9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB int...9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB into point-set topology problem in terms of the intersections ofA’s boundary (?A), interior (A 0) and (A ?) withB’s boundary (?B), interior (B 0) and exterior (B ?). It is shown in this paper that there exist some limitations of the original 9-intersection model due to its definition of an object’s exterior as its complement, and it is difficult to distinguish different disjoint relations and relations between complex objects with holes, difficult or even impossible to compute the intersections with the two object’s complements (?A∩B ?,A 0∩?B ?,A ?∩?B,A ?∩B 0 andA ?∩B ?)since the complements are infinitive. The authors suggest to re-define the exterior of spatial object by replacing the complement with its Voronoi region. A new Voronoi-based 9-intersection (VNI) is proposed and used for formalizing topological relations between spatial bojects. By improving the 9-intersection model, it is now possible to distinguish disjoint relations and to deal with objects with holes. Also it is possible to compute the exterior-based intersections and manipulate spatial relations with the VNI.展开更多
目的:探讨与分析妊娠期高血压(Hypertensive Disorders in Pregnancy,HDP)孕妇血清25-羟维生素D3(25-OH-D3)水平与胰岛素抵抗的相关性。方法:2021年4月至2023年7月选择在本院妇产科进行建档保健的孕妇122例作为研究对象,依据血压情况分...目的:探讨与分析妊娠期高血压(Hypertensive Disorders in Pregnancy,HDP)孕妇血清25-羟维生素D3(25-OH-D3)水平与胰岛素抵抗的相关性。方法:2021年4月至2023年7月选择在本院妇产科进行建档保健的孕妇122例作为研究对象,依据血压情况分为妊娠期高血压组42例与非妊娠期高血压组80例。检测所有孕妇的血清25-OH-D3含量,计算胰岛素抵抗相关指标-胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)并进行相关性分析。结果:妊娠期高血压组的血清25-OH-D3含量与非妊娠期高血压组对比降低(P<0.05)。妊娠期高血压组的胰岛素抵抗指数、胰岛β细胞功能指数显著高于非妊娠期高血压组(P<0.05)。在122例孕妇中,Pearson相关分析显示血清25-OH-D3含量与胰岛素抵抗指数、胰岛β细胞功能指数等都存在相关性(P<0.05)。多因素条件Logistic回归分析显示胰岛素抵抗指数、胰岛β细胞功能指数等为影响妊娠期高血压孕妇血清25-OH-D3水平的重要因素(P<0.05)。结论:妊娠期高血压孕妇多伴随有血清25-OH-D3水平降低与胰岛素抵抗,妊娠期高血压孕妇血清25-OH-D3水平与胰岛素抵抗存在相关性,HOMA-IR、HOMA-β等为影响血清25-OH-D3水平的重要因素。展开更多
目的观察成年期甲状腺功能减退症(简称甲减)大鼠额叶内突触结合蛋白1(Syt-1)及突触相关蛋白SNAP-25(synaptosomal associated protein of 25KD)的改变及左旋甲状腺素(T4)替代治疗后的恢复状况,探讨甲减脑损伤及恢复可能的分子机制。方...目的观察成年期甲状腺功能减退症(简称甲减)大鼠额叶内突触结合蛋白1(Syt-1)及突触相关蛋白SNAP-25(synaptosomal associated protein of 25KD)的改变及左旋甲状腺素(T4)替代治疗后的恢复状况,探讨甲减脑损伤及恢复可能的分子机制。方法药物建立成年期大鼠甲减及治疗模型,放射免疫法测定血清甲状腺激素水平,Western blot法观察Syt-1和SNAP-25在大鼠额叶的表达。结果与对照组相比,甲减组大鼠血清T3、T4水平显著降低(P<0.05),额叶突触小体内Syt-1的表达水平显著低于对照组,SNAP-25的表达水平显著高于对照组(P<0.05);T4替代治疗组与对照组比较血清T3、T4无统计学差异;Syt-1及SNAP-25的表达无统计学差异(P>0.05)。结论成年期甲减大鼠额叶内Syt-1表达减少,SNAP-25表达增加,甲状腺素治疗能使其恢复。展开更多
基金Project supported by the National Natural Science Foundation of China(No.49471059)
文摘9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB into point-set topology problem in terms of the intersections ofA’s boundary (?A), interior (A 0) and (A ?) withB’s boundary (?B), interior (B 0) and exterior (B ?). It is shown in this paper that there exist some limitations of the original 9-intersection model due to its definition of an object’s exterior as its complement, and it is difficult to distinguish different disjoint relations and relations between complex objects with holes, difficult or even impossible to compute the intersections with the two object’s complements (?A∩B ?,A 0∩?B ?,A ?∩?B,A ?∩B 0 andA ?∩B ?)since the complements are infinitive. The authors suggest to re-define the exterior of spatial object by replacing the complement with its Voronoi region. A new Voronoi-based 9-intersection (VNI) is proposed and used for formalizing topological relations between spatial bojects. By improving the 9-intersection model, it is now possible to distinguish disjoint relations and to deal with objects with holes. Also it is possible to compute the exterior-based intersections and manipulate spatial relations with the VNI.
文摘目的:探讨与分析妊娠期高血压(Hypertensive Disorders in Pregnancy,HDP)孕妇血清25-羟维生素D3(25-OH-D3)水平与胰岛素抵抗的相关性。方法:2021年4月至2023年7月选择在本院妇产科进行建档保健的孕妇122例作为研究对象,依据血压情况分为妊娠期高血压组42例与非妊娠期高血压组80例。检测所有孕妇的血清25-OH-D3含量,计算胰岛素抵抗相关指标-胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)并进行相关性分析。结果:妊娠期高血压组的血清25-OH-D3含量与非妊娠期高血压组对比降低(P<0.05)。妊娠期高血压组的胰岛素抵抗指数、胰岛β细胞功能指数显著高于非妊娠期高血压组(P<0.05)。在122例孕妇中,Pearson相关分析显示血清25-OH-D3含量与胰岛素抵抗指数、胰岛β细胞功能指数等都存在相关性(P<0.05)。多因素条件Logistic回归分析显示胰岛素抵抗指数、胰岛β细胞功能指数等为影响妊娠期高血压孕妇血清25-OH-D3水平的重要因素(P<0.05)。结论:妊娠期高血压孕妇多伴随有血清25-OH-D3水平降低与胰岛素抵抗,妊娠期高血压孕妇血清25-OH-D3水平与胰岛素抵抗存在相关性,HOMA-IR、HOMA-β等为影响血清25-OH-D3水平的重要因素。
文摘目的观察成年期甲状腺功能减退症(简称甲减)大鼠额叶内突触结合蛋白1(Syt-1)及突触相关蛋白SNAP-25(synaptosomal associated protein of 25KD)的改变及左旋甲状腺素(T4)替代治疗后的恢复状况,探讨甲减脑损伤及恢复可能的分子机制。方法药物建立成年期大鼠甲减及治疗模型,放射免疫法测定血清甲状腺激素水平,Western blot法观察Syt-1和SNAP-25在大鼠额叶的表达。结果与对照组相比,甲减组大鼠血清T3、T4水平显著降低(P<0.05),额叶突触小体内Syt-1的表达水平显著低于对照组,SNAP-25的表达水平显著高于对照组(P<0.05);T4替代治疗组与对照组比较血清T3、T4无统计学差异;Syt-1及SNAP-25的表达无统计学差异(P>0.05)。结论成年期甲减大鼠额叶内Syt-1表达减少,SNAP-25表达增加,甲状腺素治疗能使其恢复。
