Objectives To study the change in plasma hemoglobin concentration in elderly patients with primary hypertension and/or type 2 diabetes complicated with end-stage renal disease （ESRD） determined by estimated glomerul...Objectives To study the change in plasma hemoglobin concentration in elderly patients with primary hypertension and/or type 2 diabetes complicated with end-stage renal disease （ESRD） determined by estimated glomerular filtration rate. Methods Two hundred and thirty cases of Chinese patients aged 60 years or older with primary hypertension and/or type 2 diabetes complicated with chronic kidney disease were enrolled in the study. Patients with chronic kidney disease were divided into ESRD group with estimated glomemlar filtration rate less than 15 mL . min^-1.1.73 m^-2 （7.80 ± 3. 14 mL. min^-1 . 1.73 m^-2） and non-ESRD group with estimated glomerular filtration rate 15 mL.min^-1 . 1.73 m^-2（29. 76 ± 12. 90 mL.min^-1 . 1.73 m^-2） or higher. The plasma hemoglobin concentration was compared between the above two groups retrospectively. Results There was significant decrease in plasma hemoglobin concentration in ESRD group compared with non-ESRD group （74.4 ± 22. 5 g/L vs 100. 8 ± 23.0 g/L, P 〈 0. 05 ）. After stratification by sex, there was also significant decrease in plasma hemoglobin concentration both in male and female of ESRD groups compared with their respective non-ESRD groups（77. 2±22. 0 g/L vs 104. 9 ±20. 7 g/L; 69. 7 ±22. 8 g/L vs 96.4± 24.8 g/L, P 〈 0. 05, respectively）. Plasma hemoglobin concentration was positively related to estimated glomerular filtration rate significantly in patients with ESRD （ P 〈 0. 05 ）. Conclusions Plasma hemoglobin concentration is decreased significantly, and is positively related to estimated glomerular filtration rate significantly in elderly patients with primary hypertension and/or type 2 diabetes complicated with ESRD determined by estimated glomerular filtration rate.展开更多
目的:探讨糖尿病视网膜病变(DR)患者血清中沉默信息调节因子2相关酶1(SIRT1)、血管生长抑制因子-2(Vasostatin-2)含量与病变的相关性分析。方法:选取2021年4月至2024年4月本院收治的DR患者104例104眼即为DR组,根据不同病变分期分为非增...目的:探讨糖尿病视网膜病变(DR)患者血清中沉默信息调节因子2相关酶1(SIRT1)、血管生长抑制因子-2(Vasostatin-2)含量与病变的相关性分析。方法:选取2021年4月至2024年4月本院收治的DR患者104例104眼即为DR组,根据不同病变分期分为非增殖性DR(NPDR)组44例44眼和增殖性DR(PDR)组60例60眼。同期收治单纯糖尿病患者104例104眼为非DR组。采用ELISA法检测血清中SIRT1、Vasostatin-2水平。ROC曲线分析血清SIRT1、Vasostatin-2水平对DR的诊断价值。多因素Logistic回归分析影响DR发生的因素。Pearson相关性分析分析DR患者血清中SIRT1、Vasostatin-2含量与血管生成指标(VEGF、Ang-2)的关系。结果:与非DR组相比,DR组患者血清中SIRT1、Vasostatin-2水平均显著降低(P<0.05)。与NPDR组相比,PDR组患者血清中SIRT1、Vasostatin-2水平均显著降低(P<0.05)。与非DR组相比,DR组患者血清中VEGF、Ang-2水平均显著升高(P<0.05)。与血清SIRT1、Vasostatin-2水平单独检测相比,联合检测对DR诊断的AUC显著升高(Z=4.180、5.128,均P<0.05)。多因素Logistic回归分析显示,HOMA-IR(OR=3.455)、空腹血糖(OR=1.467)、SIRT1(OR=0.836)、Vasostatin-2(OR=0.767)、VEGF(OR=2.564)、Ang-2(OR=1.834)水平是DR发生的影响因素(均P<0.05)。Pearson相关性分析显示,DR患者血清中SIRT1、Vasostatin-2含量与VEGF、Ang-2均呈负相关关系(r SIRT1 vs VEGF=-0.395、r SIRT1 vs Ang-2=-0.474、r Vasostatin-2 vs VEGF=-0.323、r Vasostatin-2 vs Ang-2=-0.583,均P<0.001)。结论:DR患者血清SIRT1、Vasostatin-2水平异常降低,与DR病变分期及血管生成密切相关。展开更多
基金supported by the medical science & technology research fund of Health Bureau of Chongqing City, China(No.2004(53)04-2-154)the natural science research fund of Chongqing Science & Technology Commission in Chongqing City, China(No.CSTC,2007BB5276)
文摘Objectives To study the change in plasma hemoglobin concentration in elderly patients with primary hypertension and/or type 2 diabetes complicated with end-stage renal disease （ESRD） determined by estimated glomerular filtration rate. Methods Two hundred and thirty cases of Chinese patients aged 60 years or older with primary hypertension and/or type 2 diabetes complicated with chronic kidney disease were enrolled in the study. Patients with chronic kidney disease were divided into ESRD group with estimated glomemlar filtration rate less than 15 mL . min^-1.1.73 m^-2 （7.80 ± 3. 14 mL. min^-1 . 1.73 m^-2） and non-ESRD group with estimated glomerular filtration rate 15 mL.min^-1 . 1.73 m^-2（29. 76 ± 12. 90 mL.min^-1 . 1.73 m^-2） or higher. The plasma hemoglobin concentration was compared between the above two groups retrospectively. Results There was significant decrease in plasma hemoglobin concentration in ESRD group compared with non-ESRD group （74.4 ± 22. 5 g/L vs 100. 8 ± 23.0 g/L, P 〈 0. 05 ）. After stratification by sex, there was also significant decrease in plasma hemoglobin concentration both in male and female of ESRD groups compared with their respective non-ESRD groups（77. 2±22. 0 g/L vs 104. 9 ±20. 7 g/L; 69. 7 ±22. 8 g/L vs 96.4± 24.8 g/L, P 〈 0. 05, respectively）. Plasma hemoglobin concentration was positively related to estimated glomerular filtration rate significantly in patients with ESRD （ P 〈 0. 05 ）. Conclusions Plasma hemoglobin concentration is decreased significantly, and is positively related to estimated glomerular filtration rate significantly in elderly patients with primary hypertension and/or type 2 diabetes complicated with ESRD determined by estimated glomerular filtration rate.
文摘目的:探讨糖尿病视网膜病变(DR)患者血清中沉默信息调节因子2相关酶1(SIRT1)、血管生长抑制因子-2(Vasostatin-2)含量与病变的相关性分析。方法:选取2021年4月至2024年4月本院收治的DR患者104例104眼即为DR组,根据不同病变分期分为非增殖性DR(NPDR)组44例44眼和增殖性DR(PDR)组60例60眼。同期收治单纯糖尿病患者104例104眼为非DR组。采用ELISA法检测血清中SIRT1、Vasostatin-2水平。ROC曲线分析血清SIRT1、Vasostatin-2水平对DR的诊断价值。多因素Logistic回归分析影响DR发生的因素。Pearson相关性分析分析DR患者血清中SIRT1、Vasostatin-2含量与血管生成指标(VEGF、Ang-2)的关系。结果:与非DR组相比,DR组患者血清中SIRT1、Vasostatin-2水平均显著降低(P<0.05)。与NPDR组相比,PDR组患者血清中SIRT1、Vasostatin-2水平均显著降低(P<0.05)。与非DR组相比,DR组患者血清中VEGF、Ang-2水平均显著升高(P<0.05)。与血清SIRT1、Vasostatin-2水平单独检测相比,联合检测对DR诊断的AUC显著升高(Z=4.180、5.128,均P<0.05)。多因素Logistic回归分析显示,HOMA-IR(OR=3.455)、空腹血糖(OR=1.467)、SIRT1(OR=0.836)、Vasostatin-2(OR=0.767)、VEGF(OR=2.564)、Ang-2(OR=1.834)水平是DR发生的影响因素(均P<0.05)。Pearson相关性分析显示,DR患者血清中SIRT1、Vasostatin-2含量与VEGF、Ang-2均呈负相关关系(r SIRT1 vs VEGF=-0.395、r SIRT1 vs Ang-2=-0.474、r Vasostatin-2 vs VEGF=-0.323、r Vasostatin-2 vs Ang-2=-0.583,均P<0.001)。结论:DR患者血清SIRT1、Vasostatin-2水平异常降低,与DR病变分期及血管生成密切相关。
