Objective:To investigate the association between IL-1 Ra variable number of tandem repeat(rs2234663),IL-6-597 GA(rs1800797),IL-6-572 GC(rs1800796)and the risk of CrimeanCongo hemorrhagic fever(CCHF)in the Turkish pati...Objective:To investigate the association between IL-1 Ra variable number of tandem repeat(rs2234663),IL-6-597 GA(rs1800797),IL-6-572 GC(rs1800796)and the risk of CrimeanCongo hemorrhagic fever(CCHF)in the Turkish patients.Methods:This study included 50 patients infected with CCHF and 50 healthy controls.These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method.Results:The distribution of the IL-6-572 GC genotypes and alleles varied significantly between the patients and the controls.The subjects carrying IL-6-572 GC GG genotype and G allele had increased risk of developing CCHF compared to the control group(P=0.006,P=0.014,respectively).IL-6-572 GC GC genotype was higher in the controls than the patients(P=0.006).For the triple genotype combinations,the 1/2-GC-GG genotype combination was detected more frequently in the control group than CCHF patients(P=0.016).IL-6(-572/-597)GG-GG genotype was significantly higher in the patient group(P=0.015),while the GC-GG genotype was significantly lower in the patient group(P=0.005).Additionally,the G-G haplotype was significantly higher in the patient group(P=0.042),whereas C-G was found to be significantly lower in the patients than the control group(P=0.037).Conclusions:The results of this study suggest the IL-6-572 GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease.展开更多
文摘Objective:To investigate the association between IL-1 Ra variable number of tandem repeat(rs2234663),IL-6-597 GA(rs1800797),IL-6-572 GC(rs1800796)and the risk of CrimeanCongo hemorrhagic fever(CCHF)in the Turkish patients.Methods:This study included 50 patients infected with CCHF and 50 healthy controls.These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method.Results:The distribution of the IL-6-572 GC genotypes and alleles varied significantly between the patients and the controls.The subjects carrying IL-6-572 GC GG genotype and G allele had increased risk of developing CCHF compared to the control group(P=0.006,P=0.014,respectively).IL-6-572 GC GC genotype was higher in the controls than the patients(P=0.006).For the triple genotype combinations,the 1/2-GC-GG genotype combination was detected more frequently in the control group than CCHF patients(P=0.016).IL-6(-572/-597)GG-GG genotype was significantly higher in the patient group(P=0.015),while the GC-GG genotype was significantly lower in the patient group(P=0.005).Additionally,the G-G haplotype was significantly higher in the patient group(P=0.042),whereas C-G was found to be significantly lower in the patients than the control group(P=0.037).Conclusions:The results of this study suggest the IL-6-572 GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease.
