微RNA(microRNA,miRNA)和Piwi作用RNA(Piwi-interacting RNA,piRNA)是动物体内具有重要调控作用的两类内源小RNA分子。最近科学家相继从动物体细胞和生殖细胞中发现了一种新型内源小RNA——内源干扰小RNA(endogenous small interfering ...微RNA(microRNA,miRNA)和Piwi作用RNA(Piwi-interacting RNA,piRNA)是动物体内具有重要调控作用的两类内源小RNA分子。最近科学家相继从动物体细胞和生殖细胞中发现了一种新型内源小RNA——内源干扰小RNA(endogenous small interfering RNA,endo-siRNA)。研究表明endo-siRNA分子在结构、分布及其功能上均与miRNA和piRNA分子存在着显著的异同点。展开更多
Nucleic acid drugs represent the third wave of innovation in drug research and development,succeeding small-molecule and antibody drugs.These drugs,particularly RNA interference(RNAi)therapies,have become a pivotal fo...Nucleic acid drugs represent the third wave of innovation in drug research and development,succeeding small-molecule and antibody drugs.These drugs,particularly RNA interference(RNAi)therapies,have become a pivotal focus in the pharmaceutical industry.RNAi drugs are extensively utilized in the treatment of chronic and rare diseases due to their exceptional gene-silencing efficiency,manageable side effects,and straightforward synthesis process.This study undertook a thorough analysis of the global landscape of RNAi drug patents,highlighting the latest technological advancements and trends.We meticulously identified and cataloged the key technologies that dominated this patent landscape.The goal was to provide valuable insights and references for researchers involved in the development of RNAi drugs within the domestic pharmaceutical sector.展开更多
文摘微RNA(microRNA,miRNA)和Piwi作用RNA(Piwi-interacting RNA,piRNA)是动物体内具有重要调控作用的两类内源小RNA分子。最近科学家相继从动物体细胞和生殖细胞中发现了一种新型内源小RNA——内源干扰小RNA(endogenous small interfering RNA,endo-siRNA)。研究表明endo-siRNA分子在结构、分布及其功能上均与miRNA和piRNA分子存在着显著的异同点。
文摘Nucleic acid drugs represent the third wave of innovation in drug research and development,succeeding small-molecule and antibody drugs.These drugs,particularly RNA interference(RNAi)therapies,have become a pivotal focus in the pharmaceutical industry.RNAi drugs are extensively utilized in the treatment of chronic and rare diseases due to their exceptional gene-silencing efficiency,manageable side effects,and straightforward synthesis process.This study undertook a thorough analysis of the global landscape of RNAi drug patents,highlighting the latest technological advancements and trends.We meticulously identified and cataloged the key technologies that dominated this patent landscape.The goal was to provide valuable insights and references for researchers involved in the development of RNAi drugs within the domestic pharmaceutical sector.
