目的分析阿尔茨海默病(Alzheimer's disease,AD)患者血清叶酸、维生素B_(12)(VB_(12))、25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平,并评估这3项指标与患者认知功能和日常生活能力的相关性及其诊断AD的效能。方法选取60例AD患者...目的分析阿尔茨海默病(Alzheimer's disease,AD)患者血清叶酸、维生素B_(12)(VB_(12))、25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平,并评估这3项指标与患者认知功能和日常生活能力的相关性及其诊断AD的效能。方法选取60例AD患者(AD组)和48例体检健康老年人(对照组),检测两组血清叶酸、VB_(12)、25(OH)D水平。运用简易智力状态检查表(mini-mental state examination,MMSE)评价两组认知功能,日常生活能力量表(activity of daily living scale,ADL)评价日常生活能力;绘制ROC曲线分析诊断效能。结果AD组患者血清叶酸、VB_(12)、25(OH)D水平和MMSE、ADL评分均明显低于对照组(均P<0.05);3项血清学指标与MMSE、ADL评分呈正相关(均P<0.05)。ROC曲线显示,联合检测叶酸、VB_(12)和25(OH)D诊断AD的AUC值达0.798,敏感性78.3%,特异性72.9%,均明显高于3项指标单独使用时的结果。结论AD患者血清叶酸、VB_(12)、25(OH)D水平显著下降,并与患者的认知功能及日常生活能力衰退程度呈正相关;三者联合检测可提高对AD的诊断效能。展开更多
Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Milit...Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Military Medical Research,Xiong et al.[1]revealed the complex roles of F-box and leucine-rich repeat 6(FBXL6)and Kirsten rat sarcoma(KRAS)^(G12D) in the pathogenesis of liver cancer.This research offers critical insights into how these proteins contribute to hepatocellular carcinoma development and progression,potentially paving the way for targeted therapeutic strategies.This commentary analyzes the key findings from this study and their broader implications in oncology.展开更多
美国模拟器件公司(Analog Devices,Inc.,简称ADI)最新推出的全差分高速放大器具有业界最好的低噪声、低失真和宽动态范围,是用于驱动高速模数转换器(ADC)的理想产品。ADI公司扩展差分放大器产品种类的最新成员是AD8139和AD8137。它们专...美国模拟器件公司(Analog Devices,Inc.,简称ADI)最新推出的全差分高速放大器具有业界最好的低噪声、低失真和宽动态范围,是用于驱动高速模数转换器(ADC)的理想产品。ADI公司扩展差分放大器产品种类的最新成员是AD8139和AD8137。它们专为满足驱动12 bit～18 bit ADC的性能要求而设计,12 bit～18 bit ADC是宽带仪器仪表、通信设备、军用设备和工业设备应用的关键器件。展开更多
文摘目的分析阿尔茨海默病(Alzheimer's disease,AD)患者血清叶酸、维生素B_(12)(VB_(12))、25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平,并评估这3项指标与患者认知功能和日常生活能力的相关性及其诊断AD的效能。方法选取60例AD患者(AD组)和48例体检健康老年人(对照组),检测两组血清叶酸、VB_(12)、25(OH)D水平。运用简易智力状态检查表(mini-mental state examination,MMSE)评价两组认知功能,日常生活能力量表(activity of daily living scale,ADL)评价日常生活能力;绘制ROC曲线分析诊断效能。结果AD组患者血清叶酸、VB_(12)、25(OH)D水平和MMSE、ADL评分均明显低于对照组(均P<0.05);3项血清学指标与MMSE、ADL评分呈正相关(均P<0.05)。ROC曲线显示,联合检测叶酸、VB_(12)和25(OH)D诊断AD的AUC值达0.798,敏感性78.3%,特异性72.9%,均明显高于3项指标单独使用时的结果。结论AD患者血清叶酸、VB_(12)、25(OH)D水平显著下降,并与患者的认知功能及日常生活能力衰退程度呈正相关;三者联合检测可提高对AD的诊断效能。
基金supported by the National Natural Science Foundation of China(82271518,81971158,and 81671306)the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCFZ-2022-030)the Guiding Projects of Traditional Chinese Medicine in 2023–2024 by Hubei Provincial Administration of Traditional Chinese Medicine(ZY2023F038).
文摘Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Military Medical Research,Xiong et al.[1]revealed the complex roles of F-box and leucine-rich repeat 6(FBXL6)and Kirsten rat sarcoma(KRAS)^(G12D) in the pathogenesis of liver cancer.This research offers critical insights into how these proteins contribute to hepatocellular carcinoma development and progression,potentially paving the way for targeted therapeutic strategies.This commentary analyzes the key findings from this study and their broader implications in oncology.
文摘美国模拟器件公司(Analog Devices,Inc.,简称ADI)最新推出的全差分高速放大器具有业界最好的低噪声、低失真和宽动态范围,是用于驱动高速模数转换器(ADC)的理想产品。ADI公司扩展差分放大器产品种类的最新成员是AD8139和AD8137。它们专为满足驱动12 bit～18 bit ADC的性能要求而设计,12 bit～18 bit ADC是宽带仪器仪表、通信设备、军用设备和工业设备应用的关键器件。
