Previous studies have demonstrated a strong association between carbamazepine（CBZ）-induced Stevens-Johnson syndrome（SJS） and HLA-B 1502 in Han Chinese. Here, we extended the study of HLA-B 1502 susceptibility to t...Previous studies have demonstrated a strong association between carbamazepine（CBZ）-induced Stevens-Johnson syndrome（SJS） and HLA-B 1502 in Han Chinese. Here, we extended the study of HLA-B 1502 susceptibility to two different antiepileptic drugs, oxcarbazepine（OXC） and phenobabital（PB）. In addition, we genotyped HLA-B 1511 in a case of CBZ-induced SJS with genotype negative for HLA-B 1502. The presence of HLA-B 1502 was determined using polymerase chain reaction with sequence-specific primers（PCR-SSP）. Moreover, we genotyped HLA-B 1502 in 17 cases of antiepileptic drugs（AEDs）-induced cutaneous adverse drug reactions（cADRs）, in comparison with AEDs-tolerant（n=32） and normal controls（n=38） in the central region of China. The data showed that HLA-B 1502 was positive in 5 of 6 cases of AEDs-induced SJS（4 CBZ, 1 OXC and 1 PB）, which was significantly more frequent than AEDs-tolerant（2/32, 18 CBZ, 6 PB and 8 OXC） and normal controls（3/38）. Compared with AEDs-tolerant and normal controls, the OR for patients carrying the HLA-B 1502 with AEDs-induced SJS was 6.25（95% CI： 1.06–36.74） and 4.86（95% CI： 1.01–23.47）. The sensitivity and specificity of HLA-B 1502 for prediction of AEDs-induced SJS were 71.4%. The sensitivity and specificity of HLA-B 1502 for prediction of CBZ-induced SJS were 60% and 94%. HLA-B 1502 was not found in 11 children with maculopapular exanthema（MPE）（n=9） and hypersensitivity syndrome（HSS）（n=2）. However, we also found one case of CBZ-induced SJS who was negative for HLA-B 1502 but carried HLA-B 1511. It was suggested that the association between the CBZ-induced SJS and HLA-B 1502 allele in Han Chinese children can extend to other aromatic AEDs including OXC and PB related SJS. HLA-B 1511 may be a risk factor for some patients with CBZ-induced SJS negative for HLA-B 1502.展开更多
Model atmospheres of the close visual binary star Cou 1511 （HIP 12552） are constructed using grids of Kuruz＇s blanketed models to build the individual synthetic spectral energy distributions （SEDs） for both compo...Model atmospheres of the close visual binary star Cou 1511 （HIP 12552） are constructed using grids of Kuruz＇s blanketed models to build the individual synthetic spectral energy distributions （SEDs） for both components. These synthetic SEDs are combined together for the entire system and compared with the observational one following A1-Wardat＇s complex method for analyzing close visual binary stars. The entire observational SED of the system is used as a reference for comparison between the synthetic SED and the observed one. The parameters of both components are derived as： Teff = 6180 4- 50 K, Tebfr = 5865 ＋ 70 K, log 9a = 4.35 ± 0.12, log 9b = 4.45± 0.14, Ra = 1.262 ± 0.08 R⊙^eff, Rb = 1.006 ± 0.07 R⊙^ett, La = 2.09 -4- 0.10 L⊙ and Lb = 1.08 ± 0.12 L⊙, with spectral types F8V and G1.5V for components （a, b） respectively and age of 3.0 ± 0.9 Gyr. A modified orbit of the system is built and the masses of the two components are calculated as Ma = 1.17 ±0.11 Me and Mb = 1.06 ± 0.10 Me.展开更多
基金supported by a grant from Clinical Scientific Research of Wuhan Sanitary Bureau(No.WX11C26)research fund from Janssen Research Council of China(No.JRCC2011-01)
文摘Previous studies have demonstrated a strong association between carbamazepine（CBZ）-induced Stevens-Johnson syndrome（SJS） and HLA-B 1502 in Han Chinese. Here, we extended the study of HLA-B 1502 susceptibility to two different antiepileptic drugs, oxcarbazepine（OXC） and phenobabital（PB）. In addition, we genotyped HLA-B 1511 in a case of CBZ-induced SJS with genotype negative for HLA-B 1502. The presence of HLA-B 1502 was determined using polymerase chain reaction with sequence-specific primers（PCR-SSP）. Moreover, we genotyped HLA-B 1502 in 17 cases of antiepileptic drugs（AEDs）-induced cutaneous adverse drug reactions（cADRs）, in comparison with AEDs-tolerant（n=32） and normal controls（n=38） in the central region of China. The data showed that HLA-B 1502 was positive in 5 of 6 cases of AEDs-induced SJS（4 CBZ, 1 OXC and 1 PB）, which was significantly more frequent than AEDs-tolerant（2/32, 18 CBZ, 6 PB and 8 OXC） and normal controls（3/38）. Compared with AEDs-tolerant and normal controls, the OR for patients carrying the HLA-B 1502 with AEDs-induced SJS was 6.25（95% CI： 1.06–36.74） and 4.86（95% CI： 1.01–23.47）. The sensitivity and specificity of HLA-B 1502 for prediction of AEDs-induced SJS were 71.4%. The sensitivity and specificity of HLA-B 1502 for prediction of CBZ-induced SJS were 60% and 94%. HLA-B 1502 was not found in 11 children with maculopapular exanthema（MPE）（n=9） and hypersensitivity syndrome（HSS）（n=2）. However, we also found one case of CBZ-induced SJS who was negative for HLA-B 1502 but carried HLA-B 1511. It was suggested that the association between the CBZ-induced SJS and HLA-B 1502 allele in Han Chinese children can extend to other aromatic AEDs including OXC and PB related SJS. HLA-B 1511 may be a risk factor for some patients with CBZ-induced SJS negative for HLA-B 1502.
文摘Model atmospheres of the close visual binary star Cou 1511 （HIP 12552） are constructed using grids of Kuruz＇s blanketed models to build the individual synthetic spectral energy distributions （SEDs） for both components. These synthetic SEDs are combined together for the entire system and compared with the observational one following A1-Wardat＇s complex method for analyzing close visual binary stars. The entire observational SED of the system is used as a reference for comparison between the synthetic SED and the observed one. The parameters of both components are derived as： Teff = 6180 4- 50 K, Tebfr = 5865 ＋ 70 K, log 9a = 4.35 ± 0.12, log 9b = 4.45± 0.14, Ra = 1.262 ± 0.08 R⊙^eff, Rb = 1.006 ± 0.07 R⊙^ett, La = 2.09 -4- 0.10 L⊙ and Lb = 1.08 ± 0.12 L⊙, with spectral types F8V and G1.5V for components （a, b） respectively and age of 3.0 ± 0.9 Gyr. A modified orbit of the system is built and the masses of the two components are calculated as Ma = 1.17 ±0.11 Me and Mb = 1.06 ± 0.10 Me.
