Although the demand of ^(10)B separation has arisen in the 1930s,^(10)B/^(11)B are among the most difficult isotopes to separate due to the extremely similar relative atomic mass.Herein,we report an efficient separati...Although the demand of ^(10)B separation has arisen in the 1930s,^(10)B/^(11)B are among the most difficult isotopes to separate due to the extremely similar relative atomic mass.Herein,we report an efficient separation of ^(10)B isotopologue by engineering amino-galloyl synergistic materials via a selective adsorption and isotope exchange reaction,achieving a record-high single-stage separation factor of 1.048 with ^(10)B abundance up to 21.42%.^(11)B MAS NMR results and DFT calculations reveal that the galloyl groups exhibit inherent high affinity for B(OH)4-,forming tetrahedral sp^(3) B-galloyl complexes.The relatively higher ^(10)B–O bond energy of ^(10)B-galloyl complexes facilitates the isotope exchange between11B in B-galloyl complexes and ^(10)B in B(OH)_(3).Flowthrough dynamic separation in fixed-bed demonstrates the feasibility and potential of large-scale deployment of this method in real-world,suggesting a promising avenue for the exploitation of more efficient enrichment of ^(10)B for the sustainable nuclear energy and biomedical research.展开更多
AIM TO detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma （SA） prognosis.METHODS The Cancer Genome Atlas database was used to obtain RNA...AIM TO detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma （SA） prognosis.METHODS The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted gene co-expression network analysis （WGCNA） was used to investigate the meaningful module along with hub genes. Expression of hub genes was analyzed in 362 paraffin-embedded SA biopsy tissues by immunohistochemical staining. Patients were classified into two groups （according to expression of hub genes）： Weak expression and over-expression groups. Correlation of biomarkers with clinicopathological factors indicated patient survival.RESULTS Whole genome expression level screening identified 6,231 differentially expressed genes. Twenty-four co- expressed gene modules were identified using WGCNA. Pearson＇s correlation analysis showed that the tan module was the most relevant to tumor stage （r = 0.24, P = 7 × 10 -6）. In addition, we detected sorting nexin （SNX）10 as the hub gene of the tan module. SNX10 expression was linked to T category （P = 0.042, x2= 8.708）, N category （P = 0.000, x2= 18.778）, TNM stage （P = 0.001, x2 = 16.744） as well as tumor differentiation （P = 0.000,x2= 251.930）. Patients with high SNX10 expression tended to have longer diseasefree survival （DFS; 44.97 mo vs 33.85 mo, P = 0.000） as well as overall survival （OS; 49.95 vs 40.84 mo, P = 0.000） in univariate analysis. Multivariate analysis showed that dismal prognosis could be precisely predicted clinicopathologically using SNX10 [DFS： P = 0.014, hazard ratio （HR） = 0.698, 95% confidence interval （CI）： 0.524-0.930, OS： P = 0.017, HR = 0.704, 95%CI： 0.528-0.940].CONCLUSION This study provides a new technique for screening prognostic biomarkers of SA. Weak expression of SNX10 is linked to poor prognosis, and is a suitable prognostic biomarker of SA.展开更多
The 10kV distribution network is an essential component of the power system,and its stable operation is crucial for ensuring reliable power supply.However,various factors can lead to faults in the distribution network...The 10kV distribution network is an essential component of the power system,and its stable operation is crucial for ensuring reliable power supply.However,various factors can lead to faults in the distribution network.In order to enhance the safety and reliability of power distribution,this paper focuses on the analysis of faults in the 10kV distribution network caused by natural factors,operational factors,human factors,and equipment factors.It elucidates the various hazards resulting from distribution network faults and proposes corresponding preventive measures for different types of faults in the 10kV distribution network.The aim is to mitigate or reduce the impact of distribution network faults,ensuring the safe and stable operation of the distribution system.展开更多
Electric power plays a very important role in economic development and people's life and production, and 10kV distribution network project is the main way to improve the power system.In this paper, the current sit...Electric power plays a very important role in economic development and people's life and production, and 10kV distribution network project is the main way to improve the power system.In this paper, the current situation of construction management of 10kV distribution network project is mainly analyzed, and the quality control measures are put forward.展开更多
围绕10 kV配电网中智能开关设备的运行特性与可靠性展开系统研究,阐述了设备的组成结构与关键性能,然后从响应时间、负载变化适应能力及环境因素3方面分析其运行特性,揭示高温、高湿等极端条件对设备性能的影响。在此基础上引入平均故...围绕10 kV配电网中智能开关设备的运行特性与可靠性展开系统研究,阐述了设备的组成结构与关键性能,然后从响应时间、负载变化适应能力及环境因素3方面分析其运行特性,揭示高温、高湿等极端条件对设备性能的影响。在此基础上引入平均故障间隔时间(Mean Time Between Failure,MTBF)、平均修复时间(Mean Time To Repair,MTTR)等指标,构建设备可靠性评估体系。最后结合实际运行数据开展实地测试验证。研究表明,智能开关设备在提升配电网自动化、可靠性和运行效率方面具有重要意义。展开更多
基金supported by the National Natural Science Foundation of China(Nos.22108181,22178233)the Fund of Science and Technology on Reactor Fuel and Materials Laboratory(No.6142A06190601)+6 种基金the National Excellent Young Scientists Fund(No.00308054A1045)the National Key R&D Program of China(No.2022YFA0912800)the Talents Program of Sichuan ProvinceDouble First Class University Plan of Sichuan Universitythe State Key Laboratory of Polymer Materials Engineering(No.sklpme 2020–03–01)the Tianfu Emei Program of Sichuan Province(No.2022EC02–00073-CG)Ministry of Education Key Laboratory of Leather Chemistry and Engineering(Sichuan University)。
文摘Although the demand of ^(10)B separation has arisen in the 1930s,^(10)B/^(11)B are among the most difficult isotopes to separate due to the extremely similar relative atomic mass.Herein,we report an efficient separation of ^(10)B isotopologue by engineering amino-galloyl synergistic materials via a selective adsorption and isotope exchange reaction,achieving a record-high single-stage separation factor of 1.048 with ^(10)B abundance up to 21.42%.^(11)B MAS NMR results and DFT calculations reveal that the galloyl groups exhibit inherent high affinity for B(OH)4-,forming tetrahedral sp^(3) B-galloyl complexes.The relatively higher ^(10)B–O bond energy of ^(10)B-galloyl complexes facilitates the isotope exchange between11B in B-galloyl complexes and ^(10)B in B(OH)_(3).Flowthrough dynamic separation in fixed-bed demonstrates the feasibility and potential of large-scale deployment of this method in real-world,suggesting a promising avenue for the exploitation of more efficient enrichment of ^(10)B for the sustainable nuclear energy and biomedical research.
文摘AIM TO detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma （SA） prognosis.METHODS The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted gene co-expression network analysis （WGCNA） was used to investigate the meaningful module along with hub genes. Expression of hub genes was analyzed in 362 paraffin-embedded SA biopsy tissues by immunohistochemical staining. Patients were classified into two groups （according to expression of hub genes）： Weak expression and over-expression groups. Correlation of biomarkers with clinicopathological factors indicated patient survival.RESULTS Whole genome expression level screening identified 6,231 differentially expressed genes. Twenty-four co- expressed gene modules were identified using WGCNA. Pearson＇s correlation analysis showed that the tan module was the most relevant to tumor stage （r = 0.24, P = 7 × 10 -6）. In addition, we detected sorting nexin （SNX）10 as the hub gene of the tan module. SNX10 expression was linked to T category （P = 0.042, x2= 8.708）, N category （P = 0.000, x2= 18.778）, TNM stage （P = 0.001, x2 = 16.744） as well as tumor differentiation （P = 0.000,x2= 251.930）. Patients with high SNX10 expression tended to have longer diseasefree survival （DFS; 44.97 mo vs 33.85 mo, P = 0.000） as well as overall survival （OS; 49.95 vs 40.84 mo, P = 0.000） in univariate analysis. Multivariate analysis showed that dismal prognosis could be precisely predicted clinicopathologically using SNX10 [DFS： P = 0.014, hazard ratio （HR） = 0.698, 95% confidence interval （CI）： 0.524-0.930, OS： P = 0.017, HR = 0.704, 95%CI： 0.528-0.940].CONCLUSION This study provides a new technique for screening prognostic biomarkers of SA. Weak expression of SNX10 is linked to poor prognosis, and is a suitable prognostic biomarker of SA.
基金Tibet Autonomous Region Natural Fund Key Project(XZ202201ZR0024G)。
文摘The 10kV distribution network is an essential component of the power system,and its stable operation is crucial for ensuring reliable power supply.However,various factors can lead to faults in the distribution network.In order to enhance the safety and reliability of power distribution,this paper focuses on the analysis of faults in the 10kV distribution network caused by natural factors,operational factors,human factors,and equipment factors.It elucidates the various hazards resulting from distribution network faults and proposes corresponding preventive measures for different types of faults in the 10kV distribution network.The aim is to mitigate or reduce the impact of distribution network faults,ensuring the safe and stable operation of the distribution system.
文摘Electric power plays a very important role in economic development and people's life and production, and 10kV distribution network project is the main way to improve the power system.In this paper, the current situation of construction management of 10kV distribution network project is mainly analyzed, and the quality control measures are put forward.
文摘围绕10 kV配电网中智能开关设备的运行特性与可靠性展开系统研究,阐述了设备的组成结构与关键性能,然后从响应时间、负载变化适应能力及环境因素3方面分析其运行特性,揭示高温、高湿等极端条件对设备性能的影响。在此基础上引入平均故障间隔时间(Mean Time Between Failure,MTBF)、平均修复时间(Mean Time To Repair,MTTR)等指标,构建设备可靠性评估体系。最后结合实际运行数据开展实地测试验证。研究表明,智能开关设备在提升配电网自动化、可靠性和运行效率方面具有重要意义。
