等级保护2.0(以下简称“等保2.0”)对数据中心信息安全架构提出了合规与技术要求。文章构建四层联动架构模型,涵盖网络安全、计算环境、应用数据与安全运营4个层面,通过引入零信任访问控制、虚拟化隔离机制、数据全生命周期防护及安全...等级保护2.0(以下简称“等保2.0”)对数据中心信息安全架构提出了合规与技术要求。文章构建四层联动架构模型,涵盖网络安全、计算环境、应用数据与安全运营4个层面,通过引入零信任访问控制、虚拟化隔离机制、数据全生命周期防护及安全编排自动化响应(Security Orchestration Automation and Response,SOAR)机制,提出了一套面向等保2.0的优化实施方案。实验结果表明,优化架构在检测率、响应效率、资源占用等关键指标上相较传统架构均有显著提升。因此,优化架构具备良好的工程适配性与合规落地能力。展开更多
Long-term exposure to ambient fine particulate matter(PM2.5)may increase the risk of neurotoxicity in human populations.However,research studies on the underlying mechanisms of chronic PM2.5-induced depression-like be...Long-term exposure to ambient fine particulate matter(PM2.5)may increase the risk of neurotoxicity in human populations.However,research studies on the underlying mechanisms of chronic PM2.5-induced depression-like behaviors,and potential therapeutical strategies,remain scarce.In the present study,after long-term exposure to real-world PM2.5 for 15 weeks,male mice displayed depression-like behaviors,which were revealed using the open field and sucrose preference tests.Mechanistically,chronic PM2.5 exposure promoted astrocytic A1 polarization and disrupted reduction-oxidation balance in the mouse hippocampus.Furthermore,PM2.5-exposed mice displayed pathological damage to hippocampal neurons as well as the inhibition of nuclear factor erythroid 2-related factor 2 signaling.Astrocytic ablation of nuclear factor erythroid 2-related factor 2 exacerbated PM2.5-induced hippocampal neuronal injury in mice via the disruption of astrocyte-to-microglia communication;this finding was confirmed in mice with bilateral and unilateral hippocampal astrocytic Nfe2l2 knockdown.Importantly,the upregulation of nuclear factor erythroid 2-related factor 2 activation by procyanidin significantly ameliorated PM2.5-induced depression-like behaviors through the remodeling of astrocyte-to-microglia communication.Together,our findings shed light on the important role of hippocampal astrocytic nuclear factor erythroid 2-related factor 2 activation for maintaining astrocyte-to-microglia communication,and indicate potential research avenues for therapeutic strategies against PM2.5-induced depresson-like behaviors.展开更多
Web 2.0的出现使信息构建(IA)的内容发生了深刻变化,IA已进入"信息构建2.0"(IA2.0)阶段。在IA2.0阶段,IA作为一门学科、一种角色和一类社团的协调统一体而存在,它强调真正"以用户为中心"和"丰富的用户体验&qu...Web 2.0的出现使信息构建(IA)的内容发生了深刻变化,IA已进入"信息构建2.0"(IA2.0)阶段。在IA2.0阶段,IA作为一门学科、一种角色和一类社团的协调统一体而存在,它强调真正"以用户为中心"和"丰富的用户体验"的核心理念,以满足新环境下的用户需求。Web2.0网站的IA,是IA2.0的典型应用,也是IA2.0阶段研究的主要内容,本文将其称为网站IA2.0。文中设计了一个网站IA2.0模型,并进行了简单的实例分析。展开更多
Strained bridged rings bicyclo[3.2.1]octane and tricyclo[3.2.1.0^(2,7)]octane are prevalent in natural products known for their significant biological activities.However,strategies for efficiently synthesizing these c...Strained bridged rings bicyclo[3.2.1]octane and tricyclo[3.2.1.0^(2,7)]octane are prevalent in natural products known for their significant biological activities.However,strategies for efficiently synthesizing these complex frameworks from simple starting materials via de novo synthesis remain underexplored.This article presents an efficient strategy that combines phosphine catalysis and photocatalysis to execute a stepwise tandem reaction involving allenoates and α-cyano cinnamaldehydes,including[3+2]cyclization,[5+2]cyclization,acyl transfer,and decarboxylation reactions,synthesizing a series of functional bicyclo[3.2.1]octa-2,6-diene and tricyclo[3.2.1.0^(2,7)]oct-3-ene skeleton derivatives with excellent chemoselectivity demonstrated throughout the process.Meanwhile,the reaction can also be performed via a onepot,scalable phosphine/photocatalytic cascade process,efficiently yielding the bridged products which can serve as versatile intermediates for further applications.展开更多
系统探讨一点到多点连接(point to multi-point,P2MP)2.0技术在政企专线领域的全流程应用。通过构建分层架构设计,开发动态带宽分配模型,并在某市政务云专网开展实证验证。结果显示,带宽利用率达92.3%,传输延迟稳定在18.7 ms,故障恢复...系统探讨一点到多点连接(point to multi-point,P2MP)2.0技术在政企专线领域的全流程应用。通过构建分层架构设计,开发动态带宽分配模型,并在某市政务云专网开展实证验证。结果显示,带宽利用率达92.3%,传输延迟稳定在18.7 ms,故障恢复时间缩短至4.2 min,综合效能指数(Ec)达93.5。研究证实该技术可有效解决政企专线的高并发、低延迟与安全可靠传输需求,为数字化转型提供关键技术支撑。展开更多
文摘等级保护2.0(以下简称“等保2.0”)对数据中心信息安全架构提出了合规与技术要求。文章构建四层联动架构模型,涵盖网络安全、计算环境、应用数据与安全运营4个层面,通过引入零信任访问控制、虚拟化隔离机制、数据全生命周期防护及安全编排自动化响应(Security Orchestration Automation and Response,SOAR)机制,提出了一套面向等保2.0的优化实施方案。实验结果表明,优化架构在检测率、响应效率、资源占用等关键指标上相较传统架构均有显著提升。因此,优化架构具备良好的工程适配性与合规落地能力。
基金National Basic Research Plan Project of China,No.2023YFC3708303the National Natural Science Foundation of China,No.82241084the High-level Talent in Public Health of Beijing,No.Discipline Leaders-03-29(all to XL).
文摘Long-term exposure to ambient fine particulate matter(PM2.5)may increase the risk of neurotoxicity in human populations.However,research studies on the underlying mechanisms of chronic PM2.5-induced depression-like behaviors,and potential therapeutical strategies,remain scarce.In the present study,after long-term exposure to real-world PM2.5 for 15 weeks,male mice displayed depression-like behaviors,which were revealed using the open field and sucrose preference tests.Mechanistically,chronic PM2.5 exposure promoted astrocytic A1 polarization and disrupted reduction-oxidation balance in the mouse hippocampus.Furthermore,PM2.5-exposed mice displayed pathological damage to hippocampal neurons as well as the inhibition of nuclear factor erythroid 2-related factor 2 signaling.Astrocytic ablation of nuclear factor erythroid 2-related factor 2 exacerbated PM2.5-induced hippocampal neuronal injury in mice via the disruption of astrocyte-to-microglia communication;this finding was confirmed in mice with bilateral and unilateral hippocampal astrocytic Nfe2l2 knockdown.Importantly,the upregulation of nuclear factor erythroid 2-related factor 2 activation by procyanidin significantly ameliorated PM2.5-induced depression-like behaviors through the remodeling of astrocyte-to-microglia communication.Together,our findings shed light on the important role of hippocampal astrocytic nuclear factor erythroid 2-related factor 2 activation for maintaining astrocyte-to-microglia communication,and indicate potential research avenues for therapeutic strategies against PM2.5-induced depresson-like behaviors.
基金financial support from National Natural Science Foundation of China(Nos.82374020 and 22401025)Science&Technology Department of Sichuan Province(No.2024NSFTD0023)Xinglin Scholar Research Promotion Project of Chengdu University of TCM。
文摘Strained bridged rings bicyclo[3.2.1]octane and tricyclo[3.2.1.0^(2,7)]octane are prevalent in natural products known for their significant biological activities.However,strategies for efficiently synthesizing these complex frameworks from simple starting materials via de novo synthesis remain underexplored.This article presents an efficient strategy that combines phosphine catalysis and photocatalysis to execute a stepwise tandem reaction involving allenoates and α-cyano cinnamaldehydes,including[3+2]cyclization,[5+2]cyclization,acyl transfer,and decarboxylation reactions,synthesizing a series of functional bicyclo[3.2.1]octa-2,6-diene and tricyclo[3.2.1.0^(2,7)]oct-3-ene skeleton derivatives with excellent chemoselectivity demonstrated throughout the process.Meanwhile,the reaction can also be performed via a onepot,scalable phosphine/photocatalytic cascade process,efficiently yielding the bridged products which can serve as versatile intermediates for further applications.
文摘系统探讨一点到多点连接(point to multi-point,P2MP)2.0技术在政企专线领域的全流程应用。通过构建分层架构设计,开发动态带宽分配模型,并在某市政务云专网开展实证验证。结果显示,带宽利用率达92.3%,传输延迟稳定在18.7 ms,故障恢复时间缩短至4.2 min,综合效能指数(Ec)达93.5。研究证实该技术可有效解决政企专线的高并发、低延迟与安全可靠传输需求,为数字化转型提供关键技术支撑。
