Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptid...Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptides feature a covalent cross-link of side chains, thus effectively mimicking α-helix as inhibitors of protein-protein interactions. In this review, we category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years.展开更多
Increase a degree of freedom for one dimension dynamical system of the α-helix protein, obtaining the dynamical system model of double degree of freedom. In this new dynamical system there are the solution of double ...Increase a degree of freedom for one dimension dynamical system of the α-helix protein, obtaining the dynamical system model of double degree of freedom. In this new dynamical system there are the solution of double soliton on the polypeptide chain of α-helix protein, and the coupling intensity of the double soliton relate obviously with their center distance. The solution of the synchronous double soliton has been studied by the analytical method for two cases of the stronger and weaker coupling. The possible effect brought by tile double soliton for the protein property has been discussed.展开更多
Biopolymer-driven supramolecular chirality in aqueous media has gained significant advancements in hierarchical chiral nanostructures.However,researches on the aqueous circularly polarized luminescence(CPL)induced by ...Biopolymer-driven supramolecular chirality in aqueous media has gained significant advancements in hierarchical chiral nanostructures.However,researches on the aqueous circularly polarized luminescence(CPL)induced by supramolecular selfassembly and its mechanism have been rarely reported.Herein,we explore the hierarchical chirality transfer in self-assembled fluorescent homopolypeptide systems showing aqueous CPL,and unveil anα-helix-dominated CPL regulation mechanism.A relationship is established between molecular structure(degree of polymerization,DP),supramolecular assembly(self-assembly temperature,T_(SA)),and resulting CPL properties.The stabilization for the homopolypeptideα-helix by increasing DP and decreasing T_(SA) enables efficient chirality transfer from the polypeptide backbone to its terminal chromophore,thereby improving CPL properties.Our work elucidates the critical role ofα-helix control in aqueous CPL systems,providing insights for designing biocompatible and tunable CPL-active nanomaterials.展开更多
By combination of finite number theory and quantum information, the complete quantum information in the <em>DNA</em> genetic code has been made likely by <em>Planat et al</em>. (2020). In the p...By combination of finite number theory and quantum information, the complete quantum information in the <em>DNA</em> genetic code has been made likely by <em>Planat et al</em>. (2020). In the present contribution a varied quartic polynomial contrasting the polynomial used by <em>Planat et al</em>. is proposed that considered apart from the golden mean also the fifth power of this dominant number of nature to adapt the code information. The suggested polynomial is denoted as <em>g</em>(<em>x</em>) = <em>x</em><sup>4</sup> - <em>x</em><sup>3</sup> - (4 - <em><i style="white-space:normal;">ϕ</i></em><sup>2</sup> )<em>x</em><sup>2</sup> + (4 – <i>ϕ</i><sup>2</sup>)x + 1, where <img src="Edit_40efe764-d690-499f-8424-129f9ca46f78.bmp" alt="" /> is the golden mean. Its roots are changed to more golden mean based ones in comparison to the <em>Planat</em> polynomial. The new coefficients 4 – <em>ϕ</em><sup>2</sup> instead of 4 would implement the fifth power of the golden mean indirectly applying <img src="Edit_5b44b644-3f59-4fad-a586-ec5345ba6be4.bmp" alt="" />. As an outlook, it should be emphesized that the connection between genetic code and resonance code of the <em>DNA</em> may lead us to a full understanding of how nature stores and processes compacted information and what indeed is consciousness linking everything with each other suggestedly mediated by all-pervasive dark constituents of matter respectively energy. The number-theoretical approach to <em>DNA</em> coding leads to the question about the helical structure of the electron.展开更多
文摘Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptides feature a covalent cross-link of side chains, thus effectively mimicking α-helix as inhibitors of protein-protein interactions. In this review, we category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years.
文摘Increase a degree of freedom for one dimension dynamical system of the α-helix protein, obtaining the dynamical system model of double degree of freedom. In this new dynamical system there are the solution of double soliton on the polypeptide chain of α-helix protein, and the coupling intensity of the double soliton relate obviously with their center distance. The solution of the synchronous double soliton has been studied by the analytical method for two cases of the stronger and weaker coupling. The possible effect brought by tile double soliton for the protein property has been discussed.
基金supported by the National Key Research and Development Program of China(2023YFB3810001)the National Natural Science Foundation of China(52333007 and 52273197)+3 种基金the Guangdong Basic and Applied Basic Research Foundation(2023A1515011004)the Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001)the Science Technology Innovation Commission of Shenzhen Municipality(GJHZ20210705141810031,KQTD20210811090142053,and JCYJ20220818103007014)the Innovation and Technology Commission of Hong Kong(ITC-CNERC14SC01).
文摘Biopolymer-driven supramolecular chirality in aqueous media has gained significant advancements in hierarchical chiral nanostructures.However,researches on the aqueous circularly polarized luminescence(CPL)induced by supramolecular selfassembly and its mechanism have been rarely reported.Herein,we explore the hierarchical chirality transfer in self-assembled fluorescent homopolypeptide systems showing aqueous CPL,and unveil anα-helix-dominated CPL regulation mechanism.A relationship is established between molecular structure(degree of polymerization,DP),supramolecular assembly(self-assembly temperature,T_(SA)),and resulting CPL properties.The stabilization for the homopolypeptideα-helix by increasing DP and decreasing T_(SA) enables efficient chirality transfer from the polypeptide backbone to its terminal chromophore,thereby improving CPL properties.Our work elucidates the critical role ofα-helix control in aqueous CPL systems,providing insights for designing biocompatible and tunable CPL-active nanomaterials.
文摘By combination of finite number theory and quantum information, the complete quantum information in the <em>DNA</em> genetic code has been made likely by <em>Planat et al</em>. (2020). In the present contribution a varied quartic polynomial contrasting the polynomial used by <em>Planat et al</em>. is proposed that considered apart from the golden mean also the fifth power of this dominant number of nature to adapt the code information. The suggested polynomial is denoted as <em>g</em>(<em>x</em>) = <em>x</em><sup>4</sup> - <em>x</em><sup>3</sup> - (4 - <em><i style="white-space:normal;">ϕ</i></em><sup>2</sup> )<em>x</em><sup>2</sup> + (4 – <i>ϕ</i><sup>2</sup>)x + 1, where <img src="Edit_40efe764-d690-499f-8424-129f9ca46f78.bmp" alt="" /> is the golden mean. Its roots are changed to more golden mean based ones in comparison to the <em>Planat</em> polynomial. The new coefficients 4 – <em>ϕ</em><sup>2</sup> instead of 4 would implement the fifth power of the golden mean indirectly applying <img src="Edit_5b44b644-3f59-4fad-a586-ec5345ba6be4.bmp" alt="" />. As an outlook, it should be emphesized that the connection between genetic code and resonance code of the <em>DNA</em> may lead us to a full understanding of how nature stores and processes compacted information and what indeed is consciousness linking everything with each other suggestedly mediated by all-pervasive dark constituents of matter respectively energy. The number-theoretical approach to <em>DNA</em> coding leads to the question about the helical structure of the electron.
