2006年3月13日下午14时,前来北京外国语大学海外汉学研究中心访问的德国波鸿鲁尔大学东亚学院中国语言文学系主任冯铁(Raoul David Findeisen)教授,接受了我一个多小时的采访。从辈分上来讲冯铁教授算是我的师兄,因为他同样是在波恩大...2006年3月13日下午14时,前来北京外国语大学海外汉学研究中心访问的德国波鸿鲁尔大学东亚学院中国语言文学系主任冯铁(Raoul David Findeisen)教授,接受了我一个多小时的采访。从辈分上来讲冯铁教授算是我的师兄,因为他同样是在波恩大学师从顾彬(Wolfgang Kubin)教授攻读博士,只是出道比我早了许多年。冯铁1958年出生于瑞士,除去波恩,他先后在柏林、台北、北京等地学习过汉学、罗马语学、哲学以及比较文学。展开更多
Objective: To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS). Design: A prospective, nonran...Objective: To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS). Design: A prospective, nonrandomized, open pilot study. Setting: Dermatology department at a university hospital in Bochum, Germany. Patients: Fifteen patients with histologically confirmed severe LS. Interventions: Oral methotrexate (15 mg/wk) combined with pulsed intravenous methylprednisolone (1000 mg for 3 days monthly) for at least 6 months. Main Outcome Measures: Treatment outcome was evaluated by means of a clinical score, 20-MHz ultrasonography, and histopathologic analysis. Safety assessment included the monitoring of adverse effects and clinical laboratory parameters. Results: One patient discontinued therapy. In most of the remaining 14 patients, significant elimination of all signs of active disease (inflammation) and remarkable softening of formerly affected sclerotic skin that resulted in a decrease of the mean±SD clinical score from 10.9±5.3 at the beginning to 5.5±2.5 at the end of therapy was observed (P< .001). Clinical improvement was confirmed by histologic and ultrasonographic assessments. No serious adverse effects were noted. Conclusions: These data suggest that pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy is beneficial and safe in the treatment of patients with LS. This treatment regimen should especially be considered for severe forms of LS in which conventional treatments have failed.展开更多
文摘2006年3月13日下午14时,前来北京外国语大学海外汉学研究中心访问的德国波鸿鲁尔大学东亚学院中国语言文学系主任冯铁(Raoul David Findeisen)教授,接受了我一个多小时的采访。从辈分上来讲冯铁教授算是我的师兄,因为他同样是在波恩大学师从顾彬(Wolfgang Kubin)教授攻读博士,只是出道比我早了许多年。冯铁1958年出生于瑞士,除去波恩,他先后在柏林、台北、北京等地学习过汉学、罗马语学、哲学以及比较文学。
文摘Objective: To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS). Design: A prospective, nonrandomized, open pilot study. Setting: Dermatology department at a university hospital in Bochum, Germany. Patients: Fifteen patients with histologically confirmed severe LS. Interventions: Oral methotrexate (15 mg/wk) combined with pulsed intravenous methylprednisolone (1000 mg for 3 days monthly) for at least 6 months. Main Outcome Measures: Treatment outcome was evaluated by means of a clinical score, 20-MHz ultrasonography, and histopathologic analysis. Safety assessment included the monitoring of adverse effects and clinical laboratory parameters. Results: One patient discontinued therapy. In most of the remaining 14 patients, significant elimination of all signs of active disease (inflammation) and remarkable softening of formerly affected sclerotic skin that resulted in a decrease of the mean±SD clinical score from 10.9±5.3 at the beginning to 5.5±2.5 at the end of therapy was observed (P< .001). Clinical improvement was confirmed by histologic and ultrasonographic assessments. No serious adverse effects were noted. Conclusions: These data suggest that pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy is beneficial and safe in the treatment of patients with LS. This treatment regimen should especially be considered for severe forms of LS in which conventional treatments have failed.
