Shot-peened,case-hardened gears can fail in the tooth root due to crack initiation below the surface of the steel matrix.Here,the crack is initiated at a non-metallic inclusion in the center of a so-called fisheye.Thi...Shot-peened,case-hardened gears can fail in the tooth root due to crack initiation below the surface of the steel matrix.Here,the crack is initiated at a non-metallic inclusion in the center of a so-called fisheye.This failure type can lead to a reduced endurance fatigue limit of the gears.It is for this reason that,over the last decade,much effort has been invested by steel manufacturers to reduce the non-metallic inclusion content of gear steels so as to mitigate or even completely prevent such crack initiation.These ultra-clean gear steels were achieved by various measures in the steel production process.However,as a result,the remaining non-metallic inclusions are inhomogeneously distributed in the steel volume in terms of both size and location.However,due to the inhomogeneity of ultra-clean steels,the question arose if the values derived according to the standards are still representative of ultra-clean steel batches.The results show that the standards can still be applied,but more effort must be applied.To determine the degree of cleanliness,six microsections are currently evaluated according to steel test specification(SEP)1571,method K.It is shown that an examination of 24 microsections starting from size class 0 seems beneficial to get more reliable and comparable results of the degree of cleanliness of these ultra-clean gear steels.In addition,it is shown that a high degree of cleanliness has been achieved for all steel batches investigated with the measures taken in the steel production process.展开更多
This review evaluates the role of Glivec in the treatment of chronic myelogenous leukemia and other malignant tumors. Preclinical and clinical evidence showed that Glivec demonstrated a potent and specific inhibition...This review evaluates the role of Glivec in the treatment of chronic myelogenous leukemia and other malignant tumors. Preclinical and clinical evidence showed that Glivec demonstrated a potent and specific inhibition on BCR-ABL positive leukemias and other malignant tumors in which overexpression of c-kit and PDGFR-b played a major role in their pathogenesis. Glivec has induced complete hematologic responses in up to 98% of patients evaluated in clinical trials. It's a very successful drug that supported the idea of targeted therapy through inhibition of tyrosine kinases. Although it's still in the early stages of clinical development and the resistance to Glivec remains to be a problem needed further study, a great deal has been learned from these research and observation. And with the increasing data, molecular targeting therapy will play much more important role in the treatment of malignant tumors. With the better understanding of the pathogenesis of malignant tumors, well-designed drugs targeting the specific molecular abnormalities with higher efficacy and lower side effect will benefit numerous patients with malignant tumors.展开更多
基金The underlying research work was funded in equal proportions by the“Arbeitsgemeinschaft industrieller Forschungsvereinigungen e.V.(AiF)”,the German Federal Ministry of Economics and Technology(BMWi,IGF no.16662 N)and the FVA.The results presented in this paper were taken from the FVA research project 293 III“Späte Zahnfußbrüche/Reinheitsgrad”.More detailed information on the influence of non-metallic inclusions is given in the final report.
文摘Shot-peened,case-hardened gears can fail in the tooth root due to crack initiation below the surface of the steel matrix.Here,the crack is initiated at a non-metallic inclusion in the center of a so-called fisheye.This failure type can lead to a reduced endurance fatigue limit of the gears.It is for this reason that,over the last decade,much effort has been invested by steel manufacturers to reduce the non-metallic inclusion content of gear steels so as to mitigate or even completely prevent such crack initiation.These ultra-clean gear steels were achieved by various measures in the steel production process.However,as a result,the remaining non-metallic inclusions are inhomogeneously distributed in the steel volume in terms of both size and location.However,due to the inhomogeneity of ultra-clean steels,the question arose if the values derived according to the standards are still representative of ultra-clean steel batches.The results show that the standards can still be applied,but more effort must be applied.To determine the degree of cleanliness,six microsections are currently evaluated according to steel test specification(SEP)1571,method K.It is shown that an examination of 24 microsections starting from size class 0 seems beneficial to get more reliable and comparable results of the degree of cleanliness of these ultra-clean gear steels.In addition,it is shown that a high degree of cleanliness has been achieved for all steel batches investigated with the measures taken in the steel production process.
基金This work was supported by a grant from Nanjing Science & Technology Foundation.
文摘This review evaluates the role of Glivec in the treatment of chronic myelogenous leukemia and other malignant tumors. Preclinical and clinical evidence showed that Glivec demonstrated a potent and specific inhibition on BCR-ABL positive leukemias and other malignant tumors in which overexpression of c-kit and PDGFR-b played a major role in their pathogenesis. Glivec has induced complete hematologic responses in up to 98% of patients evaluated in clinical trials. It's a very successful drug that supported the idea of targeted therapy through inhibition of tyrosine kinases. Although it's still in the early stages of clinical development and the resistance to Glivec remains to be a problem needed further study, a great deal has been learned from these research and observation. And with the increasing data, molecular targeting therapy will play much more important role in the treatment of malignant tumors. With the better understanding of the pathogenesis of malignant tumors, well-designed drugs targeting the specific molecular abnormalities with higher efficacy and lower side effect will benefit numerous patients with malignant tumors.
