Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
Driven by the wave of informatization and intelligence,the smart city has become a new trend of global urban development.The intelligent transformation of energy systems is of great importance to a smart city.The Inte...Driven by the wave of informatization and intelligence,the smart city has become a new trend of global urban development.The intelligent transformation of energy systems is of great importance to a smart city.The Internet helps the sustainable development of smart cities by optimizing resource allocation,improving utilization efficiency,and promoting market competition.This study analyzes the current situation and problems of energy Internet supporting smart cities and finds that policy environment,technology maturity,market demand,and industrial chain integration have a significant positive impact on its development.Based on this,relevant strategies are proposed to provide theoretical and practical guidance for the integrated development of smart cities and the energy Internet.展开更多
BACKGROUND Neurodevelopmental delays encompass a wide range of conditions that impair cognitive,motor,and social functioning,often increasing the risk of psychiatric comorbidities.Children with these delays frequently...BACKGROUND Neurodevelopmental delays encompass a wide range of conditions that impair cognitive,motor,and social functioning,often increasing the risk of psychiatric comorbidities.Children with these delays frequently present with disorders such as attention-deficit/hyperactivity disorder(ADHD),anxiety,and behavioral disturbances,which can significantly affect development and quality of life.While genetic predisposition has been linked to these comorbidities,growing evidence highlights the role of environmental factors,including prenatal and early-life stressors.However,the interaction between genetic susceptibility and environmental influences remains poorly understood.Identifying specific genetic variants,environmental risks,and their interactions is essential for early detection and targeted interventions.AIM To investigate the combined effects of genetic and environmental factors on psychiatric comorbidities in children with neurodevelopmental delays,elucidate underlying mechanisms,and inform clinical management strategies.METHODS This retrospective cohort study included 80 children with confirmed neurodevelopmental delays and 40 age-and sex-matched typically developing controls.Comprehensive clinical and psychiatric evaluations,genetic testing(chromosomal microarray analysis and targeted next-generation sequencing),and environmental exposure assessments were conducted.Statistical analyses explored associations between genetic variants and psychiatric comorbidities,environmental risk factors,and gene-environment interactions.RESULTS Children with neurodevelopmental delays exhibited significantly higher rates of psychiatric comorbidities(70.0%)compared to controls(15.0%),with ADHD(42.5%),anxiety disorders(28.8%),and behavioral disorders(23.8%)being the most common.Pathogenic genetic variants were identified in specific pathways associated with distinct psychiatric presentations:Glutamatergic signaling variants were linked to anxiety disorders(odds ratio=3.8),dopaminergic system variants to ADHD(odds ratio=4.2),and synaptic function variants to both behavioral and anxiety disorders.Environmental factors,particularly prenatal maternal stress,early childhood adversity,and family dysfunction were strong predictors of psychiatric outcomes(β=0.42).Significant gene-environment interactions were identified,indicating that environmental exposure can moderate the effects of genetic risks on psychiatric outcomes.CONCLUSION Psychiatric comorbidities in children with neurodevelopmental delays are significantly influenced by both genetic and environmental factors,with complex interactions between the two.These findings underscore the need for integrated assessments and targeted interventions addressing both biological and environmental contributors to improve outcomes in this vulnerable population.展开更多
Ecological network(EN)identification and optimization is an essential research tool for safeguarding regional ecological security patterns and planning territorial space.Especially for the ecologically fragile inland ...Ecological network(EN)identification and optimization is an essential research tool for safeguarding regional ecological security patterns and planning territorial space.Especially for the ecologically fragile inland river basins,EN optimization is of significance in ensuring regional ecological security and virtuous cycle of ecosystems.In addition,EN is a dynamically changing structural system that is more applicable to the regional development by optimizing it from comprehensive future development perspective.EN of Shiyang River basin was constructed on account of the circuit theory,and land use/cover changes(LUCC)of the basin in 2035 was predicted by PLUS model,so as to explore the ecological conservation priorities and formulate optimization strategies.54 ecological sources(ESs)were identified,covering an area of 12,198 km^(2),mainly in the southern basin.133 ecological corridors(ECs)with an area of 3,176.92 km^(2)were extracted.38 ecological pinchpoints(EPs)and 22 ecological barriers(EBs)were identified respectively,which were mainly distributed in the lower basin.To effectively enhance the connectivity of EN in Minqin County,which has the worst ecological environment,we added five stepping stones based on the Ant Forest project.In addition,the optimal EPS is selected according to the development and limitation needs of inland river basins and the threat degree of warning points(WPs)under different scenarios.Scientific and reasonable optimization of future urban layout to prevent WPs can effectively alleviate the contradiction between ecological protection and economic development.The study is intended to provide basis for ecological sustainable development and rational planning territorial space in Shiyang River basin,as well as opinion for EN optimization in inland river basin.展开更多
BACKGROUND First-time mothers may encounter various problems during postpartum,which can result in negative emotions that can affect infant care.In today’s Internet era,continuous nursing services can be provided to ...BACKGROUND First-time mothers may encounter various problems during postpartum,which can result in negative emotions that can affect infant care.In today’s Internet era,continuous nursing services can be provided to mothers and their babies after delivery through Internet-based platforms.This approach can help reduce negative emotions of primiparas and promote better health for both mothers and babies.AIM To explore the effect of Internet Plus-based postpartum healthcare services on postpartum depression of primiparas and neonatal growth and development and thus provide a scientific basis for strengthening postpartum healthcare measures and better protect maternal and child health.METHODS The study retrospectively collected data of primiparas and their newborns who underwent prenatal examination and successfully delivered at the Ninth People’s Hospital of Suzhou City.The observation group included 30 primiparas and their newborns who received Internet Plus-based postpartum healthcare services between July and December 2024.According to the principle of matching(1:1)control study,the control group included 30 primiparas and their newborns who received routine postpartum healthcare services between January and June 2024.The maternal role adaptation questionnaire scores,breastfeeding rates,Edinburgh postnatal depression scale(EPDS)scores,and newborn growth and development(height,head circumference,and weight)were compared between the two groups at the time of discharge after delivery and 6-week postpartum follow-up.RESULTS Upon hospital discharge,the two groups did not demonstrate significant differences in maternal role adaptation scores,breastfeeding rates,EPDS scores,as well as newborn height,head circumference,and weight at birth(P>0.05).At the 6-week postpartum follow-up,the maternal role adaptation score and breastfeeding rate were higher in the observation group than in the control group(P<0.05).In addition,one case of postpartum depression was reported in the observation group and eight in the control group.Moreover,the control group exhibited a significant increase in EPDS scores compared with scores at hospital discharge(P<0.05),whereas the observation group showed only a marginal,nonsignificant increase in EPDS scores(P>0.05).The EPDS score of the observation group was significantly lower than that of the control group(P<0.05),indicating a lower risk of postpartum depression in the observation group.The length,head circumference,and weight of the newborns 6 weeks after birth were increased compared with those at birth,and the growth rate was higher in the observation group than in the control group(P<0.05),indicating better growth and development in the observation group.CONCLUSION Internet Plus-based postpartum healthcare services improve maternal role adaptation,increase breastfeeding rates,mitigate postpartum depression risk,and promote neonatal growth and development in primiparas.展开更多
BACKGROUND Mesenchymal stem cells(MSCs)and their secretome have significant potential in promoting hair follicle development.However,the effects of MSC therapy have been reported to vary due to their heterogeneous cha...BACKGROUND Mesenchymal stem cells(MSCs)and their secretome have significant potential in promoting hair follicle development.However,the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics.Different sources of MSCs or culture systems may cause heterogeneity of exosomes.AIM To define the potential of human adipose-derived MSC exosomes(hADSC-Exos)and human umbilical cord-derived MSC exosomes(hUCMSC-Exos)for improving dermal papillary cell proliferation in androgenetic alopecia.METHODS We conducted liquid chromatography-mass spectrometry proteomic analysis of hADSC-Exos and hUCMSC-Exos.Liquid chromatography-mass spectrometry suggested that hADSC-Exos were related to metabolism and immunity.Additionally,the hADSC-Exo proteins regulated the cell cycle and other 9 functional groups.RESULTS We verified that hADSC-Exos inhibited glycogen synthase kinase-3βexpression by activating the Wnt/β-catenin signaling pathway via cell division cycle protein 42,and enhanced dermal papillary cell proliferation and migration.Excess dihydrotestosterone caused androgenetic alopecia by shortening the hair follicle growth phase,but hADSC-Exos reversed these effects.CONCLUSION This study indicated that hair development is influenced by hADSC-Exo-mediated cell-to-cell communication via the Wnt/β-catenin pathway.展开更多
The use ofrenewable energyisan important way toachieve sustainable agriculturalandeconomic development.However,there are differences in accessto renewable energy between the Global North and Global South.This study ut...The use ofrenewable energyisan important way toachieve sustainable agriculturalandeconomic development.However,there are differences in accessto renewable energy between the Global North and Global South.This study utilisedan autoregressive distributed lag-error correctionmodel and thedata spanning from 1991to 2021 to comparatively analyse the dynamic relationship amongrenewable energy consumption,the value of agricultural production,gross domestic product(GDP),economic diversificationindex,urban population,the total water extraction for agricultural withdrawal,and trade balancein the Netherlands and South Africa.In the shortrun,renewable energy consumption was increased by the value of agricultural productionbut decreased by GDPin South Africa.In the longrun,renewable energy consumption and GDP increased the value of agricultural production,while the value of agricultural production also increased GDP in South Africa.However,in the Netherlands,there was no short-and long-run relationship betweenrenewable energy consumption and agricultural and economic development.The results revealedthat there was a short-and long-run relationship in South Africa.Moreover,in the Netherlands,the adjustment speed was-1.46 forrenewable energy consumption with an error correction of 0.68 a(8.22 months).In South Africa,the adjustment speedwas-1.28 forrenewable energy consumption with an error correction of 0.78 a(9.38 months).Therefore,compared to South Africa,renewable energy consumptionin the Netherlands takes less time to return to balance after a shock.Thesefindings signify different trajectories on sectoral and economic transition initiatives spurred usingrenewable energy between the Netherlands and South Africa.Policy relating to initiatives such as“agro-energy communities”in Global South countries such as South Africa should be emphasised to promote the use of renewable energy in the agricultural sector.展开更多
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OEC...This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OECD).Using panel data from 2000 to 2021,the study employs several econometric techniques,including fixed effects,feasible generalized least squares,two-stage least squares,and the generalized method of moments.Our primary findings reveal that unemployment has a significant negative impact on CO_(2)emissions,thereby supporting the validity of the EPC hypothesis within OECD countries.This suggests a trade-off between unemployment and reductions in CO_(2)emissions.Similarly,the results validate the EKC hypothesis,with further analysis indicating that the EKC exhibits an N-shaped curve-an important contribution to the literature on environmental dynamics in advanced economies.Additionally,the results show that both trade openness and renewable energy usage have significantly improved environmental quality in OECD economies.Finally,extensive causality testing identifies both one-way and two-way causal relationships among the key variables examined.These findings have important policy implications for the management of environmental quality and macroeconomic variables in the OECD context.展开更多
The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the...The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the concept of constructing a network society also emerged in China.Over the past 30 years,China has made significant progress and achievements in constructing a network society,both in terms of its fundamental construction and social development.It is important that these advancements be summarized and reviewed.China’s network society construction can be divided into two relatively independent yet interconnected components,based on their focal points:its foundational infrastructure and its social development.These two components of China’s network society are managed by different departments.China has integrated the fundamental construction of its network society with the social development of its network society,thereby achieving unified planning,collaborative advancement,and coordinated development.This approach aims to harmonize two aspects:building China’s cyberspace strength and contributing to Chinese informatization,thereby advancing Chinese modernization.展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event ...Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.展开更多
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute cour...Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.展开更多
Learning and talent development(LTD)aims to enhance an organisation’s performance,the need for LTD to link to the organisation’s overall business strategy,which also be described as linkage/alignment,is more imperat...Learning and talent development(LTD)aims to enhance an organisation’s performance,the need for LTD to link to the organisation’s overall business strategy,which also be described as linkage/alignment,is more imperative than ever in this rapid changing environment.This paper aims to explore how Network Rail utilise LTD strategies to support its overall business strategies.展开更多
Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey＇s fibers ...Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey＇s fibers of the periodontal ligament （PDL）. However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 （Bmp2） in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 （PO）, followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2gene is removed from Sp7＋ （Osterix＋） cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC （Nfic）, periostin and α-SMA＋ cells. Third, there is a failure to produce vascular endothelial growth factor A （VEGF-A） in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOsp7-cre＇EGFe. Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOsp7-cre＇EGFe. These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation.展开更多
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
基金Research and Innovation Team Building Project of Qingdao City University(QCU23TDKJO1)。
文摘Driven by the wave of informatization and intelligence,the smart city has become a new trend of global urban development.The intelligent transformation of energy systems is of great importance to a smart city.The Internet helps the sustainable development of smart cities by optimizing resource allocation,improving utilization efficiency,and promoting market competition.This study analyzes the current situation and problems of energy Internet supporting smart cities and finds that policy environment,technology maturity,market demand,and industrial chain integration have a significant positive impact on its development.Based on this,relevant strategies are proposed to provide theoretical and practical guidance for the integrated development of smart cities and the energy Internet.
文摘BACKGROUND Neurodevelopmental delays encompass a wide range of conditions that impair cognitive,motor,and social functioning,often increasing the risk of psychiatric comorbidities.Children with these delays frequently present with disorders such as attention-deficit/hyperactivity disorder(ADHD),anxiety,and behavioral disturbances,which can significantly affect development and quality of life.While genetic predisposition has been linked to these comorbidities,growing evidence highlights the role of environmental factors,including prenatal and early-life stressors.However,the interaction between genetic susceptibility and environmental influences remains poorly understood.Identifying specific genetic variants,environmental risks,and their interactions is essential for early detection and targeted interventions.AIM To investigate the combined effects of genetic and environmental factors on psychiatric comorbidities in children with neurodevelopmental delays,elucidate underlying mechanisms,and inform clinical management strategies.METHODS This retrospective cohort study included 80 children with confirmed neurodevelopmental delays and 40 age-and sex-matched typically developing controls.Comprehensive clinical and psychiatric evaluations,genetic testing(chromosomal microarray analysis and targeted next-generation sequencing),and environmental exposure assessments were conducted.Statistical analyses explored associations between genetic variants and psychiatric comorbidities,environmental risk factors,and gene-environment interactions.RESULTS Children with neurodevelopmental delays exhibited significantly higher rates of psychiatric comorbidities(70.0%)compared to controls(15.0%),with ADHD(42.5%),anxiety disorders(28.8%),and behavioral disorders(23.8%)being the most common.Pathogenic genetic variants were identified in specific pathways associated with distinct psychiatric presentations:Glutamatergic signaling variants were linked to anxiety disorders(odds ratio=3.8),dopaminergic system variants to ADHD(odds ratio=4.2),and synaptic function variants to both behavioral and anxiety disorders.Environmental factors,particularly prenatal maternal stress,early childhood adversity,and family dysfunction were strong predictors of psychiatric outcomes(β=0.42).Significant gene-environment interactions were identified,indicating that environmental exposure can moderate the effects of genetic risks on psychiatric outcomes.CONCLUSION Psychiatric comorbidities in children with neurodevelopmental delays are significantly influenced by both genetic and environmental factors,with complex interactions between the two.These findings underscore the need for integrated assessments and targeted interventions addressing both biological and environmental contributors to improve outcomes in this vulnerable population.
基金funded by the National Natural Science Foundation of China(Grant No.42101276)。
文摘Ecological network(EN)identification and optimization is an essential research tool for safeguarding regional ecological security patterns and planning territorial space.Especially for the ecologically fragile inland river basins,EN optimization is of significance in ensuring regional ecological security and virtuous cycle of ecosystems.In addition,EN is a dynamically changing structural system that is more applicable to the regional development by optimizing it from comprehensive future development perspective.EN of Shiyang River basin was constructed on account of the circuit theory,and land use/cover changes(LUCC)of the basin in 2035 was predicted by PLUS model,so as to explore the ecological conservation priorities and formulate optimization strategies.54 ecological sources(ESs)were identified,covering an area of 12,198 km^(2),mainly in the southern basin.133 ecological corridors(ECs)with an area of 3,176.92 km^(2)were extracted.38 ecological pinchpoints(EPs)and 22 ecological barriers(EBs)were identified respectively,which were mainly distributed in the lower basin.To effectively enhance the connectivity of EN in Minqin County,which has the worst ecological environment,we added five stepping stones based on the Ant Forest project.In addition,the optimal EPS is selected according to the development and limitation needs of inland river basins and the threat degree of warning points(WPs)under different scenarios.Scientific and reasonable optimization of future urban layout to prevent WPs can effectively alleviate the contradiction between ecological protection and economic development.The study is intended to provide basis for ecological sustainable development and rational planning territorial space in Shiyang River basin,as well as opinion for EN optimization in inland river basin.
基金Supported by 2024 Academy Level Research Start up Fund,No.YK202434.
文摘BACKGROUND First-time mothers may encounter various problems during postpartum,which can result in negative emotions that can affect infant care.In today’s Internet era,continuous nursing services can be provided to mothers and their babies after delivery through Internet-based platforms.This approach can help reduce negative emotions of primiparas and promote better health for both mothers and babies.AIM To explore the effect of Internet Plus-based postpartum healthcare services on postpartum depression of primiparas and neonatal growth and development and thus provide a scientific basis for strengthening postpartum healthcare measures and better protect maternal and child health.METHODS The study retrospectively collected data of primiparas and their newborns who underwent prenatal examination and successfully delivered at the Ninth People’s Hospital of Suzhou City.The observation group included 30 primiparas and their newborns who received Internet Plus-based postpartum healthcare services between July and December 2024.According to the principle of matching(1:1)control study,the control group included 30 primiparas and their newborns who received routine postpartum healthcare services between January and June 2024.The maternal role adaptation questionnaire scores,breastfeeding rates,Edinburgh postnatal depression scale(EPDS)scores,and newborn growth and development(height,head circumference,and weight)were compared between the two groups at the time of discharge after delivery and 6-week postpartum follow-up.RESULTS Upon hospital discharge,the two groups did not demonstrate significant differences in maternal role adaptation scores,breastfeeding rates,EPDS scores,as well as newborn height,head circumference,and weight at birth(P>0.05).At the 6-week postpartum follow-up,the maternal role adaptation score and breastfeeding rate were higher in the observation group than in the control group(P<0.05).In addition,one case of postpartum depression was reported in the observation group and eight in the control group.Moreover,the control group exhibited a significant increase in EPDS scores compared with scores at hospital discharge(P<0.05),whereas the observation group showed only a marginal,nonsignificant increase in EPDS scores(P>0.05).The EPDS score of the observation group was significantly lower than that of the control group(P<0.05),indicating a lower risk of postpartum depression in the observation group.The length,head circumference,and weight of the newborns 6 weeks after birth were increased compared with those at birth,and the growth rate was higher in the observation group than in the control group(P<0.05),indicating better growth and development in the observation group.CONCLUSION Internet Plus-based postpartum healthcare services improve maternal role adaptation,increase breastfeeding rates,mitigate postpartum depression risk,and promote neonatal growth and development in primiparas.
基金Supported by the Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai and the China Postdoctoral Science Foundation,No.2022M722409.
文摘BACKGROUND Mesenchymal stem cells(MSCs)and their secretome have significant potential in promoting hair follicle development.However,the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics.Different sources of MSCs or culture systems may cause heterogeneity of exosomes.AIM To define the potential of human adipose-derived MSC exosomes(hADSC-Exos)and human umbilical cord-derived MSC exosomes(hUCMSC-Exos)for improving dermal papillary cell proliferation in androgenetic alopecia.METHODS We conducted liquid chromatography-mass spectrometry proteomic analysis of hADSC-Exos and hUCMSC-Exos.Liquid chromatography-mass spectrometry suggested that hADSC-Exos were related to metabolism and immunity.Additionally,the hADSC-Exo proteins regulated the cell cycle and other 9 functional groups.RESULTS We verified that hADSC-Exos inhibited glycogen synthase kinase-3βexpression by activating the Wnt/β-catenin signaling pathway via cell division cycle protein 42,and enhanced dermal papillary cell proliferation and migration.Excess dihydrotestosterone caused androgenetic alopecia by shortening the hair follicle growth phase,but hADSC-Exos reversed these effects.CONCLUSION This study indicated that hair development is influenced by hADSC-Exo-mediated cell-to-cell communication via the Wnt/β-catenin pathway.
基金research supported wholly by the National Research Foundation (NRF) of South Africathe Dutch Research Council (NWO) Project (UID 129352)
文摘The use ofrenewable energyisan important way toachieve sustainable agriculturalandeconomic development.However,there are differences in accessto renewable energy between the Global North and Global South.This study utilisedan autoregressive distributed lag-error correctionmodel and thedata spanning from 1991to 2021 to comparatively analyse the dynamic relationship amongrenewable energy consumption,the value of agricultural production,gross domestic product(GDP),economic diversificationindex,urban population,the total water extraction for agricultural withdrawal,and trade balancein the Netherlands and South Africa.In the shortrun,renewable energy consumption was increased by the value of agricultural productionbut decreased by GDPin South Africa.In the longrun,renewable energy consumption and GDP increased the value of agricultural production,while the value of agricultural production also increased GDP in South Africa.However,in the Netherlands,there was no short-and long-run relationship betweenrenewable energy consumption and agricultural and economic development.The results revealedthat there was a short-and long-run relationship in South Africa.Moreover,in the Netherlands,the adjustment speed was-1.46 forrenewable energy consumption with an error correction of 0.68 a(8.22 months).In South Africa,the adjustment speedwas-1.28 forrenewable energy consumption with an error correction of 0.78 a(9.38 months).Therefore,compared to South Africa,renewable energy consumptionin the Netherlands takes less time to return to balance after a shock.Thesefindings signify different trajectories on sectoral and economic transition initiatives spurred usingrenewable energy between the Netherlands and South Africa.Policy relating to initiatives such as“agro-energy communities”in Global South countries such as South Africa should be emphasised to promote the use of renewable energy in the agricultural sector.
文摘China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
文摘This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OECD).Using panel data from 2000 to 2021,the study employs several econometric techniques,including fixed effects,feasible generalized least squares,two-stage least squares,and the generalized method of moments.Our primary findings reveal that unemployment has a significant negative impact on CO_(2)emissions,thereby supporting the validity of the EPC hypothesis within OECD countries.This suggests a trade-off between unemployment and reductions in CO_(2)emissions.Similarly,the results validate the EKC hypothesis,with further analysis indicating that the EKC exhibits an N-shaped curve-an important contribution to the literature on environmental dynamics in advanced economies.Additionally,the results show that both trade openness and renewable energy usage have significantly improved environmental quality in OECD economies.Finally,extensive causality testing identifies both one-way and two-way causal relationships among the key variables examined.These findings have important policy implications for the management of environmental quality and macroeconomic variables in the OECD context.
基金“Research on Social Change and Network Society Planning in the Internet of Everything Era”(ID:21BSH005),a project under the National Social Science Fund of China
文摘The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the concept of constructing a network society also emerged in China.Over the past 30 years,China has made significant progress and achievements in constructing a network society,both in terms of its fundamental construction and social development.It is important that these advancements be summarized and reviewed.China’s network society construction can be divided into two relatively independent yet interconnected components,based on their focal points:its foundational infrastructure and its social development.These two components of China’s network society are managed by different departments.China has integrated the fundamental construction of its network society with the social development of its network society,thereby achieving unified planning,collaborative advancement,and coordinated development.This approach aims to harmonize two aspects:building China’s cyberspace strength and contributing to Chinese informatization,thereby advancing Chinese modernization.
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
文摘Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金supported by the National Key Research and Development Program of China,No.2022YFC2703101(to YC)the National Natural Science Fundation of China,No.82371422(to YC)+1 种基金the National Innovation and Entrepreneurship Training Program for College Students,No.202310611408(to XW)the 1·3·5 Project for Disciplines of Excellence Clinical Research Fund,West China Hospital,Sichuan University,No.2023HXFH032(to YC)。
文摘Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.
文摘Learning and talent development(LTD)aims to enhance an organisation’s performance,the need for LTD to link to the organisation’s overall business strategy,which also be described as linkage/alignment,is more imperative than ever in this rapid changing environment.This paper aims to explore how Network Rail utilise LTD strategies to support its overall business strategies.
基金partly supported by research grant funding:NIH-NIAMS R01- AR054616 (SEH), NIH-NIDCR T32-DE14318 (Rakian) and F32-DE018865 (Yang)supported by UTHSCSA, NIH-NCI P30-CA54174 (CTRC at UTHSCSA) and NIH-NIA P01-AG19316supported by Open Fund of State Key Laboratory of Oral Diseases, Sichuan University
文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey＇s fibers of the periodontal ligament （PDL）. However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 （Bmp2） in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 （PO）, followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2gene is removed from Sp7＋ （Osterix＋） cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC （Nfic）, periostin and α-SMA＋ cells. Third, there is a failure to produce vascular endothelial growth factor A （VEGF-A） in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOsp7-cre＇EGFe. Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOsp7-cre＇EGFe. These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation.
