates synthesis crystal structure hydrogen bonds
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2D-3D registration for 3D analysis of lower limb alignment in a weight-bearing condition 被引量:2
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作者 SHIM Eungjune KIM Youngjun +3 位作者 LEE Deukhee LEE Byung Hoon WOO Sungkyung LEE Kunwoo 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2018年第1期59-70,共12页
X-ray imaging is the conventional method for diagnosing the orthopedic condition of a patient. Computerized Tomography(CT) scanning is another diagnostic method that provides patient’s 3D anatomical information. Howe... X-ray imaging is the conventional method for diagnosing the orthopedic condition of a patient. Computerized Tomography(CT) scanning is another diagnostic method that provides patient’s 3D anatomical information. However, both methods have limitations when diagnosing the whole leg; X-ray imaging does not provide 3D information, and normal CT scanning cannot be performed with a standing posture. Obtaining 3D data regarding the whole leg in a standing posture is clinically important because it enables 3D analysis in the weight bearing condition.Based on these clinical needs, a hardware-based bi-plane X-ray imaging system has been developed; it uses two orthogonal X-ray images. However, such methods have not been made available in general clinics because of the hight cost. Therefore, we proposed a widely adaptive method for 2 D X-ray image and 3D CT scan data. By this method, it is possible to threedimensionally analyze the whole leg in standing posture. The optimal position that generates the most similar image is the captured X-ray image. The algorithm verifies the similarity using the performance of the proposed method by simulation-based experiments. Then, we analyzed the internal-external rotation angle of the femur using real patient data. Approximately 10.55 degrees of internal rotations were found relative to the defined anterior-posterior direction. In this paper, we present a useful registration method using the conventional X-ray image and 3D CT scan data to analyze the whole leg in the weight-bearing condition. 展开更多
关键词 2d-3d registration 3d analysis X-RAY CT simulated annealing
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Synthesis,Bioactivity and Crystal Structure Analysis of Novel Benzo[d]isothiazol-3(2H)-ones 被引量:7
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作者 王向辉 林强 +2 位作者 尹学琼 游诚航 杨建新 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第8期1170-1174,共5页
Two compounds,3-oxo-N-o-tolylbenzo[d]isothiazole-2(3H)-carboxamide (1) and N-(2-methoxyphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide (2),were synthesized from the initial compound benzo[d]isothiazol-3... Two compounds,3-oxo-N-o-tolylbenzo[d]isothiazole-2(3H)-carboxamide (1) and N-(2-methoxyphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide (2),were synthesized from the initial compound benzo[d]isothiazol-3(2H)-one (BIT) and characterized by 1 H NMR,IR and elemental analysis,respectively.The single crystals of compounds 1 and 2 were obtained and determined by X-ray diffraction analysis.The preliminary results of biological activity experiment show that some of the title compounds exhibited a favorable antimicrobial activity. 展开更多
关键词 benzo[d]isothiazol-32H)-one (BIT) crystal structure antimicrobial activity
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A new method to create depth information based on lighting analysis for 2D/3D conversion 被引量:1
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作者 Hyunho Han Gangseong Lee +2 位作者 Jongyong Lee Jinsoo Kim Sanghun Lee 《Journal of Central South University》 SCIE EI CAS 2013年第10期2715-2719,共5页
A new method creating depth information for 2D/3D conversion was proposed. The distance between objects is determined by the distances between objects and light source position which is estimated by the analysis of th... A new method creating depth information for 2D/3D conversion was proposed. The distance between objects is determined by the distances between objects and light source position which is estimated by the analysis of the image. The estimated lighting value is used to normalize the image. A threshold value is determined by some weighted operation between the original image and the normalized image. By applying the threshold value to the original image, background area is removed. Depth information of interested area is calculated from the lighting changes. The final 3D images converted with the proposed method are used to verify its effectiveness. 展开更多
关键词 LIGHTING analysis depth INFORMATION focus/defocus INFORMATION 2d/3d CONVERSION
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Three-dimensional visualization helps surgoens to make surgical decision:The 3D-ViDru trial-a randomized trial
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作者 Esther Giehl-Brown Frederic Konrad +5 位作者 Steffen Löck Johannes Schweipert Felix Schön Jens-Peter Kühn Jürgen Weitz Carina Riediger 《Hepatobiliary & Pancreatic Diseases International》 2026年第1期52-61,共10页
Background:Successful liver resection in oncologic surgery depends on safety,precision,and efficacy,all of which require a thorough understanding of liver anatomy.Contrast-enhanced computed tomography(CT)-generated th... Background:Successful liver resection in oncologic surgery depends on safety,precision,and efficacy,all of which require a thorough understanding of liver anatomy.Contrast-enhanced computed tomography(CT)-generated three-dimensional(3D)models have been proposed as a valuable tool to enhance this understanding.However,a systematic comparison of different display modalities across professional groups has not yet been performed.Methods:In this prospective,monocentric randomized trial,we compared high-resolution twodimensional(2D)CT images of liver malignancies with their corresponding standardized,non-colored 3D virtual and printed models in facilitating anatomical and spatial understanding as well as surgical decision-making.A total of 91 participants,including 40 surgeons,10 radiologists,and 41 students,evaluated six clinical cases(three centrally and three peripherally located liver malignancies).Each participant assessed one central and one peripheral case per display modality,presented in a random order.Results:Compared to 2D CT images,both 3D virtual and printed models significantly improved the identification of tumor location(P<0.001),enhanced the comprehension of spatial relationships with adjacent liver and portal veins(P<0.001 and P=0.019,respectively),and facilitated clinical decisionmaking(P<0.001).No significant difference was observed between virtual and printed models in terms of effectiveness.Within the different groups,surgeons and students,but not radiologists,more accurately identified tumor location and spatial relationships with adjacent liver and portal veins using 3D models.Subjectively,most surgeons and students preferred 3D printed models over virtual models and 2D CT images.Conclusions:This study demonstrated that standardized,non-colored 3D virtual and printed models equally help preoperative anatomical understanding and decision-making,particularly for surgeons and students.By isolating the influence of display modality,our findings clarify prior inconsistent results and support the integration of cost-effective 3D visualization by applying virtual models into surgical planning and education.Preference for printed models despite comparable efficacy highlights the importance of user-centered implementation strategies. 展开更多
关键词 High-resolution 2d CT images 3d virtual models 3d printed models Surgical oncology Liver surgery Surgical decision-making
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Differentiating the 2D Passivation from Amorphous Passivation in Perovskite Solar Cells
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作者 Xiaojian Zheng Shehzad Ahmed +12 位作者 Yu Zhang Guoqiang Xu Junyu Wang Di Lu Tingshu Shi Jun Tang Lei Yan Wei Chen Peigang Han Zhixin Liu Danish Khan Xingzhu Wang Zeguo Tang 《Nano-Micro Letters》 2026年第2期631-643,共13页
The introduction of two-dimensional(2D)perovskite layers on top of three-dimensional(3D)perovskite films enhances the performance and stability of perovskite solar cells(PSCs).However,the electronic effect of the spac... The introduction of two-dimensional(2D)perovskite layers on top of three-dimensional(3D)perovskite films enhances the performance and stability of perovskite solar cells(PSCs).However,the electronic effect of the spacer cation and the quality of the 2D capping layer are critical factors in achieving the required results.In this study,we compared two fluorinated salts:4-(trifluoromethyl)benzamidine hydrochloride(4TF-BA·HCl)and 4-fluorobenzamidine hydrochloride(4F-BA·HCl)to engineer the 3D/2D perovskite films.Surprisingly,4F-BA formed a high-performance 3D/2D heterojunction,while4TF-BA produced an amorphous layer on the perovskite films.Our findings indicate that the balanced intramolecular charge polarization,which leads to effective hydrogen bonding,is more favorable in 4F-BA than in 4TF-BA,promoting the formation of a crystalline 2D perovskite.Nevertheless,4TF-BA managed to improve efficiency to 24%,surpassing the control device,primarily due to the natural passivation capabilities of benzamidine.Interestingly,the devices based on 4F-BA demonstrated an efficiency exceeding 25%with greater longevity under various storage conditions compared to 4TF-BA-based and the control devices. 展开更多
关键词 3d/2d perovskite films Benzamidine Amorphous passivation 2d passivation Inverted perovskite solar cells
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