Strong seismic excitation and fault dislocation are likely to occur simultaneously in high-intensity seismic zones,causing severe damage to tunnels crossing active fault zones.This paper aims to develop a novel analyt...Strong seismic excitation and fault dislocation are likely to occur simultaneously in high-intensity seismic zones,causing severe damage to tunnels crossing active fault zones.This paper aims to develop a novel analytical solution to determine the longitudinal mechanical responses of tunnels subjected to the combined effects of seismic waves and strike-slip faulting.Adopting the elastic springbeam model,the seismic waves are modelled as shear horizontal(SH)waves and the fault dislocation follows an S-shaped pattern;the superposition principle for free-fielddisplacements caused by both effects is assumed.In addition,the transmission and reflectionof seismic waves at the fault-rock geological interface and the tangential contact conditions at the tunnel-rock interface are considered.The analytical model is validated against numerical simulations,confirmingits accuracy in calculating tunnel responses.Moreover,a parametric study is conducted to evaluate the impact of key factors,including fault displacement,fault zone width,fault dip angle,earthquake frequency,rock conditions,tunnel lining stiffness,and tangential contact conditions,on tunnel responses.Compared with each effect alone,the combined effects of seismic waves and strike-slip faulting significantlychange the tunnel deformation and internal forces,leading to increased tunnel responses,especially within the fault zone and near the fault-rock interfaces.Depending on specificparameters,tunnel responses can be classifiedinto seismic-dominated,faulting-dominated,and seismic-faulting coupled responses on the basis of the relative contributions of each effect.The proposed analytical solution can be applied to quickly predict the longitudinal mechanical behaviour of tunnels under such combined effects in engineering applications.展开更多
Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understandi...Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.展开更多
Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao)...Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao),wheat(Xiaomai),and jujube(Dazao),it functions to nourish the heart and calm the mind,harmonize the middle burner and regulate Qi,and alleviate urgency and restlessness.As its clinical application has expanded from traditional emotional disorders to neurological,endocrine,and various psychosomatic diseases,establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks.Modern analytical methods,typified by chromatography,spectroscopy,and their hyphenated techniques,with their high sensitivity,high resolution,and powerful substance characterization capabilities,have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula.This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition,establishing fingerprint profiles,controlling process quality,and researching the pharmacodynamic material basis of Ganmai Dazao Decoction.Furthermore,it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers.Finally,it provides an outlook on future directions and challenges,including technological integration and innovation,standardization of whole-process quality control systems,and evidence-based research aimed at internationalization.展开更多
Rotational computed laminography(CL)has broad application potential in three-dimensional imaging of plate-like objects because it only requires X-rays to pass through the tested object in the thickness direction durin...Rotational computed laminography(CL)has broad application potential in three-dimensional imaging of plate-like objects because it only requires X-rays to pass through the tested object in the thickness direction during the imaging process.In this study,a rectangular cross-section field-of-view rotational CL(RC-CL)is proposed for circuit board imaging.Compared to other rotational CL systems,the field of view is the largest and most suitable for rectangular circuit boards.Meanwhile,as the imaging geometry of RC-CL is significantly different from that of cone-beam CT,the Feldkamp-Davis-Kress(FDK)reconstruction algorithm cannot be used directly.However,transferring the projection data to fit into the CBCT geometry using two-dimensional interpolation introduces interpolation errors.Therefore,an FDK-type analytical reconstruction algorithm applicable to RC-CL was developed.The effectiveness of the method was validated through numerical experiments,and the influence of the tilt angle on the reconstruction results was analyzed.Finally,the RC-CL technique was applied to real defect detection research on circuit boards.展开更多
A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which ca...A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which can accurately describe the strain and stress states in IF.Based on strain analysis,the model can predict the material thickness distribution and neck height after IF.By considering contact area,strain characteristics,material thickness changes,and friction,the model can predict specific moments and corresponding values of maximum axial forming force and maximum horizontal forming force during IF.In addition,an IF experiment involving different tool diameters,flanging diameters,and opening hole diameters is conducted.On the basis of the experimental strain paths,the strain characteristics of different deformation zones are studied,and the stable strain ratio is quantitatively described through two dimensionless parameters:relative tool diameter and relative hole diameter.Then,the changing of material thickness and forming force in IF,and the variation of minimum material thickness,neck height,maximum axial forming force,and maximum horizontal forming force with flanging parameters are studied,and the reliability of the analytical model is verified in this process.Finally,the influence of the horizontal forming force on the tool design and the fluctuation of the forming force are explained.展开更多
Waterproof performance of gaskets between segments is the focus of shield tunnels.This paper proposed an analytical method for determining seepage characteristics at tunnel-gasketed joints based on the hydraulic fract...Waterproof performance of gaskets between segments is the focus of shield tunnels.This paper proposed an analytical method for determining seepage characteristics at tunnel-gasketed joints based on the hydraulic fracturing theories.First,the mathematical model was established,and the seepage governing equation and boundary conditions were obtained.Second,three dimensionless parameters were introduced for simplifying the expressions,and the seepage governing equations were normalized.Third,analytical expressions were derived for the interface opening and liquid pressure.Moreover,the influencing factors of seepage process at the gasketed interface were analyzed.Parametric analyses revealed that,in the normalized criterion of liquid viscosity,the liquid tip coordinate was influenced by the degree of negative pressure in the liquid lag region,which was related to the initial contact stress.The coordinate of the liquid tip affected the liquid pressure distribution and the interface opening,which were analyzed under different liquid tip coordinate conditions.Finally,under two limit states,comparative analysis showed that the results of the variation trend of the proposed method agree well with those of previous research.Overall,the proposed analytical method provides a novel solution for the design of the waterproof in shield tunnels.展开更多
Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by...Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.展开更多
A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance m...A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance method.Firstly,an altitude-energy profile is designed,and the bank angle is derived analytically as the initial iteration value for the predictor-corrector method.The predictor-corrector guidance method has been improved by deriving an analytical form for predicting the range-to-go error,which greatly accelerates the iterative speed.Then,a segmented guidance algorithm is proposed.The above analytically predictor-corrector guidance method is adopted when the energy exceeds an energy threshold.When the energy is less than the threshold,the equidistant test method is used to calculate the bank angle command,which ensures guidance accuracy as well as computational efficiency.Additionally,an adaptive guidance cycle strategy is applied to reduce the computational time of the reentry guidance trajectory.Finally,the accuracy and robustness of the proposed method are verified through a series of simulations and Monte-Carlo experiments.Compared with the traditional integral method,the proposed method requires 75%less computation time on average and achieves a lower landing error.展开更多
The focus of green analytical chemistry(GAC)is to minimize the negative impacts of analytical procedures on human safety,human health,and the environment.Several factors,such as the reagents used,sample collection,sam...The focus of green analytical chemistry(GAC)is to minimize the negative impacts of analytical procedures on human safety,human health,and the environment.Several factors,such as the reagents used,sample collection,sample processing,instruments,energy consumed,and the quantities of hazardous materials and waste generated during analytical procedures,need to be considered in the evaluation of the greenness of analytical assays.In this study,we propose a greenness evaluation metric for analytical methods(GEMAM).The new greenness metric is simple,flexible,and comprehensive.The evaluation criteria are based on both the 12 principles of GAC(SIGNIFICANCE)and the 10 factors of sample preparation,and the results are presented on a 0–10 scale.The GEMAM calculation process is easy to perform,and its results are easy to interpret.The output of GEMAM is a pictogram that can provide both qualitative and quantitative information based on color and number.展开更多
This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass ...This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass transfer coefficients and air psychrometric correlations, the model provides insights into the impact of design and operational parameters on the exchanger cooling performance. Validated against an established numerical model, it accurately simulates cooling behavior with a Root Mean Square Deviation of 0.43 - 1.18˚C under varying inlet air conditions. The results show that tube geometry, including equivalent diameter, flatness ratio, and length significantly influences cooling outcomes. Smaller diameters enhance wet-bulb effectiveness but reduce cooling capacity, while increased flatness and length improve both. For example, extending the flatness ratio of a 15 mm diameter, 0.6 m long tube from 1 (circular) to 4 raises the exchange surface area from 0.028 to 0.037 m2, increasing wet-bulb effectiveness from 60% to 71%. Recommended diameters range from 5 mm for tubes under 0.5 m to 1 cm for tubes 0.5 to 1 m in length. Optimal air velocities depend on tube length: 1 m/s for tubes under 0.8 m, 1.5 m/s for lengths of 0.8 to 1.2 m, and up to 2 m/s for longer tubes. This model offers a practical alternative to complex numerical and CFD methods, with potential applications in cooling tower optimization for thermal and nuclear power plants and geothermal heat exchangers.展开更多
For the solution of peridynamic equations of motion,a meshless approach is typically used instead of utilizing semi-analytical or mesh-based approaches.In contrast,the literature has limited analytical solutions.This ...For the solution of peridynamic equations of motion,a meshless approach is typically used instead of utilizing semi-analytical or mesh-based approaches.In contrast,the literature has limited analytical solutions.This study develops a novel analytical solution for one-dimensional peridynamic models,considering the effect of damping.After demonstrating the details of the analytical solution,various demonstration problems are presented.First,the free vibration of a damped system is considered for under-damped and critically damped conditions.Peridynamic solutions and results from the classical theory are compared against each other,and excellent agreement is observed between the two approaches.Next,forced vibration analyses of undamped and damped conditions are performed.In addition,the effect of horizon size is investigated.It is shown that for smaller horizon sizes,peridynamic results agree well with classical results,whereas results from these two approaches deviate from each other as the horizon size increases.展开更多
1.Discipline origins In 1984,“analytical pharmacology”was firstly used in the paper entitled“The future of analytical pharmacologyda personal view”by Dr.J.S.Cridland,director of a clinical pharmacological laborato...1.Discipline origins In 1984,“analytical pharmacology”was firstly used in the paper entitled“The future of analytical pharmacologyda personal view”by Dr.J.S.Cridland,director of a clinical pharmacological laboratory at Department of Pharmacology,University of Cape Town.He proposed“Analytical pharmacology is at present usually a tool of clinical pharmacology”,which is mainly used for therapeutic drug monitoring,analysis of clinical pharmacokinetics,and toxicological screening to provide a basis for reasonable medication and clinical dose adjustment[1].In 1984,W.J.Black,Director of Wellcome Research Laboratories,was offered a personal Chair at King's College Hospital School of Medicine and Dentistry,part of King's College London.He chose“Analytical Pharmacology”as a title for the Chair[2].展开更多
The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies ...The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies using vari‑ous analytical methods have identified peculiar trends in various illnesses,with Firmicutes being the most prevalent phylum,followed by Bacteroidetes,Proteobacteria,and Actinobacteria.However,more Firmicutes and fewer Bac‑teroidetes have been observed in cats infected with Feline coronavirus.Alterations in the composition of these gut microbiota can be solved by microbiota modification through dietary fiber,probiotics,and fecal microbiota transplan‑tation.Therefore,it is critical to understand the composition of the gut microbiota,the changes in and roles of the gut environment,and the importance of these concepts for overall health while considering the exchange of microbes between humans and domestic animals.This review provides comprehensive information on feline gut microbiota composition,modulation,and analytic methods used for characterizing the gut microbiota.展开更多
Enhancing ecological security for sustainable social,economic,and environmental development is a key focus of current research and a practical necessity for ecological management.However,the integration of retrospecti...Enhancing ecological security for sustainable social,economic,and environmental development is a key focus of current research and a practical necessity for ecological management.However,the integration of retrospective ecological security assessments with future trend predictions and fine-scale targeted regulations remains inadequate,limiting effective ecological governance and sustainable regional development.Guided by Social-Economic-Natural Complex Ecosystems(SENCE)theory,this study proposes an analytical framework that integrates ecological security assessment,prediction,and zoning management.The Daqing River Basin,a typical river basin in the North China Plain,was selected as a case study.The results indicate that overall ecological security in the Daqing River Basin improved from a“Moderate”level to a“Relatively Safe”level between 2000 and 2020;however,spatial heterogeneity persisted,with higher ecological security in northwestern and eastern regions and lower ecological security in the central region.Approximately 62% of the Basin experienced an improvement in ecological security level,except in the major urban areas of Beijing,Tianjin,and Hebei,where ecological security deteriorated.From 2025 to 2040,the overall ecological security of the Daqing River Basin is expected to improve and remain at the“Relatively Safe”level.However,spatial heterogeneity will be further aggravated as the ecological security of major urban areas continues to deteriorate.Ecological security management zones and regulation strategies are proposed at the regional and county scales to emphasize integrated regulation for the entire basin and major urban areas.The proposed analytical framework provides valuable insights for advancing theoretical research on ecological security.The case study offers a practical reference for ecological security enhancement in river basins and other regions facing significant human-land conflicts.展开更多
This study presents a theoretical analysis of the perforation process of finite-thickness metal plates(with a thickness ratio of T_0/D = 0.6–1.5) under normal impact by spherical-nosed projectiles. The model is valid...This study presents a theoretical analysis of the perforation process of finite-thickness metal plates(with a thickness ratio of T_0/D = 0.6–1.5) under normal impact by spherical-nosed projectiles. The model is validated over an impact velocity range of 180–1247 m/s. The entire penetration process is divided into three stages: the crater formation stage, the steady stage, and the shear stage. A thicknessdependent dynamic cavity expansion resistance model is first introduced to quantitatively describe the axial resistance experienced by the projectile during the tip-entry and steady stages. Subsequently, a thickness-related damage parameter is proposed to refine the resistance expression during the transition from the steady stage to the shear stage, thereby eliminating discontinuities in resistance across stages. When the projectile fully perforates the target, the model predicts a gradual decay of resistance to zero as the residual ligament thickness vanishes, which better reflects the actual physical behavior. The model is validated using four sets of experimental conditions. In addition, to illustrate the model's applicability more intuitively, a numerical simulation case from the literature is reproduced, and the resulting resistance-time curve is compared with the model output. The results demonstrate that the proposed model agrees well with experimental data in terms of residual velocity, ballistic limit, and penetration resistance. Finally, a method for adjusting the threshold parameter within the resistance function is provided, and the influence of this coefficient on the model predictions is discussed.展开更多
Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined...Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined laboratory analytical indicators associated with positive blood culture results.Methods Blood cultures collected from Peking Union Medical College Hospital between January 1,2020,and December 31,2022,were retrospectively analyzed.The mode of transportation(piping logistics delivery vs.staff),source of blood cultures(outpatient/emergency department vs.inpatient department),rotation of personnel,and time of reception(8:00–19:59 vs.20:00–07:59)were compared between blood culture-positive and-negative results.Results Between 2020 and 2022,the total positive rate of blood culture was 8.07%.The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department(12.46%vs.5.83%;P<0.0001).The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation.The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1–2 h or>2 h(P<0.0170).Conclusion Laboratory analytical indicators such as patient source,transportation mode,and personnel rotation significantly impacted the positive detection rate or time of blood culture.展开更多
Multicriteria Decision Analysis(MCDA)has been integrated with GIS modelling by many studies to aid the decision-making process.This integration enhances modelling by incorporating spatial relationships and using advan...Multicriteria Decision Analysis(MCDA)has been integrated with GIS modelling by many studies to aid the decision-making process.This integration enhances modelling by incorporating spatial relationships and using advanced techniques,including the combination of Frequency Ratio(FR)and Analytical Hierarchical Process(AHP),also known as FR-AHP.Although methods like Two-Steps Floating Catchment Area(2SFCA),AHP,and FR are widely applied in measuring accessibility,they have limitations in terms of threshold sensitivity and subjectivity.Hence,this study used FR-AHP,which combines the data-driven strength of FR and the structured decision-making technique of AHP to provide a more reliable evaluation of spatial accessibility.This study aims to integrate FR-AHP with GIS to derive campus spatial accessibility in Shah Alam.Campus spatial accessibility can be measured by using location and distance between origin and destination,topological accessibility for nodes and paths,and contiguous accessibility for surfaces.Understanding these concepts is crucial for determining the appropriate technique.This study utilizedMCDA,GIS-basedFR,andAHPmethods tomodel spatial accessibility in activemobility andpublic transport areas,calculating estimation index values and analyzing comparisons between physical factors.A sample survey was conducted among the university’s students to gather information on their origin and destination,as well as the type of transportation used by students.The data were used in calculating the weightage of each physical factor using the FR-AHP method.Then,the Campus Spatial Accessibility Index(CSAI)was determined by using GIS IndexModelling.By using the model,the index was classified into five(5)classes from Very Low to Very High.The results show that Section 2 has the highest accessibility,while the area with the lowest accessibility index is Jalan Zamrud and Jalan Permata,located in Section 7.To analyze the efficiency of FR-AHP,the CSAI was also derived using theweightage derived fromFR only.The comparisons revealed that the results derived using FR-AHP are closer to reality than those derived using FR only,as it incorporates human preferences in accessibility.Hence,the findings suggest that the integration of FR-AHP could provide better CSAI than FR only.展开更多
Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents followi...Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents following land reclamation.Tidal equa-tions are analytically solved using infinite series,deriving expressions for tidal levels and currents in narrow bays with varying topog-raphy.Tidal levels,influenced by topographic variations,are characterized by amplitude and phase lag of their complex amplitude.These levels demonstrate high sensitivity to longitudinal slope variations but remain relatively stable under lateral slope changes.Un-der constant topographic slopes,even minor changes in bay length can drastically modify amplitude and phase lag,highlighting the sensitivity of tidal dynamics to geometric alterations.Tidal velocity notably increases with steeper longitudinal slopes and modestly rises with elevated lateral slopes.However,changes in longitudinal and lateral slopes do not considerably alter flow patterns.While external forces predominantly regulate tidal velocity with negligible effects on flow patterns,endogenous resistance influences veloci-ty but minimally impacts flow structure.These findings enhance the understanding of tidal responses to geometric and topographic changes,providing valuable guidance for land reclamation projects and coastal management strategies.展开更多
In this study,an analytical investigation is carried out to assess the impact of magnetic field-dependent(MFD)viscosity on the momentum and heat transfers inside the boundary layer of a Jeffrey fluid flowing over a ho...In this study,an analytical investigation is carried out to assess the impact of magnetic field-dependent(MFD)viscosity on the momentum and heat transfers inside the boundary layer of a Jeffrey fluid flowing over a horizontally elongating sheet,while taking into account the effects of ohmic dissipation.By applying similarity transformations,the original nonlinear governing equations with partial derivatives are transformed into ordinary differential equations.Analytical expressions for the momentum and energy equations are derived,incorporating the influence of MFD viscosity on the Jeffrey fluid.Then the impact of different parameters is assessed,including magnetic viscosity,magnetic interaction,retardation time,Deborah number,and Eckert number,on the velocity and temperature profiles in the boundary layer.The findings reveal that an increase in magnetic viscosity leads to a decrease in the local Nusselt number,thereby impairing heat transfer.Moreover,a higher retardation time enhances the local Nusselt number by thinning the momentum and thermal boundary layers,while a higher Deborah number decreases the local Nusselt number due to the reduction in fluid viscosity.展开更多
Flume experiments play a pivotal role in studying wave propagation,with wave elements typically assumed to remain constant in the perpendicular direction.However,evident cross wave phenomena were observed within flume...Flume experiments play a pivotal role in studying wave propagation,with wave elements typically assumed to remain constant in the perpendicular direction.However,evident cross wave phenomena were observed within flumes under certain conditions.This paper presents new analytical solutions for both primary and cross waves on double shoals in a flume via linear shallow-water equations,which may be used to idealize dynamic experimental configurations of coral reefs.The primary waves on double shoals are described by the associated Legendre functions,whereas the ultimate solutions are derived by considering the incident and reflected waves in front of a bathymetry and the transmitted waves positioned behind it.The effects of the angular frequency and topographic parameters on the primary waves are subsequently analyzed.Cross waves on double shoals constitute a type of topographically trapped wave whose solutions are formulated by combining the first and second types of the associated Legendre functions.The angular frequency is not only determined by the wavenumber but also influenced by the topographic parameters.Numerical experiments are conducted to investigate the generation mechanism of cross waves.The consistency between the numerical results and analytical solutions confirms the validity of the new analytical framework of cross waves on double shoals.展开更多
基金supported by the National Natural Science Foundation of China(No.41941018)Shanghai Gaofeng Discipline Construction Funding.
文摘Strong seismic excitation and fault dislocation are likely to occur simultaneously in high-intensity seismic zones,causing severe damage to tunnels crossing active fault zones.This paper aims to develop a novel analytical solution to determine the longitudinal mechanical responses of tunnels subjected to the combined effects of seismic waves and strike-slip faulting.Adopting the elastic springbeam model,the seismic waves are modelled as shear horizontal(SH)waves and the fault dislocation follows an S-shaped pattern;the superposition principle for free-fielddisplacements caused by both effects is assumed.In addition,the transmission and reflectionof seismic waves at the fault-rock geological interface and the tangential contact conditions at the tunnel-rock interface are considered.The analytical model is validated against numerical simulations,confirmingits accuracy in calculating tunnel responses.Moreover,a parametric study is conducted to evaluate the impact of key factors,including fault displacement,fault zone width,fault dip angle,earthquake frequency,rock conditions,tunnel lining stiffness,and tangential contact conditions,on tunnel responses.Compared with each effect alone,the combined effects of seismic waves and strike-slip faulting significantlychange the tunnel deformation and internal forces,leading to increased tunnel responses,especially within the fault zone and near the fault-rock interfaces.Depending on specificparameters,tunnel responses can be classifiedinto seismic-dominated,faulting-dominated,and seismic-faulting coupled responses on the basis of the relative contributions of each effect.The proposed analytical solution can be applied to quickly predict the longitudinal mechanical behaviour of tunnels under such combined effects in engineering applications.
基金supported by the National Social Science Fund of China(NSSFC):NSSFC Major Project“Exploration and Practice in the Development of Chinese Economics Since the Modern Era”(Grant No.17ZDA034)NSSFC Key Project“The Status and Value of Traditional Chinese Economic Thought”(Grant No.17AJL006)NSSFC General Project“The Transformation and Evolution of Chinese Economic Thought During the Republican Era”(Grant No.22BJL130).
文摘Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.
文摘Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao),wheat(Xiaomai),and jujube(Dazao),it functions to nourish the heart and calm the mind,harmonize the middle burner and regulate Qi,and alleviate urgency and restlessness.As its clinical application has expanded from traditional emotional disorders to neurological,endocrine,and various psychosomatic diseases,establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks.Modern analytical methods,typified by chromatography,spectroscopy,and their hyphenated techniques,with their high sensitivity,high resolution,and powerful substance characterization capabilities,have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula.This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition,establishing fingerprint profiles,controlling process quality,and researching the pharmacodynamic material basis of Ganmai Dazao Decoction.Furthermore,it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers.Finally,it provides an outlook on future directions and challenges,including technological integration and innovation,standardization of whole-process quality control systems,and evidence-based research aimed at internationalization.
基金supported by the National Key Research and Development Program of China(No.2022YFF0607802)。
文摘Rotational computed laminography(CL)has broad application potential in three-dimensional imaging of plate-like objects because it only requires X-rays to pass through the tested object in the thickness direction during the imaging process.In this study,a rectangular cross-section field-of-view rotational CL(RC-CL)is proposed for circuit board imaging.Compared to other rotational CL systems,the field of view is the largest and most suitable for rectangular circuit boards.Meanwhile,as the imaging geometry of RC-CL is significantly different from that of cone-beam CT,the Feldkamp-Davis-Kress(FDK)reconstruction algorithm cannot be used directly.However,transferring the projection data to fit into the CBCT geometry using two-dimensional interpolation introduces interpolation errors.Therefore,an FDK-type analytical reconstruction algorithm applicable to RC-CL was developed.The effectiveness of the method was validated through numerical experiments,and the influence of the tilt angle on the reconstruction results was analyzed.Finally,the RC-CL technique was applied to real defect detection research on circuit boards.
基金supported in part by financial support from the National Key R&D Program of China(No.2023YFB3407003)the National Natural Science Foundation of China(No.52375378).
文摘A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which can accurately describe the strain and stress states in IF.Based on strain analysis,the model can predict the material thickness distribution and neck height after IF.By considering contact area,strain characteristics,material thickness changes,and friction,the model can predict specific moments and corresponding values of maximum axial forming force and maximum horizontal forming force during IF.In addition,an IF experiment involving different tool diameters,flanging diameters,and opening hole diameters is conducted.On the basis of the experimental strain paths,the strain characteristics of different deformation zones are studied,and the stable strain ratio is quantitatively described through two dimensionless parameters:relative tool diameter and relative hole diameter.Then,the changing of material thickness and forming force in IF,and the variation of minimum material thickness,neck height,maximum axial forming force,and maximum horizontal forming force with flanging parameters are studied,and the reliability of the analytical model is verified in this process.Finally,the influence of the horizontal forming force on the tool design and the fluctuation of the forming force are explained.
基金Project(52278421)supported by the National Natural Science Foundation of ChinaProject(2024ZZTS0754)supported by the Fundamental Research Funds for the Central Universities of Central South University,China+2 种基金Project(2023CXQD067)supported by the Central South University Innovation-Driven Research Programme,ChinaProject(2022QNRC001)supported by Young Elite Scientists Sponsorship Program by CASTProject(2023TJ-N24)supported by the Youth Talent Program by China Railway Society and the Hunan Provincial Science and Technology Promotion Talent Project。
文摘Waterproof performance of gaskets between segments is the focus of shield tunnels.This paper proposed an analytical method for determining seepage characteristics at tunnel-gasketed joints based on the hydraulic fracturing theories.First,the mathematical model was established,and the seepage governing equation and boundary conditions were obtained.Second,three dimensionless parameters were introduced for simplifying the expressions,and the seepage governing equations were normalized.Third,analytical expressions were derived for the interface opening and liquid pressure.Moreover,the influencing factors of seepage process at the gasketed interface were analyzed.Parametric analyses revealed that,in the normalized criterion of liquid viscosity,the liquid tip coordinate was influenced by the degree of negative pressure in the liquid lag region,which was related to the initial contact stress.The coordinate of the liquid tip affected the liquid pressure distribution and the interface opening,which were analyzed under different liquid tip coordinate conditions.Finally,under two limit states,comparative analysis showed that the results of the variation trend of the proposed method agree well with those of previous research.Overall,the proposed analytical method provides a novel solution for the design of the waterproof in shield tunnels.
文摘Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.
基金National Natural Science Foundation of China(Nos.61773387 and 62022061).
文摘A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance method.Firstly,an altitude-energy profile is designed,and the bank angle is derived analytically as the initial iteration value for the predictor-corrector method.The predictor-corrector guidance method has been improved by deriving an analytical form for predicting the range-to-go error,which greatly accelerates the iterative speed.Then,a segmented guidance algorithm is proposed.The above analytically predictor-corrector guidance method is adopted when the energy exceeds an energy threshold.When the energy is less than the threshold,the equidistant test method is used to calculate the bank angle command,which ensures guidance accuracy as well as computational efficiency.Additionally,an adaptive guidance cycle strategy is applied to reduce the computational time of the reentry guidance trajectory.Finally,the accuracy and robustness of the proposed method are verified through a series of simulations and Monte-Carlo experiments.Compared with the traditional integral method,the proposed method requires 75%less computation time on average and achieves a lower landing error.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.:81603182 and 81703607)the Fundamental Research Funds for the Central Universities,China(Grant Nos.:DUT21RC(3)057,DUT23YG226,DUT24MS018,and DUT23YG228)+1 种基金the Natural Science Foundation of Liaoning Province,China(Grant No.:2023-MSBA-018)the Open Funding of Cancer Hospital of Dalian University of Technology,China(Grant No.:2024-ZLKF-33).
文摘The focus of green analytical chemistry(GAC)is to minimize the negative impacts of analytical procedures on human safety,human health,and the environment.Several factors,such as the reagents used,sample collection,sample processing,instruments,energy consumed,and the quantities of hazardous materials and waste generated during analytical procedures,need to be considered in the evaluation of the greenness of analytical assays.In this study,we propose a greenness evaluation metric for analytical methods(GEMAM).The new greenness metric is simple,flexible,and comprehensive.The evaluation criteria are based on both the 12 principles of GAC(SIGNIFICANCE)and the 10 factors of sample preparation,and the results are presented on a 0–10 scale.The GEMAM calculation process is easy to perform,and its results are easy to interpret.The output of GEMAM is a pictogram that can provide both qualitative and quantitative information based on color and number.
文摘This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass transfer coefficients and air psychrometric correlations, the model provides insights into the impact of design and operational parameters on the exchanger cooling performance. Validated against an established numerical model, it accurately simulates cooling behavior with a Root Mean Square Deviation of 0.43 - 1.18˚C under varying inlet air conditions. The results show that tube geometry, including equivalent diameter, flatness ratio, and length significantly influences cooling outcomes. Smaller diameters enhance wet-bulb effectiveness but reduce cooling capacity, while increased flatness and length improve both. For example, extending the flatness ratio of a 15 mm diameter, 0.6 m long tube from 1 (circular) to 4 raises the exchange surface area from 0.028 to 0.037 m2, increasing wet-bulb effectiveness from 60% to 71%. Recommended diameters range from 5 mm for tubes under 0.5 m to 1 cm for tubes 0.5 to 1 m in length. Optimal air velocities depend on tube length: 1 m/s for tubes under 0.8 m, 1.5 m/s for lengths of 0.8 to 1.2 m, and up to 2 m/s for longer tubes. This model offers a practical alternative to complex numerical and CFD methods, with potential applications in cooling tower optimization for thermal and nuclear power plants and geothermal heat exchangers.
文摘For the solution of peridynamic equations of motion,a meshless approach is typically used instead of utilizing semi-analytical or mesh-based approaches.In contrast,the literature has limited analytical solutions.This study develops a novel analytical solution for one-dimensional peridynamic models,considering the effect of damping.After demonstrating the details of the analytical solution,various demonstration problems are presented.First,the free vibration of a damped system is considered for under-damped and critically damped conditions.Peridynamic solutions and results from the classical theory are compared against each other,and excellent agreement is observed between the two approaches.Next,forced vibration analyses of undamped and damped conditions are performed.In addition,the effect of horizon size is investigated.It is shown that for smaller horizon sizes,peridynamic results agree well with classical results,whereas results from these two approaches deviate from each other as the horizon size increases.
文摘1.Discipline origins In 1984,“analytical pharmacology”was firstly used in the paper entitled“The future of analytical pharmacologyda personal view”by Dr.J.S.Cridland,director of a clinical pharmacological laboratory at Department of Pharmacology,University of Cape Town.He proposed“Analytical pharmacology is at present usually a tool of clinical pharmacology”,which is mainly used for therapeutic drug monitoring,analysis of clinical pharmacokinetics,and toxicological screening to provide a basis for reasonable medication and clinical dose adjustment[1].In 1984,W.J.Black,Director of Wellcome Research Laboratories,was offered a personal Chair at King's College Hospital School of Medicine and Dentistry,part of King's College London.He chose“Analytical Pharmacology”as a title for the Chair[2].
基金funded this manuscript for the Central Universities(Grant Nos.2662023DKPY004 and 2662021DKQD005).
文摘The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies using vari‑ous analytical methods have identified peculiar trends in various illnesses,with Firmicutes being the most prevalent phylum,followed by Bacteroidetes,Proteobacteria,and Actinobacteria.However,more Firmicutes and fewer Bac‑teroidetes have been observed in cats infected with Feline coronavirus.Alterations in the composition of these gut microbiota can be solved by microbiota modification through dietary fiber,probiotics,and fecal microbiota transplan‑tation.Therefore,it is critical to understand the composition of the gut microbiota,the changes in and roles of the gut environment,and the importance of these concepts for overall health while considering the exchange of microbes between humans and domestic animals.This review provides comprehensive information on feline gut microbiota composition,modulation,and analytic methods used for characterizing the gut microbiota.
基金supported by the project of the National Natural Science Foundation of China(42330705).
文摘Enhancing ecological security for sustainable social,economic,and environmental development is a key focus of current research and a practical necessity for ecological management.However,the integration of retrospective ecological security assessments with future trend predictions and fine-scale targeted regulations remains inadequate,limiting effective ecological governance and sustainable regional development.Guided by Social-Economic-Natural Complex Ecosystems(SENCE)theory,this study proposes an analytical framework that integrates ecological security assessment,prediction,and zoning management.The Daqing River Basin,a typical river basin in the North China Plain,was selected as a case study.The results indicate that overall ecological security in the Daqing River Basin improved from a“Moderate”level to a“Relatively Safe”level between 2000 and 2020;however,spatial heterogeneity persisted,with higher ecological security in northwestern and eastern regions and lower ecological security in the central region.Approximately 62% of the Basin experienced an improvement in ecological security level,except in the major urban areas of Beijing,Tianjin,and Hebei,where ecological security deteriorated.From 2025 to 2040,the overall ecological security of the Daqing River Basin is expected to improve and remain at the“Relatively Safe”level.However,spatial heterogeneity will be further aggravated as the ecological security of major urban areas continues to deteriorate.Ecological security management zones and regulation strategies are proposed at the regional and county scales to emphasize integrated regulation for the entire basin and major urban areas.The proposed analytical framework provides valuable insights for advancing theoretical research on ecological security.The case study offers a practical reference for ecological security enhancement in river basins and other regions facing significant human-land conflicts.
基金supported by the National Natural Science Foundation of China (Grant Nos.U2341244,12172179,11772160)。
文摘This study presents a theoretical analysis of the perforation process of finite-thickness metal plates(with a thickness ratio of T_0/D = 0.6–1.5) under normal impact by spherical-nosed projectiles. The model is validated over an impact velocity range of 180–1247 m/s. The entire penetration process is divided into three stages: the crater formation stage, the steady stage, and the shear stage. A thicknessdependent dynamic cavity expansion resistance model is first introduced to quantitatively describe the axial resistance experienced by the projectile during the tip-entry and steady stages. Subsequently, a thickness-related damage parameter is proposed to refine the resistance expression during the transition from the steady stage to the shear stage, thereby eliminating discontinuities in resistance across stages. When the projectile fully perforates the target, the model predicts a gradual decay of resistance to zero as the residual ligament thickness vanishes, which better reflects the actual physical behavior. The model is validated using four sets of experimental conditions. In addition, to illustrate the model's applicability more intuitively, a numerical simulation case from the literature is reproduced, and the resulting resistance-time curve is compared with the model output. The results demonstrate that the proposed model agrees well with experimental data in terms of residual velocity, ballistic limit, and penetration resistance. Finally, a method for adjusting the threshold parameter within the resistance function is provided, and the influence of this coefficient on the model predictions is discussed.
基金supported by grants from the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-074)Peking Union Medical College Hospital Research Funding for Postdoc(kyfyjj202320).
文摘Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined laboratory analytical indicators associated with positive blood culture results.Methods Blood cultures collected from Peking Union Medical College Hospital between January 1,2020,and December 31,2022,were retrospectively analyzed.The mode of transportation(piping logistics delivery vs.staff),source of blood cultures(outpatient/emergency department vs.inpatient department),rotation of personnel,and time of reception(8:00–19:59 vs.20:00–07:59)were compared between blood culture-positive and-negative results.Results Between 2020 and 2022,the total positive rate of blood culture was 8.07%.The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department(12.46%vs.5.83%;P<0.0001).The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation.The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1–2 h or>2 h(P<0.0170).Conclusion Laboratory analytical indicators such as patient source,transportation mode,and personnel rotation significantly impacted the positive detection rate or time of blood culture.
文摘Multicriteria Decision Analysis(MCDA)has been integrated with GIS modelling by many studies to aid the decision-making process.This integration enhances modelling by incorporating spatial relationships and using advanced techniques,including the combination of Frequency Ratio(FR)and Analytical Hierarchical Process(AHP),also known as FR-AHP.Although methods like Two-Steps Floating Catchment Area(2SFCA),AHP,and FR are widely applied in measuring accessibility,they have limitations in terms of threshold sensitivity and subjectivity.Hence,this study used FR-AHP,which combines the data-driven strength of FR and the structured decision-making technique of AHP to provide a more reliable evaluation of spatial accessibility.This study aims to integrate FR-AHP with GIS to derive campus spatial accessibility in Shah Alam.Campus spatial accessibility can be measured by using location and distance between origin and destination,topological accessibility for nodes and paths,and contiguous accessibility for surfaces.Understanding these concepts is crucial for determining the appropriate technique.This study utilizedMCDA,GIS-basedFR,andAHPmethods tomodel spatial accessibility in activemobility andpublic transport areas,calculating estimation index values and analyzing comparisons between physical factors.A sample survey was conducted among the university’s students to gather information on their origin and destination,as well as the type of transportation used by students.The data were used in calculating the weightage of each physical factor using the FR-AHP method.Then,the Campus Spatial Accessibility Index(CSAI)was determined by using GIS IndexModelling.By using the model,the index was classified into five(5)classes from Very Low to Very High.The results show that Section 2 has the highest accessibility,while the area with the lowest accessibility index is Jalan Zamrud and Jalan Permata,located in Section 7.To analyze the efficiency of FR-AHP,the CSAI was also derived using theweightage derived fromFR only.The comparisons revealed that the results derived using FR-AHP are closer to reality than those derived using FR only,as it incorporates human preferences in accessibility.Hence,the findings suggest that the integration of FR-AHP could provide better CSAI than FR only.
基金supported by the National Natural Sci-ence Foundation of China(No.U2106204)the Shanxi Water Conservancy Science and Technology Re-search and Extension Project(No.2023ZF19).
文摘Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents following land reclamation.Tidal equa-tions are analytically solved using infinite series,deriving expressions for tidal levels and currents in narrow bays with varying topog-raphy.Tidal levels,influenced by topographic variations,are characterized by amplitude and phase lag of their complex amplitude.These levels demonstrate high sensitivity to longitudinal slope variations but remain relatively stable under lateral slope changes.Un-der constant topographic slopes,even minor changes in bay length can drastically modify amplitude and phase lag,highlighting the sensitivity of tidal dynamics to geometric alterations.Tidal velocity notably increases with steeper longitudinal slopes and modestly rises with elevated lateral slopes.However,changes in longitudinal and lateral slopes do not considerably alter flow patterns.While external forces predominantly regulate tidal velocity with negligible effects on flow patterns,endogenous resistance influences veloci-ty but minimally impacts flow structure.These findings enhance the understanding of tidal responses to geometric and topographic changes,providing valuable guidance for land reclamation projects and coastal management strategies.
基金supported by the United Arab Emirates University,Al Ain,United Arab Emirates,under Grant No.12R283.
文摘In this study,an analytical investigation is carried out to assess the impact of magnetic field-dependent(MFD)viscosity on the momentum and heat transfers inside the boundary layer of a Jeffrey fluid flowing over a horizontally elongating sheet,while taking into account the effects of ohmic dissipation.By applying similarity transformations,the original nonlinear governing equations with partial derivatives are transformed into ordinary differential equations.Analytical expressions for the momentum and energy equations are derived,incorporating the influence of MFD viscosity on the Jeffrey fluid.Then the impact of different parameters is assessed,including magnetic viscosity,magnetic interaction,retardation time,Deborah number,and Eckert number,on the velocity and temperature profiles in the boundary layer.The findings reveal that an increase in magnetic viscosity leads to a decrease in the local Nusselt number,thereby impairing heat transfer.Moreover,a higher retardation time enhances the local Nusselt number by thinning the momentum and thermal boundary layers,while a higher Deborah number decreases the local Nusselt number due to the reduction in fluid viscosity.
基金financially supported by the National Natural Science Foundation of China (Grant No. 52071128)the Natural Science Foundation of Jiangsu Basic Research Program (Grant No. BK20220082)
文摘Flume experiments play a pivotal role in studying wave propagation,with wave elements typically assumed to remain constant in the perpendicular direction.However,evident cross wave phenomena were observed within flumes under certain conditions.This paper presents new analytical solutions for both primary and cross waves on double shoals in a flume via linear shallow-water equations,which may be used to idealize dynamic experimental configurations of coral reefs.The primary waves on double shoals are described by the associated Legendre functions,whereas the ultimate solutions are derived by considering the incident and reflected waves in front of a bathymetry and the transmitted waves positioned behind it.The effects of the angular frequency and topographic parameters on the primary waves are subsequently analyzed.Cross waves on double shoals constitute a type of topographically trapped wave whose solutions are formulated by combining the first and second types of the associated Legendre functions.The angular frequency is not only determined by the wavenumber but also influenced by the topographic parameters.Numerical experiments are conducted to investigate the generation mechanism of cross waves.The consistency between the numerical results and analytical solutions confirms the validity of the new analytical framework of cross waves on double shoals.
