Objectives:The increasing number of elderly patients with severe aortic valve stenosis undergoing transcatheter aortic valve replacement(TAVR)has prompted concerns regarding their clinical outcomes compared with the y...Objectives:The increasing number of elderly patients with severe aortic valve stenosis undergoing transcatheter aortic valve replacement(TAVR)has prompted concerns regarding their clinical outcomes compared with the younger population.This study evaluated the outcomes of TAVR on the basis of age group(<80 or≥80 years)amongVietnamese patients with severe aortic valve stenosis at intermediate surgical risk.Methods:From March 2017 to December 2022,21 patients≥80 years of age and 69 patients<80 years of age under-went TAVI at a single center.Clinical characteristics,procedures,and outcomes at 30 days and 1 year were compared with the Valve Academic Research Consortium(VARC-2)criteria.Results:Patients≥80 years of age had a higher prevalence of comorbidities but no significant differences in other clinical characteristics and procedures.No statistically significant differences were observed in procedural mortality(4.8%vs.0.0%,P=0.233),30-day mortality(5.0%vs.1.5%,P=0.405),and 1-year mortality(11.8%vs.3.7%,P=0.241)between age groups.Major endpoints at specified time points also showed no significant differences.Conclusions:TAVR in patients with aortic stenosis at intermediate surgical risk has similar clinical outcomes at 30 days and 1 year,according to VARC-2 criteria,with no statistically significant age-associated differences(≥80 vs.<80 years).However,further studies with larger patient populations are needed to better understand the effects of age on TAVI outcomes in patients with similar characteristics.展开更多
Local arrangement of atoms in supercooled liquid Ni_(80)P_(20) alloy has been investigated by using NPT-MD simulation techniques based on the effective pair Potentials derived for Ni-P system. Bond-orientational order...Local arrangement of atoms in supercooled liquid Ni_(80)P_(20) alloy has been investigated by using NPT-MD simulation techniques based on the effective pair Potentials derived for Ni-P system. Bond-orientational order, the long-range correlation function and symmetrical parameters by pair-analysis approach have been calculated for supercooled liquid Ni_(80)P_(20) alloy. Results show. that in case of Ni_(80) .P_(20) alloy, the local structure is all random-like whether the centre of cluster is located at atoms Ni or P. It indicates that the icosahedral symmetry is not the unique model to describe the microstructure in supercooled liquid metals.展开更多
文摘Objectives:The increasing number of elderly patients with severe aortic valve stenosis undergoing transcatheter aortic valve replacement(TAVR)has prompted concerns regarding their clinical outcomes compared with the younger population.This study evaluated the outcomes of TAVR on the basis of age group(<80 or≥80 years)amongVietnamese patients with severe aortic valve stenosis at intermediate surgical risk.Methods:From March 2017 to December 2022,21 patients≥80 years of age and 69 patients<80 years of age under-went TAVI at a single center.Clinical characteristics,procedures,and outcomes at 30 days and 1 year were compared with the Valve Academic Research Consortium(VARC-2)criteria.Results:Patients≥80 years of age had a higher prevalence of comorbidities but no significant differences in other clinical characteristics and procedures.No statistically significant differences were observed in procedural mortality(4.8%vs.0.0%,P=0.233),30-day mortality(5.0%vs.1.5%,P=0.405),and 1-year mortality(11.8%vs.3.7%,P=0.241)between age groups.Major endpoints at specified time points also showed no significant differences.Conclusions:TAVR in patients with aortic stenosis at intermediate surgical risk has similar clinical outcomes at 30 days and 1 year,according to VARC-2 criteria,with no statistically significant age-associated differences(≥80 vs.<80 years).However,further studies with larger patient populations are needed to better understand the effects of age on TAVI outcomes in patients with similar characteristics.
文摘Local arrangement of atoms in supercooled liquid Ni_(80)P_(20) alloy has been investigated by using NPT-MD simulation techniques based on the effective pair Potentials derived for Ni-P system. Bond-orientational order, the long-range correlation function and symmetrical parameters by pair-analysis approach have been calculated for supercooled liquid Ni_(80)P_(20) alloy. Results show. that in case of Ni_(80) .P_(20) alloy, the local structure is all random-like whether the centre of cluster is located at atoms Ni or P. It indicates that the icosahedral symmetry is not the unique model to describe the microstructure in supercooled liquid metals.
