Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model...Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model based on the Congyou platform.Through the building block curriculum system,the HarmonyOS technology stack is decoupled into dynamic capability units,and a multi-disciplinary cross-case library is jointly built with Huawei,which significantly improves the synchronization of teaching content and industrial technology.This paper innovatively designs an AI collaborative teaching system,which employs knowledge graphs to plan learning paths,utilizes virtual equipment clusters to simulate development environments,and establishes a“diagnosis-feedback-enhancement”closed loop through AI-based review,thereby effectively improving students’development efficiency and code reuse rate.A three-dimensional evaluation model integrating task outcomes,process performance,and innovation is constructed,incorporating indicators such as code standardization and an innovation index to strengthen the cultivation of engineering thinking and innovative ability.Furthermore,a data-driven support platform is built to generate student competency profiles,open up the“credit-competency-certification”pathway,promote the transformation of course achievements into contributions to the Huawei ecosystem,and significantly shorten the job adaptation cycle for graduates.The research results provide a replicable paradigm for the cultivation of domestic operating system talents.展开更多
The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal...The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa.展开更多
By encouraging collaboration,attracting young entrepreneurs,and setting up village-invested enterprises,rural communities in Zhejiang Province are growing their income streams.“Over the past years,we have seen more a...By encouraging collaboration,attracting young entrepreneurs,and setting up village-invested enterprises,rural communities in Zhejiang Province are growing their income streams.“Over the past years,we have seen more and more tourists coming to our village,and their stay here has grown longer.Many even said they don’t want to leave,”Pan Chunlin,a resident of Yucun Village in Anji County of Huzhou City,east China’s Zhejiang Province,told China Today.Pan is the owner of the Chunlin Lodge,a bed&breakfast(B&B)which received more than 70,000 visitors last year,generating over RMB 4 million in revenue.展开更多
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.展开更多
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.展开更多
This study systematically reviews the development history and key technological breakthroughs of large gas fields in the Ordos Basin,and summarizes the development models of three gas reservoir types,low-permeability ...This study systematically reviews the development history and key technological breakthroughs of large gas fields in the Ordos Basin,and summarizes the development models of three gas reservoir types,low-permeability carbonate,low-permeability sandstone and tight sandstone,as well as the progress in deep coal-rock gas development.The current challenges and future development directions are also discussed.Mature development models have been formed for the three representative types of gas reservoirs in the Ordos Basin:(1)Low-permeability carbonate reservoir development model featuring groove fine-scale characterization and three-dimensional vertical succession between Upper and Lower Paleozoic formations.(2)Low-permeability sandstone reservoir development model emphasizing horizontal well pressure-depletion production and vertical well pressure-controlled production.(3)Tight sandstone gas reservoir development model focusing on single-well productivity enhancement and well placement optimization.In deep coal-rock gas development,significant progress has been achieved in reservoir evaluation,sweet spot prediction,and geosteering of horizontal wells.The three types of reservoirs have entered the mid-to-late stages of the development,when the main challenge lies in accurately characterizing residual gas,evaluating secondary gas-bearing layers,and developing precise potential-tapping strategies.In contrast,for the early-stage development of deep coal-rock gas,continuous technological upgrades and cost reduction are essential to achieving economically viable large-scale development.Four key directions of future research and technological breakthroughs are proposed:(1)Utilizing dual-porosity(fracture-matrix)modeling techniques in low-permeability carbonate reservoirs to delineate the volume and distribution of remaining gas in secondary pay zones,supporting well pattern optimization and production enhancement of existing wells.(2)Integrating well-log and seismic data to characterize reservoir spatial distribution of successive strata,enhancing drilling success rates in low-permeability sandstone reservoirs.(3)Utilizing the advantages of horizontal wells to penetrate effective reservoirs laterally,achieving meter-scale quantification of small-scale single sand bodies in tight gas reservoirs,and applying high-resolution 3D geological models to clarify the distribution of remaining gas and guide well placement optimization.(4)Further strengthening the evaluation of deep coal-rock gas in terms of resource potential,well type and pattern,reservoir stimulation,single-well performance,and economic viability.展开更多
In the area of reservoir engineering,the optimization of oil and gas production is a complex task involving a myriad of interconnected decision variables shaping the production system's infrastructure.Traditionall...In the area of reservoir engineering,the optimization of oil and gas production is a complex task involving a myriad of interconnected decision variables shaping the production system's infrastructure.Traditionally,this optimization process was centered on a single objective,such as net present value,return on investment,cumulative oil production,or cumulative water production.However,the inherent complexity of reservoir exploration necessitates a departure from this single-objective approach.Mul-tiple conflicting production and economic indicators must now be considered to enable more precise and robust decision-making.In response to this challenge,researchers have embarked on a journey to explore field development optimization of multiple conflicting criteria,employing the formidable tools of multi-objective optimization algorithms.These algorithms delve into the intricate terrain of production strategy design,seeking to strike a delicate balance between the often-contrasting objectives.Over the years,a plethora of these algorithms have emerged,ranging from a priori methods to a posteriori approach,each offering unique insights and capabilities.This survey endeavors to encapsulate,catego-rize,and scrutinize these invaluable contributions to field development optimization,which grapple with the complexities of multiple conflicting objective functions.Beyond the overview of existing methodologies,we delve into the persisting challenges faced by researchers and practitioners alike.Notably,the application of multi-objective optimization techniques to production optimization is hin-dered by the resource-intensive nature of reservoir simulation,especially when confronted with inherent uncertainties.As a result of this survey,emerging opportunities have been identified that will serve as catalysts for pivotal research endeavors in the future.As intelligent and more efficient algo-rithms continue to evolve,the potential for addressing hitherto insurmountable field development optimization obstacles becomes increasingly viable.This discussion on future prospects aims to inspire critical research,guiding the way toward innovative solutions in the ever-evolving landscape of oil and gas production optimization.展开更多
[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the ...[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the research subject to examine the effects of three different configuration modes:three rows with one film,four rows with one film,and six rows with one film,on the growth and development of cotton,as well as on yield and the amount of residual film in the field.[Results]In comparison to the configuration modes of four rows with one film and six rows with one film,the development process in the row spacing configuration mode of three rows with one film was accelerated by 1-4 d.This configuration mode exhibited variability in several agronomic traits,particularly in plant height,the number of fruiting branches per plant,and the number of leaves per plant,with the observed trend indicating T3>T2>T1.Conversely,the height of the first fruiting branch node displayed an inverse trend.In terms of yield composition,no significant differences were observed in boll weight and yield among various configuration modes.However,T3 exhibited the highest boll weight at 5.68 g and a yield of 462.67 kg/667 m 2.Additionally,significant differences were noted in harvesting density and the number of bolls per plant.T3 demonstrated the lowest harvesting density at 1.11×104 plants/666.7 m 2,the highest number of bolls per plant at 8.63,and the highest boll opening rate at 97.48%.Furthermore,T3 also resulted in the least amount of agricultural film residue during the current season.[Conclusions]Among the three planting configuration modes examined,the low-density planting configuration mode consisting of three rows and one film demonstrated a significant advantage at the individual plant level.This approach yielded results comparable to those of the high density planting configuration mode while also reducing costs.Furthermore,low density planting positively influenced the cotton boll opening rate,leading to a decreased amount of residual film and promoting ecological health within the agricultural land.展开更多
Based on the comprehensive analysis of data from petrology and mineralogy,well logging,seismic surveys,paleontology,and geochemistry,a detailed research was conducted on paleoenvironmental and paleoclimatic conditions...Based on the comprehensive analysis of data from petrology and mineralogy,well logging,seismic surveys,paleontology,and geochemistry,a detailed research was conducted on paleoenvironmental and paleoclimatic conditions,and modeling of the source rocks in the second member of the Eocene Wenchang Formation(Wen 2 Member)in the Northern Shunde Subsag at the southwestern margin of the Pearl River Mouth Basin.The Wen 2 Member hosts excellent,thick lacustrine source rocks with strong longitudinal heterogeneity and an average total organic carbon(TOC)content of over 4.9%.The Wen 2 Member can be divided into three units(I,II,III)from bottom to top.Unit I features excellent source rocks with Type I organic matters(average TOC of 5.9%)primarily sourced from lake organisms;Unit II hosts source rocks dominated by Type II2 organic matters(average TOC of 2.2%),which are originated from mixed sources dominated by terrestrial input.Unit III contains good to excellent source rocks dominated by Type II1 organic matters(average TOC of 4.9%),which are mainly contributed by lake organisms and partially by terrestrial input.Under the background of rapid subsidence and limited source supply during intense rifting period in the Eocene,excellent source rocks were developed in Wen 2 Member in the Northern Shunde Subsag under the coordinated control of warm and humid climate,volcanic activity,and deep-water reducing conditions.During the deposition of Unit I,the warm and humid climate and volcanic activity promoted the proliferation of lake algaes,primarily Granodiscus,resulting in high initial productivity,and deep-water reducing conditions enabled satisfactory preservation of organic matters.These factors jointly controlled the development and occurrence of excellent source rocks.During the deposition of Unit II,a transition from warm to cool and semi-arid paleoclimatic conditions led to a decrease in lake algaes and initial productivity.Additionally,enhanced terrestrial input and shallow-water,weakly oxidizing water conditions caused a significant dilution and decomposition of organic matters,degrading the quality of source rocks.During the deposition of Unit III,when the paleoclimatic conditions are cool and humid,Pediastrum and Botryococcus began to thrive,leading to an increase in productivity.Meanwhile,the reducing environment of semi-deep water facilitated the preservation of excellent source rocks,albeit slightly inferior to those in Unit I.The study results clarify the differential origins and development models of various source rocks in the Shunde Sag,offering valuable guidance for evaluating source rocks and selecting petroleum exploration targets in similar marginal sags.展开更多
Integrated urban-rural development is an inevitable choice for promoting Chinese modernization.High-quality integrated urban-rural development is essentially a practical response to the current multi-factor and multi-...Integrated urban-rural development is an inevitable choice for promoting Chinese modernization.High-quality integrated urban-rural development is essentially a practical response to the current multi-factor and multi-sectoral challenges in urban-rural relations,and plays an important role in implementing the new development philosophy,which promotes Chinese modernization.The theoretical logic supporting the function it plays in enabling Chinese modernization lies in the following aspects:it leverages the free flow of population and resources between urban and rural areas and thus facilitates the balanced development of China’s modernization;it advances the common prosperity of all people through its new type of urban-rural and industrial-agricultural relations;it fosters the coordinated development of the material and spiritual civilizations through the integration of urban and rural cultures;it promotes steering the modernization toward green development through the joint building and managing of the overall urban-rural ecosystem;and it drives modernization in a harmonious and stable direction through integrated urban-rural development.Currently,integrated urban-rural development still faces challenges such as restrictions on the two-way flow of factors,the low efficiency of industrial coordination and support,unequal access to public service facilities,and the insufficient use of land.Therefore,based on the strategic framework of urban-rural integrated development,it is necessary to continuously promote Chinese modernization through high-quality integrated urban-rural development from the perspectives of deepening institutional coordination,expanding the application of digital intelligence in urban and rural industries,optimizing public services,and improving land management.展开更多
Shanghai is blazing a new development track powered by dual engines:one is intelligent manufacturing empowered by cutting-edge technologies,and the other is green development driven by low-carbon and energy-saving sol...Shanghai is blazing a new development track powered by dual engines:one is intelligent manufacturing empowered by cutting-edge technologies,and the other is green development driven by low-carbon and energy-saving solutions.On September 10,China Today visited two enterprises in Shanghai-Shanghai Schneider Electric Industrial Control Co.,Ltd.and Huaqin Technology Co.,Ltd.-to observe firsthand how global investment and local innovation are jointly shaping Shanghai’s future of high-quality development.展开更多
The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,arti...The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider UAVs as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical reference and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.展开更多
The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,arti...The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider unmanned aerial vehicles(UAVs)as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical references and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.展开更多
Sliding mode control(SMC)is a well-known robust nonlinear control method with strong robustness and fast response which has been widely used in many applications.This paper introduces the major results of SMC design m...Sliding mode control(SMC)is a well-known robust nonlinear control method with strong robustness and fast response which has been widely used in many applications.This paper introduces the major results of SMC design methods that the authors have achieved in the last decade.Undoubtedly,our results are obtained based on many other researchers'pioneer work in the literature which will not be discussed in detail here.Notably,our development has a main focus on tackling practical issues such that a proposed or enhanced SMC approach is effectively applicable to motion control systems.Issues on sliding function and adaptive gain designs in SMC and their control features will be both discussed in this paper.Those issues comprise fast convergent speed,predefined convergent time,input saturation restriction,chattering reduction,and unknown disturbance suppression.Lastly,conclusion and a few remarks on future research directions are presented.展开更多
As a representative enterprise in the retail industry,MINISO takes cost leadership and product differentiation as its core strategy to compete actively in the global market.However,multi-brand retailers continue to ap...As a representative enterprise in the retail industry,MINISO takes cost leadership and product differentiation as its core strategy to compete actively in the global market.However,multi-brand retailers continue to appear in the domestic market and the existing“dollar stores”in the foreign market already have a certain number of loyal customers.Therefore,MINISO needs to understand its principles for creating,delivering,and capturing value.By strengthening its own competitive advantages,it could achieve differentiation when confronting challenges in both domestic and international markets.Based on the analysis of MINISO’s business model canvas,this paper puts forward corresponding strategic development suggestions.展开更多
Higher-order modes of the neutron diffusion/transport equation can be used to study the temporal behavior of nuclear reactors and can be applied in modal analysis, transient analysis, and online monitoring of the reac...Higher-order modes of the neutron diffusion/transport equation can be used to study the temporal behavior of nuclear reactors and can be applied in modal analysis, transient analysis, and online monitoring of the reactor core. Both the deterministic method and the Monte Carlo(MC) method can be used to solve the higher-order modes. However, MC method, compared to the deterministic method, faces challenges in terms of computational efficiency and α mode calculation stability, whereas the deterministic method encounters issues arising from homogenization-related geometric and energy spectra adaptation.Based on the higher-order mode diffusion calculation code HARMONY, we developed a new higher-order mode calculation code, HARMONY2.0, which retains the functionality of computing λ and α higher-order modes from HARMONY1.0, but enhances the ability to treat complex geometries and arbitrary energy spectra using the MC-deterministic hybrid two-step strategy. In HARMONY2.0, the mesh homogenized multigroup constants were obtained using OpenMC in the first step,and higher-order modes were then calculated with the mesh homogenized core diffusion model using the implicitly restarted Arnoldi method(IRAM), which was also adopted in the HARMONY1.0 code. In addition, to improve the calculation efficiency, particularly in large higher-order modes, event-driven parallelization/domain decomposition methods are embedded in the HARMONY2.0 code to accelerate the inner iteration of λ∕α mode using OpenMP. Furthermore, the higher-order modes of complex geometric models, such as Hoogenboom and ATR reactors for λ mode and the MUSE-4 experiment facility for the prompt α mode, were computed using diffusion theory.展开更多
The Hengduan Mountains region(HMR)is one of the most densely distributed and severe flash flood disaster-prone areas in southwest China.It is also a key area for major engineering projects and beautiful countryside co...The Hengduan Mountains region(HMR)is one of the most densely distributed and severe flash flood disaster-prone areas in southwest China.It is also a key area for major engineering projects and beautiful countryside construction in Southwest China.However,previous studies have not systematically summarized the development characteristics and formation modes of flash flood disasters in the HMR,which limits the development of theoretical and technical system for flood control.In this study,we focused on the physical processes of flash flood disasters in the HMR,including generation,movement,and disaster formation,and clarified the dominant disaster-inducing conditions(multiple humid monsoon circulation,high potential energy and high heterogenous underlying surface)and disaster development characteristics(high spatio-temporal heterogeneity,highly concentrated energy,chain and cascading effects,and clustered occurrence)of flash floods in the HMR.Based on the entire processes of flash flood disasters,three major formation modes have been summarized:the runoff generation mode of vegetation-hydrology-soil coupling dominated by high hydraulic gradient in mountainous areas,strong flow-sediment coupling movement,and serious disaster losses due to high exposure of disaster bearing objects.Finally,based on the issues in previous research,four future research challenges for flash flood disaster in the HMR were proposed.Our study provides insights into disaster prevention and reduction research,including fundamental theoretical system,precise risk assessment of regional disasters,and accurate early warning and forecasting of flash floods.展开更多
This paper focuses on rural music education in the context of rural revitalization,deeply analyzes its current resource situation,and points out that tangible resources face shortages of teachers,inappropriate textboo...This paper focuses on rural music education in the context of rural revitalization,deeply analyzes its current resource situation,and points out that tangible resources face shortages of teachers,inappropriate textbooks,and outdated teaching facilities,while intangible resources are confronted with the loss of folk music culture and the weakening of educational foundations due to cultural ecological changes.Resources are characterized by dispersion,scarcity,and inefficient utilization.In response to these difficulties,this paper proposes integration paths for teachers,textbooks,teaching facilities,and folk music culture resources.Additionally,it constructs a diversified development model that combines rural tourism with music activities,develops characteristic music education industries,and integrates rural cultural construction.Simultaneously,it identifies funding shortages and outdated concepts as major obstacles and proposes targeted strategies such as expanding funding channels and changing inherent concepts.The aim is to promote the development of rural music education and contribute to the revitalization of rural culture.展开更多
Under the background of"Digital Commerce for Rural Vitalization",rural E-commerce has experienced rapid development.However,agricultural products like strawberries,often produced by small-scale,fragmented,an...Under the background of"Digital Commerce for Rural Vitalization",rural E-commerce has experienced rapid development.However,agricultural products like strawberries,often produced by small-scale,fragmented,and less competitive individual farmers,struggle to meet the compliance and scalability demands of E-commerce,thereby constraining high-quality local economic development.Aiming to address this issue,this paper,guided by relevant policies and strategies,employs case analysis and logical deduction to explore the industrialization path of the"Cooperative+E-commerce"model for the strawberry industry.The research finds that by optimizing the cooperative's organizational structure,implementing multi-channel E-commerce strategies,upgrading the supply chain(including cold chain and quality traceability),and engaging in collaborative brand building,a robust industrial system can be formed.Supplemented by benefit evaluation,policy support,and regulatory oversight,this system can effectively bridge small-scale production with the broader market.This study concludes that this pathway can enhance the added value of the strawberry industry,increase farmer incomes,and provide practical insights for promoting high-quality local economic development.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
文摘Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model based on the Congyou platform.Through the building block curriculum system,the HarmonyOS technology stack is decoupled into dynamic capability units,and a multi-disciplinary cross-case library is jointly built with Huawei,which significantly improves the synchronization of teaching content and industrial technology.This paper innovatively designs an AI collaborative teaching system,which employs knowledge graphs to plan learning paths,utilizes virtual equipment clusters to simulate development environments,and establishes a“diagnosis-feedback-enhancement”closed loop through AI-based review,thereby effectively improving students’development efficiency and code reuse rate.A three-dimensional evaluation model integrating task outcomes,process performance,and innovation is constructed,incorporating indicators such as code standardization and an innovation index to strengthen the cultivation of engineering thinking and innovative ability.Furthermore,a data-driven support platform is built to generate student competency profiles,open up the“credit-competency-certification”pathway,promote the transformation of course achievements into contributions to the Huawei ecosystem,and significantly shorten the job adaptation cycle for graduates.The research results provide a replicable paradigm for the cultivation of domestic operating system talents.
文摘The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa.
文摘By encouraging collaboration,attracting young entrepreneurs,and setting up village-invested enterprises,rural communities in Zhejiang Province are growing their income streams.“Over the past years,we have seen more and more tourists coming to our village,and their stay here has grown longer.Many even said they don’t want to leave,”Pan Chunlin,a resident of Yucun Village in Anji County of Huzhou City,east China’s Zhejiang Province,told China Today.Pan is the owner of the Chunlin Lodge,a bed&breakfast(B&B)which received more than 70,000 visitors last year,generating over RMB 4 million in revenue.
基金supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG)the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
文摘Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.
基金supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC)the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ)+1 种基金the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ)Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
文摘The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.
文摘This study systematically reviews the development history and key technological breakthroughs of large gas fields in the Ordos Basin,and summarizes the development models of three gas reservoir types,low-permeability carbonate,low-permeability sandstone and tight sandstone,as well as the progress in deep coal-rock gas development.The current challenges and future development directions are also discussed.Mature development models have been formed for the three representative types of gas reservoirs in the Ordos Basin:(1)Low-permeability carbonate reservoir development model featuring groove fine-scale characterization and three-dimensional vertical succession between Upper and Lower Paleozoic formations.(2)Low-permeability sandstone reservoir development model emphasizing horizontal well pressure-depletion production and vertical well pressure-controlled production.(3)Tight sandstone gas reservoir development model focusing on single-well productivity enhancement and well placement optimization.In deep coal-rock gas development,significant progress has been achieved in reservoir evaluation,sweet spot prediction,and geosteering of horizontal wells.The three types of reservoirs have entered the mid-to-late stages of the development,when the main challenge lies in accurately characterizing residual gas,evaluating secondary gas-bearing layers,and developing precise potential-tapping strategies.In contrast,for the early-stage development of deep coal-rock gas,continuous technological upgrades and cost reduction are essential to achieving economically viable large-scale development.Four key directions of future research and technological breakthroughs are proposed:(1)Utilizing dual-porosity(fracture-matrix)modeling techniques in low-permeability carbonate reservoirs to delineate the volume and distribution of remaining gas in secondary pay zones,supporting well pattern optimization and production enhancement of existing wells.(2)Integrating well-log and seismic data to characterize reservoir spatial distribution of successive strata,enhancing drilling success rates in low-permeability sandstone reservoirs.(3)Utilizing the advantages of horizontal wells to penetrate effective reservoirs laterally,achieving meter-scale quantification of small-scale single sand bodies in tight gas reservoirs,and applying high-resolution 3D geological models to clarify the distribution of remaining gas and guide well placement optimization.(4)Further strengthening the evaluation of deep coal-rock gas in terms of resource potential,well type and pattern,reservoir stimulation,single-well performance,and economic viability.
基金the support of EPIC - Energy Production Innovation Center, hosted by the University of Campinas (UNICAMP) and sponsored by Equinor Brazil and FAPESP - Sao Paulo Research Foundation (2021/04878- 7 and 2017/15736-3)financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior Brasil (CAPES) - Financing Code 001
文摘In the area of reservoir engineering,the optimization of oil and gas production is a complex task involving a myriad of interconnected decision variables shaping the production system's infrastructure.Traditionally,this optimization process was centered on a single objective,such as net present value,return on investment,cumulative oil production,or cumulative water production.However,the inherent complexity of reservoir exploration necessitates a departure from this single-objective approach.Mul-tiple conflicting production and economic indicators must now be considered to enable more precise and robust decision-making.In response to this challenge,researchers have embarked on a journey to explore field development optimization of multiple conflicting criteria,employing the formidable tools of multi-objective optimization algorithms.These algorithms delve into the intricate terrain of production strategy design,seeking to strike a delicate balance between the often-contrasting objectives.Over the years,a plethora of these algorithms have emerged,ranging from a priori methods to a posteriori approach,each offering unique insights and capabilities.This survey endeavors to encapsulate,catego-rize,and scrutinize these invaluable contributions to field development optimization,which grapple with the complexities of multiple conflicting objective functions.Beyond the overview of existing methodologies,we delve into the persisting challenges faced by researchers and practitioners alike.Notably,the application of multi-objective optimization techniques to production optimization is hin-dered by the resource-intensive nature of reservoir simulation,especially when confronted with inherent uncertainties.As a result of this survey,emerging opportunities have been identified that will serve as catalysts for pivotal research endeavors in the future.As intelligent and more efficient algo-rithms continue to evolve,the potential for addressing hitherto insurmountable field development optimization obstacles becomes increasingly viable.This discussion on future prospects aims to inspire critical research,guiding the way toward innovative solutions in the ever-evolving landscape of oil and gas production optimization.
基金Supported by China Agriculture(Cotton)Research System(CARS-15-46)Intellectual Aid Xinjiang Innovation and Expansion Talent Program of Xinjiang Uygur Autonomous Region(2024500207).
文摘[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the research subject to examine the effects of three different configuration modes:three rows with one film,four rows with one film,and six rows with one film,on the growth and development of cotton,as well as on yield and the amount of residual film in the field.[Results]In comparison to the configuration modes of four rows with one film and six rows with one film,the development process in the row spacing configuration mode of three rows with one film was accelerated by 1-4 d.This configuration mode exhibited variability in several agronomic traits,particularly in plant height,the number of fruiting branches per plant,and the number of leaves per plant,with the observed trend indicating T3>T2>T1.Conversely,the height of the first fruiting branch node displayed an inverse trend.In terms of yield composition,no significant differences were observed in boll weight and yield among various configuration modes.However,T3 exhibited the highest boll weight at 5.68 g and a yield of 462.67 kg/667 m 2.Additionally,significant differences were noted in harvesting density and the number of bolls per plant.T3 demonstrated the lowest harvesting density at 1.11×104 plants/666.7 m 2,the highest number of bolls per plant at 8.63,and the highest boll opening rate at 97.48%.Furthermore,T3 also resulted in the least amount of agricultural film residue during the current season.[Conclusions]Among the three planting configuration modes examined,the low-density planting configuration mode consisting of three rows and one film demonstrated a significant advantage at the individual plant level.This approach yielded results comparable to those of the high density planting configuration mode while also reducing costs.Furthermore,low density planting positively influenced the cotton boll opening rate,leading to a decreased amount of residual film and promoting ecological health within the agricultural land.
基金Supported by the Research Project of China National Offshore Oil Corporation(SCKY-2023-HN-3)。
文摘Based on the comprehensive analysis of data from petrology and mineralogy,well logging,seismic surveys,paleontology,and geochemistry,a detailed research was conducted on paleoenvironmental and paleoclimatic conditions,and modeling of the source rocks in the second member of the Eocene Wenchang Formation(Wen 2 Member)in the Northern Shunde Subsag at the southwestern margin of the Pearl River Mouth Basin.The Wen 2 Member hosts excellent,thick lacustrine source rocks with strong longitudinal heterogeneity and an average total organic carbon(TOC)content of over 4.9%.The Wen 2 Member can be divided into three units(I,II,III)from bottom to top.Unit I features excellent source rocks with Type I organic matters(average TOC of 5.9%)primarily sourced from lake organisms;Unit II hosts source rocks dominated by Type II2 organic matters(average TOC of 2.2%),which are originated from mixed sources dominated by terrestrial input.Unit III contains good to excellent source rocks dominated by Type II1 organic matters(average TOC of 4.9%),which are mainly contributed by lake organisms and partially by terrestrial input.Under the background of rapid subsidence and limited source supply during intense rifting period in the Eocene,excellent source rocks were developed in Wen 2 Member in the Northern Shunde Subsag under the coordinated control of warm and humid climate,volcanic activity,and deep-water reducing conditions.During the deposition of Unit I,the warm and humid climate and volcanic activity promoted the proliferation of lake algaes,primarily Granodiscus,resulting in high initial productivity,and deep-water reducing conditions enabled satisfactory preservation of organic matters.These factors jointly controlled the development and occurrence of excellent source rocks.During the deposition of Unit II,a transition from warm to cool and semi-arid paleoclimatic conditions led to a decrease in lake algaes and initial productivity.Additionally,enhanced terrestrial input and shallow-water,weakly oxidizing water conditions caused a significant dilution and decomposition of organic matters,degrading the quality of source rocks.During the deposition of Unit III,when the paleoclimatic conditions are cool and humid,Pediastrum and Botryococcus began to thrive,leading to an increase in productivity.Meanwhile,the reducing environment of semi-deep water facilitated the preservation of excellent source rocks,albeit slightly inferior to those in Unit I.The study results clarify the differential origins and development models of various source rocks in the Shunde Sag,offering valuable guidance for evaluating source rocks and selecting petroleum exploration targets in similar marginal sags.
基金the Research on the Original Contribution and Global Significance of the Concept of Community with a Shared Future for Mankind from a Historical Materialist Perspective(Project No.:20&ZD026)a major project of the National Social Science Foundation of China.
文摘Integrated urban-rural development is an inevitable choice for promoting Chinese modernization.High-quality integrated urban-rural development is essentially a practical response to the current multi-factor and multi-sectoral challenges in urban-rural relations,and plays an important role in implementing the new development philosophy,which promotes Chinese modernization.The theoretical logic supporting the function it plays in enabling Chinese modernization lies in the following aspects:it leverages the free flow of population and resources between urban and rural areas and thus facilitates the balanced development of China’s modernization;it advances the common prosperity of all people through its new type of urban-rural and industrial-agricultural relations;it fosters the coordinated development of the material and spiritual civilizations through the integration of urban and rural cultures;it promotes steering the modernization toward green development through the joint building and managing of the overall urban-rural ecosystem;and it drives modernization in a harmonious and stable direction through integrated urban-rural development.Currently,integrated urban-rural development still faces challenges such as restrictions on the two-way flow of factors,the low efficiency of industrial coordination and support,unequal access to public service facilities,and the insufficient use of land.Therefore,based on the strategic framework of urban-rural integrated development,it is necessary to continuously promote Chinese modernization through high-quality integrated urban-rural development from the perspectives of deepening institutional coordination,expanding the application of digital intelligence in urban and rural industries,optimizing public services,and improving land management.
文摘Shanghai is blazing a new development track powered by dual engines:one is intelligent manufacturing empowered by cutting-edge technologies,and the other is green development driven by low-carbon and energy-saving solutions.On September 10,China Today visited two enterprises in Shanghai-Shanghai Schneider Electric Industrial Control Co.,Ltd.and Huaqin Technology Co.,Ltd.-to observe firsthand how global investment and local innovation are jointly shaping Shanghai’s future of high-quality development.
文摘The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider UAVs as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical reference and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.
文摘The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider unmanned aerial vehicles(UAVs)as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical references and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.
基金supported by the Natural Science Basic Research Program of Shaanxi with Grant No.2025JC-YBQN-807。
文摘Sliding mode control(SMC)is a well-known robust nonlinear control method with strong robustness and fast response which has been widely used in many applications.This paper introduces the major results of SMC design methods that the authors have achieved in the last decade.Undoubtedly,our results are obtained based on many other researchers'pioneer work in the literature which will not be discussed in detail here.Notably,our development has a main focus on tackling practical issues such that a proposed or enhanced SMC approach is effectively applicable to motion control systems.Issues on sliding function and adaptive gain designs in SMC and their control features will be both discussed in this paper.Those issues comprise fast convergent speed,predefined convergent time,input saturation restriction,chattering reduction,and unknown disturbance suppression.Lastly,conclusion and a few remarks on future research directions are presented.
文摘As a representative enterprise in the retail industry,MINISO takes cost leadership and product differentiation as its core strategy to compete actively in the global market.However,multi-brand retailers continue to appear in the domestic market and the existing“dollar stores”in the foreign market already have a certain number of loyal customers.Therefore,MINISO needs to understand its principles for creating,delivering,and capturing value.By strengthening its own competitive advantages,it could achieve differentiation when confronting challenges in both domestic and international markets.Based on the analysis of MINISO’s business model canvas,this paper puts forward corresponding strategic development suggestions.
基金supported by the National Natural Science Foundation of China(No.U2267207)Science and Technology on Reactor System Design Technology Laboratory(No.KFKT-05-FWHTWU-2023004).
文摘Higher-order modes of the neutron diffusion/transport equation can be used to study the temporal behavior of nuclear reactors and can be applied in modal analysis, transient analysis, and online monitoring of the reactor core. Both the deterministic method and the Monte Carlo(MC) method can be used to solve the higher-order modes. However, MC method, compared to the deterministic method, faces challenges in terms of computational efficiency and α mode calculation stability, whereas the deterministic method encounters issues arising from homogenization-related geometric and energy spectra adaptation.Based on the higher-order mode diffusion calculation code HARMONY, we developed a new higher-order mode calculation code, HARMONY2.0, which retains the functionality of computing λ and α higher-order modes from HARMONY1.0, but enhances the ability to treat complex geometries and arbitrary energy spectra using the MC-deterministic hybrid two-step strategy. In HARMONY2.0, the mesh homogenized multigroup constants were obtained using OpenMC in the first step,and higher-order modes were then calculated with the mesh homogenized core diffusion model using the implicitly restarted Arnoldi method(IRAM), which was also adopted in the HARMONY1.0 code. In addition, to improve the calculation efficiency, particularly in large higher-order modes, event-driven parallelization/domain decomposition methods are embedded in the HARMONY2.0 code to accelerate the inner iteration of λ∕α mode using OpenMP. Furthermore, the higher-order modes of complex geometric models, such as Hoogenboom and ATR reactors for λ mode and the MUSE-4 experiment facility for the prompt α mode, were computed using diffusion theory.
基金The Second Tibetan Plateau Scientific Expedition and Research Program,No.2019QZKK0903-02National Key R&D Program of China,No.2022YFC3002902National Natural Science Foundation of China,No.42201086。
文摘The Hengduan Mountains region(HMR)is one of the most densely distributed and severe flash flood disaster-prone areas in southwest China.It is also a key area for major engineering projects and beautiful countryside construction in Southwest China.However,previous studies have not systematically summarized the development characteristics and formation modes of flash flood disasters in the HMR,which limits the development of theoretical and technical system for flood control.In this study,we focused on the physical processes of flash flood disasters in the HMR,including generation,movement,and disaster formation,and clarified the dominant disaster-inducing conditions(multiple humid monsoon circulation,high potential energy and high heterogenous underlying surface)and disaster development characteristics(high spatio-temporal heterogeneity,highly concentrated energy,chain and cascading effects,and clustered occurrence)of flash floods in the HMR.Based on the entire processes of flash flood disasters,three major formation modes have been summarized:the runoff generation mode of vegetation-hydrology-soil coupling dominated by high hydraulic gradient in mountainous areas,strong flow-sediment coupling movement,and serious disaster losses due to high exposure of disaster bearing objects.Finally,based on the issues in previous research,four future research challenges for flash flood disaster in the HMR were proposed.Our study provides insights into disaster prevention and reduction research,including fundamental theoretical system,precise risk assessment of regional disasters,and accurate early warning and forecasting of flash floods.
文摘This paper focuses on rural music education in the context of rural revitalization,deeply analyzes its current resource situation,and points out that tangible resources face shortages of teachers,inappropriate textbooks,and outdated teaching facilities,while intangible resources are confronted with the loss of folk music culture and the weakening of educational foundations due to cultural ecological changes.Resources are characterized by dispersion,scarcity,and inefficient utilization.In response to these difficulties,this paper proposes integration paths for teachers,textbooks,teaching facilities,and folk music culture resources.Additionally,it constructs a diversified development model that combines rural tourism with music activities,develops characteristic music education industries,and integrates rural cultural construction.Simultaneously,it identifies funding shortages and outdated concepts as major obstacles and proposes targeted strategies such as expanding funding channels and changing inherent concepts.The aim is to promote the development of rural music education and contribute to the revitalization of rural culture.
基金General Project of Philosophy and Social Sciences Research in Universities of Jiangsu Province,2024(2024SJYB1650).
文摘Under the background of"Digital Commerce for Rural Vitalization",rural E-commerce has experienced rapid development.However,agricultural products like strawberries,often produced by small-scale,fragmented,and less competitive individual farmers,struggle to meet the compliance and scalability demands of E-commerce,thereby constraining high-quality local economic development.Aiming to address this issue,this paper,guided by relevant policies and strategies,employs case analysis and logical deduction to explore the industrialization path of the"Cooperative+E-commerce"model for the strawberry industry.The research finds that by optimizing the cooperative's organizational structure,implementing multi-channel E-commerce strategies,upgrading the supply chain(including cold chain and quality traceability),and engaging in collaborative brand building,a robust industrial system can be formed.Supplemented by benefit evaluation,policy support,and regulatory oversight,this system can effectively bridge small-scale production with the broader market.This study concludes that this pathway can enhance the added value of the strawberry industry,increase farmer incomes,and provide practical insights for promoting high-quality local economic development.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
