After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
AIM:To evaluate the efficacy and safety of decellularized conjunctival stroma(DCS)as a novel biomaterial by comparing its grafting outcomes with amniotic membrane(AM)when used for conjunctival reconstruction after pri...AIM:To evaluate the efficacy and safety of decellularized conjunctival stroma(DCS)as a novel biomaterial by comparing its grafting outcomes with amniotic membrane(AM)when used for conjunctival reconstruction after primary pterygium excision.METHODS:This randomized,parallel-controlled study with allocation concealment enrolled 40 patients with primary pterygium.Participants were randomly assigned to two groups using the sealed envelope method:the DCS group(n=20)and the AM group(n=18),receiving DCS and AM grafts respectively.Slit-lamp photography of the operative eyes was performed preoperatively and at 1,3,5,7,10,30,90,and 180d postoperatively.Best-corrected visual acuity(BCVA)and symptom scores were recorded simultaneously.In vivo confocal microscopy was conducted at 3 and 6mo postoperatively.RESULTS:All participants exhibited improved postoperative symptoms.The mean age was 60±9y(male/female ratio:6/14)in the DCS group and 56±12y(male/female ratio:7/11)in the AM group.The average epithelial healing time was 9.89±3.54d in the DCS group and 8.17±1.34d in the AM group(P=0.084).One recurrence case was observed in each group.Postoperative graft hemorrhage was significantly more severe in the DCS group than in the AM group only at 30d postoperatively(P=0.011).In vivo confocal microscopy revealed conjunctival epithelial cell growth in both groups at 90d postoperatively,while clear corneo-conjunctival cell boundaries were observed until 180d postoperatively.CONCLUSION:DCS used in primary pterygium surgery has a safety profile comparable to AM.It promotes rapid postoperative conjunctival healing,achieves a relatively low pterygium recurrence rate,and yields outcomes similar to AM.DCS provides a novel biomaterial option for conjunctival reconstruction after pterygium excision and the treatment of other conjunctival injuries.展开更多
This paper presents a novel method for reconstructing a highly accurate 3D nose model of the human from 2D images and pre-marked landmarks based on algorithmic methods.The study focuses on the reconstruction of a 3D n...This paper presents a novel method for reconstructing a highly accurate 3D nose model of the human from 2D images and pre-marked landmarks based on algorithmic methods.The study focuses on the reconstruction of a 3D nose model tailored for applications in healthcare and cosmetic surgery.The approach leverages advanced image processing techniques,3D Morphable Models(3DMM),and deformation techniques to overcome the limita-tions of deep learning models,particularly addressing the interpretability issues commonly encountered in medical applications.The proposed method estimates the 3D coordinates of landmark points using a 3D structure estimation algorithm.Sub-landmarks are extracted through image processing techniques and interpolation.The initial surface is generated using a 3DMM,though its accuracy remains limited.To enhance precision,deformation techniques are applied,utilizing the coordinates of 76 identified landmarks and sub-landmarks.The resulting 3D nose model is constructed based on algorithmic methods and pre-marked landmarks.Evaluation of the 3D model is conducted by comparing landmark distances and shape similarity with expert-determined ground truth on 30 Vietnamese volunteers aged 18 to 47,all of whom were either preparing for or required nasal surgery.Experimental results demonstrate a strong agreement between the reconstructed 3D model and the ground truth.The method achieved a mean landmark distance error of 0.631 mm and a shape error of 1.738 mm,demonstrating its potential for medical applications.展开更多
BACKGROUND Eyelid reconstruction is an intricate process,addressing both aesthetic and functional aspects post-trauma or oncological surgery.Aesthetic concerns and oncological radicality guide personalized approaches....BACKGROUND Eyelid reconstruction is an intricate process,addressing both aesthetic and functional aspects post-trauma or oncological surgery.Aesthetic concerns and oncological radicality guide personalized approaches.The complex anatomy,involving anterior and posterior lamellae,requires tailored reconstruction for optimal functionality.AIM To formulate an eyelid reconstruction algorithm through an extensive literature review and to validate it by juxtaposing surgical outcomes from Cattinara Hos-in dry eye and tears,which may lead to long-term consequences such as chronic conjunctivitis,discomfort,or photo-phobia.To prevent this issue,scars should be oriented vertically or perpendicularly to the free eyelid margin when the size of the tumor allows.In employing a malar flap to repair a lower eyelid defect,the malar incision must ascend diagonally;this facilitates enhanced flap advancement and mitigates ectropion by restricting vertical traction.Conse-quently,it is imperative to maintain that the generated tension remains consistently horizontal and never vertical[9].Lagophthalmos is a disorder characterized by the inability to completely close the eyelids,leading to corneal exposure and an increased risk of keratitis or ulceration;it may arise following upper eyelid surgery.To avert this issue,it is essential to preserve a minimum of 1 cm of skin between the superior edge of the excision and the inferior boundary of the eyebrow.Epiphora may occur in cancers involving the lacrimal puncta,requiring their removal.As previously stated,when employing a glabellar flap to rectify medial canthal abnormalities,it is essential to prevent a trapdoor effect or thickening of the flap relative to the eyelid skin to which it is affixed.Constraints about our proposed algorithm enco-mpass limited sample sizes and possible publication biases in existing studies.Subsequent investigations ought to examine long-term results to further refine the algorithm.Future research should evaluate the algorithm across varied populations and examine the impact of novel graft materials on enhancing reconstructive outcomes.CONCLUSION Eyelid reconstruction remains one of the most intriguing challenges for a plastic surgeon today.The most fascinating aspect of this discipline is the need to restore the functionality of such an essential structure while maintaining its aesthetics.In our opinion,creating decision-making algorithms can facilitate reaching this goal by allowing for the individualization of the reconstructive path while minimizing the incidence of complications.The fact that we have decreased the incidence of severe complications is a sign that the work is moving in the right direction.The fact that there has been no need for reintervention,neither for reconstructive issues nor for inadequate oncological radicality,overall signifies greater patient satisfaction as they do not have to undergo the stress of new surgeries.Even the minor complic-ations recorded are in line with those reported in the literature,and,even more importantly for patients,they are of limited duration.In our experience,after a year of application,we can say that the objective has been achieved,but much more can still be done.Behind every work,a scientific basis must be continually renewed and refreshed to maintain high-quality standards.Therefore,searching for possible alternative solutions to be included in one’s surgical armamentarium is fundamental to providing the patient with a fully personalized option.展开更多
Data reconstruction is a crucial step in seismic data preprocessing.To improve reconstruction speed and save memory,the commonly used three-dimensional(3D)seismic data reconstruction method divides the missing data in...Data reconstruction is a crucial step in seismic data preprocessing.To improve reconstruction speed and save memory,the commonly used three-dimensional(3D)seismic data reconstruction method divides the missing data into a series of time slices and independently reconstructs each time slice.However,when this strategy is employed,the potential correlations between two adjacent time slices are ignored,which degrades reconstruction performance.Therefore,this study proposes the use of a two-dimensional curvelet transform and the fast iterative shrinkage thresholding algorithm for data reconstruction.Based on the significant overlapping characteristics between the curvelet coefficient support sets of two adjacent time slices,a weighted operator is constructed in the curvelet domain using the prior support set provided by the previous reconstructed time slice to delineate the main energy distribution range,eff ectively providing prior information for reconstructing adjacent slices.Consequently,the resulting weighted fast iterative shrinkage thresholding algorithm can be used to reconstruct 3D seismic data.The processing of synthetic and field data shows that the proposed method has higher reconstruction accuracy and faster computational speed than the conventional fast iterative shrinkage thresholding algorithm for handling missing 3D seismic data.展开更多
In order to derive the linac photon spectrum accurately both the prior constrained model and the genetic algorithm GA are employed using the measured percentage depth dose PDD data and the Monte Carlo simulated monoen...In order to derive the linac photon spectrum accurately both the prior constrained model and the genetic algorithm GA are employed using the measured percentage depth dose PDD data and the Monte Carlo simulated monoenergetic PDDs where two steps are involved.First the spectrum is modeled as a prior analytical function with two parameters αand Ep optimized with the GA.Secondly the linac photon spectrum is modeled as a discretization constrained model optimized with the GA. The solved analytical function in the first step is used to generate initial solutions for the GA’s first run in this step.The method is applied to the Varian iX linear accelerator to derive the energy spectra of its 6 and 15 MV photon beams.The experimental results show that both the reconstructed spectrums and the derived PDDs with the proposed method are in good agreement with those calculated using the Monte Carlo simulation.展开更多
A new method to accelerate the convergent rate of the space-alternatinggeneralized expectation-maximization (SAGE) algorithm is proposed. The new rescaled block-iterativeSAGE (RBI-SAGE) algorithm combines the RBI algo...A new method to accelerate the convergent rate of the space-alternatinggeneralized expectation-maximization (SAGE) algorithm is proposed. The new rescaled block-iterativeSAGE (RBI-SAGE) algorithm combines the RBI algorithm with the SAGE algorithm for PET imagereconstruction. In the new approach, the projection data is partitioned into disjoint blocks; eachiteration step involves only one of these blocks. SAGE updates the parameters sequentially in eachblock. In experiments, the RBI-SAGE algorithm and classical SAGE algorithm are compared in theapplication on positron emission tomography (PET) image reconstruction. Simulation results show thatRBI-SAGE has better performance than SAGE in both convergence and image quality.展开更多
With the development of the compressive sensing theory, the image reconstruction from the projections viewed in limited angles is one of the hot problems in the research of computed tomography technology. This paper d...With the development of the compressive sensing theory, the image reconstruction from the projections viewed in limited angles is one of the hot problems in the research of computed tomography technology. This paper develops an iterative algorithm for image reconstruction, which can fit the most cases. This method gives an image reconstruction flow with the difference image vector, which is based on the concept that the difference image vector between the reconstructed and the reference image is sparse enough. Then the l1-norm minimization method is used to reconstruct the difference vector to recover the image for flat subjects in limited angles. The algorithm has been tested with a thin planar phantom and a real object in limited-view projection data. Moreover, all the studies showed the satisfactory results in accuracy at a rather high reconstruction speed.展开更多
Underwater imaging is widely used in ocean,river and lake exploration,but it is affected by properties of water and the optics.In order to solve the lower-resolution underwater image formed by the influence of water a...Underwater imaging is widely used in ocean,river and lake exploration,but it is affected by properties of water and the optics.In order to solve the lower-resolution underwater image formed by the influence of water and light,the image super-resolution reconstruction technique is applied to the underwater image processing.This paper addresses the problem of generating super-resolution underwater images by convolutional neural network framework technology.We research the degradation model of underwater images,and analyze the lower-resolution factors of underwater images in different situations,and compare different traditional super-resolution image reconstruction algorithms.We further show that the algorithm of super-resolution using deep convolution networks(SRCNN)which applied to super-resolution underwater images achieves good results.展开更多
In conventional computed tomography （CT） reconstruction based on fixed voltage, the projective data often ap- pear overexposed or underexposed, as a result, the reconstructive results are poor. To solve this problem...In conventional computed tomography （CT） reconstruction based on fixed voltage, the projective data often ap- pear overexposed or underexposed, as a result, the reconstructive results are poor. To solve this problem, variable voltage CT reconstruction has been proposed. The effective projective sequences of a structural component are obtained through the variable voltage. The total variation is adjusted and minimized to optimize the reconstructive results on the basis of iterative image using algebraic reconstruction technique （ART）. In the process of reconstruction, the reconstructive image of low voltage is used as an initial value of the effective proiective reconstruction of the adjacent high voltage, and so on until to the highest voltage according to the gray weighted algorithm. Thereby the complete structural information is reconstructed. Simulation results show that the proposed algorithm can completely reflect the information of a complicated structural com- ponent, and the pixel values are more stable than those of the conventional.展开更多
In this paper, an approximate analytical algorithm in the form of direct Fourier reconstruction is obtained for the recon- struction of data functions arisen from ^-scheme short-scan sin- gle-photon emission computed ...In this paper, an approximate analytical algorithm in the form of direct Fourier reconstruction is obtained for the recon- struction of data functions arisen from ^-scheme short-scan sin- gle-photon emission computed tomography（SPECT） with uniform attenuation, and the modified central slice theorem is developed. Numerical simulations are conducted to demonstrate the effec- tiveness of the developed method.展开更多
An intuitive 2D model of circular electrical impedance tomography （EIT） sensor with small size electrodes is established based on the theory of analytic functions. The validation of the model is proved using the res...An intuitive 2D model of circular electrical impedance tomography （EIT） sensor with small size electrodes is established based on the theory of analytic functions. The validation of the model is proved using the result from the solution of Laplace equation. Suggestions on to electrode optimization and explanation to the ill-condition property of the sensitivity matrix are provided based on the model, which takes electrode distance into account and can be generalized to the sensor with any simple connected region through a conformal transformation. Image reconstruction algorithms based on the model are implemented to show feasibility of the model using experimental data collected from the EIT system developed in Tianjin University. In the simulation with a human chestlike configuration, electrical conductivity distributions are reconstructed using equi-potential backprojection （EBP） and Tikhonov regularization （TR） based on a conformal transformation of the model. The algorithms based on the model are suitable for online image reconstruction and the reconstructed results are aood both in size and position.展开更多
The signal processing problem has become increasingly complex and demand high acquisition system,this paper proposes a new method to reconstruct the structure phased array structural health monitoring signal.The metho...The signal processing problem has become increasingly complex and demand high acquisition system,this paper proposes a new method to reconstruct the structure phased array structural health monitoring signal.The method is derived from the compressive sensing theory and the signal is reconstructed by using the basis pursuit algorithm to process the ultrasonic phased array signals.According to the principles of the compressive sensing and signal processing method,non-sparse ultrasonic signals are converted to sparse signals by using sparse transform.The sparse coefficients are obtained by sparse decomposition of the original signal,and then the observation matrix is constructed according to the corresponding sparse coefficients.Finally,the original signal is reconstructed by using basis pursuit algorithm,and error analysis is carried on.Experimental research analysis shows that the signal reconstruction method can reduce the signal complexity and required the space efficiently.展开更多
In the post-genomic biology era,the reconstruction of gene regulatory networks from microarray gene expression data is very important to understand the underlying biological system,and it has been a challenging task i...In the post-genomic biology era,the reconstruction of gene regulatory networks from microarray gene expression data is very important to understand the underlying biological system,and it has been a challenging task in bioinformatics.The Bayesian network model has been used in reconstructing the gene regulatory network for its advantages,but how to determine the network structure and parameters is still important to be explored.This paper proposes a two-stage structure learning algorithm which integrates immune evolution algorithm to build a Bayesian network.The new algorithm is evaluated with the use of both simulated and yeast cell cycle data.The experimental results indicate that the proposed algorithm can find many of the known real regulatory relationships from literature and predict the others unknown with high validity and accuracy.展开更多
Lots of noises and heterogeneous objects with various sizes coexist in a complex image,such as an ore image;the classical image thresholding method cannot effectively distinguish between ores.To segment ore objects wi...Lots of noises and heterogeneous objects with various sizes coexist in a complex image,such as an ore image;the classical image thresholding method cannot effectively distinguish between ores.To segment ore objects with various sizes simultaneously,two adaptive windows in the image were chosen for each pixel;the gray value of windows was calculated by Otsu＇s threshold method.To extract the object skeleton,the definition principle of distance transformation templates was proposed.The ores linked together in a binary image were separated by distance transformation and gray reconstruction.The seed region of each object was picked up from the local maximum gray region of the reconstruction image.Starting from these seed regions,the watershed method was used to segment ore object effectively.The proposed algorithm marks and segments most objects from complex images precisely.展开更多
3D image reconstruction for weather radar data can not only help the weatherman to improve the forecast efficiency and accuracy, but also help people to understand the weather conditions easily and quickly. Marching C...3D image reconstruction for weather radar data can not only help the weatherman to improve the forecast efficiency and accuracy, but also help people to understand the weather conditions easily and quickly. Marching Cubes (MC) algorithm in the surface rendering has more excellent applicability in 3D reconstruction for the slice images;it may shorten the time to find and calculate the isosurface from raw volume data, reflect the shape structure more accurately. In this paper, we discuss a method to reconstruct the 3D weather cloud image by using the proposed Cube Weighting Interpolation (CWI) and MC algorithm. Firstly, we detail the steps of CWI, apply it to project the raw radar data into the cubes and obtain the equally spaced cloud slice images, then employ MC algorithm to draw the isosurface. Some experiments show that our method has a good effect and simple operation, which may provide an intuitive and effective reference for realizing the 3D surface reconstruction and meteorological image stereo visualization.展开更多
Objective To investigate the image quality, radiation dose and diagnostic value of the low-tube-voltage high-pitch dual-source computed tomography(DSCT) with sinogram affirmed iterative reconstruction(SAFIRE) for non-...Objective To investigate the image quality, radiation dose and diagnostic value of the low-tube-voltage high-pitch dual-source computed tomography(DSCT) with sinogram affirmed iterative reconstruction(SAFIRE) for non-enhanced abdominal and pelvic scans. Methods This institutional review board-approved prospective study included 64 patients who gave written informed consent for additional abdominal and pelvic scan with DSCT in the period from November to December 2012. The patients underwent standard non-enhanced CT scans(protocol 1) [tube voltage of 120 k Vp/pitch of 0.9/filtered back-projection(FBP) reconstruction] followed by high-pitch non-enhanced CT scans(protocol 2)(100 k Vp/3.0/SAFIRE). The total scan time, mean CT number, signal-to-noise ratio(SNR), image quality, lesion detectability and radiation dose were compared between the two protocols. Results The total scan time of protocol 2 was significantly shorter than that of protocol 1(1.4±0.1 seconds vs. 7.6±0.6 seconds, P<0.001). There was no significant difference between protocol 1 and protocol 2 in mean CT number of all organs(liver, 55.4±6.3 HU vs. 56.1±6.8 HU, P=0.214; pancreas, 43.6±5.9 HU vs. 43.7±5.8 HU, P=0.785; spleen, 47.9±3.9 HU vs. 49.4±4.3 HU, P=0.128; kidney, 32.2±2.3 HU vs. 33.1±2.3 HU, P=0.367; abdominal aorta, 44.8±5.6 HU vs. 45.0±5.5 HU, P=0.499; psoas muscle, 50.7±4.1 HU vs. 50.3±4.5 HU, P=0.279). SNR on images of protocol 2 was higher than that of protocol 1(liver, 5.0±1.2 vs. 4.5±1.1, P<0.001; pancreas, 4.0±1.0 vs. 3.6±0.8, P<0.001; spleen, 4.7±1.0 vs. 4.1±0.9, P<0.001; kidney, 3.1±0.6 vs. 2.8±0.6, P<0.001; abdominal aorta, 4.1±1.0 vs. 3.8±1.0, P<0.001; psoas muscle, 4.5±1.1 vs. 4.3±1.2, P=0.012). The overall image noise of protocol 2 was lower than that of protocol1(9.8±3.1 HU vs. 11.1±3.0 HU, P<0.001). Image quality of protocol 2 was good but lower than that of protocol 1(4.1±0.7 vs. 4.6±0.5, P<0.001). Protocol 2 perceived 229 of 234 lesions(97.9%) that were detected in protocol 1 in the abdomen and pelvis. Radiation dose of protocol 2 was lower than that of protocol 1(4.4±0.4 m Sv vs. 7.3±2.4 m Sv, P<0.001) and the mean dose reduction was 41.4%. Conclusion The high-pitch DSCT with SAFIRE can shorten scan time and reduce radiation dose while preserving image quality in non-enhanced abdominal and pelvic scans.展开更多
Fluorescence molecular tomography(FMT)is a fast-developing optical imaging modalitythat has great potential in early diagnosis of disease and drugs development.However,recon-struction algorithms have to address a high...Fluorescence molecular tomography(FMT)is a fast-developing optical imaging modalitythat has great potential in early diagnosis of disease and drugs development.However,recon-struction algorithms have to address a highly ill-posed problem to fulfll 3D reconstruction inFMT.In this contribution,we propose an efficient iterative algorithm to solve the large-scalereconstruction problem,in which the sparsity of fluorescent targets is taken as useful a prioriinformation in designing the reconstruction algorithm.In the implementation,a fast sparseapproximation scheme combined with a stage-wise learning strategy enable the algorithm to dealwith the ill-posed inverse problem at reduced computational costs.We validate the proposed fastiterative method with numerical simulation on a digital mouse model.Experimental results demonstrate that our method is robust for different finite element meshes and different Poissonnoise levels.展开更多
Compton camera-based prompt gamma(PG) imaging has been proposed for range verification during proton therapy. However, a deviation between the PG and dose distributions, as well as the difference between the reconstru...Compton camera-based prompt gamma(PG) imaging has been proposed for range verification during proton therapy. However, a deviation between the PG and dose distributions, as well as the difference between the reconstructed PG and exact values, limit the effectiveness of the approach in accurate range monitoring during clinical applications. The aim of the study was to realize a PG-based dose reconstruction with a Compton camera, thereby further improving the prediction accuracy of in vivo range verification and providing a novel method for beam monitoring during proton therapy. In this paper, we present an approach based on a subset-driven origin ensemble with resolution recovery and a double evolutionary algorithm to reconstruct the dose depth profile(DDP) from the gamma events obtained by a cadmium-zinc-telluride Compton camera with limited position and energy resolution. Simulations of proton pencil beams with clinical particle rate irradiating phantoms made of different materials and the CT-based thoracic phantom were used to evaluate the feasibility of the proposed method. The results show that for the monoenergetic proton pencil beam irradiating homogeneous-material box phantom,the accuracy of the reconstructed DDP was within 0.3 mm for range prediction and within 5.2% for dose prediction. In particular, for 1.6-Gy irradiation in the therapy simulation of thoracic tumors, the range deviation of the reconstructed spreadout Bragg peak was within 0.8 mm, and the relative dose deviation in the peak area was less than 7% compared to the exact values. The results demonstrate the potential and feasibility of the proposed method in future Compton-based accurate dose reconstruction and range verification during proton therapy.展开更多
In application of tomography imaging, limited-angle problem is a quite practical and important issue.In this paper, an iterative reprojection-reconstruction(IRR) algorithm using a modified Papoulis-Gerchberg(PG)iterat...In application of tomography imaging, limited-angle problem is a quite practical and important issue.In this paper, an iterative reprojection-reconstruction(IRR) algorithm using a modified Papoulis-Gerchberg(PG)iterative scheme is developed for reconstruction from limited-angle projections which contain noise. The proposed algorithm has two iterative update processes, one is the extrapolation of unknown data, and the other is the modification of the known noisy observation data. And the algorithm introduces scaling factors to control the two processes, respectively. The convergence of the algorithm is guaranteed, and the method of choosing the scaling factors is given with energy constraints. The simulation result demonstrates our conclusions and indicates that the algorithm proposed in this paper can obviously improve the reconstruction quality.展开更多
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
文摘After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
基金Supported by grants from the National Natural Science Foundation of China(No.82171018,No.82371022)Beijing Hospitals Authority’s Ascent Plan(No.DFL20240202)+2 种基金The Youth Beijing Scholars Program(No.022)High Level Public Health Technical Talents Construction Project from Beijing(Jie Y)Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(No.2023YFC2410401).
文摘AIM:To evaluate the efficacy and safety of decellularized conjunctival stroma(DCS)as a novel biomaterial by comparing its grafting outcomes with amniotic membrane(AM)when used for conjunctival reconstruction after primary pterygium excision.METHODS:This randomized,parallel-controlled study with allocation concealment enrolled 40 patients with primary pterygium.Participants were randomly assigned to two groups using the sealed envelope method:the DCS group(n=20)and the AM group(n=18),receiving DCS and AM grafts respectively.Slit-lamp photography of the operative eyes was performed preoperatively and at 1,3,5,7,10,30,90,and 180d postoperatively.Best-corrected visual acuity(BCVA)and symptom scores were recorded simultaneously.In vivo confocal microscopy was conducted at 3 and 6mo postoperatively.RESULTS:All participants exhibited improved postoperative symptoms.The mean age was 60±9y(male/female ratio:6/14)in the DCS group and 56±12y(male/female ratio:7/11)in the AM group.The average epithelial healing time was 9.89±3.54d in the DCS group and 8.17±1.34d in the AM group(P=0.084).One recurrence case was observed in each group.Postoperative graft hemorrhage was significantly more severe in the DCS group than in the AM group only at 30d postoperatively(P=0.011).In vivo confocal microscopy revealed conjunctival epithelial cell growth in both groups at 90d postoperatively,while clear corneo-conjunctival cell boundaries were observed until 180d postoperatively.CONCLUSION:DCS used in primary pterygium surgery has a safety profile comparable to AM.It promotes rapid postoperative conjunctival healing,achieves a relatively low pterygium recurrence rate,and yields outcomes similar to AM.DCS provides a novel biomaterial option for conjunctival reconstruction after pterygium excision and the treatment of other conjunctival injuries.
文摘This paper presents a novel method for reconstructing a highly accurate 3D nose model of the human from 2D images and pre-marked landmarks based on algorithmic methods.The study focuses on the reconstruction of a 3D nose model tailored for applications in healthcare and cosmetic surgery.The approach leverages advanced image processing techniques,3D Morphable Models(3DMM),and deformation techniques to overcome the limita-tions of deep learning models,particularly addressing the interpretability issues commonly encountered in medical applications.The proposed method estimates the 3D coordinates of landmark points using a 3D structure estimation algorithm.Sub-landmarks are extracted through image processing techniques and interpolation.The initial surface is generated using a 3DMM,though its accuracy remains limited.To enhance precision,deformation techniques are applied,utilizing the coordinates of 76 identified landmarks and sub-landmarks.The resulting 3D nose model is constructed based on algorithmic methods and pre-marked landmarks.Evaluation of the 3D model is conducted by comparing landmark distances and shape similarity with expert-determined ground truth on 30 Vietnamese volunteers aged 18 to 47,all of whom were either preparing for or required nasal surgery.Experimental results demonstrate a strong agreement between the reconstructed 3D model and the ground truth.The method achieved a mean landmark distance error of 0.631 mm and a shape error of 1.738 mm,demonstrating its potential for medical applications.
文摘BACKGROUND Eyelid reconstruction is an intricate process,addressing both aesthetic and functional aspects post-trauma or oncological surgery.Aesthetic concerns and oncological radicality guide personalized approaches.The complex anatomy,involving anterior and posterior lamellae,requires tailored reconstruction for optimal functionality.AIM To formulate an eyelid reconstruction algorithm through an extensive literature review and to validate it by juxtaposing surgical outcomes from Cattinara Hos-in dry eye and tears,which may lead to long-term consequences such as chronic conjunctivitis,discomfort,or photo-phobia.To prevent this issue,scars should be oriented vertically or perpendicularly to the free eyelid margin when the size of the tumor allows.In employing a malar flap to repair a lower eyelid defect,the malar incision must ascend diagonally;this facilitates enhanced flap advancement and mitigates ectropion by restricting vertical traction.Conse-quently,it is imperative to maintain that the generated tension remains consistently horizontal and never vertical[9].Lagophthalmos is a disorder characterized by the inability to completely close the eyelids,leading to corneal exposure and an increased risk of keratitis or ulceration;it may arise following upper eyelid surgery.To avert this issue,it is essential to preserve a minimum of 1 cm of skin between the superior edge of the excision and the inferior boundary of the eyebrow.Epiphora may occur in cancers involving the lacrimal puncta,requiring their removal.As previously stated,when employing a glabellar flap to rectify medial canthal abnormalities,it is essential to prevent a trapdoor effect or thickening of the flap relative to the eyelid skin to which it is affixed.Constraints about our proposed algorithm enco-mpass limited sample sizes and possible publication biases in existing studies.Subsequent investigations ought to examine long-term results to further refine the algorithm.Future research should evaluate the algorithm across varied populations and examine the impact of novel graft materials on enhancing reconstructive outcomes.CONCLUSION Eyelid reconstruction remains one of the most intriguing challenges for a plastic surgeon today.The most fascinating aspect of this discipline is the need to restore the functionality of such an essential structure while maintaining its aesthetics.In our opinion,creating decision-making algorithms can facilitate reaching this goal by allowing for the individualization of the reconstructive path while minimizing the incidence of complications.The fact that we have decreased the incidence of severe complications is a sign that the work is moving in the right direction.The fact that there has been no need for reintervention,neither for reconstructive issues nor for inadequate oncological radicality,overall signifies greater patient satisfaction as they do not have to undergo the stress of new surgeries.Even the minor complic-ations recorded are in line with those reported in the literature,and,even more importantly for patients,they are of limited duration.In our experience,after a year of application,we can say that the objective has been achieved,but much more can still be done.Behind every work,a scientific basis must be continually renewed and refreshed to maintain high-quality standards.Therefore,searching for possible alternative solutions to be included in one’s surgical armamentarium is fundamental to providing the patient with a fully personalized option.
基金National Natural Science Foundation of China under Grant 42304145Jiangxi Provincial Natural Science Foundation under Grant 20242BAB26051,20242BAB25191 and 20232BAB213077+1 种基金Foundation of National Key Laboratory of Uranium Resources Exploration-Mining and Nuclear Remote Sensing under Grant 2024QZ-TD-13Open Fund(FW0399-0002)of SINOPEC Key Laboratory of Geophysics。
文摘Data reconstruction is a crucial step in seismic data preprocessing.To improve reconstruction speed and save memory,the commonly used three-dimensional(3D)seismic data reconstruction method divides the missing data into a series of time slices and independently reconstructs each time slice.However,when this strategy is employed,the potential correlations between two adjacent time slices are ignored,which degrades reconstruction performance.Therefore,this study proposes the use of a two-dimensional curvelet transform and the fast iterative shrinkage thresholding algorithm for data reconstruction.Based on the significant overlapping characteristics between the curvelet coefficient support sets of two adjacent time slices,a weighted operator is constructed in the curvelet domain using the prior support set provided by the previous reconstructed time slice to delineate the main energy distribution range,eff ectively providing prior information for reconstructing adjacent slices.Consequently,the resulting weighted fast iterative shrinkage thresholding algorithm can be used to reconstruct 3D seismic data.The processing of synthetic and field data shows that the proposed method has higher reconstruction accuracy and faster computational speed than the conventional fast iterative shrinkage thresholding algorithm for handling missing 3D seismic data.
文摘In order to derive the linac photon spectrum accurately both the prior constrained model and the genetic algorithm GA are employed using the measured percentage depth dose PDD data and the Monte Carlo simulated monoenergetic PDDs where two steps are involved.First the spectrum is modeled as a prior analytical function with two parameters αand Ep optimized with the GA.Secondly the linac photon spectrum is modeled as a discretization constrained model optimized with the GA. The solved analytical function in the first step is used to generate initial solutions for the GA’s first run in this step.The method is applied to the Varian iX linear accelerator to derive the energy spectra of its 6 and 15 MV photon beams.The experimental results show that both the reconstructed spectrums and the derived PDDs with the proposed method are in good agreement with those calculated using the Monte Carlo simulation.
文摘A new method to accelerate the convergent rate of the space-alternatinggeneralized expectation-maximization (SAGE) algorithm is proposed. The new rescaled block-iterativeSAGE (RBI-SAGE) algorithm combines the RBI algorithm with the SAGE algorithm for PET imagereconstruction. In the new approach, the projection data is partitioned into disjoint blocks; eachiteration step involves only one of these blocks. SAGE updates the parameters sequentially in eachblock. In experiments, the RBI-SAGE algorithm and classical SAGE algorithm are compared in theapplication on positron emission tomography (PET) image reconstruction. Simulation results show thatRBI-SAGE has better performance than SAGE in both convergence and image quality.
基金Project supported by the National Basic Research Program of China(Grant No.2006CB7057005)the National High Technology Research and Development Program of China(Grant No.2009AA012200)the National Natural Science Foundation of China (Grant No.60672104)
文摘With the development of the compressive sensing theory, the image reconstruction from the projections viewed in limited angles is one of the hot problems in the research of computed tomography technology. This paper develops an iterative algorithm for image reconstruction, which can fit the most cases. This method gives an image reconstruction flow with the difference image vector, which is based on the concept that the difference image vector between the reconstructed and the reference image is sparse enough. Then the l1-norm minimization method is used to reconstruct the difference vector to recover the image for flat subjects in limited angles. The algorithm has been tested with a thin planar phantom and a real object in limited-view projection data. Moreover, all the studies showed the satisfactory results in accuracy at a rather high reconstruction speed.
基金This work is supported by Hainan Provincial Natural Science Foundation of China(project number:20166235)project supported by the Education Department of Hainan Province(project number:Hnky2017-57).
文摘Underwater imaging is widely used in ocean,river and lake exploration,but it is affected by properties of water and the optics.In order to solve the lower-resolution underwater image formed by the influence of water and light,the image super-resolution reconstruction technique is applied to the underwater image processing.This paper addresses the problem of generating super-resolution underwater images by convolutional neural network framework technology.We research the degradation model of underwater images,and analyze the lower-resolution factors of underwater images in different situations,and compare different traditional super-resolution image reconstruction algorithms.We further show that the algorithm of super-resolution using deep convolution networks(SRCNN)which applied to super-resolution underwater images achieves good results.
文摘In conventional computed tomography （CT） reconstruction based on fixed voltage, the projective data often ap- pear overexposed or underexposed, as a result, the reconstructive results are poor. To solve this problem, variable voltage CT reconstruction has been proposed. The effective projective sequences of a structural component are obtained through the variable voltage. The total variation is adjusted and minimized to optimize the reconstructive results on the basis of iterative image using algebraic reconstruction technique （ART）. In the process of reconstruction, the reconstructive image of low voltage is used as an initial value of the effective proiective reconstruction of the adjacent high voltage, and so on until to the highest voltage according to the gray weighted algorithm. Thereby the complete structural information is reconstructed. Simulation results show that the proposed algorithm can completely reflect the information of a complicated structural com- ponent, and the pixel values are more stable than those of the conventional.
基金Supported by the National Natural Science Foundation of China(61271398)the Natural Science Foundation of Ningbo(2012A610031)
文摘In this paper, an approximate analytical algorithm in the form of direct Fourier reconstruction is obtained for the recon- struction of data functions arisen from ^-scheme short-scan sin- gle-photon emission computed tomography（SPECT） with uniform attenuation, and the modified central slice theorem is developed. Numerical simulations are conducted to demonstrate the effec- tiveness of the developed method.
基金Supported by National Natural Science Foundation of China (No.60532020,60301008,60472077,50337020), the High Tech-nique Research and Development Program of China (No.2001AA413210).
文摘An intuitive 2D model of circular electrical impedance tomography （EIT） sensor with small size electrodes is established based on the theory of analytic functions. The validation of the model is proved using the result from the solution of Laplace equation. Suggestions on to electrode optimization and explanation to the ill-condition property of the sensitivity matrix are provided based on the model, which takes electrode distance into account and can be generalized to the sensor with any simple connected region through a conformal transformation. Image reconstruction algorithms based on the model are implemented to show feasibility of the model using experimental data collected from the EIT system developed in Tianjin University. In the simulation with a human chestlike configuration, electrical conductivity distributions are reconstructed using equi-potential backprojection （EBP） and Tikhonov regularization （TR） based on a conformal transformation of the model. The algorithms based on the model are suitable for online image reconstruction and the reconstructed results are aood both in size and position.
基金This project is supported by the National Natural Science Foundation of China(Grant No.51305211)Natural Science Foundation of Jiangsu(Grant No.BK20160955)Jiangsu Government Scholarship for Overseas Studies,College students practice and innovation training project of Jiangsu province(Grant No.201710300218),and the PAPD。
文摘The signal processing problem has become increasingly complex and demand high acquisition system,this paper proposes a new method to reconstruct the structure phased array structural health monitoring signal.The method is derived from the compressive sensing theory and the signal is reconstructed by using the basis pursuit algorithm to process the ultrasonic phased array signals.According to the principles of the compressive sensing and signal processing method,non-sparse ultrasonic signals are converted to sparse signals by using sparse transform.The sparse coefficients are obtained by sparse decomposition of the original signal,and then the observation matrix is constructed according to the corresponding sparse coefficients.Finally,the original signal is reconstructed by using basis pursuit algorithm,and error analysis is carried on.Experimental research analysis shows that the signal reconstruction method can reduce the signal complexity and required the space efficiently.
基金supported by National Natural Science Foundation of China (Grant Nos. 60433020, 60175024 and 60773095)European Commission under grant No. TH/Asia Link/010 (111084)the Key Science-Technology Project of the National Education Ministry of China (Grant No. 02090),and the Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, P. R. China
文摘In the post-genomic biology era,the reconstruction of gene regulatory networks from microarray gene expression data is very important to understand the underlying biological system,and it has been a challenging task in bioinformatics.The Bayesian network model has been used in reconstructing the gene regulatory network for its advantages,but how to determine the network structure and parameters is still important to be explored.This paper proposes a two-stage structure learning algorithm which integrates immune evolution algorithm to build a Bayesian network.The new algorithm is evaluated with the use of both simulated and yeast cell cycle data.The experimental results indicate that the proposed algorithm can find many of the known real regulatory relationships from literature and predict the others unknown with high validity and accuracy.
基金supported by the National Key Technologies R & D Program of China (No.2009BAB48B02)the National High-Tech Research and Development Program of China (Nos.2010AA060278600 and 2008AA062101)
文摘Lots of noises and heterogeneous objects with various sizes coexist in a complex image,such as an ore image;the classical image thresholding method cannot effectively distinguish between ores.To segment ore objects with various sizes simultaneously,two adaptive windows in the image were chosen for each pixel;the gray value of windows was calculated by Otsu＇s threshold method.To extract the object skeleton,the definition principle of distance transformation templates was proposed.The ores linked together in a binary image were separated by distance transformation and gray reconstruction.The seed region of each object was picked up from the local maximum gray region of the reconstruction image.Starting from these seed regions,the watershed method was used to segment ore object effectively.The proposed algorithm marks and segments most objects from complex images precisely.
文摘3D image reconstruction for weather radar data can not only help the weatherman to improve the forecast efficiency and accuracy, but also help people to understand the weather conditions easily and quickly. Marching Cubes (MC) algorithm in the surface rendering has more excellent applicability in 3D reconstruction for the slice images;it may shorten the time to find and calculate the isosurface from raw volume data, reflect the shape structure more accurately. In this paper, we discuss a method to reconstruct the 3D weather cloud image by using the proposed Cube Weighting Interpolation (CWI) and MC algorithm. Firstly, we detail the steps of CWI, apply it to project the raw radar data into the cubes and obtain the equally spaced cloud slice images, then employ MC algorithm to draw the isosurface. Some experiments show that our method has a good effect and simple operation, which may provide an intuitive and effective reference for realizing the 3D surface reconstruction and meteorological image stereo visualization.
文摘Objective To investigate the image quality, radiation dose and diagnostic value of the low-tube-voltage high-pitch dual-source computed tomography(DSCT) with sinogram affirmed iterative reconstruction(SAFIRE) for non-enhanced abdominal and pelvic scans. Methods This institutional review board-approved prospective study included 64 patients who gave written informed consent for additional abdominal and pelvic scan with DSCT in the period from November to December 2012. The patients underwent standard non-enhanced CT scans(protocol 1) [tube voltage of 120 k Vp/pitch of 0.9/filtered back-projection(FBP) reconstruction] followed by high-pitch non-enhanced CT scans(protocol 2)(100 k Vp/3.0/SAFIRE). The total scan time, mean CT number, signal-to-noise ratio(SNR), image quality, lesion detectability and radiation dose were compared between the two protocols. Results The total scan time of protocol 2 was significantly shorter than that of protocol 1(1.4±0.1 seconds vs. 7.6±0.6 seconds, P<0.001). There was no significant difference between protocol 1 and protocol 2 in mean CT number of all organs(liver, 55.4±6.3 HU vs. 56.1±6.8 HU, P=0.214; pancreas, 43.6±5.9 HU vs. 43.7±5.8 HU, P=0.785; spleen, 47.9±3.9 HU vs. 49.4±4.3 HU, P=0.128; kidney, 32.2±2.3 HU vs. 33.1±2.3 HU, P=0.367; abdominal aorta, 44.8±5.6 HU vs. 45.0±5.5 HU, P=0.499; psoas muscle, 50.7±4.1 HU vs. 50.3±4.5 HU, P=0.279). SNR on images of protocol 2 was higher than that of protocol 1(liver, 5.0±1.2 vs. 4.5±1.1, P<0.001; pancreas, 4.0±1.0 vs. 3.6±0.8, P<0.001; spleen, 4.7±1.0 vs. 4.1±0.9, P<0.001; kidney, 3.1±0.6 vs. 2.8±0.6, P<0.001; abdominal aorta, 4.1±1.0 vs. 3.8±1.0, P<0.001; psoas muscle, 4.5±1.1 vs. 4.3±1.2, P=0.012). The overall image noise of protocol 2 was lower than that of protocol1(9.8±3.1 HU vs. 11.1±3.0 HU, P<0.001). Image quality of protocol 2 was good but lower than that of protocol 1(4.1±0.7 vs. 4.6±0.5, P<0.001). Protocol 2 perceived 229 of 234 lesions(97.9%) that were detected in protocol 1 in the abdomen and pelvis. Radiation dose of protocol 2 was lower than that of protocol 1(4.4±0.4 m Sv vs. 7.3±2.4 m Sv, P<0.001) and the mean dose reduction was 41.4%. Conclusion The high-pitch DSCT with SAFIRE can shorten scan time and reduce radiation dose while preserving image quality in non-enhanced abdominal and pelvic scans.
基金supported by the National Natural Science Foundation of China(Grant No.61372046)the Research Fund for the Doctoral Program ofHigher Education of China(New Teachers)(Grant No.20116101120018)+4 种基金the China Postdoctoral Sci-ence_Foundation_Funded Project(Grant_Nos.2011M501467 and 2012T50814)the Natural Sci-ence Basic Research Plan in Shaanxi Province of China(Grant No.2011JQ1006)the Fund amental Research Funds for the Central Universities(Grant No.GK201302007)Science and Technology Plan Program in Shaanxi Province of China(Grant Nos.2012 KJXX-29 and 2013K12-20-12)the Scienceand Technology Plan Program in Xi'an of China(Grant No.CXY 1348(2)).
文摘Fluorescence molecular tomography(FMT)is a fast-developing optical imaging modalitythat has great potential in early diagnosis of disease and drugs development.However,recon-struction algorithms have to address a highly ill-posed problem to fulfll 3D reconstruction inFMT.In this contribution,we propose an efficient iterative algorithm to solve the large-scalereconstruction problem,in which the sparsity of fluorescent targets is taken as useful a prioriinformation in designing the reconstruction algorithm.In the implementation,a fast sparseapproximation scheme combined with a stage-wise learning strategy enable the algorithm to dealwith the ill-posed inverse problem at reduced computational costs.We validate the proposed fastiterative method with numerical simulation on a digital mouse model.Experimental results demonstrate that our method is robust for different finite element meshes and different Poissonnoise levels.
基金supported by Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation)(No.7191005)。
文摘Compton camera-based prompt gamma(PG) imaging has been proposed for range verification during proton therapy. However, a deviation between the PG and dose distributions, as well as the difference between the reconstructed PG and exact values, limit the effectiveness of the approach in accurate range monitoring during clinical applications. The aim of the study was to realize a PG-based dose reconstruction with a Compton camera, thereby further improving the prediction accuracy of in vivo range verification and providing a novel method for beam monitoring during proton therapy. In this paper, we present an approach based on a subset-driven origin ensemble with resolution recovery and a double evolutionary algorithm to reconstruct the dose depth profile(DDP) from the gamma events obtained by a cadmium-zinc-telluride Compton camera with limited position and energy resolution. Simulations of proton pencil beams with clinical particle rate irradiating phantoms made of different materials and the CT-based thoracic phantom were used to evaluate the feasibility of the proposed method. The results show that for the monoenergetic proton pencil beam irradiating homogeneous-material box phantom,the accuracy of the reconstructed DDP was within 0.3 mm for range prediction and within 5.2% for dose prediction. In particular, for 1.6-Gy irradiation in the therapy simulation of thoracic tumors, the range deviation of the reconstructed spreadout Bragg peak was within 0.8 mm, and the relative dose deviation in the peak area was less than 7% compared to the exact values. The results demonstrate the potential and feasibility of the proposed method in future Compton-based accurate dose reconstruction and range verification during proton therapy.
文摘In application of tomography imaging, limited-angle problem is a quite practical and important issue.In this paper, an iterative reprojection-reconstruction(IRR) algorithm using a modified Papoulis-Gerchberg(PG)iterative scheme is developed for reconstruction from limited-angle projections which contain noise. The proposed algorithm has two iterative update processes, one is the extrapolation of unknown data, and the other is the modification of the known noisy observation data. And the algorithm introduces scaling factors to control the two processes, respectively. The convergence of the algorithm is guaranteed, and the method of choosing the scaling factors is given with energy constraints. The simulation result demonstrates our conclusions and indicates that the algorithm proposed in this paper can obviously improve the reconstruction quality.
