A series of diatomite supported Cu/Ni bimetallic catalysts were prepared using the co-impregnation method to improve the efficiency and selectivity toward methyl 12-hydroxystearate in the hydrogenation of methyl ricin...A series of diatomite supported Cu/Ni bimetallic catalysts were prepared using the co-impregnation method to improve the efficiency and selectivity toward methyl 12-hydroxystearate in the hydrogenation of methyl ricinoleate.The catalysts were characterized using X-ray diffraction(XRD),transmission electron microscopy(TEM),scanning electron microscopy and energy dispersive X-ray spectroscopy(SEM-EDS),X-ray photoelectron spectroscopy(XPS)and temperature programmed reduction(H2-TPR).All the characterization results verified the formation of highly dispersed Cu/Ni alloy on support.Moreover,by subtly regulating the Ni/Cu molar ratio as well as the reaction parameters,the hydrogenation of methyl ricinoleate to methyl 12-hydroxystearate proceeded efficiently and selectively,affording 97%yield of methyl 12-hydroxystearate and nearly equivalent conversion of methyl ricinoleate under 2 MPa H2 pressure and at 130 C in 4 h with only 1 wt%of the catalyst Ni7Cu1/diatomite(based on methyl ricinoleate).Besides,the supported Cu–Ni bimetallic catalyst is stable during recycle and reuse.After five cycles of reuse,much catalytic activity is still preserved.Therefore,this low-cost and stable bimetallic catalyst would be promising for the hydrogenation of methyl ricinoleate to methyl 12-hydroxystearate,representing an example of green catalysis for efficiently conversion of biomass to value-added chemicals and materials.展开更多
目的探讨新生儿呼吸窘迫综合征(NRDS)患儿肺超声纹理特征、肺部12分区超声评分与预后不良的相关性,并分析其对预后不良风险的预测价值。方法选取2021年8月至2024年12月南阳市第一人民医院128例NRDS患儿为研究对象,根据预后情况分为预后...目的探讨新生儿呼吸窘迫综合征(NRDS)患儿肺超声纹理特征、肺部12分区超声评分与预后不良的相关性,并分析其对预后不良风险的预测价值。方法选取2021年8月至2024年12月南阳市第一人民医院128例NRDS患儿为研究对象,根据预后情况分为预后良好组、预后不良组。比较两组临床资料、肺超声纹理特征、肺部12分区超声评分。采用列联相关性/Spearman相关性分析肺超声纹理特征、肺部12分区超声评分与NRDS患儿病情程度的关系。logistic回归分析预后不良风险的影响因素。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)评价肺超声纹理特征、肺部12分区超声评分对预后不良风险的预测价值。结果128例NRDS患儿治疗后预后良好98例,预后不良30例;预后不良组胎龄、出生体重、出生1 min Apgar评分、动脉血氧分压(PaO_(2))、氧合指数低于预后良好组,动脉血二氧化碳分压(PaCO_(2))、持续气道正压通气(CPAP)时间、有创机械通气占比高于预后良好组(P<0.05);预后不良组对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分高于预后良好组(P<0.05);肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分与出生1 min Apgar评分、PaO_(2)、氧合指数呈负相关,与PaCO_(2)呈正相关(P<0.05);肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分是NRDS患儿预后不良风险的独立影响因素(P<0.05);肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分联合预测预后不良风险的AUC高于各指标单项预测(P<0.001)。结论NRDS预后不良患儿肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差及肺部12分区超声评分较预后良好患儿升高,其与病情指标密切相关,且为预后不良风险的独立影响因素,联合检测其水平在预测患儿预后不良风险方面具有临床应用价值。展开更多
基金supported by the National Program on Key Research Project(2016YFA0602900)Nankai University Engineering Research Center for Castor and also supported by"the Fundamental Research Funds for the Central Universities",Nankai University(000082).
文摘A series of diatomite supported Cu/Ni bimetallic catalysts were prepared using the co-impregnation method to improve the efficiency and selectivity toward methyl 12-hydroxystearate in the hydrogenation of methyl ricinoleate.The catalysts were characterized using X-ray diffraction(XRD),transmission electron microscopy(TEM),scanning electron microscopy and energy dispersive X-ray spectroscopy(SEM-EDS),X-ray photoelectron spectroscopy(XPS)and temperature programmed reduction(H2-TPR).All the characterization results verified the formation of highly dispersed Cu/Ni alloy on support.Moreover,by subtly regulating the Ni/Cu molar ratio as well as the reaction parameters,the hydrogenation of methyl ricinoleate to methyl 12-hydroxystearate proceeded efficiently and selectively,affording 97%yield of methyl 12-hydroxystearate and nearly equivalent conversion of methyl ricinoleate under 2 MPa H2 pressure and at 130 C in 4 h with only 1 wt%of the catalyst Ni7Cu1/diatomite(based on methyl ricinoleate).Besides,the supported Cu–Ni bimetallic catalyst is stable during recycle and reuse.After five cycles of reuse,much catalytic activity is still preserved.Therefore,this low-cost and stable bimetallic catalyst would be promising for the hydrogenation of methyl ricinoleate to methyl 12-hydroxystearate,representing an example of green catalysis for efficiently conversion of biomass to value-added chemicals and materials.
文摘目的探讨新生儿呼吸窘迫综合征(NRDS)患儿肺超声纹理特征、肺部12分区超声评分与预后不良的相关性,并分析其对预后不良风险的预测价值。方法选取2021年8月至2024年12月南阳市第一人民医院128例NRDS患儿为研究对象,根据预后情况分为预后良好组、预后不良组。比较两组临床资料、肺超声纹理特征、肺部12分区超声评分。采用列联相关性/Spearman相关性分析肺超声纹理特征、肺部12分区超声评分与NRDS患儿病情程度的关系。logistic回归分析预后不良风险的影响因素。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)评价肺超声纹理特征、肺部12分区超声评分对预后不良风险的预测价值。结果128例NRDS患儿治疗后预后良好98例,预后不良30例;预后不良组胎龄、出生体重、出生1 min Apgar评分、动脉血氧分压(PaO_(2))、氧合指数低于预后良好组,动脉血二氧化碳分压(PaCO_(2))、持续气道正压通气(CPAP)时间、有创机械通气占比高于预后良好组(P<0.05);预后不良组对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分高于预后良好组(P<0.05);肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分与出生1 min Apgar评分、PaO_(2)、氧合指数呈负相关,与PaCO_(2)呈正相关(P<0.05);肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分是NRDS患儿预后不良风险的独立影响因素(P<0.05);肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差、肺部12分区超声评分联合预测预后不良风险的AUC高于各指标单项预测(P<0.001)。结论NRDS预后不良患儿肺超声纹理特征对比度、集群阴影、差异性、逆差距、和方差及肺部12分区超声评分较预后良好患儿升高,其与病情指标密切相关,且为预后不良风险的独立影响因素,联合检测其水平在预测患儿预后不良风险方面具有临床应用价值。
