The ability to noninvasively manipulate and isolate specific cell populations in vivo is critical for advancing real-time diagnostics,precision medicine,and immunological research.Here,we present a novel and broadly a...The ability to noninvasively manipulate and isolate specific cell populations in vivo is critical for advancing real-time diagnostics,precision medicine,and immunological research.Here,we present a novel and broadly applicable optical trapping system based on a custom-designed 2×3 optical tweezer array,which enables the real-time interception and manipulation of circulating leukocytes in live animals.By utilizing intrinsic velocity differences between leukocytes and red blood cells,the system achieves stable trapping of individual leukocytes in vessels 15-20μm in diameter and decelerates multiple cells in vessels greater than 20μm.Notably,it also enables the optical blockage of lymphatic vessels exceeding 50μm,a previously unreported capability.This label-free,noninvasive approach operates without repeated blood draws and is compatible with diverse vessel geometries and flow dynamics.The system offers a generalizable solution for in vivo cell extraction and analysis,paving the way for high-precision single-cell technologies in biomedical research and clinical translation.展开更多
Sparse array design has significant implications for improving the accuracy of direction of arrival(DOA)estimation of non-circular(NC)signals.We propose an extended nested array with a filled sensor(ENAFS)based on the...Sparse array design has significant implications for improving the accuracy of direction of arrival(DOA)estimation of non-circular(NC)signals.We propose an extended nested array with a filled sensor(ENAFS)based on the hole-filling strategy.Specifically,we first introduce the improved nested array(INA)and prove its properties.Subsequently,we extend the sum-difference coarray(SDCA)by adding an additional sensor to fill the holes.Thus the larger uniform degrees of freedom(uDOFs)and virtual array aperture(VAA)can be abtained,and the ENAFS is designed.Finally,the simulation results are given to verify the superiority of the proposed ENAFS in terms of DOF,mutual coupling and estimation performance.展开更多
Commercial phosphor-converted white LEDs(pc-WLEDs)face two inherent limitations,namely blue light hazard and low color rendering index,due to the use of blue LEDs as excitation source.To address these challenges,viole...Commercial phosphor-converted white LEDs(pc-WLEDs)face two inherent limitations,namely blue light hazard and low color rendering index,due to the use of blue LEDs as excitation source.To address these challenges,violet LEDs are proposed as an alternative solution.Currently,phosphors that can be efficiently excited by violet light(with wavelengths from 400 to 420 nm)remain under development still.In this study,we utilize large language models to construct a comprehensive database of Eu^(2+)and Ce^(3+)doped phosphors for discovering novel violet-excited phosphors.A total of 822 phosphor data entries,including elemental compositions,crystal structures and excitation/emission wavelengths,have been extracted and validated from 9551 research papers.Compared with Ce^(3+)doped phosphors,the Eu^(2+)are in general more suited for violet-excited phosphors,as well as red-emitting phosphors.In particular,Eu^(2+)doped nitrides and sulfides are worth of exploration for violet-excited phosphors.This database is expected to be useful in the future development of phosphors for pc-WLEDs based on artificial intelligence methods.The datasets in this article are listed in Science Data Bank at http://doi.org/10.57760/sciencedb.34314.展开更多
The complex Red River fault zone(RRFZ),which is situated in the southwestern region of China and separates the Indochina plate and South China blocks,has diverse seismic activities in different segments.To reveal the ...The complex Red River fault zone(RRFZ),which is situated in the southwestern region of China and separates the Indochina plate and South China blocks,has diverse seismic activities in different segments.To reveal the detailed geometric characteristics of the RRFZ at different sections and to better understand the seismogenic environment,in 2022 and 2023 we deployed 7 seismic dense linear arrays,consisting of 574 nodal stations,across the RRFZ in the northern and southern segments near the towns Midu,Gasa,Zhega,Dazhai,Xinzhai,and Taoyuan.The linear arrays,which extend from 2.4 to 12.5 km in length with station intervals ranging between 40 and140 m,recorded seismic ambient noise for approximately one month.Using the extended range phase shift method,we extract the phase velocity dispersion curves of the Rayleigh waves between 0.9 and 10 Hz,which are then used to invert for the high resolution shearwave velocity structures across the RRFZ beneath the linear arrays.The key findings are:(1)the 7 imaged sections of the RRFZ exhibit quite similar structures,with higher velocities on the SW side and lower velocities on the NE side;the velocity variation is consistent with the surface geological structures along the RRFZ;(2)the shear-wave velocities on the SW side of the RRFZ at the northern Midu section and southern Gasa-Dazhai sections are generally higher than their counterparts in the southern Xinzhai-Taoyuan sections,which reflects lithological variations from the marble-dominated Paleoproterozoic Along basement to the gneiss dominated Paleoproterozoic Qingshuihe basement;(3)from the northern Midu section to the southern region where the RRFZ intersects with the Xiaojiang Fault,the major faults of the RRFZ exhibit a consistent high-angle,NE-dipping structure;(4)the low shear-wave velocities immediately to the NE of the velocity boundary may indicate a faulted zone due to long-term shearing,where excessive amplifications of ground motions could occur.This study provides new insights into the characteristics of the shallow structures of the RRFZ.展开更多
基金funding from the National Key Research and Development Program of China(2021YFF0502900)special fund for Research on the National Major Research Instruments of China(62027824)+2 种基金the National Natural Science Foundation of China(U24A20314)the Key Research and Development Program of Anhui Province in China(2022a05020028)the Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province.
文摘The ability to noninvasively manipulate and isolate specific cell populations in vivo is critical for advancing real-time diagnostics,precision medicine,and immunological research.Here,we present a novel and broadly applicable optical trapping system based on a custom-designed 2×3 optical tweezer array,which enables the real-time interception and manipulation of circulating leukocytes in live animals.By utilizing intrinsic velocity differences between leukocytes and red blood cells,the system achieves stable trapping of individual leukocytes in vessels 15-20μm in diameter and decelerates multiple cells in vessels greater than 20μm.Notably,it also enables the optical blockage of lymphatic vessels exceeding 50μm,a previously unreported capability.This label-free,noninvasive approach operates without repeated blood draws and is compatible with diverse vessel geometries and flow dynamics.The system offers a generalizable solution for in vivo cell extraction and analysis,paving the way for high-precision single-cell technologies in biomedical research and clinical translation.
基金supported by China National Science Foundations(Nos.62371225,62371227)。
文摘Sparse array design has significant implications for improving the accuracy of direction of arrival(DOA)estimation of non-circular(NC)signals.We propose an extended nested array with a filled sensor(ENAFS)based on the hole-filling strategy.Specifically,we first introduce the improved nested array(INA)and prove its properties.Subsequently,we extend the sum-difference coarray(SDCA)by adding an additional sensor to fill the holes.Thus the larger uniform degrees of freedom(uDOFs)and virtual array aperture(VAA)can be abtained,and the ENAFS is designed.Finally,the simulation results are given to verify the superiority of the proposed ENAFS in terms of DOF,mutual coupling and estimation performance.
基金National Key Research and Development Program of China(2021YFB3500501)。
文摘Commercial phosphor-converted white LEDs(pc-WLEDs)face two inherent limitations,namely blue light hazard and low color rendering index,due to the use of blue LEDs as excitation source.To address these challenges,violet LEDs are proposed as an alternative solution.Currently,phosphors that can be efficiently excited by violet light(with wavelengths from 400 to 420 nm)remain under development still.In this study,we utilize large language models to construct a comprehensive database of Eu^(2+)and Ce^(3+)doped phosphors for discovering novel violet-excited phosphors.A total of 822 phosphor data entries,including elemental compositions,crystal structures and excitation/emission wavelengths,have been extracted and validated from 9551 research papers.Compared with Ce^(3+)doped phosphors,the Eu^(2+)are in general more suited for violet-excited phosphors,as well as red-emitting phosphors.In particular,Eu^(2+)doped nitrides and sulfides are worth of exploration for violet-excited phosphors.This database is expected to be useful in the future development of phosphors for pc-WLEDs based on artificial intelligence methods.The datasets in this article are listed in Science Data Bank at http://doi.org/10.57760/sciencedb.34314.
基金funded by the National Key Research and Development Project of China(Grant No.2021YFC3000600)the China Earthquake Science Experiment Field-Cross-fault Observation Array-Red River Fault Scientific Drilling Project Geophysical Prospecting Site Selection Project+2 种基金Anhui Province Science and Technology Breakthrough Plan Project(Key Project,202423l10050030)the Earthquake Science and Technology Spark Program of the China Earthquake Administration(XH23020YA)the Anhui Mengcheng National Geophysical Observatory Joint Open Fund(MENGO-202307)。
文摘The complex Red River fault zone(RRFZ),which is situated in the southwestern region of China and separates the Indochina plate and South China blocks,has diverse seismic activities in different segments.To reveal the detailed geometric characteristics of the RRFZ at different sections and to better understand the seismogenic environment,in 2022 and 2023 we deployed 7 seismic dense linear arrays,consisting of 574 nodal stations,across the RRFZ in the northern and southern segments near the towns Midu,Gasa,Zhega,Dazhai,Xinzhai,and Taoyuan.The linear arrays,which extend from 2.4 to 12.5 km in length with station intervals ranging between 40 and140 m,recorded seismic ambient noise for approximately one month.Using the extended range phase shift method,we extract the phase velocity dispersion curves of the Rayleigh waves between 0.9 and 10 Hz,which are then used to invert for the high resolution shearwave velocity structures across the RRFZ beneath the linear arrays.The key findings are:(1)the 7 imaged sections of the RRFZ exhibit quite similar structures,with higher velocities on the SW side and lower velocities on the NE side;the velocity variation is consistent with the surface geological structures along the RRFZ;(2)the shear-wave velocities on the SW side of the RRFZ at the northern Midu section and southern Gasa-Dazhai sections are generally higher than their counterparts in the southern Xinzhai-Taoyuan sections,which reflects lithological variations from the marble-dominated Paleoproterozoic Along basement to the gneiss dominated Paleoproterozoic Qingshuihe basement;(3)from the northern Midu section to the southern region where the RRFZ intersects with the Xiaojiang Fault,the major faults of the RRFZ exhibit a consistent high-angle,NE-dipping structure;(4)the low shear-wave velocities immediately to the NE of the velocity boundary may indicate a faulted zone due to long-term shearing,where excessive amplifications of ground motions could occur.This study provides new insights into the characteristics of the shallow structures of the RRFZ.
