目的探讨血清补体C1q/肿瘤坏死因子相关蛋白13(CTRP13)与妊娠期糖尿病(GDM)的相关性.方法选取GDM患者为GDM组(n=55),正常妊娠者为NGT组(n=50).对比两组基线资料及血清CTRP13水平.Logistic回归分析GDM影响因素,Pearson相关性分析血清CTR...目的探讨血清补体C1q/肿瘤坏死因子相关蛋白13(CTRP13)与妊娠期糖尿病(GDM)的相关性.方法选取GDM患者为GDM组(n=55),正常妊娠者为NGT组(n=50).对比两组基线资料及血清CTRP13水平.Logistic回归分析GDM影响因素,Pearson相关性分析血清CTRP13与临床指标的相关性,多元线性回归分析血清CTRP13的影响因素.结果相较于NGT组,GDM组FPG、1hPG、2hPG、FIns、HOMA-IR、HbA1c、IL-6、TNF-α增高,血清CTRP13水平降低(56.90±10.73 ng/mL vs 75.98±15.20 ng/mL)(P<0.05).两组年龄、孕周、BMI、SBP、DBP、TG、TC、LDL-C、HDL-C比较差异无统计学意义(P>0.05).血清CTRP13与FPG、1hPG、2hPG、HOMA-IR、IL-6及TNF-α呈负相关(P<0.05).FPG、IL-6是CTRP13的影响因素.HOMA-IR及CTRP13是GDM的影响因素.结论GDM患者血清CTRP13低表达,是GDM的独立危险因素,CTRP13可能参与GDM病程进展.展开更多
Water was a key factor restricting the plantation in sandy areas. Foliar δ^(13)C value regarded as an indicator of longterm water use efficiency(WUE) of plants was generally used to evaluate the adaptability of plant...Water was a key factor restricting the plantation in sandy areas. Foliar δ^(13)C value regarded as an indicator of longterm water use efficiency(WUE) of plants was generally used to evaluate the adaptability of plants to arid and semi-arid environment. In Horqin sandy land of China, the foliar δ^(13)C values of 114 species in 35 families naturally growing in the area, and 15 species of sand-fixing trees and shrubs were measured and analyzed in 2012. The results showed that 97 species in all 114 species were C_3 plants and only 17 species were C_4 plants. Most C_4 plants belonged to Gramineae family. The foliar δ^(13)C value of C_3 plants was between -25.000 and -31.075‰ with an average of-28.226‰, while those of C_4 plants between -12.578 and -16.334‰, with an average of -13.678‰. The δ^(13)C values of mature leaves collected in August were averagely 0.85‰ less than that of juvenile leaves collected in June. The foliar δ^(13)C values and WUE of 15 sand-fixing tree species in Horqin sandy land ranked in the order as: S.vulgaris >H.rhamnoides >C.ovata >P.mongolica >T.chinensis >R.typhina >S.matsudana >E.angustifolia >U.pumila >S.gordejevii >X.sorbifolia >C.microphylla >H.fruticosum >C.korshinskii >E.bungeanus.展开更多
A class of nonlocal boundary value probl em s for elliptic systems in the unbounded domains are considered. Under suitable c onditions, the existence of solution and the comparison theorem for the boundary value prob...A class of nonlocal boundary value probl em s for elliptic systems in the unbounded domains are considered. Under suitable c onditions, the existence of solution and the comparison theorem for the boundary value problems are studied.展开更多
目的探究血清分泌型卷曲相关蛋白5(secreted frizzled related protein 5,SFRP-5)、C-X-C基序趋化因子配体16(C-X-C motif chemokine ligand 16,CXCL16)对心肌梗死患者经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗后...目的探究血清分泌型卷曲相关蛋白5(secreted frizzled related protein 5,SFRP-5)、C-X-C基序趋化因子配体16(C-X-C motif chemokine ligand 16,CXCL16)对心肌梗死患者经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗后心力衰竭(heart failure,HF)发生的预测价值。方法选取2022年6月至2024年1月于保定市第二中心医院实施PCI治疗的心肌梗死患者152例为研究对象。术后随访1年,根据患者是否发生HF分为HF组和(n=47)非HF组(n=105)。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)法检测PCI治疗前患者血清SFRP-5、CXCL16的浓度;采用多因素Logistic回归法分析影响心肌梗死患者PCI治疗后HF发生的因素;绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析血清SFRP-5、CXCL16浓度对心肌梗死患者PCI治疗后HF发生的预测价值。结果与非HF组患者比较,HF组患者性别、体质量指数(body mass index,BMI)、吸烟史、原发性高血压(高血压)史、糖尿病史、收缩压、舒张压及血肌酐(serum creatinine,Scr)、空腹血糖、总胆固醇浓度比较,差异无统计学意义(P>0.05);血清SFRP-5浓度显著降低,年龄及纤维蛋白原、CXCL16浓度浓度显著升高,差异有统计学意义(P<0.05)。年龄(OR=1.712)、纤维蛋白原(OR=2.240)、CXCL16浓度升高(OR=3.948),SFRP-5浓度降低(OR=0.284)均是影响心肌梗死患者PCI治疗后HF发生的危险因素(P<0.05)。血清SFRP-5、CXCL16浓度单独预测心肌梗死患者PCI治疗后HF发生的曲线下面积(area under the curve,AUC)分别为0.698(95%CI:0.619~0.770)、0.801(95%CI:0.729~0.861),二者联合预测的AUC为0.952(95%CI:0.905~0.980),灵敏度为91.49%,特异度为91.43%。联合预测价值显著高于单一指标预测(Z_(三者联合-SFRP-5)=5.839、Z_(三者联合-CXCL16)=3.564,P<0.05)。结论血清SFRP-5、CXCL16浓度对心肌梗死患者PCI治疗后HF发生具有一定的预测价值,且二者联合的预测价值更高。展开更多
文摘目的探讨血清补体C1q/肿瘤坏死因子相关蛋白13(CTRP13)与妊娠期糖尿病(GDM)的相关性.方法选取GDM患者为GDM组(n=55),正常妊娠者为NGT组(n=50).对比两组基线资料及血清CTRP13水平.Logistic回归分析GDM影响因素,Pearson相关性分析血清CTRP13与临床指标的相关性,多元线性回归分析血清CTRP13的影响因素.结果相较于NGT组,GDM组FPG、1hPG、2hPG、FIns、HOMA-IR、HbA1c、IL-6、TNF-α增高,血清CTRP13水平降低(56.90±10.73 ng/mL vs 75.98±15.20 ng/mL)(P<0.05).两组年龄、孕周、BMI、SBP、DBP、TG、TC、LDL-C、HDL-C比较差异无统计学意义(P>0.05).血清CTRP13与FPG、1hPG、2hPG、HOMA-IR、IL-6及TNF-α呈负相关(P<0.05).FPG、IL-6是CTRP13的影响因素.HOMA-IR及CTRP13是GDM的影响因素.结论GDM患者血清CTRP13低表达,是GDM的独立危险因素,CTRP13可能参与GDM病程进展.
基金Supported by the Scientific Research Project of Hebei Higher Education(QN2015306)National Key Technology Research and Development Program of China during the 12th Five-Year Plan(2012BAD16B0302)
文摘Water was a key factor restricting the plantation in sandy areas. Foliar δ^(13)C value regarded as an indicator of longterm water use efficiency(WUE) of plants was generally used to evaluate the adaptability of plants to arid and semi-arid environment. In Horqin sandy land of China, the foliar δ^(13)C values of 114 species in 35 families naturally growing in the area, and 15 species of sand-fixing trees and shrubs were measured and analyzed in 2012. The results showed that 97 species in all 114 species were C_3 plants and only 17 species were C_4 plants. Most C_4 plants belonged to Gramineae family. The foliar δ^(13)C value of C_3 plants was between -25.000 and -31.075‰ with an average of-28.226‰, while those of C_4 plants between -12.578 and -16.334‰, with an average of -13.678‰. The δ^(13)C values of mature leaves collected in August were averagely 0.85‰ less than that of juvenile leaves collected in June. The foliar δ^(13)C values and WUE of 15 sand-fixing tree species in Horqin sandy land ranked in the order as: S.vulgaris >H.rhamnoides >C.ovata >P.mongolica >T.chinensis >R.typhina >S.matsudana >E.angustifolia >U.pumila >S.gordejevii >X.sorbifolia >C.microphylla >H.fruticosum >C.korshinskii >E.bungeanus.
文摘A class of nonlocal boundary value probl em s for elliptic systems in the unbounded domains are considered. Under suitable c onditions, the existence of solution and the comparison theorem for the boundary value problems are studied.
文摘目的探究血清分泌型卷曲相关蛋白5(secreted frizzled related protein 5,SFRP-5)、C-X-C基序趋化因子配体16(C-X-C motif chemokine ligand 16,CXCL16)对心肌梗死患者经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗后心力衰竭(heart failure,HF)发生的预测价值。方法选取2022年6月至2024年1月于保定市第二中心医院实施PCI治疗的心肌梗死患者152例为研究对象。术后随访1年,根据患者是否发生HF分为HF组和(n=47)非HF组(n=105)。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)法检测PCI治疗前患者血清SFRP-5、CXCL16的浓度;采用多因素Logistic回归法分析影响心肌梗死患者PCI治疗后HF发生的因素;绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析血清SFRP-5、CXCL16浓度对心肌梗死患者PCI治疗后HF发生的预测价值。结果与非HF组患者比较,HF组患者性别、体质量指数(body mass index,BMI)、吸烟史、原发性高血压(高血压)史、糖尿病史、收缩压、舒张压及血肌酐(serum creatinine,Scr)、空腹血糖、总胆固醇浓度比较,差异无统计学意义(P>0.05);血清SFRP-5浓度显著降低,年龄及纤维蛋白原、CXCL16浓度浓度显著升高,差异有统计学意义(P<0.05)。年龄(OR=1.712)、纤维蛋白原(OR=2.240)、CXCL16浓度升高(OR=3.948),SFRP-5浓度降低(OR=0.284)均是影响心肌梗死患者PCI治疗后HF发生的危险因素(P<0.05)。血清SFRP-5、CXCL16浓度单独预测心肌梗死患者PCI治疗后HF发生的曲线下面积(area under the curve,AUC)分别为0.698(95%CI:0.619~0.770)、0.801(95%CI:0.729~0.861),二者联合预测的AUC为0.952(95%CI:0.905~0.980),灵敏度为91.49%,特异度为91.43%。联合预测价值显著高于单一指标预测(Z_(三者联合-SFRP-5)=5.839、Z_(三者联合-CXCL16)=3.564,P<0.05)。结论血清SFRP-5、CXCL16浓度对心肌梗死患者PCI治疗后HF发生具有一定的预测价值,且二者联合的预测价值更高。
