Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) foll...Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) following a simple exposure technique. A known quantity of the irritant was kept in an adapter fitted with glass exposure chamber, heated, and the vapor thus generated was purged into the chamber. The restrained mouse inhaled the vapor, and the resultant depression of respiratory rate was recorded on a polygraph. Fifty percent depression of the respiration rate and the corresponding air concentration of the irritant was determined by obtaining the linear curve fitting equation and putting the value of Y=50. It was concluded that inhalation of CR vapor was 2. 66 times more irritating than that of CN in mice. The employed exposure method also proved to be simple, sensitive, easy t0 operate,and may also prove useful in evaluating irritation of upper respiratory tract fOllowing the inhalation of vapors of various chemicals.展开更多
Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Liste...Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects ofCN vapour inhalation. This may be attributed to immunotoxic effects of CN on Tcells mediated macrophage functions.展开更多
文摘Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) following a simple exposure technique. A known quantity of the irritant was kept in an adapter fitted with glass exposure chamber, heated, and the vapor thus generated was purged into the chamber. The restrained mouse inhaled the vapor, and the resultant depression of respiratory rate was recorded on a polygraph. Fifty percent depression of the respiration rate and the corresponding air concentration of the irritant was determined by obtaining the linear curve fitting equation and putting the value of Y=50. It was concluded that inhalation of CR vapor was 2. 66 times more irritating than that of CN in mice. The employed exposure method also proved to be simple, sensitive, easy t0 operate,and may also prove useful in evaluating irritation of upper respiratory tract fOllowing the inhalation of vapors of various chemicals.
文摘Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects ofCN vapour inhalation. This may be attributed to immunotoxic effects of CN on Tcells mediated macrophage functions.
