Let F be an algebraically closed field of characteristic zero, and L be a basic classical Lie superalgebra except A（n, n） over F. In this paper, we prove that every 2-local superderivation on L is a superderivation....Let F be an algebraically closed field of characteristic zero, and L be a basic classical Lie superalgebra except A（n, n） over F. In this paper, we prove that every 2-local superderivation on L is a superderivation. Furthermore, we give an example to show that a subalgebra of spl（2, 2） admits a 2-local superderivation which is not a superderivation.展开更多
Using the theory of derivations on finitely generated and graded Lie algebras, we determine that derivations of the BMS-Weyl algebra are all inner. On this basis, it is proved that every 2-local derivation of the BMS-...Using the theory of derivations on finitely generated and graded Lie algebras, we determine that derivations of the BMS-Weyl algebra are all inner. On this basis, it is proved that every 2-local derivation of the BMS-Weyl algebra is a derivation.展开更多
Let G be a basic classical Lie superalgebra except A(n, n) and D(2, 1, α) over the complex number field C. Using existence of a non-degenerate invariant bilinear form and root space decomposition, we prove that every...Let G be a basic classical Lie superalgebra except A(n, n) and D(2, 1, α) over the complex number field C. Using existence of a non-degenerate invariant bilinear form and root space decomposition, we prove that every 2-local automorphism on G is an automorphism. Furthermore, we give an example of a 2-local automorphism which is not an automorphism on a subalgebra of Lie superalgebra spl(3, 3).展开更多
目的:联会复合体蛋白2(synaptonemal complex protein 2,SYCP2)是一种睾丸癌相关蛋白质,在多种生殖道恶性肿瘤中呈异常表达,并可能与卵巢癌和乳腺癌化学治疗反应相关。目前,有关SYCP2与局部晚期宫颈癌(locally advanced cervical cancer...目的:联会复合体蛋白2(synaptonemal complex protein 2,SYCP2)是一种睾丸癌相关蛋白质,在多种生殖道恶性肿瘤中呈异常表达,并可能与卵巢癌和乳腺癌化学治疗反应相关。目前,有关SYCP2与局部晚期宫颈癌(locally advanced cervical cancer,LACC)患者新辅助化疗(neoadjuvant chemotherapy,NACT)疗效的相关性研究仍显不足。本研究旨在探讨LACC患者SYCP2表达水平与NACT疗效的关系。方法:选取2021年6月至2024年6月郑州大学第一附属医院、第二附属医院及第三附属医院收治的87例LACC患者为研究对象,并根据患者病理组织切片中SYCP2表达将其分为SYCP2高表达组(n=46)和SYCP2低表达组(n=41)。2组患者术前均接受2个周期的NACT。比较2组患者化学治疗后的近期疗效(客观缓解率)、化学治疗前后血清鳞状上皮细胞癌抗原(squamous cell carcinoma antigen,SCCA)水平变化、生活质量[欧洲癌症研究与治疗组织生活质量核心问卷(European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30,EORTC QLQ-C30)]及不良反应发生情况。结果:免疫组织化学结果显示,正常宫颈组织中SYCP2呈阴性表达,LACC患者肿瘤组织中SYCP2呈阳性表达。SYCP2低表达组患者客观缓解率为80.49%,高于SYCP2高表达组患者的60.87%,差异有统计学意义(P<0.05)。治疗后,2组患者血清SCCA水平均降低,且SYCP2低表达组患者血清SCCA水平低于SYCP2高表达组患者,差异均有统计学意义(均P<0.001)。治疗后,2组患者EORTC QLQ-C30评分均提高,且SYCP2低表达组患者EORTC QLQ-C30评分高于SYCP2高表达组患者,差异均有统计学意义(均P<0.001)。SYCP2低表达组和SYCP2高表达组患者治疗期间Ⅲ~Ⅳ级不良反应发生率分别为36.59%(15/41)和36.96%(17/46),差异无统计学意义(χ^(2)=0.001,P=0.971)。结论:与SYCP2低表达LACC患者相比,LACC患者SYCP2高表达与NACT客观缓解率较低、化学治疗后血清SCCA水平较高及生活质量较低相关,SYCP2或可作为预测LACC患者NACT疗效的潜在分子标志物。展开更多
深部咸水含水层具有巨大的CO_(2)封存潜力,研究致密砂岩CO_(2)-水两相驱替机制对实现高效安全的CO_(2)咸水层封存具有重要意义。对两个具有不同孔隙结构特征的低渗透砂岩开展了CO_(2)-水两相驱替试验,利用核磁共振(nuclear magnetic res...深部咸水含水层具有巨大的CO_(2)封存潜力,研究致密砂岩CO_(2)-水两相驱替机制对实现高效安全的CO_(2)咸水层封存具有重要意义。对两个具有不同孔隙结构特征的低渗透砂岩开展了CO_(2)-水两相驱替试验,利用核磁共振(nuclear magnetic resonance,NMR)和磁共振成像(magnetic resonance imaging,MRI)技术对气驱和吸水两个阶段气水两相的分布进行了定量及可视化研究,分析了岩芯孔径分布、非均质性及渗透率差异等对两相驱替特征的影响机制。研究表明在气驱阶段CO_(2)相优先被捕获在较大的孔隙中,大孔分布较多的岩芯表现出更高的CO_(2)饱和度;但在吸水阶段小孔占比更高、渗透率更低的岩芯内捕获的CO_(2)相不易被水驱走,表现出更高的CO_(2)封存效率;岩芯局部渗透率变化对最终的残余气分布影响显著,渗透率较低的区域具有更高的最终残余气饱和度和封存效率。研究可进一步完善CO_(2)咸水含水层封存项目中的储层优选、高效封存以及安全性评估等理论体系。展开更多
In this paper a new approach for PBL simulation, the non-local closure scheme based on the transient turbulence theory has been used. It was set up as an alternative to local closure schemes which physical concept is ...In this paper a new approach for PBL simulation, the non-local closure scheme based on the transient turbulence theory has been used. It was set up as an alternative to local closure schemes which physical concept is reasonable and distinct. A 2-D non-local closure model was developed in order to study the PBL structure and simulatesome interesting atmospheric processes over non-ulliform underlying surface, especially under the convective and unique weather conditions, such as sea-land circulation and the TIBL structure. The modelled results show good agreement with field measurement.展开更多
目的研究粉尘螨主要变应原Der f 2在螨体内的定位。方法采用免疫荧光抗原定位观察。先制备Der f 2单克隆抗体,再制作粉尘螨石蜡切片。切片经二甲苯脱蜡及梯度乙醇脱水,入3%H2O2孵育10 min,PBS漂洗后依次加入单克隆抗体血清37℃孵育1 h...目的研究粉尘螨主要变应原Der f 2在螨体内的定位。方法采用免疫荧光抗原定位观察。先制备Der f 2单克隆抗体,再制作粉尘螨石蜡切片。切片经二甲苯脱蜡及梯度乙醇脱水,入3%H2O2孵育10 min,PBS漂洗后依次加入单克隆抗体血清37℃孵育1 h、生物素标记的羊抗鼠IgG抗体(1∶100)室温孵育60 min、抗生物素蛋白-生物素过氧化物酶-异硫氰酸荧光素复合物(SABC-FITC)(1∶100)室温孵育60 min。PBS漂洗,伊文氏蓝处理切片5min,最后丙三醇封片。用抗重组Der f2单克隆抗体作一抗孵育,再选用抗鼠IgG荧光抗体为二抗,经荧光染色,观察Der f2在螨体内的位置。用正常小鼠血清(1∶100)代替小鼠单克隆抗体血清作为阴性对照。结果粉尘螨Der f2在中肠组织(包括中肠和后肠)和肠内容物均显示较强阳性,特别是肠内容物更明显。结论Der f 2分布于粉尘螨的中肠组织及其肠内容物。展开更多
目的探讨过敏性疾病主要变应原之一德国小蠊Bla g 2的定位。方法制作德国小蠊石蜡切片,在本室克隆、表达和纯化出Bla g 2蛋白的基础上,按常规方法免疫小鼠,分离血清用作一抗,荧光染色后在光镜下观察Bla g 2在虫体内的定位。结果用rBla ...目的探讨过敏性疾病主要变应原之一德国小蠊Bla g 2的定位。方法制作德国小蠊石蜡切片,在本室克隆、表达和纯化出Bla g 2蛋白的基础上,按常规方法免疫小鼠,分离血清用作一抗,荧光染色后在光镜下观察Bla g 2在虫体内的定位。结果用rBla g 2免疫小鼠血清孵育的切片中,中肠肠腔上皮细胞和肠内容物显示强阳性,免疫小鼠血清孵育的粪便颗粒也显示阳性结果。而其生殖、排泄系统等脏器均呈阴性反应。结论本研究发现德国小蠊II类变应原Bla g 2存在于中肠肠腔上皮组织、肠内容物和粪便颗粒中,对进一步进行德国小蠊特异性抗原的分离、纯化及疫苗的研究提供了理论参考。展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.11471090)
文摘Let F be an algebraically closed field of characteristic zero, and L be a basic classical Lie superalgebra except A（n, n） over F. In this paper, we prove that every 2-local superderivation on L is a superderivation. Furthermore, we give an example to show that a subalgebra of spl（2, 2） admits a 2-local superderivation which is not a superderivation.
基金National Natural Science Foundation of China(11971315)。
文摘Using the theory of derivations on finitely generated and graded Lie algebras, we determine that derivations of the BMS-Weyl algebra are all inner. On this basis, it is proved that every 2-local derivation of the BMS-Weyl algebra is a derivation.
基金supported by the National Natural Science Foundation of China(Grant No.11471090)
文摘Let G be a basic classical Lie superalgebra except A(n, n) and D(2, 1, α) over the complex number field C. Using existence of a non-degenerate invariant bilinear form and root space decomposition, we prove that every 2-local automorphism on G is an automorphism. Furthermore, we give an example of a 2-local automorphism which is not an automorphism on a subalgebra of Lie superalgebra spl(3, 3).
文摘目的:联会复合体蛋白2(synaptonemal complex protein 2,SYCP2)是一种睾丸癌相关蛋白质,在多种生殖道恶性肿瘤中呈异常表达,并可能与卵巢癌和乳腺癌化学治疗反应相关。目前,有关SYCP2与局部晚期宫颈癌(locally advanced cervical cancer,LACC)患者新辅助化疗(neoadjuvant chemotherapy,NACT)疗效的相关性研究仍显不足。本研究旨在探讨LACC患者SYCP2表达水平与NACT疗效的关系。方法:选取2021年6月至2024年6月郑州大学第一附属医院、第二附属医院及第三附属医院收治的87例LACC患者为研究对象,并根据患者病理组织切片中SYCP2表达将其分为SYCP2高表达组(n=46)和SYCP2低表达组(n=41)。2组患者术前均接受2个周期的NACT。比较2组患者化学治疗后的近期疗效(客观缓解率)、化学治疗前后血清鳞状上皮细胞癌抗原(squamous cell carcinoma antigen,SCCA)水平变化、生活质量[欧洲癌症研究与治疗组织生活质量核心问卷(European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30,EORTC QLQ-C30)]及不良反应发生情况。结果:免疫组织化学结果显示,正常宫颈组织中SYCP2呈阴性表达,LACC患者肿瘤组织中SYCP2呈阳性表达。SYCP2低表达组患者客观缓解率为80.49%,高于SYCP2高表达组患者的60.87%,差异有统计学意义(P<0.05)。治疗后,2组患者血清SCCA水平均降低,且SYCP2低表达组患者血清SCCA水平低于SYCP2高表达组患者,差异均有统计学意义(均P<0.001)。治疗后,2组患者EORTC QLQ-C30评分均提高,且SYCP2低表达组患者EORTC QLQ-C30评分高于SYCP2高表达组患者,差异均有统计学意义(均P<0.001)。SYCP2低表达组和SYCP2高表达组患者治疗期间Ⅲ~Ⅳ级不良反应发生率分别为36.59%(15/41)和36.96%(17/46),差异无统计学意义(χ^(2)=0.001,P=0.971)。结论:与SYCP2低表达LACC患者相比,LACC患者SYCP2高表达与NACT客观缓解率较低、化学治疗后血清SCCA水平较高及生活质量较低相关,SYCP2或可作为预测LACC患者NACT疗效的潜在分子标志物。
文摘深部咸水含水层具有巨大的CO_(2)封存潜力,研究致密砂岩CO_(2)-水两相驱替机制对实现高效安全的CO_(2)咸水层封存具有重要意义。对两个具有不同孔隙结构特征的低渗透砂岩开展了CO_(2)-水两相驱替试验,利用核磁共振(nuclear magnetic resonance,NMR)和磁共振成像(magnetic resonance imaging,MRI)技术对气驱和吸水两个阶段气水两相的分布进行了定量及可视化研究,分析了岩芯孔径分布、非均质性及渗透率差异等对两相驱替特征的影响机制。研究表明在气驱阶段CO_(2)相优先被捕获在较大的孔隙中,大孔分布较多的岩芯表现出更高的CO_(2)饱和度;但在吸水阶段小孔占比更高、渗透率更低的岩芯内捕获的CO_(2)相不易被水驱走,表现出更高的CO_(2)封存效率;岩芯局部渗透率变化对最终的残余气分布影响显著,渗透率较低的区域具有更高的最终残余气饱和度和封存效率。研究可进一步完善CO_(2)咸水含水层封存项目中的储层优选、高效封存以及安全性评估等理论体系。
文摘In this paper a new approach for PBL simulation, the non-local closure scheme based on the transient turbulence theory has been used. It was set up as an alternative to local closure schemes which physical concept is reasonable and distinct. A 2-D non-local closure model was developed in order to study the PBL structure and simulatesome interesting atmospheric processes over non-ulliform underlying surface, especially under the convective and unique weather conditions, such as sea-land circulation and the TIBL structure. The modelled results show good agreement with field measurement.
文摘目的研究粉尘螨主要变应原Der f 2在螨体内的定位。方法采用免疫荧光抗原定位观察。先制备Der f 2单克隆抗体,再制作粉尘螨石蜡切片。切片经二甲苯脱蜡及梯度乙醇脱水,入3%H2O2孵育10 min,PBS漂洗后依次加入单克隆抗体血清37℃孵育1 h、生物素标记的羊抗鼠IgG抗体(1∶100)室温孵育60 min、抗生物素蛋白-生物素过氧化物酶-异硫氰酸荧光素复合物(SABC-FITC)(1∶100)室温孵育60 min。PBS漂洗,伊文氏蓝处理切片5min,最后丙三醇封片。用抗重组Der f2单克隆抗体作一抗孵育,再选用抗鼠IgG荧光抗体为二抗,经荧光染色,观察Der f2在螨体内的位置。用正常小鼠血清(1∶100)代替小鼠单克隆抗体血清作为阴性对照。结果粉尘螨Der f2在中肠组织(包括中肠和后肠)和肠内容物均显示较强阳性,特别是肠内容物更明显。结论Der f 2分布于粉尘螨的中肠组织及其肠内容物。
文摘目的探讨过敏性疾病主要变应原之一德国小蠊Bla g 2的定位。方法制作德国小蠊石蜡切片,在本室克隆、表达和纯化出Bla g 2蛋白的基础上,按常规方法免疫小鼠,分离血清用作一抗,荧光染色后在光镜下观察Bla g 2在虫体内的定位。结果用rBla g 2免疫小鼠血清孵育的切片中,中肠肠腔上皮细胞和肠内容物显示强阳性,免疫小鼠血清孵育的粪便颗粒也显示阳性结果。而其生殖、排泄系统等脏器均呈阴性反应。结论本研究发现德国小蠊II类变应原Bla g 2存在于中肠肠腔上皮组织、肠内容物和粪便颗粒中,对进一步进行德国小蠊特异性抗原的分离、纯化及疫苗的研究提供了理论参考。
