Y chromosome microdeletions are an important cause of male infertility.At present,research on the Y chromosome is mainly focused on analyzing the loss of large segments of the azoospermia factor a/b/c(AZFa/b/c)gene,an...Y chromosome microdeletions are an important cause of male infertility.At present,research on the Y chromosome is mainly focused on analyzing the loss of large segments of the azoospermia factor a/b/c(AZFa/b/c)gene,and few studies have reported the impact of unit point deletion in the AZF band on fertility.This study analyzed the effect of sperm quality after sY1192 loss in 116 patients.The sY1192-independent deletion accounted for 41.4%(48/116).Eight patterns were found in the deletions associated with sY1192.The rate of sperm detection was similar in the semen of patients with the independent sY1192 deletion and the combined sY1192 deletions(52.1%vs 50.0%).The patients with only sY1192 gene loss had a higher probability of sperm detection than the patients whose sY1192 gene locus existed,but other gene loci were lost(52.1%vs 32.0%).The hormone levels were similar in patients with sY1192 deletion alone and in those with sY1192 deletion and other types of microdeletions in the presence of the sY1192 locus.After multiple intracytoplasmic sperm injection(ICSI)attempts,the pregnancy rate of spouses of men with sY1192-independent deletions was similar to that of other types of microdeletions,but the fertilization and cleavage rates were higher.We observed that eight deletion patterns were observed for sY1192 microdeletions of AZFb/c,dominated by the independent deletion of sY1192.After ICSI,the fertilization rate and cleavage rate of the sY1192-independent microdeletion were higher than those of other Y chromosome microdeletion types,but there was no significant difference in pregnancy outcomes.展开更多
ISO 19650系列是使用建筑信息模型(BIM)时信息管理的新国际标准,由国际公认的BIM专家组基于英国1192系列的制定。英国1192系列在降低风险、提高可预测性和实现更好的业务成果方面已在世界上证明了其成功。本文回答了建筑业经常提出的&qu...ISO 19650系列是使用建筑信息模型(BIM)时信息管理的新国际标准,由国际公认的BIM专家组基于英国1192系列的制定。英国1192系列在降低风险、提高可预测性和实现更好的业务成果方面已在世界上证明了其成功。本文回答了建筑业经常提出的"何时开始使用ISO 19650"的问题。展开更多
基金supported by the funding from the Joint Funds for the Innovation of Science and Technology,Fujian Province(Grant No.2023Y9385)Major Scientific Research Program for Young and Middleaged Health Professionals of Fujian Province,China(Grant No.2022ZQNZD010).
文摘Y chromosome microdeletions are an important cause of male infertility.At present,research on the Y chromosome is mainly focused on analyzing the loss of large segments of the azoospermia factor a/b/c(AZFa/b/c)gene,and few studies have reported the impact of unit point deletion in the AZF band on fertility.This study analyzed the effect of sperm quality after sY1192 loss in 116 patients.The sY1192-independent deletion accounted for 41.4%(48/116).Eight patterns were found in the deletions associated with sY1192.The rate of sperm detection was similar in the semen of patients with the independent sY1192 deletion and the combined sY1192 deletions(52.1%vs 50.0%).The patients with only sY1192 gene loss had a higher probability of sperm detection than the patients whose sY1192 gene locus existed,but other gene loci were lost(52.1%vs 32.0%).The hormone levels were similar in patients with sY1192 deletion alone and in those with sY1192 deletion and other types of microdeletions in the presence of the sY1192 locus.After multiple intracytoplasmic sperm injection(ICSI)attempts,the pregnancy rate of spouses of men with sY1192-independent deletions was similar to that of other types of microdeletions,but the fertilization and cleavage rates were higher.We observed that eight deletion patterns were observed for sY1192 microdeletions of AZFb/c,dominated by the independent deletion of sY1192.After ICSI,the fertilization rate and cleavage rate of the sY1192-independent microdeletion were higher than those of other Y chromosome microdeletion types,but there was no significant difference in pregnancy outcomes.
