A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.展开更多
For short-term PV power prediction,based on interval type-2 Takagi-Sugeno-Kang fuzzy logic systems(IT2 TSK FLS),combined with improved grey wolf optimizer(IGWO)algorithm,an IGWO-IT2 TSK FLS method was proposed.Compare...For short-term PV power prediction,based on interval type-2 Takagi-Sugeno-Kang fuzzy logic systems(IT2 TSK FLS),combined with improved grey wolf optimizer(IGWO)algorithm,an IGWO-IT2 TSK FLS method was proposed.Compared with the type-1 TSK fuzzy logic system method,interval type-2 fuzzy sets could simultaneously model both intra-personal uncertainty and inter-personal uncertainty based on the training of the existing error back propagation(BP)algorithm,and the IGWO algorithm was used for training the model premise and consequent parameters to further improve the predictive performance of the model.By improving the gray wolf optimization algorithm,the early convergence judgment mechanism,nonlinear cosine adjustment strategy,and Levy flight strategy were introduced to improve the convergence speed of the algorithm and avoid the problem of falling into local optimum.The interval type-2 TSK FLS method based on the IGWO algorithm was applied to the real-world photovoltaic power time series forecasting instance.Under the same conditions,it was also compared with different IT2 TSK FLS methods,such as type I TSK FLS method,BP algorithm,genetic algorithm,differential evolution,particle swarm optimization,biogeography optimization,gray wolf optimization,etc.Experimental results showed that the proposed method based on IGWO algorithm outperformed other methods in performance,showing its effectiveness and application potential.展开更多
Frequency modulated continuous wave(FMCW)radar is an advantageous sensor scheme for target estimation and environmental perception.However,existing algorithms based on discrete Fourier transform(DFT),multiple signal c...Frequency modulated continuous wave(FMCW)radar is an advantageous sensor scheme for target estimation and environmental perception.However,existing algorithms based on discrete Fourier transform(DFT),multiple signal classification(MUSIC)and compressed sensing,etc.,cannot achieve both low complexity and high resolution simultaneously.This paper proposes an efficient 2-D MUSIC algorithm for super-resolution target estimation/tracking based on FMCW radar.Firstly,we enhance the efficiency of 2-D MUSIC azimuth-range spectrum estimation by incorporating 2-D DFT and multi-level resolution searching strategy.Secondly,we apply the gradient descent method to tightly integrate the spatial continuity of object motion into spectrum estimation when processing multi-epoch radar data,which improves the efficiency of continuous target tracking.These two approaches have improved the algorithm efficiency by nearly 2-4 orders of magnitude without losing accuracy and resolution.Simulation experiments are conducted to validate the effectiveness of the algorithm in both single-epoch estimation and multi-epoch tracking scenarios.展开更多
Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinfor...Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinforce-ment learning(DRL)theory and an improved Multi-Agent Deep Deterministic Policy Gradient(MADDPG-D2)algorithm with a dual experience replay pool and a dual noise based on multi-agent architecture is proposed to improve the efficiency of DTA.The algorithm is based on the traditional Multi-Agent Deep Deterministic Policy Gradient(MADDPG)algorithm,and considers the introduction of a double noise mechanism to increase the action exploration space in the early stage of the algorithm,and the introduction of a double experience pool to improve the data utilization rate;at the same time,in order to accelerate the training speed and efficiency of the agents,and to solve the cold-start problem of the training,the a priori knowledge technology is applied to the training of the algorithm.Finally,the MADDPG-D2 algorithm is compared and analyzed based on the digital battlefield of ground and air confrontation.The experimental results show that the agents trained by the MADDPG-D2 algorithm have higher win rates and average rewards,can utilize the resources more reasonably,and better solve the problem of the traditional single agent algorithms facing the difficulty of solving the problem in the high-dimensional decision space.The MADDPG-D2 algorithm based on multi-agent architecture proposed in this paper has certain superiority and rationality in DTA.展开更多
基金supported by the National Natural Science Foundation of China(32273037 and 32102636)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)+4 种基金Laboratory of Lingnan Modern Agriculture Project(NT2021007)the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098)the 111 Center(D20008)the double first-class discipline promotion project(2023B10564003)the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
文摘A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.
基金supported by National Natural Science Foundation of China(No.12172157)Key Project of Natural Science Foundation of Gansu Province(No.25JRRA150)Key Research and Development Planning Project of Gansu Province(No.23YFWA0007).
文摘For short-term PV power prediction,based on interval type-2 Takagi-Sugeno-Kang fuzzy logic systems(IT2 TSK FLS),combined with improved grey wolf optimizer(IGWO)algorithm,an IGWO-IT2 TSK FLS method was proposed.Compared with the type-1 TSK fuzzy logic system method,interval type-2 fuzzy sets could simultaneously model both intra-personal uncertainty and inter-personal uncertainty based on the training of the existing error back propagation(BP)algorithm,and the IGWO algorithm was used for training the model premise and consequent parameters to further improve the predictive performance of the model.By improving the gray wolf optimization algorithm,the early convergence judgment mechanism,nonlinear cosine adjustment strategy,and Levy flight strategy were introduced to improve the convergence speed of the algorithm and avoid the problem of falling into local optimum.The interval type-2 TSK FLS method based on the IGWO algorithm was applied to the real-world photovoltaic power time series forecasting instance.Under the same conditions,it was also compared with different IT2 TSK FLS methods,such as type I TSK FLS method,BP algorithm,genetic algorithm,differential evolution,particle swarm optimization,biogeography optimization,gray wolf optimization,etc.Experimental results showed that the proposed method based on IGWO algorithm outperformed other methods in performance,showing its effectiveness and application potential.
基金funded by the National Natural Science Foundation of China,grant number 42074176,U1939204。
文摘Frequency modulated continuous wave(FMCW)radar is an advantageous sensor scheme for target estimation and environmental perception.However,existing algorithms based on discrete Fourier transform(DFT),multiple signal classification(MUSIC)and compressed sensing,etc.,cannot achieve both low complexity and high resolution simultaneously.This paper proposes an efficient 2-D MUSIC algorithm for super-resolution target estimation/tracking based on FMCW radar.Firstly,we enhance the efficiency of 2-D MUSIC azimuth-range spectrum estimation by incorporating 2-D DFT and multi-level resolution searching strategy.Secondly,we apply the gradient descent method to tightly integrate the spatial continuity of object motion into spectrum estimation when processing multi-epoch radar data,which improves the efficiency of continuous target tracking.These two approaches have improved the algorithm efficiency by nearly 2-4 orders of magnitude without losing accuracy and resolution.Simulation experiments are conducted to validate the effectiveness of the algorithm in both single-epoch estimation and multi-epoch tracking scenarios.
基金This research was funded by the Project of the National Natural Science Foundation of China,Grant Number 62106283.
文摘Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinforce-ment learning(DRL)theory and an improved Multi-Agent Deep Deterministic Policy Gradient(MADDPG-D2)algorithm with a dual experience replay pool and a dual noise based on multi-agent architecture is proposed to improve the efficiency of DTA.The algorithm is based on the traditional Multi-Agent Deep Deterministic Policy Gradient(MADDPG)algorithm,and considers the introduction of a double noise mechanism to increase the action exploration space in the early stage of the algorithm,and the introduction of a double experience pool to improve the data utilization rate;at the same time,in order to accelerate the training speed and efficiency of the agents,and to solve the cold-start problem of the training,the a priori knowledge technology is applied to the training of the algorithm.Finally,the MADDPG-D2 algorithm is compared and analyzed based on the digital battlefield of ground and air confrontation.The experimental results show that the agents trained by the MADDPG-D2 algorithm have higher win rates and average rewards,can utilize the resources more reasonably,and better solve the problem of the traditional single agent algorithms facing the difficulty of solving the problem in the high-dimensional decision space.The MADDPG-D2 algorithm based on multi-agent architecture proposed in this paper has certain superiority and rationality in DTA.
