Innovation and entrepreneurship education has become one of the important directions of higher education reform,but innovation and entrepreneurship education in medical colleges generally lags behind other discipline ...Innovation and entrepreneurship education has become one of the important directions of higher education reform,but innovation and entrepreneurship education in medical colleges generally lags behind other discipline universities or comprehensive universities.Actively exploring the training mode of innovation and entrepreneurship talents is of great significance for cultivating innovative medical talents needed by the country and society.At present,innovation and entrepreneurship education in higher medical colleges is facing many challenges,the most important of which include the lack of concept in innovation and entrepreneurship education,medical students’weak awareness of innovation and entrepreneurship,and poor construction of innovation and entrepreneurship teaching staff.To address these challenges,we will introduce incentive measures for innovation and entrepreneurship education at the college level,and improve the guarantee and incentive mechanisms for innovation and entrepreneurship education;create an“Innovation and Entrepreneurship Education Platform”for teachers and students to exchange ideas on innovation and entrepreneurship;start building a high-quality team of innovation and entrepreneurship teachers,promote the continuous improvement of the quality of innovation and entrepreneurship education,and ensure the quality of medical talent training.展开更多
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philologica...Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.展开更多
The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of con...The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of contemporary medicine that includes fundamental medical and health sciences,clinical medicine,and public health.Nevertheless,the present phase of medical advancement encounters significant challenges,particularly in effectively translating basic research findings into practical applications in clinical and public health settings.Scientists increasingly collaborate with clinical experts to overcome these obstacles and address specific clinical issues by delving deeper into fundamental mechanisms.This collaborative effort has created a new interdisciplinary field:engineering medicine(EngMed),which focuses on addressing clinical and public health needs by integrating various scientific disciplines.This article discusses the definition,key tasks,significance,educational implications,and future trends in EngMed.展开更多
The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pat...The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal ...Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.展开更多
Gastrointestinal(GI)cancers remain a leading cause of cancer-related morbidity and mortality worldwide.Artificial intelligence(AI),particularly machine learning and deep learning(DL),has shown promise in enhancing can...Gastrointestinal(GI)cancers remain a leading cause of cancer-related morbidity and mortality worldwide.Artificial intelligence(AI),particularly machine learning and deep learning(DL),has shown promise in enhancing cancer detection,diagnosis,and prognostication.A narrative review of literature published from January 2015 to march 2025 was conducted using PubMed,Web of Science,and Scopus.Search terms included"gastrointestinal cancer","artificial intelligence","machine learning","deep learning","radiomics","multimodal detection"and"predictive modeling".Studies were included if they focused on clinically relevant AI applications in GI oncology.AI algorithms for GI cancer detection have achieved high performance across imaging modalities,with endoscopic DL systems reporting accuracies of 85%-97%for polyp detection and segmentation.Radiomics-based models have predicted molecular biomarkers such as programmed cell death ligand 2 expression with area under the curves up to 0.92.Large language models applied to radiology reports demonstrated diagnostic accuracy comparable to junior radiologists(78.9%vs 80.0%),though without incremental value when combined with human interpretation.Multimodal AI approaches integrating imaging,pathology,and clinical data show emerging potential for precision oncology.AI in GI oncology has reached clinically relevant accuracy levels in multiple diagnostic tasks,with multimodal approaches and predictive biomarker modeling offering new opportunities for personalized care.However,broader validation,integration into clinical workflows,and attention to ethical,legal,and social implications remain critical for widespread adoption.展开更多
Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short...Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short-chain fatty acids,and influence immune responses.However,their diversity and functional differences have created challenges for their development and therapeutic use.Recent studies have shown that specific Prevotella species,such as P.copri,P.intestinalis,and P.histicola,can strengthen gut barrier integrity and reduce metabolic imbalances.Notably,Prevotella populations can be increased through high-fiber or herbal-based treatments.Traditional herbal medicines,including fiber-rich decoctions,also demonstrate the potential to boost endogenous Prevotella communities,enhance microbial fermentation,and improve glucose and lipid balance.This perspective examines the context-dependent roles of Prevotella spp.,with emphasis on the functional heterogeneity of key species such as P.copri,suggests a framework for combining herbal modulation with species-level microbiota profiling,and outlines a research plan to explore microbe-herb synergy in treating obesity,type 2 diabetes,and related metabolic disorders.This strategy offers a new,ecology-based approach to complement standard metabolic interventions.展开更多
The etiopathogenesis of gastrointestinal diseases is varied in nature.Various etiogenic factors described are infective,inflammatory,viral,bacterial,parasitic,dietary and lifestyle change.Rare causative agents are imm...The etiopathogenesis of gastrointestinal diseases is varied in nature.Various etiogenic factors described are infective,inflammatory,viral,bacterial,parasitic,dietary and lifestyle change.Rare causative agents are immunological,and others associated as idiopathic,are undiagnosed by all possible means.Some of the rare diseases are congenital in nature,passing from the parent to the child.Many of the undiagnosed diseases are now being diagnosed as genetic and the genes have been implicated as a causative agent.There is a search for newer treatments for such diseases,which is called genomic medicine.Genomic medicine is an emerging medical discipline that involves the use of genomic information about an individual.This is used both for diagnostic as well as therapeutic decisions to improve the current health domain and pave the way for policymakers for its clinical use.In the developing era of precision medicine,genomics,epigenomics,environmental exposure,and other data would be used to more accurately guide individual diagnosis and treatment.Genomic medicine is already making an impact in the fields of oncology,pharmacology,rare,infectious and many undiagnosed diseases.It is beginning to fuel new approaches in certain medical specialties.Oncology is at the leading edge of incorporating genomics,as diagnostics for genetic and genomic markers are increasingly included in cancer screening,and to guide tailored treatment strategies.Genetics and genetic medicine have been reported to play a role in gastroenterology in several ways,including genetic testing(hereditary pancreatitis and hereditary gastrointestinal cancer syndromes).Genetic testing can also help subtype diseases,such as classifying pancreatitis as idiopathic or hereditary.Gene therapy is a promising approach for treating gastrointestinal diseases that are not effectively treated by conventional pharmaceuticals and surgeries.Gene therapy strategies include gene addition,gene editing,messenger RNA therapy,and gene silencing.Understanding genetic determinants,advances in genetics,have led to a better understanding of the genetic factors that contribute to human disease.Family-member risk stratification and genetic diagnosis can help identify family members who are at risk,which can lead to preventive treatments,lifestyle recommendations,and routine follow ups.Selecting target genes helps identify the gene targets associated with each gastrointestinal disease.Common gastrointestinal diseases associated with genetic abnormalities include-inflammatory bowel disease,gastroesophageal reflux disease,non-alcoholic fatty liver disease,and irritable bowel syndrome.With advancing tools and technology,research in the search of newer and individualized treatment,genes and genetic medicines are expected to play a significant role in human health and gastroenterology.展开更多
Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by mosquito vectors[1].Its clinical manifestations include high fever,headache,muscle and joint pain,and rash.It holds a significa...Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by mosquito vectors[1].Its clinical manifestations include high fever,headache,muscle and joint pain,and rash.It holds a significant position in global public health.In recent years,its incidence has continued to rise worldwide[2],making it one of the major diseases threatening human health.The disease course of dengue fever is divided into three typical phases:the acute febrile phase,the critical phase,and the recovery phase.While most patients experience mild symptoms,some may progress to severe dengue and potentially fatal outcomes if not promptly and effectively treated during the critical phase.展开更多
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ...High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).展开更多
Chronic pain,characterized by pain lasting for more than three months,is a debilitating condition frequently caused by conditions such as fibromyalgia,arthritis,neuropathy,and migraine[1-3].
The construction of new medicine is a strategic plan proposed by the Party and the state for the development of medical education in the new era,which brings new opportunities and challenges to the cultivation of gene...The construction of new medicine is a strategic plan proposed by the Party and the state for the development of medical education in the new era,which brings new opportunities and challenges to the cultivation of general medical talents.Based on the connotation of the new medical construction,we will promote the construction of a comprehensive medical talent training system.By creating a characteristic general education curriculum system,building a high-level clinical practice teaching base,creating an innovation and entrepreneurship education platform for the First Affiliated Hospital of Xi’an Medical University,and reforming and improving the internal incentive mechanism for teachers,we aim to cultivate comprehensive medical talents who are“useful,competent,capable,and able to stay,”and contribute to the construction of a healthy China.展开更多
Objective:To explore the application value of a new empowerment teaching method based on Kirkpatrick’s evaluation model in teaching Chinese medicine nursing in otorhinolaryngology.Methods:60 nurses who practiced in t...Objective:To explore the application value of a new empowerment teaching method based on Kirkpatrick’s evaluation model in teaching Chinese medicine nursing in otorhinolaryngology.Methods:60 nurses who practiced in the otolaryngology department of our hospital from June 2022 to October 2024 were included in the study and equally divided into two groups using a convenient sampling method.30 nurses who chose traditional Chinese medicine skill teaching management were included in the control group,and 30 nurses who chose the new empowerment teaching method based on Kirkpatrick’s evaluation model were included in the observation group.Relevant indicators such as clinical teaching environment perception,theoretical knowledge scores of Chinese medicine nursing,and excellent rate of practical operation assessment were compared.Results:The nurses in the observation group had higher scores for clinical teaching environment perception than the control group(P<0.05).However,the midterm and final exam scores for theoretical knowledge of Chinese medicine nursing were higher in the observation group than in the control group(P<0.05).Compared with the control group,the observation group had a higher excellent rate of practical operation assessment(93.33%>73.33%)and a higher Chinese medicine nursing ability score[(215.69±19.73)points>(184.87±15.66)points](P<0.05).Conclusion:Applying the new empowerment teaching method based on Kirkpatrick’s evaluation model to Chinese medicine nursing teaching in otolaryngology can help nurses understand the theoretical knowledge of Chinese medicine nursing and optimize the clinical teaching environment,thereby promoting their practical skills and Chinese medicine nursing abilities.展开更多
Objective:With the continuous changes in social production,the consumption th inking of the masses obviously cannot keep up with the speed of social developmen t,and insurance disputes are increasingly emerging.Among ...Objective:With the continuous changes in social production,the consumption th inking of the masses obviously cannot keep up with the speed of social developmen t,and insurance disputes are increasingly emerging.Among them,the shortcomings of personal injury claims are not prominent,and the theoretical knowledge is not co mplete.In order to improve the quality of professional talents and reduce claims dis putes,the feasibility of integrating forensic medicine into personal injury claims is ex plored.Methods:The professional attributes,subject attributes,knowledge system an d employment data of forensic medicine are analyzed and compared with the actual work of personal injury claims.Main results:Forensic medicine has its uniqueness i n on-site investigation,injury-disease relationship analysis,and resolution of doubts.I t is irreplaceable by other subjects.The subject attributes are consistent with the pe rsonal injury claims major,and personal injury claims itself has basic medical courses,so it is easier to accept forensic medicine.Conclusion:Under the current social bac kground,through the study of the forensic medicine system in the personal injury cl aims major,it has positive practical significance for its professional construction and talent training.展开更多
Traditional Chinese medicine(TCM)possesses original theoretical advantages and thousands of years of human experience of its application and plays an important role in the prevention and treatment of infectious diseas...Traditional Chinese medicine(TCM)possesses original theoretical advantages and thousands of years of human experience of its application and plays an important role in the prevention and treatment of infectious diseases and major chronic illnesses.With the support of national policies,the advantages of the“five major resources”of TCM are gradually being realized,ushering the enterprise and industry of TCM into a new era of high-quality development.展开更多
Recent years have witnessed significant advances in the development of novel techniques and methodologies for identifying active ingredients in traditional Chinese medicine(TCM),substantially advancing research and de...Recent years have witnessed significant advances in the development of novel techniques and methodologies for identifying active ingredients in traditional Chinese medicine(TCM),substantially advancing research and development efforts.Spectrum-effect correlation analysis,affinity ultrafiltration,high-content screening(HCS)imaging,and cell membrane chromatography(CMC)have emerged as essential tools,effectively linking TCM chemical constituents to their biological effects,thereby enabling efficient active ingredient screening.Additionally,molecular interaction analysis provides deeper insights into TCM-biomolecule interaction mechanisms,enhancing understanding of its therapeutic potential.Computer-aided techniques facilitate TCM active ingredient identification,optimizing the screening process for efficiency and cost-effectiveness.Molecular probe technology,as an emerging methodology,enables precise and rapid screening for novel therapeutic drug discovery.Ongoing technological advancement in this field indicates promising future developments,potentially leading to more effective and targeted TCM-based therapies.展开更多
Hepatocellular carcinoma(HCC)represents the most prevalent form of primary liver cancer,characterized by high mortality rates,frequent recurrence and metastasis,poor clinical prognosis,and a complex pathogenesis with ...Hepatocellular carcinoma(HCC)represents the most prevalent form of primary liver cancer,characterized by high mortality rates,frequent recurrence and metastasis,poor clinical prognosis,and a complex pathogenesis with limited therapeutic options.Autophagy plays a pivotal role in the immune response and functions as a lysosome-mediated degradation mechanism essential for recycling cellular components and eliminating aggregated proteins,damaged organelles,and invasive pathogens,thereby maintaining cellular function and dynamic homeostasis.Additionally,autophagy regulates several critical proteins and signaling pathways,including mammalian target of the rapamycin(mTOR),Beclin-1,the phosphatidylinositol 3-kinase/protein kinase B/mTOR signaling pathway,the Hippo/yes-associated protein signaling pathway,and the Janus kinase/signal transducer of activation signaling pathway.This regulatory capa-city of autophagy can potentially prevent or delay the progression of HCC.Nowadays,many studies have shown that different types of herbal monomers such as the more common quercetin,baicalein,berberine and emodin can further regulate autophagy and exert preventive and therapeutic effects on HCC through the modulation of mTOR and other related signaling pathways and so on.In this paper,we examine the mechanisms of autophagy,key proteins and signaling pathways involved,and the modulation of autophagy by Chinese medicine monomers in the prevention and treatment of HCC.This review aims to provide valuable insights for the development of Chinese medicine strategies against HCC and to inform the rational use of these therapies in clinical practice.展开更多
Clarivate and Elsevier have recently released the 2024 Journal Citation Reports(JCR)and CiteScore,respectively.We are delighted to share the exciting news that Chinese Medicine and Culture(CMC)has achieved its first i...Clarivate and Elsevier have recently released the 2024 Journal Citation Reports(JCR)and CiteScore,respectively.We are delighted to share the exciting news that Chinese Medicine and Culture(CMC)has achieved its first impact factor(IF)of 0.5!It ranks in Q2 in the category of History&Philosophy of Science,and in Q4 in the category of Integrative&Complementary Medicine,marking a major breakthrough!展开更多
基金2024 Innovation and Entrepreneurship Education Reform Special Project of Xi’an Medical University“Research on the Construction of Innovation and Entrepreneurship Talent Training Model Based on the‘Innovation and Entrepreneurship Education Platform’”(2024CCJG-01)2024 Education and Teaching Reform Research Project of Xi’an Medical University“Research on the Cultivation System of Applied,Composite,and Innovative Talents in General Medicine under the Background of New Medicine”(2024JG-04)。
文摘Innovation and entrepreneurship education has become one of the important directions of higher education reform,but innovation and entrepreneurship education in medical colleges generally lags behind other discipline universities or comprehensive universities.Actively exploring the training mode of innovation and entrepreneurship talents is of great significance for cultivating innovative medical talents needed by the country and society.At present,innovation and entrepreneurship education in higher medical colleges is facing many challenges,the most important of which include the lack of concept in innovation and entrepreneurship education,medical students’weak awareness of innovation and entrepreneurship,and poor construction of innovation and entrepreneurship teaching staff.To address these challenges,we will introduce incentive measures for innovation and entrepreneurship education at the college level,and improve the guarantee and incentive mechanisms for innovation and entrepreneurship education;create an“Innovation and Entrepreneurship Education Platform”for teachers and students to exchange ideas on innovation and entrepreneurship;start building a high-quality team of innovation and entrepreneurship teachers,promote the continuous improvement of the quality of innovation and entrepreneurship education,and ensure the quality of medical talent training.
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
基金supported by The China Ethnic Medicine Association Research Grant(No.2023MY055-81)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(2023GLLHD177,2023GLLH0174)Inner Mongolia Autonomous Region Regional Medical Center for Specialized Care(2025).
文摘Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.
基金supported by the National Natural Science Innovative Research Group Project(61821002)the Frontier Funda-mental Research Program of Jiangsu Province for Leading Technology(BK20222002).
文摘The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of contemporary medicine that includes fundamental medical and health sciences,clinical medicine,and public health.Nevertheless,the present phase of medical advancement encounters significant challenges,particularly in effectively translating basic research findings into practical applications in clinical and public health settings.Scientists increasingly collaborate with clinical experts to overcome these obstacles and address specific clinical issues by delving deeper into fundamental mechanisms.This collaborative effort has created a new interdisciplinary field:engineering medicine(EngMed),which focuses on addressing clinical and public health needs by integrating various scientific disciplines.This article discusses the definition,key tasks,significance,educational implications,and future trends in EngMed.
基金supported by the National Natural Science Foundation of China(82574477)the Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan(QN202426)+5 种基金Jiangsu Province“333 High-level Talents Training Project”((2024)3-0189)Youth Talent Support Project of the Jiangsu Association for Science and Technology(TJ-2023-053)Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials(KF202401)Fundamental Research Program of Shanxi Province(202403021221211)the research project supported by the Shanxi Scholarship Council of China(No.2023-158)Open Project of Key Laboratory of Tibetan Medicine Basic Research,Ministry of Education.
文摘The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金supported by the Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
文摘Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.
文摘Gastrointestinal(GI)cancers remain a leading cause of cancer-related morbidity and mortality worldwide.Artificial intelligence(AI),particularly machine learning and deep learning(DL),has shown promise in enhancing cancer detection,diagnosis,and prognostication.A narrative review of literature published from January 2015 to march 2025 was conducted using PubMed,Web of Science,and Scopus.Search terms included"gastrointestinal cancer","artificial intelligence","machine learning","deep learning","radiomics","multimodal detection"and"predictive modeling".Studies were included if they focused on clinically relevant AI applications in GI oncology.AI algorithms for GI cancer detection have achieved high performance across imaging modalities,with endoscopic DL systems reporting accuracies of 85%-97%for polyp detection and segmentation.Radiomics-based models have predicted molecular biomarkers such as programmed cell death ligand 2 expression with area under the curves up to 0.92.Large language models applied to radiology reports demonstrated diagnostic accuracy comparable to junior radiologists(78.9%vs 80.0%),though without incremental value when combined with human interpretation.Multimodal AI approaches integrating imaging,pathology,and clinical data show emerging potential for precision oncology.AI in GI oncology has reached clinically relevant accuracy levels in multiple diagnostic tasks,with multimodal approaches and predictive biomarker modeling offering new opportunities for personalized care.However,broader validation,integration into clinical workflows,and attention to ethical,legal,and social implications remain critical for widespread adoption.
基金supported by the National Research Foundation of Korea(2020R1F1A1074155).
文摘Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short-chain fatty acids,and influence immune responses.However,their diversity and functional differences have created challenges for their development and therapeutic use.Recent studies have shown that specific Prevotella species,such as P.copri,P.intestinalis,and P.histicola,can strengthen gut barrier integrity and reduce metabolic imbalances.Notably,Prevotella populations can be increased through high-fiber or herbal-based treatments.Traditional herbal medicines,including fiber-rich decoctions,also demonstrate the potential to boost endogenous Prevotella communities,enhance microbial fermentation,and improve glucose and lipid balance.This perspective examines the context-dependent roles of Prevotella spp.,with emphasis on the functional heterogeneity of key species such as P.copri,suggests a framework for combining herbal modulation with species-level microbiota profiling,and outlines a research plan to explore microbe-herb synergy in treating obesity,type 2 diabetes,and related metabolic disorders.This strategy offers a new,ecology-based approach to complement standard metabolic interventions.
文摘The etiopathogenesis of gastrointestinal diseases is varied in nature.Various etiogenic factors described are infective,inflammatory,viral,bacterial,parasitic,dietary and lifestyle change.Rare causative agents are immunological,and others associated as idiopathic,are undiagnosed by all possible means.Some of the rare diseases are congenital in nature,passing from the parent to the child.Many of the undiagnosed diseases are now being diagnosed as genetic and the genes have been implicated as a causative agent.There is a search for newer treatments for such diseases,which is called genomic medicine.Genomic medicine is an emerging medical discipline that involves the use of genomic information about an individual.This is used both for diagnostic as well as therapeutic decisions to improve the current health domain and pave the way for policymakers for its clinical use.In the developing era of precision medicine,genomics,epigenomics,environmental exposure,and other data would be used to more accurately guide individual diagnosis and treatment.Genomic medicine is already making an impact in the fields of oncology,pharmacology,rare,infectious and many undiagnosed diseases.It is beginning to fuel new approaches in certain medical specialties.Oncology is at the leading edge of incorporating genomics,as diagnostics for genetic and genomic markers are increasingly included in cancer screening,and to guide tailored treatment strategies.Genetics and genetic medicine have been reported to play a role in gastroenterology in several ways,including genetic testing(hereditary pancreatitis and hereditary gastrointestinal cancer syndromes).Genetic testing can also help subtype diseases,such as classifying pancreatitis as idiopathic or hereditary.Gene therapy is a promising approach for treating gastrointestinal diseases that are not effectively treated by conventional pharmaceuticals and surgeries.Gene therapy strategies include gene addition,gene editing,messenger RNA therapy,and gene silencing.Understanding genetic determinants,advances in genetics,have led to a better understanding of the genetic factors that contribute to human disease.Family-member risk stratification and genetic diagnosis can help identify family members who are at risk,which can lead to preventive treatments,lifestyle recommendations,and routine follow ups.Selecting target genes helps identify the gene targets associated with each gastrointestinal disease.Common gastrointestinal diseases associated with genetic abnormalities include-inflammatory bowel disease,gastroesophageal reflux disease,non-alcoholic fatty liver disease,and irritable bowel syndrome.With advancing tools and technology,research in the search of newer and individualized treatment,genes and genetic medicines are expected to play a significant role in human health and gastroenterology.
文摘Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by mosquito vectors[1].Its clinical manifestations include high fever,headache,muscle and joint pain,and rash.It holds a significant position in global public health.In recent years,its incidence has continued to rise worldwide[2],making it one of the major diseases threatening human health.The disease course of dengue fever is divided into three typical phases:the acute febrile phase,the critical phase,and the recovery phase.While most patients experience mild symptoms,some may progress to severe dengue and potentially fatal outcomes if not promptly and effectively treated during the critical phase.
文摘High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).
基金supported by the National Natural Science Foundation of China(T2241028)the STI2030-Major Projects[2021ZD0203000(2021ZD0203003)]the Chinese Academy of Sciences Hundred Talents Program.
文摘Chronic pain,characterized by pain lasting for more than three months,is a debilitating condition frequently caused by conditions such as fibromyalgia,arthritis,neuropathy,and migraine[1-3].
基金2024 Education and Teaching Reform Research Project of Xi’an Medical University(JG2024-04):Research on the Training System of Applied,Compound,and Innovative Talents in General Practice under the Background of New Medicine2024 Innovation and Entrepreneurship Education Reform Special Project of Xi’an Medical University(2024CCJG-01):Research on the Construction of Innovation and Entrepreneurship Talent Training Model Based on the“Innovation and Entrepreneurship Education Platform”。
文摘The construction of new medicine is a strategic plan proposed by the Party and the state for the development of medical education in the new era,which brings new opportunities and challenges to the cultivation of general medical talents.Based on the connotation of the new medical construction,we will promote the construction of a comprehensive medical talent training system.By creating a characteristic general education curriculum system,building a high-level clinical practice teaching base,creating an innovation and entrepreneurship education platform for the First Affiliated Hospital of Xi’an Medical University,and reforming and improving the internal incentive mechanism for teachers,we aim to cultivate comprehensive medical talents who are“useful,competent,capable,and able to stay,”and contribute to the construction of a healthy China.
文摘Objective:To explore the application value of a new empowerment teaching method based on Kirkpatrick’s evaluation model in teaching Chinese medicine nursing in otorhinolaryngology.Methods:60 nurses who practiced in the otolaryngology department of our hospital from June 2022 to October 2024 were included in the study and equally divided into two groups using a convenient sampling method.30 nurses who chose traditional Chinese medicine skill teaching management were included in the control group,and 30 nurses who chose the new empowerment teaching method based on Kirkpatrick’s evaluation model were included in the observation group.Relevant indicators such as clinical teaching environment perception,theoretical knowledge scores of Chinese medicine nursing,and excellent rate of practical operation assessment were compared.Results:The nurses in the observation group had higher scores for clinical teaching environment perception than the control group(P<0.05).However,the midterm and final exam scores for theoretical knowledge of Chinese medicine nursing were higher in the observation group than in the control group(P<0.05).Compared with the control group,the observation group had a higher excellent rate of practical operation assessment(93.33%>73.33%)and a higher Chinese medicine nursing ability score[(215.69±19.73)points>(184.87±15.66)points](P<0.05).Conclusion:Applying the new empowerment teaching method based on Kirkpatrick’s evaluation model to Chinese medicine nursing teaching in otolaryngology can help nurses understand the theoretical knowledge of Chinese medicine nursing and optimize the clinical teaching environment,thereby promoting their practical skills and Chinese medicine nursing abilities.
文摘Objective:With the continuous changes in social production,the consumption th inking of the masses obviously cannot keep up with the speed of social developmen t,and insurance disputes are increasingly emerging.Among them,the shortcomings of personal injury claims are not prominent,and the theoretical knowledge is not co mplete.In order to improve the quality of professional talents and reduce claims dis putes,the feasibility of integrating forensic medicine into personal injury claims is ex plored.Methods:The professional attributes,subject attributes,knowledge system an d employment data of forensic medicine are analyzed and compared with the actual work of personal injury claims.Main results:Forensic medicine has its uniqueness i n on-site investigation,injury-disease relationship analysis,and resolution of doubts.I t is irreplaceable by other subjects.The subject attributes are consistent with the pe rsonal injury claims major,and personal injury claims itself has basic medical courses,so it is easier to accept forensic medicine.Conclusion:Under the current social bac kground,through the study of the forensic medicine system in the personal injury cl aims major,it has positive practical significance for its professional construction and talent training.
基金supported by the Strategic Research and Consultation Project of the Chinese Academy of Engineering(2023-PP-05,2025-PP-15)。
文摘Traditional Chinese medicine(TCM)possesses original theoretical advantages and thousands of years of human experience of its application and plays an important role in the prevention and treatment of infectious diseases and major chronic illnesses.With the support of national policies,the advantages of the“five major resources”of TCM are gradually being realized,ushering the enterprise and industry of TCM into a new era of high-quality development.
基金supported by the National Natural Science Foundation of China (Nos. 22175078, 52373287, 82404846, and 22467002)the Natural Science Foundation of Jiangsu Province of China (No. BK20241597)the Fundamental Research Funds for the Central Universities (No. 2632024TD05)
文摘Recent years have witnessed significant advances in the development of novel techniques and methodologies for identifying active ingredients in traditional Chinese medicine(TCM),substantially advancing research and development efforts.Spectrum-effect correlation analysis,affinity ultrafiltration,high-content screening(HCS)imaging,and cell membrane chromatography(CMC)have emerged as essential tools,effectively linking TCM chemical constituents to their biological effects,thereby enabling efficient active ingredient screening.Additionally,molecular interaction analysis provides deeper insights into TCM-biomolecule interaction mechanisms,enhancing understanding of its therapeutic potential.Computer-aided techniques facilitate TCM active ingredient identification,optimizing the screening process for efficiency and cost-effectiveness.Molecular probe technology,as an emerging methodology,enables precise and rapid screening for novel therapeutic drug discovery.Ongoing technological advancement in this field indicates promising future developments,potentially leading to more effective and targeted TCM-based therapies.
文摘Hepatocellular carcinoma(HCC)represents the most prevalent form of primary liver cancer,characterized by high mortality rates,frequent recurrence and metastasis,poor clinical prognosis,and a complex pathogenesis with limited therapeutic options.Autophagy plays a pivotal role in the immune response and functions as a lysosome-mediated degradation mechanism essential for recycling cellular components and eliminating aggregated proteins,damaged organelles,and invasive pathogens,thereby maintaining cellular function and dynamic homeostasis.Additionally,autophagy regulates several critical proteins and signaling pathways,including mammalian target of the rapamycin(mTOR),Beclin-1,the phosphatidylinositol 3-kinase/protein kinase B/mTOR signaling pathway,the Hippo/yes-associated protein signaling pathway,and the Janus kinase/signal transducer of activation signaling pathway.This regulatory capa-city of autophagy can potentially prevent or delay the progression of HCC.Nowadays,many studies have shown that different types of herbal monomers such as the more common quercetin,baicalein,berberine and emodin can further regulate autophagy and exert preventive and therapeutic effects on HCC through the modulation of mTOR and other related signaling pathways and so on.In this paper,we examine the mechanisms of autophagy,key proteins and signaling pathways involved,and the modulation of autophagy by Chinese medicine monomers in the prevention and treatment of HCC.This review aims to provide valuable insights for the development of Chinese medicine strategies against HCC and to inform the rational use of these therapies in clinical practice.
文摘Clarivate and Elsevier have recently released the 2024 Journal Citation Reports(JCR)and CiteScore,respectively.We are delighted to share the exciting news that Chinese Medicine and Culture(CMC)has achieved its first impact factor(IF)of 0.5!It ranks in Q2 in the category of History&Philosophy of Science,and in Q4 in the category of Integrative&Complementary Medicine,marking a major breakthrough!
