<div style="text-align:justify;"> A generalized optical filterless approach to achieve photonic generation of frequency 16-tupling millimeter-wave (mm-wave) signal based on two cascaded dual-parallel M...<div style="text-align:justify;"> A generalized optical filterless approach to achieve photonic generation of frequency 16-tupling millimeter-wave (mm-wave) signal based on two cascaded dual-parallel Mach-Zehnder modulators (DPMZMs) is presented. A theoretical analysis leading to the operating conditions to achieve frequency 16-tupling is developed. Different modulation indices (MIs) can be implemented to achieve the frequency multiplication by adjusting the delay of tunable optical delay line (TODL). It is confirmed by simulation that the proposed scheme is effective, and the radio frequency spurious suppression ratio (RFSSR) of the generated frequency 16-tupling signal can be as high as 40 dB when the sub-MZMs have extinction ratios of 30 dB. Influencing factors such as extinction ratio, DC bias drift, phase shift deviation and RF voltage deviation on the performance of optical sideband suppression ratio (OSSR) and RFSSR are also investigated. </div>展开更多
Wu et al recently applied multi-region 16S rRNA sequencing to characterize the gastric cancer microbiome,demonstrating improved taxonomic resolution and detection sensitivity over conventional single-region approaches...Wu et al recently applied multi-region 16S rRNA sequencing to characterize the gastric cancer microbiome,demonstrating improved taxonomic resolution and detection sensitivity over conventional single-region approaches.While the study represents a valuable methodological step forward,it remains limited by singlecenter design,lack of quantitative calibration,and insufficient control for contamination and inter-laboratory variability.This editorial critically appraises these methodological gaps and emphasizes that future efforts must focus on harmonized,consensus-driven workflows to ensure reproducibility and clinical reliability.The translational potential of multi-region 16S lies in moving from descriptive microbial profiling to actionable clinical integration,particularly for recurrence prediction,treatment-response monitoring,and perioperative complication risk assessment.By addressing these methodological,economic,and ethical challenges,the field can advance toward evidence-based and clinically deployable microbiome-guided precision oncology.展开更多
目的探讨血清甲壳质酶蛋白40(chitinase protein 40,YKL-40)、Clara细胞蛋白16(Clara cell protein 16,CC16)对急性阑尾炎(acute appendicitis,AA)患儿手术切口感染的预测价值。方法河北北方学院附属第一医院小儿外科2021年10月至2023...目的探讨血清甲壳质酶蛋白40(chitinase protein 40,YKL-40)、Clara细胞蛋白16(Clara cell protein 16,CC16)对急性阑尾炎(acute appendicitis,AA)患儿手术切口感染的预测价值。方法河北北方学院附属第一医院小儿外科2021年10月至2023年10月收治的324例行腹腔镜手术的AA患儿,根据患儿腹腔镜手术30 d后的切口感染情况分为感染组(n=40)和未感染者组(n=284),ELISA测定血清YKL-40、CC16水平,多因素Logistic回归分析影响AA患儿发生手术切口感染的因素;采用受试者工作特征(ROC)曲线分析血清YKL-40、CC16对AA患儿发生手术切口感染的预测价值,Pearson法分析发生切口感染的AA患者血清YKL-40、CC16水平的相关性。结果感染组和未感染组患儿的身高、合并阑尾穿孔、体重、切口长度、腹腔引流管留置、切口探查、性别、年龄、疾病持续时间、白细胞计数、术前体温及术中出血量情况比较,差异无统计学意义(P>0.05);感染组较非感染组手术操作时间≥1 h的患儿比例及血清YKL-40水平增加,血清CC16水平降低(P<0.05);YKL-40是AA患儿发生手术切口感染的危险因素,CC16是保护因素(P<0.05);血清YKL-40、CC16及联合预测AA患儿发生手术切口感染的AUC为0.805、0.833、0.899,二者联合优于单独预测价值(Z=3.372、2.032,P=0.001、0.042);感染组患儿血清YKL-40、CC16水平呈负相关(r=-0.730,P<0.001)。结论AA患儿手术切口感染者较未感染者血清YKL-40水平升高、CC16水平降低,二者对AA患儿发生手术切口感染具有一定的预测价值。展开更多
文摘<div style="text-align:justify;"> A generalized optical filterless approach to achieve photonic generation of frequency 16-tupling millimeter-wave (mm-wave) signal based on two cascaded dual-parallel Mach-Zehnder modulators (DPMZMs) is presented. A theoretical analysis leading to the operating conditions to achieve frequency 16-tupling is developed. Different modulation indices (MIs) can be implemented to achieve the frequency multiplication by adjusting the delay of tunable optical delay line (TODL). It is confirmed by simulation that the proposed scheme is effective, and the radio frequency spurious suppression ratio (RFSSR) of the generated frequency 16-tupling signal can be as high as 40 dB when the sub-MZMs have extinction ratios of 30 dB. Influencing factors such as extinction ratio, DC bias drift, phase shift deviation and RF voltage deviation on the performance of optical sideband suppression ratio (OSSR) and RFSSR are also investigated. </div>
文摘Wu et al recently applied multi-region 16S rRNA sequencing to characterize the gastric cancer microbiome,demonstrating improved taxonomic resolution and detection sensitivity over conventional single-region approaches.While the study represents a valuable methodological step forward,it remains limited by singlecenter design,lack of quantitative calibration,and insufficient control for contamination and inter-laboratory variability.This editorial critically appraises these methodological gaps and emphasizes that future efforts must focus on harmonized,consensus-driven workflows to ensure reproducibility and clinical reliability.The translational potential of multi-region 16S lies in moving from descriptive microbial profiling to actionable clinical integration,particularly for recurrence prediction,treatment-response monitoring,and perioperative complication risk assessment.By addressing these methodological,economic,and ethical challenges,the field can advance toward evidence-based and clinically deployable microbiome-guided precision oncology.
文摘目的探讨血清甲壳质酶蛋白40(chitinase protein 40,YKL-40)、Clara细胞蛋白16(Clara cell protein 16,CC16)对急性阑尾炎(acute appendicitis,AA)患儿手术切口感染的预测价值。方法河北北方学院附属第一医院小儿外科2021年10月至2023年10月收治的324例行腹腔镜手术的AA患儿,根据患儿腹腔镜手术30 d后的切口感染情况分为感染组(n=40)和未感染者组(n=284),ELISA测定血清YKL-40、CC16水平,多因素Logistic回归分析影响AA患儿发生手术切口感染的因素;采用受试者工作特征(ROC)曲线分析血清YKL-40、CC16对AA患儿发生手术切口感染的预测价值,Pearson法分析发生切口感染的AA患者血清YKL-40、CC16水平的相关性。结果感染组和未感染组患儿的身高、合并阑尾穿孔、体重、切口长度、腹腔引流管留置、切口探查、性别、年龄、疾病持续时间、白细胞计数、术前体温及术中出血量情况比较,差异无统计学意义(P>0.05);感染组较非感染组手术操作时间≥1 h的患儿比例及血清YKL-40水平增加,血清CC16水平降低(P<0.05);YKL-40是AA患儿发生手术切口感染的危险因素,CC16是保护因素(P<0.05);血清YKL-40、CC16及联合预测AA患儿发生手术切口感染的AUC为0.805、0.833、0.899,二者联合优于单独预测价值(Z=3.372、2.032,P=0.001、0.042);感染组患儿血清YKL-40、CC16水平呈负相关(r=-0.730,P<0.001)。结论AA患儿手术切口感染者较未感染者血清YKL-40水平升高、CC16水平降低,二者对AA患儿发生手术切口感染具有一定的预测价值。
