Electrolyte additives are pivotal for stable cycling of rechargeable sodium-ion batteries(SIBs),which dictate the creation of the protective interface film on electrodes.Cyclic sulfur-containing additives,such as1,3,2...Electrolyte additives are pivotal for stable cycling of rechargeable sodium-ion batteries(SIBs),which dictate the creation of the protective interface film on electrodes.Cyclic sulfur-containing additives,such as1,3,2-dioxathiolane-2,2-dioxide(DTD),with the structure of sulfur surrounded by four oxygen atoms,have been proposed but less knowledge is available on the relationship between their molecular structures and interfacial stability.This work compares two similar molecule structure of cyclic sulfurcontaining additives,DTD and ethylene sulfite(ES),to investigate their effects on the electrochemical performance of NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)(NFM)||hard carbon(HC)pouch cells.Therein,ES with the structure of sulfur surrounded by three oxygen atoms,as electrolyte additive,is investigated in the SIBs for the first time.It is shown that adding 3.0%ES or 2.0%DTD(the optimal proportion)in the Control electrolyte(1 M NaPF_(6)in EC:EMC=3:7 with 5.0%FEC in weight)can improve cyclic stability and rate performance,respectively.Even under the high-temperature conditions,both ES and DTD exhibit good performance,but DTD is superior.Combinations of electrochemical methods,multi-spectroscopy,and theoretical calculations have been employed to evaluate and compare the effects of ES and DTD on sodium-ion battery.They reveal that ES and DTD can generate different content and composition by redox reaction on cathode and anode surface.The more and effective high-valence sulfur-containing components for DTD are the main reason to explain the better effect on DTD.This work shares new insights into the relationship between cyclic sulfur-containing additive molecule structure and electrolyte-electrode interface films effect,which fills the blanks of previous research.展开更多
目的:分析钢板内固定、髓内钉+前螺钉内固定治疗胫骨下1/3螺旋形骨折合并后踝骨折的临床疗效。方法:回顾性收集我院2021年1月至2023年12月收治的80例胫骨下1/3螺旋形骨折合并后踝骨折患者临床资料,根据所采用内固定方式不同进行分组,其...目的:分析钢板内固定、髓内钉+前螺钉内固定治疗胫骨下1/3螺旋形骨折合并后踝骨折的临床疗效。方法:回顾性收集我院2021年1月至2023年12月收治的80例胫骨下1/3螺旋形骨折合并后踝骨折患者临床资料,根据所采用内固定方式不同进行分组,其中A组42例,予以髓内钉+前螺钉内固定,B组38例,予以钢板内固定,两组术后随访12m。比较A组、B组手术指标、术后疼痛、踝关节与膝关节功能、并发症、生活质量。结果:两组手术时长比较无明显差异,A组术中出血量少于B组(P<0.05),愈合时间、住院时间短于B组(P<0.05);A组术后1 m、3 m视觉模拟评分(Visual analogue scale,VAS)低于B组(P<0.05);术后6 m、术后1 y,A组踝-后足评分(American Orthopedic Foot and Ankle Society Score,AOFAS)、膝关节评分(Hospital for Special Surgery,HSS)明显高于B组(P<0.05);两组并发症发生率比较无明显差异。结论:相较于钢板内固定,髓内钉+前螺钉内固定治疗胫骨下1/3螺旋形骨折合并后踝骨折有助于促进预后恢复,缓解术后疼痛,促进踝膝关节功能恢复。展开更多
Objectives:Immunomodulatory drugs(IMiDs),functioning as molecular glue degraders,have been approved for treating various hematological malignancies;however,the inevitable acquired drug resistance resulting from their ...Objectives:Immunomodulatory drugs(IMiDs),functioning as molecular glue degraders,have been approved for treating various hematological malignancies;however,the inevitable acquired drug resistance resulting from their skeletal similarity and hematological toxicities poses significant obstacles to their clinical treatment.The study aimed to develop degraders with potent efficiency and low toxicity.Methods:Phenotypic profiling,elaborate structure-activity relationships(SAR),rational drug design and degradation profiles investigations,quantitative proteomics analysis and cell-based functional studies,and pharmacokinetic studies were conducted to develop more potent degraders.Results:This study developed novel CRBN-binding moieties throughmethylene deletion in lenalidomide’s isoindole core.Lead compounds MGD-A7 and MGD-C9 demonstrated superior antiproliferative efficacy vs.IMiDs,with submicromolar potency.MGD-A7 and MGD-C9 significantly and selectively induced the degradation of Ikaros Family Zinc Finger Proteins 1 and 3(IKZF1/3)with nanomolar potency via a CRBN-dependent pathway.Mechanistically,MGD-A7 and MGD-C9 dramatically induced cell apoptosis and G1 cell cycle arrest and MGDC9 exhibited favorable pharmacokinetic properties in vivo.Furthermore,MGD-C9 exhibited significant synergistic effects with standard-of-care agents in various hematological malignancy cells.Conclusions:These results indicate that MGD-C9 could act as a highly effective CRBN ligand and is expected to become a candidate drug for the treatment of hematological malignancies.展开更多
基金supported by the National Natural Science Foundation of China(21875076)the Guangdong Provincial International Joint Research Center for Energy Storage Materials(2023A0505090009)the Science and Technology Planning Project of Guangzhou City(2023B03J1278)。
文摘Electrolyte additives are pivotal for stable cycling of rechargeable sodium-ion batteries(SIBs),which dictate the creation of the protective interface film on electrodes.Cyclic sulfur-containing additives,such as1,3,2-dioxathiolane-2,2-dioxide(DTD),with the structure of sulfur surrounded by four oxygen atoms,have been proposed but less knowledge is available on the relationship between their molecular structures and interfacial stability.This work compares two similar molecule structure of cyclic sulfurcontaining additives,DTD and ethylene sulfite(ES),to investigate their effects on the electrochemical performance of NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)(NFM)||hard carbon(HC)pouch cells.Therein,ES with the structure of sulfur surrounded by three oxygen atoms,as electrolyte additive,is investigated in the SIBs for the first time.It is shown that adding 3.0%ES or 2.0%DTD(the optimal proportion)in the Control electrolyte(1 M NaPF_(6)in EC:EMC=3:7 with 5.0%FEC in weight)can improve cyclic stability and rate performance,respectively.Even under the high-temperature conditions,both ES and DTD exhibit good performance,but DTD is superior.Combinations of electrochemical methods,multi-spectroscopy,and theoretical calculations have been employed to evaluate and compare the effects of ES and DTD on sodium-ion battery.They reveal that ES and DTD can generate different content and composition by redox reaction on cathode and anode surface.The more and effective high-valence sulfur-containing components for DTD are the main reason to explain the better effect on DTD.This work shares new insights into the relationship between cyclic sulfur-containing additive molecule structure and electrolyte-electrode interface films effect,which fills the blanks of previous research.
文摘目的:分析钢板内固定、髓内钉+前螺钉内固定治疗胫骨下1/3螺旋形骨折合并后踝骨折的临床疗效。方法:回顾性收集我院2021年1月至2023年12月收治的80例胫骨下1/3螺旋形骨折合并后踝骨折患者临床资料,根据所采用内固定方式不同进行分组,其中A组42例,予以髓内钉+前螺钉内固定,B组38例,予以钢板内固定,两组术后随访12m。比较A组、B组手术指标、术后疼痛、踝关节与膝关节功能、并发症、生活质量。结果:两组手术时长比较无明显差异,A组术中出血量少于B组(P<0.05),愈合时间、住院时间短于B组(P<0.05);A组术后1 m、3 m视觉模拟评分(Visual analogue scale,VAS)低于B组(P<0.05);术后6 m、术后1 y,A组踝-后足评分(American Orthopedic Foot and Ankle Society Score,AOFAS)、膝关节评分(Hospital for Special Surgery,HSS)明显高于B组(P<0.05);两组并发症发生率比较无明显差异。结论:相较于钢板内固定,髓内钉+前螺钉内固定治疗胫骨下1/3螺旋形骨折合并后踝骨折有助于促进预后恢复,缓解术后疼痛,促进踝膝关节功能恢复。
基金supported by the National Natural Science Foundation of China(No.82404417)Key Project of North China University of Science and Technology(ZD-YG-202408)State Key Laboratory of National Security Specially Needed Medicines Program(No.LTMC2022ZZ006).
文摘Objectives:Immunomodulatory drugs(IMiDs),functioning as molecular glue degraders,have been approved for treating various hematological malignancies;however,the inevitable acquired drug resistance resulting from their skeletal similarity and hematological toxicities poses significant obstacles to their clinical treatment.The study aimed to develop degraders with potent efficiency and low toxicity.Methods:Phenotypic profiling,elaborate structure-activity relationships(SAR),rational drug design and degradation profiles investigations,quantitative proteomics analysis and cell-based functional studies,and pharmacokinetic studies were conducted to develop more potent degraders.Results:This study developed novel CRBN-binding moieties throughmethylene deletion in lenalidomide’s isoindole core.Lead compounds MGD-A7 and MGD-C9 demonstrated superior antiproliferative efficacy vs.IMiDs,with submicromolar potency.MGD-A7 and MGD-C9 significantly and selectively induced the degradation of Ikaros Family Zinc Finger Proteins 1 and 3(IKZF1/3)with nanomolar potency via a CRBN-dependent pathway.Mechanistically,MGD-A7 and MGD-C9 dramatically induced cell apoptosis and G1 cell cycle arrest and MGDC9 exhibited favorable pharmacokinetic properties in vivo.Furthermore,MGD-C9 exhibited significant synergistic effects with standard-of-care agents in various hematological malignancy cells.Conclusions:These results indicate that MGD-C9 could act as a highly effective CRBN ligand and is expected to become a candidate drug for the treatment of hematological malignancies.
