This paper focuses on the 2-median location improvement problem on tree networks and the problem is to modify the weights of edges at the minimum cost such that the overall sum of the weighted distance of the vertices...This paper focuses on the 2-median location improvement problem on tree networks and the problem is to modify the weights of edges at the minimum cost such that the overall sum of the weighted distance of the vertices to the respective closest one of two prescribed vertices in the modified network is upper bounded by a given value.l1 norm and l∞norm are used to measure the total modification cost. These two problems have a strong practical application background and important theoretical research value. It is shown that such problems can be transformed into a series of sum-type and bottleneck-type continuous knapsack problems respectively.Based on the property of the optimal solution two O n2 algorithms for solving the two problems are proposed where n is the number of vertices on the tree.展开更多
目的探讨妊娠期抑郁症对大鼠中缝核色氨酸羟化酶2(TPH2)表达的影响。方法选取月龄、体质量相近的Wistar大鼠,合笼受孕后将孕鼠随机分为实验组、对照组。实验组给予18 d慢性不可预见性的温和应激(CUMS)制备妊娠期抑郁症大鼠模型,对照组...目的探讨妊娠期抑郁症对大鼠中缝核色氨酸羟化酶2(TPH2)表达的影响。方法选取月龄、体质量相近的Wistar大鼠,合笼受孕后将孕鼠随机分为实验组、对照组。实验组给予18 d慢性不可预见性的温和应激(CUMS)制备妊娠期抑郁症大鼠模型,对照组在正常条件下饲养。采用旷场实验和1%蔗糖水偏爱实验对大鼠进行行为学评分,采用免疫组化SP法测定大鼠中缝核TPH2的表达。结果 18 d CUMS后,实验组大鼠旷场实验评分、蔗糖水消耗实验结果及中缝核TPH2表达量低于对照组(P均<0.01)。实验组大鼠18 d CUMS前后水平运动得分差与TPH2表达量呈负相关(r=-0.71),垂直运动得分差与TPH2表达量呈负相关(r=-0.74),中央格停留时间差与TPH2表达量呈正相关(r=0.64),蔗糖水消耗量差与TPH2表达量呈负相关(r=-0.69)。结论妊娠期抑郁症模型大鼠中缝核TPH2表达量下降可能与妊娠期抑郁症的发生有关。展开更多
目的以Meta分析的方法定量评估HER-2/neu基因扩增/或表达增强状态与上皮性卵巢癌患者手术后的中位生存期和5年生存率的关联性。方法检索、筛选1989年以来所有论述HER-2/neu状态与患者预后关系的中、英文回顾性研究文献。在Ludwig中心符...目的以Meta分析的方法定量评估HER-2/neu基因扩增/或表达增强状态与上皮性卵巢癌患者手术后的中位生存期和5年生存率的关联性。方法检索、筛选1989年以来所有论述HER-2/neu状态与患者预后关系的中、英文回顾性研究文献。在Ludwig中心符号轶(Centered signed rank)和DerSimonian-Laird等方法基础上对各研究提供的生存数据进行统计分析。结果共纳入25篇文献,3251例患者。HER-2/neu表达率为27.1%[95%CI(0,54.8%)],与病理分期、分型和分级无关。HER-2/neu阳性者中位生存期平均减少0.65年,5年生存率下降[HR=1.22,95%CI(1.09,1.36)]。亚组分析显示,HER-2/neu蛋白表达与预后关系最明确,强阳性者5年内死亡风险增加,且对铂类化疗药物的反应性减低。结论在妇科肿瘤临床中,将HER-2/neu作为常规的病理指标使用,有助于进行合理的预后评估,并制定个体化化疗方案。展开更多
基金The National Natural Science Foundation of China(No.10801031)
文摘This paper focuses on the 2-median location improvement problem on tree networks and the problem is to modify the weights of edges at the minimum cost such that the overall sum of the weighted distance of the vertices to the respective closest one of two prescribed vertices in the modified network is upper bounded by a given value.l1 norm and l∞norm are used to measure the total modification cost. These two problems have a strong practical application background and important theoretical research value. It is shown that such problems can be transformed into a series of sum-type and bottleneck-type continuous knapsack problems respectively.Based on the property of the optimal solution two O n2 algorithms for solving the two problems are proposed where n is the number of vertices on the tree.
文摘目的探讨妊娠期抑郁症对大鼠中缝核色氨酸羟化酶2(TPH2)表达的影响。方法选取月龄、体质量相近的Wistar大鼠,合笼受孕后将孕鼠随机分为实验组、对照组。实验组给予18 d慢性不可预见性的温和应激(CUMS)制备妊娠期抑郁症大鼠模型,对照组在正常条件下饲养。采用旷场实验和1%蔗糖水偏爱实验对大鼠进行行为学评分,采用免疫组化SP法测定大鼠中缝核TPH2的表达。结果 18 d CUMS后,实验组大鼠旷场实验评分、蔗糖水消耗实验结果及中缝核TPH2表达量低于对照组(P均<0.01)。实验组大鼠18 d CUMS前后水平运动得分差与TPH2表达量呈负相关(r=-0.71),垂直运动得分差与TPH2表达量呈负相关(r=-0.74),中央格停留时间差与TPH2表达量呈正相关(r=0.64),蔗糖水消耗量差与TPH2表达量呈负相关(r=-0.69)。结论妊娠期抑郁症模型大鼠中缝核TPH2表达量下降可能与妊娠期抑郁症的发生有关。
文摘目的以Meta分析的方法定量评估HER-2/neu基因扩增/或表达增强状态与上皮性卵巢癌患者手术后的中位生存期和5年生存率的关联性。方法检索、筛选1989年以来所有论述HER-2/neu状态与患者预后关系的中、英文回顾性研究文献。在Ludwig中心符号轶(Centered signed rank)和DerSimonian-Laird等方法基础上对各研究提供的生存数据进行统计分析。结果共纳入25篇文献,3251例患者。HER-2/neu表达率为27.1%[95%CI(0,54.8%)],与病理分期、分型和分级无关。HER-2/neu阳性者中位生存期平均减少0.65年,5年生存率下降[HR=1.22,95%CI(1.09,1.36)]。亚组分析显示,HER-2/neu蛋白表达与预后关系最明确,强阳性者5年内死亡风险增加,且对铂类化疗药物的反应性减低。结论在妇科肿瘤临床中,将HER-2/neu作为常规的病理指标使用,有助于进行合理的预后评估,并制定个体化化疗方案。
