目的:分析格列吡嗪与二甲双胍联用治疗新发初诊2型糖尿病患者的应用价值。方法:研究对象选取2024年4月至2025年4月在本院收治的102例初诊2型糖尿病患者,以信封法随机分为联合组和二甲双胍组,两组均51例,二甲双胍组予以二甲双胍治疗,联...目的:分析格列吡嗪与二甲双胍联用治疗新发初诊2型糖尿病患者的应用价值。方法:研究对象选取2024年4月至2025年4月在本院收治的102例初诊2型糖尿病患者,以信封法随机分为联合组和二甲双胍组,两组均51例,二甲双胍组予以二甲双胍治疗,联合组予以格列吡嗪联合二甲双胍治疗,两组患者均干预3 m。比较两组血糖水平、空腹C肽、餐后2 h C肽、胰岛β细胞功能指数(Homeostasis model assessment-β,HOMA-β)、胰岛抵抗指数(Homeostasis model assessment-IR,HOMA-IR),统计不良反应。结果:治疗后,联合组在降低糖化血红蛋白、空腹血糖、餐后2 h血糖方面均优于二甲双胍组(P<0.05),两组空腹及餐后2 h C肽均较治疗前有显著升高(P<0.05),且联合组空腹及餐后2 h C肽均高于二甲双胍组(P<0.05),联合组HOMA-β高于二甲双胍组(P<0.05),HOMA-IR低于二甲双胍组(P<0.05),两组不良反应比较无明显差异(P>0.05)。结论:格列吡嗪与二甲双胍联合治疗新发2型糖尿病具有协同降糖效果,能有效改善胰岛β细胞功能,安全性良好。展开更多
Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: ...Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: A total of 167 subjects, 50 newly diagnosed type 2 diabetic subjects and 117 non-diabetic subjects were included in the study. Obese and overweight newly diagnosed type 2 diabetic patients were matched for age and BMI with obese and overweight non-diabetic subjects. Only postmenopausal women were selected. The following biomarkers were analyzed: fasting glucose, HbA1c, fasting insulin, fasting proinsulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, adiponectin, leptin, hs-CRP, urine albumin/creatinine ratio. 75 g oral glucose tolerance test was performed in all subjects. Ultrasound imaging was used to evaluate IMT of the common carotid artery. Results: CIMT was greater in newly diagnosed type 2 patients compared to non-diabetic subjects. When analyzed by BMI, the difference regarding CIMT between diabetic and non-diabetic subjects was significant only in overweight subjects, in both sexes. In univariate analysis in men with newly diagnosed type 2 diabetes, CIMT was positively correlated with age, SBP, triglycerides, leptin and negatively correlated with HDL-cholesterol and in women CIMT was positively correlated with SBP and leptin. Independent determinants of CIMT in patients with newly diagnosed type 2 diabetes were in men age (β = 0.556, p = 0.0028) and log leptin (β = 0.393, p = 0.049) and in women systolic blood pressure (β = 0.48, p = 0.026). Conclusions: Subclinical atherosclerosis is present in newly diagnosed type 2 diabetic subjects. Body fat accumulation in men and hypertension in postmenopausal women have a primary role in increase carotid intima-media thickness.展开更多
Objective:To investigate the effect of liraglutide combined with basal insulin on blood glucose control, lipid metabolism and oxidative stress in patients with newly diagnosed type 2 diabetes mellitus complicated by o...Objective:To investigate the effect of liraglutide combined with basal insulin on blood glucose control, lipid metabolism and oxidative stress in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.Methods: A total of 58 patients with newly diagnosed type 2 diabetes mellitus complicated by obesity who were diagnosed and treated in Xi'an No. 4 Hospital between February 2017 and August 2017 were divided into the control group (n=29) who received basal insulin therapy and the liraglutide group (n=29) who received liraglutide combined with basal insulin therapy according to random number table. The differences in the levels of glycolipid metabolism indexes and the contents of oxidative stress indexes were compared between the two groups before and after treatment.Results: Before treatment, the differences in the levels of glycolipid metabolism indexes in peripheral blood and the contents of oxidative stress indexes in serum were not statistically significant between the two groups. After 1 month of treatment, glucose metabolism indexes FBG and HOMA-IR levels in peripheral blood of liraglutide group were lower than those of control group;lipid metabolism indexes TC, TG, ApoB levels in peripheral blood were lower than those of control group, ApoA1 level was higher than those of control group;serum oxidation indexes MDA and LHP contents were lower than those of control group whereas anti-oxidation indexes GSH-Px and T-AOC contents were higher than those of control group.Conclusion: Liraglutide combined with basal insulin therapy can further control the glucolipid metabolism levels and inhibit the systemic oxidative stress response in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.展开更多
ZJZ-2 system has the following functions: (1) Real-time on-line sampling and FFT analysis (32 channel); (2) Data aquisition, analysis and storage during start-up and shut-down; (3) Alarming, emergency recognition and ...ZJZ-2 system has the following functions: (1) Real-time on-line sampling and FFT analysis (32 channel); (2) Data aquisition, analysis and storage during start-up and shut-down; (3) Alarming, emergency recognition and fault retrieval; (4) Data aquisition, analysis and storage during daily operation; (5) Recall of historic data; (6) Output of routine reports and tables; (7) Analysis of vibration behaviour: Bode plot, polar plot, spectrum, cascade, waveform, shaft orbit, trend, etc;展开更多
目的探讨初治肺结核合并2型糖尿病患者(pulmonary tuberculosis combined with type 2 diabetes mellitus,PTB-T2DM)抗结核治疗过程中出现肝损伤及预后不良的影响因素,以期为降低肝损伤发生率和改善预后提供参考。方法采用回顾性队列研...目的探讨初治肺结核合并2型糖尿病患者(pulmonary tuberculosis combined with type 2 diabetes mellitus,PTB-T2DM)抗结核治疗过程中出现肝损伤及预后不良的影响因素,以期为降低肝损伤发生率和改善预后提供参考。方法采用回顾性队列研究,连续性纳入2018年11月至2023年11月广元市精神卫生中心收治的符合入组标准的170例在抗结核治疗过程中出现肝损伤的PTB-T2DM患者作为肝损伤组,并根据性别、年龄按1∶2匹配同期完成抗结核治疗且未出现肝损伤的340例PTB-T2DM患者作为对照组。回顾性收集受试者病历资料及相关生化指标,采用多因素Cox比例风险回归模型分析影响肝损伤发生的高危因素。随访8个月后,依据患者预后情况将肝损伤组分成2个亚组,分析患者出现肝损伤后预后不良情况及其影响因素。结果与对照组相比,肝损伤组患者空腹血糖水平明显升高,而白蛋白与球蛋白比值、血红蛋白水平显著下降(P<0.05);在调整了混杂因素后,受教育程度、饮酒史、白蛋白与球蛋白比值、糖尿病病程、抗结核治疗药物是初治PTB-T2DM患者抗结核治疗过程中发生肝损伤风险的独立影响因素。预后不良发生率为14.12%,多因素Cox比例风险回归分析显示,肝损伤时血糖控制不良、诊断延迟、就诊延迟、未规律服药、出现发生肝损伤时间≥8周、从出现消化道症状和(或)出现肾功能损伤到停结核药物的间隔时间较长均是引发初治PTBT2DM患者出现肝损伤后预后不良的独立危险因素(P<0.05)。结论初治PTB-T2DM患者抗结核治疗过程中预后不良发生率均较高,且受多重影响因素。尤其血糖控制不良、诊断延迟、出现发生肝损伤时间≥8周、从出现消化道症状到停结核药物的间隔时间较长者,发生肝损伤及不良预后的风险更高。展开更多
文摘目的:分析格列吡嗪与二甲双胍联用治疗新发初诊2型糖尿病患者的应用价值。方法:研究对象选取2024年4月至2025年4月在本院收治的102例初诊2型糖尿病患者,以信封法随机分为联合组和二甲双胍组,两组均51例,二甲双胍组予以二甲双胍治疗,联合组予以格列吡嗪联合二甲双胍治疗,两组患者均干预3 m。比较两组血糖水平、空腹C肽、餐后2 h C肽、胰岛β细胞功能指数(Homeostasis model assessment-β,HOMA-β)、胰岛抵抗指数(Homeostasis model assessment-IR,HOMA-IR),统计不良反应。结果:治疗后,联合组在降低糖化血红蛋白、空腹血糖、餐后2 h血糖方面均优于二甲双胍组(P<0.05),两组空腹及餐后2 h C肽均较治疗前有显著升高(P<0.05),且联合组空腹及餐后2 h C肽均高于二甲双胍组(P<0.05),联合组HOMA-β高于二甲双胍组(P<0.05),HOMA-IR低于二甲双胍组(P<0.05),两组不良反应比较无明显差异(P>0.05)。结论:格列吡嗪与二甲双胍联合治疗新发2型糖尿病具有协同降糖效果,能有效改善胰岛β细胞功能,安全性良好。
文摘Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: A total of 167 subjects, 50 newly diagnosed type 2 diabetic subjects and 117 non-diabetic subjects were included in the study. Obese and overweight newly diagnosed type 2 diabetic patients were matched for age and BMI with obese and overweight non-diabetic subjects. Only postmenopausal women were selected. The following biomarkers were analyzed: fasting glucose, HbA1c, fasting insulin, fasting proinsulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, adiponectin, leptin, hs-CRP, urine albumin/creatinine ratio. 75 g oral glucose tolerance test was performed in all subjects. Ultrasound imaging was used to evaluate IMT of the common carotid artery. Results: CIMT was greater in newly diagnosed type 2 patients compared to non-diabetic subjects. When analyzed by BMI, the difference regarding CIMT between diabetic and non-diabetic subjects was significant only in overweight subjects, in both sexes. In univariate analysis in men with newly diagnosed type 2 diabetes, CIMT was positively correlated with age, SBP, triglycerides, leptin and negatively correlated with HDL-cholesterol and in women CIMT was positively correlated with SBP and leptin. Independent determinants of CIMT in patients with newly diagnosed type 2 diabetes were in men age (β = 0.556, p = 0.0028) and log leptin (β = 0.393, p = 0.049) and in women systolic blood pressure (β = 0.48, p = 0.026). Conclusions: Subclinical atherosclerosis is present in newly diagnosed type 2 diabetic subjects. Body fat accumulation in men and hypertension in postmenopausal women have a primary role in increase carotid intima-media thickness.
文摘Objective:To investigate the effect of liraglutide combined with basal insulin on blood glucose control, lipid metabolism and oxidative stress in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.Methods: A total of 58 patients with newly diagnosed type 2 diabetes mellitus complicated by obesity who were diagnosed and treated in Xi'an No. 4 Hospital between February 2017 and August 2017 were divided into the control group (n=29) who received basal insulin therapy and the liraglutide group (n=29) who received liraglutide combined with basal insulin therapy according to random number table. The differences in the levels of glycolipid metabolism indexes and the contents of oxidative stress indexes were compared between the two groups before and after treatment.Results: Before treatment, the differences in the levels of glycolipid metabolism indexes in peripheral blood and the contents of oxidative stress indexes in serum were not statistically significant between the two groups. After 1 month of treatment, glucose metabolism indexes FBG and HOMA-IR levels in peripheral blood of liraglutide group were lower than those of control group;lipid metabolism indexes TC, TG, ApoB levels in peripheral blood were lower than those of control group, ApoA1 level was higher than those of control group;serum oxidation indexes MDA and LHP contents were lower than those of control group whereas anti-oxidation indexes GSH-Px and T-AOC contents were higher than those of control group.Conclusion: Liraglutide combined with basal insulin therapy can further control the glucolipid metabolism levels and inhibit the systemic oxidative stress response in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.
文摘ZJZ-2 system has the following functions: (1) Real-time on-line sampling and FFT analysis (32 channel); (2) Data aquisition, analysis and storage during start-up and shut-down; (3) Alarming, emergency recognition and fault retrieval; (4) Data aquisition, analysis and storage during daily operation; (5) Recall of historic data; (6) Output of routine reports and tables; (7) Analysis of vibration behaviour: Bode plot, polar plot, spectrum, cascade, waveform, shaft orbit, trend, etc;
文摘目的探讨初治肺结核合并2型糖尿病患者(pulmonary tuberculosis combined with type 2 diabetes mellitus,PTB-T2DM)抗结核治疗过程中出现肝损伤及预后不良的影响因素,以期为降低肝损伤发生率和改善预后提供参考。方法采用回顾性队列研究,连续性纳入2018年11月至2023年11月广元市精神卫生中心收治的符合入组标准的170例在抗结核治疗过程中出现肝损伤的PTB-T2DM患者作为肝损伤组,并根据性别、年龄按1∶2匹配同期完成抗结核治疗且未出现肝损伤的340例PTB-T2DM患者作为对照组。回顾性收集受试者病历资料及相关生化指标,采用多因素Cox比例风险回归模型分析影响肝损伤发生的高危因素。随访8个月后,依据患者预后情况将肝损伤组分成2个亚组,分析患者出现肝损伤后预后不良情况及其影响因素。结果与对照组相比,肝损伤组患者空腹血糖水平明显升高,而白蛋白与球蛋白比值、血红蛋白水平显著下降(P<0.05);在调整了混杂因素后,受教育程度、饮酒史、白蛋白与球蛋白比值、糖尿病病程、抗结核治疗药物是初治PTB-T2DM患者抗结核治疗过程中发生肝损伤风险的独立影响因素。预后不良发生率为14.12%,多因素Cox比例风险回归分析显示,肝损伤时血糖控制不良、诊断延迟、就诊延迟、未规律服药、出现发生肝损伤时间≥8周、从出现消化道症状和(或)出现肾功能损伤到停结核药物的间隔时间较长均是引发初治PTBT2DM患者出现肝损伤后预后不良的独立危险因素(P<0.05)。结论初治PTB-T2DM患者抗结核治疗过程中预后不良发生率均较高,且受多重影响因素。尤其血糖控制不良、诊断延迟、出现发生肝损伤时间≥8周、从出现消化道症状到停结核药物的间隔时间较长者,发生肝损伤及不良预后的风险更高。
