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Subwavelength beam manipulation via multiple-metal slits coupled by disk-shaped nanocavity
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作者 郑改革 徐林华 +1 位作者 裴世鑫 陈云云 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第3期320-325,共6页
A novel plasmonic structure consisting of three nano-scaled slits coupled by nano-disk-shaped nanocavities is pro- posed to produce subwavelength focusing and beam bending at optical frequencies. The incident light pa... A novel plasmonic structure consisting of three nano-scaled slits coupled by nano-disk-shaped nanocavities is pro- posed to produce subwavelength focusing and beam bending at optical frequencies. The incident light passes through the metal slits in the form of surface plasmon polaritons (SPPs) ,and then scatters into radiation fields. Numerical simulations using finite-difference time-domain (FDTD) method show that the transmitted fields through the design example can gener- ate light focusing and deflection by altering the refractive index of the coupled nanocavity. The simulation results indicate that the focal spot is beyond the diffraction limit. Light impinges on the surface at an angle to the optical axis will add an extra planar phase front that interferes with the asymmetric phase front of the plasmonic lens, leading to a larger bending angle off the axial direction. The advantages of the proposed plasmonic lens are smaller device size and ease of fabrication. Such geometries offer the potential to be controlled by using nano-positior!i0g systems for applications in dynamic beam shaping and scanning on the nanoscale. 展开更多
关键词 beam manipulation surface plasmon subwavelength slits
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Slit3/Robo1通路探讨健骨颗粒对大鼠骨量丢失模型的影响
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作者 陈赛楠 黄云梅 +3 位作者 周芬 王志强 魏振朴 林燕萍 《中国骨质疏松杂志》 北大核心 2025年第3期313-320,共8页
目的观察健骨颗粒对去卵巢快速骨量丢失模型大鼠H型血管和Slit3/Robo1通路的影响,探讨其补虚化瘀的潜在作用机制。方法采用双侧卵巢切除术制备SD大鼠模型,灌胃干预6周,micro-CT观察胫骨近端微观结构,免疫荧光染色观察H型血管,ELISA检测... 目的观察健骨颗粒对去卵巢快速骨量丢失模型大鼠H型血管和Slit3/Robo1通路的影响,探讨其补虚化瘀的潜在作用机制。方法采用双侧卵巢切除术制备SD大鼠模型,灌胃干预6周,micro-CT观察胫骨近端微观结构,免疫荧光染色观察H型血管,ELISA检测血清CTX和BALP,Real-time PCR检测股骨Slit3和Robo1 mRNA的表达水平,免疫组织化学染色观察Slit3蛋白的表达水平,Western Blot检测Robo1蛋白的表达水平。结果模型组骨密度、骨小梁体积分数、骨小梁数量和骨小梁厚度均显著降低(P<0.01)和骨小梁分离度显著增大(P<0.001),H型血管阳性面积占比显著降低(P<0.001),Slit3 mRNA和蛋白表达水平显著升高(P<0.01),Robo1 mRNA和蛋白表达水平未见显著变化。与模型组相比,健骨颗粒组骨密度升高(P<0.05)和骨小梁分离度降低(P<0.001),H型血管阳性面积占比升高(P<0.05),血清CTX水平显著降低(P<0.001)、BALP水平略降低,Slit3 mRNA表达略下调和蛋白平均光密度值显著下降(P<0.05),Robo1 mRNA和蛋白表达水平显著升高(P<0.01)。结论健骨颗粒可通过Slit3/Robo1信号通路促进H型血管新生,提高骨量和改善骨微结构发挥抗骨质疏松的作用。 展开更多
关键词 绝经后骨质疏松症 健骨颗粒 H型血管 slit3/Robo1信号通路
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基于改进的DISK算法的农林航拍图配准研究
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作者 董一波 刘立群 《软件工程》 2025年第1期28-32,共5页
针对无人机的农林航拍图像配准算法存在特征点识别较少、特征点匹配不精准等问题,提出了一种改进的离散关键点(Discrete Key point,DISK)算法。该算法首先采用梯度策略DISK算法对特征点进行有效描述;其次采用基于深度学习局部特征的匹... 针对无人机的农林航拍图像配准算法存在特征点识别较少、特征点匹配不精准等问题,提出了一种改进的离散关键点(Discrete Key point,DISK)算法。该算法首先采用梯度策略DISK算法对特征点进行有效描述;其次采用基于深度学习局部特征的匹配方法进行预匹配;最后利用RANSAC算法去除离群点,筛选匹配结果。为验证算法的有效性,选取了几组农业航拍图像的数据集进行实验比较。实验结果显示,与经典的SIFT、Dark feat算法及原始的DISK算法相比,改进的DISK算法显著提高了匹配精度,匹配精度由41.7%提升至98.9%,充分满足农林航拍图的匹配需求。 展开更多
关键词 农林航拍图 梯度策率 局部特征 图像配准 disk算法
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Hot Disk热常数分析仪测定深层岩土导热系数试验研究
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作者 朱坤浩 石岩 《吉林建筑大学学报》 2025年第2期76-81,共6页
地热能等可再生能源正在推动能源结构改革,逐步取代一次能源。中深层地热能较浅层地热能具有更好的稳定性与更大的利用潜力,研究中深层地热能具有更深远意义。中深层地热能开发利用受多因素影响,岩土导热系数是影响因素之一。试验基于SD... 地热能等可再生能源正在推动能源结构改革,逐步取代一次能源。中深层地热能较浅层地热能具有更好的稳定性与更大的利用潜力,研究中深层地热能具有更深远意义。中深层地热能开发利用受多因素影响,岩土导热系数是影响因素之一。试验基于SDZ-3000快速测井平台测定的实际工程现场地温数据,利用Hot Disk热常数分析仪测定地下1 870~2 015 m处开采出的中深层岩土屑的导热系数,其值为2.25 W·(m·K)^(-1),该深度下实际岩土导热系数为2.30 W·(m·K)^(-1),二者相差较小,验证了预测原位地层岩土导热系数试验的可行性。 展开更多
关键词 中深层地热能 岩土导热系数 Hot disk热常数分析仪 中深层岩土屑
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SLIT3蛋白与绝经后骨质疏松症相关性及诊断意义
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作者 刘树华 曾韵杰 +8 位作者 杨东升 付赛 陈桐莹 杨贻富 林静 陈丹妍 杨磬雨 万雷 黄宏兴 《中国骨质疏松杂志》 北大核心 2025年第11期1561-1567,共7页
目的探讨狭缝引导配体3(slit guidance ligand 3,SLIT3)蛋白与绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)发病的关联性及其作为诊断标志物的预测价值,并通过构建成骨细胞特异敲除SLIT3基因的小鼠模型,验证SLIT3对骨代谢的影... 目的探讨狭缝引导配体3(slit guidance ligand 3,SLIT3)蛋白与绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)发病的关联性及其作为诊断标志物的预测价值,并通过构建成骨细胞特异敲除SLIT3基因的小鼠模型,验证SLIT3对骨代谢的影响。方法前瞻性病例对照研究和动物模型实验相结合。首先,收集294例绝经后患者的临床资料及血清,根据骨密度结果分为PMOP组(232例)和非骨质疏松症组(NOP,62例),测定患者血清中SLIT3、Osterix、RUNX2、β-CTX、TP1NP、N-MID OC的含量。比较两组受试者的基线数据及以上研究指标的表达水平;分析SLIT3与骨密度(bone mineral density,BMD)、OSX、RUNX2及骨转换指标(β-CTX、TP1NP、N-MID OC)的相关关系;纳入各项指标分析PMOP的危险因素;通过随机森林算法及构建受试者工作特征曲线进一步评价SLIT3对PMOP的预测效能。为了进一步验证SLIT3在骨代谢中的作用,构建成骨细胞特异性敲除SLIT3基因(SLIT3 flox/flox,BGLAP-cre)的C57BL/6小鼠,分为假手术组及去卵巢模型组,构建去卵巢模型,分析SLIT3对骨微结构的影响。结果与PMOP组患者相比,NOP组体重、腰椎平均骨密度、SLIT3、OSX、RUNX2蛋白水平更高,结果存在统计学差异。Spearman相关分析表明SLIT3蛋白水平与BMD、RUNX2、OSX蛋白水平均呈正相关关系(P<0.001);Logistic回归分析提示SLIT3水平是PMOP发生的独立危险因素。随机森林算法显示SLIT3蛋白水平在PMOP的发生中具有重要意义。同时ROC曲线证实SLIT3对PMOP具有良好的预测价值(AUC=0.857,95%CI:0.794~0.920,P<0.001)。动物实验证明,与Sham SLIT3 fl/fl组相比,OVX SLIT3 fl/fl组BV/TV、Tb.N更低而Tb.Sp和SMI指数明显增加(P<0.05);同时不论是假手术组还是去卵巢模型组,在组内与SLIT3 fl/fl组对照时,SLIT3 fl/fl;BGLAP-cre组全身骨密度和BV/TV更低,差异具有统计学意义(P<0.05)。结论血清中SLIT3蛋白水平可用于评估体内骨形成状态,SLIT3蛋白水平是PMOP的独立危险因素,且具有良好的预测作用,能为PMOP的预防及治疗提供一定的临床监测依据,临床患者若血清中SLIT3含量<2.32 ng/mL,则需警惕PMOP的发生。成骨细胞来源的SLIT3对维持骨量具有重要意义。 展开更多
关键词 骨质疏松症 狭缝引导配体3 疾病预测 绝经后女性 slit3基因敲除小鼠
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Towards a blank design method for manufacturing big-tapered profiled ring disk by spinning-rolling process 被引量:1
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作者 Xuechao LI Lianggang GUO +1 位作者 Xiaoqing CHEN Heng LI 《Chinese Journal of Aeronautics》 2025年第1期70-86,共17页
The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficien... The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process. 展开更多
关键词 Blank design method Spinning-rolling process Big-tapered profiled ring disk Rolling ratio Intelligent FE simulation
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磁共振成像联合血清SLIT3、Smad4在膝关节退行性骨关节炎患者关节损伤程度中的评估价值
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作者 朱洁 闫苗苗 +2 位作者 王剑 刘荣 崔涛涛 《中国CT和MRI杂志》 2025年第11期173-176,共4页
目的探究磁共振成像(MRI)联合血清神经轴突生长因子3(SLIT3)、Smad同源物4(Smad4)在膝关节退行性骨关节炎(OA)患者关节损伤程度中的评估价值。方法选取本院2021年9月至2023年9月收治的膝关节退行性OA患者180例作为观察对象,所有患者均进... 目的探究磁共振成像(MRI)联合血清神经轴突生长因子3(SLIT3)、Smad同源物4(Smad4)在膝关节退行性骨关节炎(OA)患者关节损伤程度中的评估价值。方法选取本院2021年9月至2023年9月收治的膝关节退行性OA患者180例作为观察对象,所有患者均进行MRI检查;血清SLIT3、Smad4采用ELISA检测,以关节镜为金标准,采用四格表分析MRI对关节软骨损伤以及膝关节退行性OA患者关节损伤程度的诊断价值。绘制ROC曲线分析MRI、血清SLIT3、Smad4对膝关节退行性OA患者关节中重度损伤的评估价值。结果MRI和关节镜对关节炎症状的检出率比较无差异(P>0.05)。MRI检测出现膝关节退行性OA患者关节损伤轻度136例,中度35例,重度9例,其诊断轻度的准确度98.89%,中度的准确度96.67%,重度的准确度97.78%。轻度、中度和重度组血清SLIT3、Smad4水平依次降低(P<0.05)。根据ROC曲线得知,MRI、血清SLIT3、Smad4评估膝关节退行性OA患者关节中重度损伤的AUC为0.911、0.875、0.825,三者联合评估膝关节退行性OA患者关节中重度损伤的AUC为0.978,三者联合优于各自单独预测(_(Z联合vs MRI)=2.553,Z_(联合vs SLIT3)=2.586,Z_(联合vs Smad4)=2.567,P均<0.05)。结论膝关节退行性OA患者中血清SLIT3、Smad4水平随着关节损伤程度的升高而降低,MRI诊断膝关节退行性OA患者关节损伤程度的准确度较高,MRI联合血清SLIT3、Smad4可提高对膝关节退行性OA患者关节损伤程度的评估价值。 展开更多
关键词 磁共振成像 神经轴突生长因子3 Smad同源物4 膝关节退行性骨关节炎 损伤程度
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Probability of detection and anomaly distribution modeling for surface defects in tenon-groove structures of aeroengine disks 被引量:1
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作者 Hongzhuo LIU Disi YANG +3 位作者 Han YAN Zixu GUO Dawei HUANG Xiaojun YAN 《Chinese Journal of Aeronautics》 2025年第10期363-383,共21页
To ensure the structural integrity of life-limiting component of aeroengines,Probabilistic Damage Tolerance(PDT)assessment is applied to evaluate the failure risk as required by airworthiness regulations and military ... To ensure the structural integrity of life-limiting component of aeroengines,Probabilistic Damage Tolerance(PDT)assessment is applied to evaluate the failure risk as required by airworthiness regulations and military standards.The PDT method holds the view that there exist defects such as machining scratches and service cracks in the tenon-groove structures of aeroengine disks.However,it is challenging to conduct PDT assessment due to the scarcity of effective Probability of Detection(POD)model and anomaly distribution model.Through a series of Nondestructive Testing(NDT)experiments,the POD model of real cracks in tenon-groove structures is constructed for the first time by employing the Transfer Function Method(TFM).A novel anomaly distribution model is derived through the utilization of the POD model,instead of using the infeasible field data accumulation method.Subsequently,a framework for calculating the Probability of Failure(POF)of the tenon-groove structures is established,and the aforementioned two models exert a significant influence on the results of POF. 展开更多
关键词 Aeroengine disks Anomaly distribution Probabilistic damage tolerance Probability of detection(POD) Structural integrity Tenon-groove structures Transfer functions
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糖尿病肾脏疾病小鼠尿外泌体微小RNA-145-5p表达及与SLIT-ROBO鸟苷三磷酸酶激活蛋白2靶向关系的研究
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作者 韩璐璐 王生海 +1 位作者 姚明言 宋茜茜 《中国糖尿病杂志》 北大核心 2025年第9期701-706,共6页
目的 探讨DKD小鼠尿外泌体微小RNA(miR)-145-5p表达及与SLIT-ROBO鸟苷三磷酸酶激活蛋白2(Srgap2)的靶向关系。方法 11只db/db小鼠随机BG≥16.7mmol/L为DKD组,10只C57BL/6J野生型小鼠为正常对照(NC)组。提取各组尿外泌体,RT-qPCR检测尿... 目的 探讨DKD小鼠尿外泌体微小RNA(miR)-145-5p表达及与SLIT-ROBO鸟苷三磷酸酶激活蛋白2(Srgap2)的靶向关系。方法 11只db/db小鼠随机BG≥16.7mmol/L为DKD组,10只C57BL/6J野生型小鼠为正常对照(NC)组。提取各组尿外泌体,RT-qPCR检测尿外泌体及肾脏mi R-145-5p表达,Pearson相关分析尿外泌体mi R-145-5p与UACR及糖脂代谢指标的相关性。双荧光素酶报告基因验证mi R-145-5p和Srgap2的靶向关系。Western blot检测肾组织Srgap2蛋白表达及Rho激酶(ROCK)活性。结果 DKD组体重、FPG、HbA_(1)c、FIns、TC、UACR、尿外泌体和肾组织miR-145-5p及p-肌球蛋白磷酸酶靶亚基1蛋白表达高于NC组(P<0.05),Srgap2蛋白表达低于NC组(P<0.05)。Pearson相关分析显示,外泌体miR-145-5p与UACR及FPG、HbA_(1)c、TC呈正相关(r=0.836、0.888、0.843、0.882,P<0.05)。mi R-145-5p可直接靶向Srgap2蛋白并激活ROCK通路。结论 DKD小鼠尿外泌体miR-145-5p表达显著升高,miR-145-5p/Srgap2/ROCK轴可能与DKD小鼠肾损伤密切相关,有望成为DKD的生物标志物及治疗靶点。 展开更多
关键词 糖尿病肾脏疾病 尿外泌体 微小RNA-145-5p slit-ROBO鸟苷三磷酸酶激活蛋白2 生物学标志物
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Deuteration of Water in Protoplanetary Disks During Luminosity Outbursts:Model Predictions for FU Ori Disks
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作者 Anastasiia Topchieva Tamara Molyarova Anton Vasyunin 《Research in Astronomy and Astrophysics》 2025年第12期261-272,共12页
Luminosity outbursts of FU Ori-type objects(FUors)allow us to observe in the gas the molecules that are typically present in the ice in protoplanetary disks.In particular,the fraction of deuterated water,which is usua... Luminosity outbursts of FU Ori-type objects(FUors)allow us to observe in the gas the molecules that are typically present in the ice in protoplanetary disks.In particular,the fraction of deuterated water,which is usually mostly frozen in the midplane of a protoplanetary disk,has been measured for the first time in the gas of the disk around FUor V883 Ori.We test the hypothesis that the observed high HDO/H_(2)O ratio in the V883 Ori protoplanetary disk can be explained by luminosity outbursts of different amplitude,including a series of two consecutive outbursts.Using the ANDES astrochemical code,we modeled the distributions of water and deuterated water abundances under the action of luminosity outbursts of different amplitudes(from 400 to10,000 L_(⊙))and at different stellar luminosities at the pre-outburst stage.We show that the best agreement with the observed HDO/H_(2)O profile is obtained for outburst amplitudes of 2000 and 10,000 L_(⊙),while the observed bolometric luminosity of V883 Ori does not exceed 400 L_(⊙).We discuss possible reasons for this discrepancy,including the presence of past luminosity outbursts,the age of the star,and the influence of additional heating mechanisms in the midplane of the protoplanetary disk.We also consider how the high observed HDO/H_(2)O ratio may be related to the evolution of the chemical composition of the ice in the protoplanetary disk and the chemical processes activated under outburst conditions. 展开更多
关键词 ASTROCHEMISTRY interplanetary medium protoplanetary disks
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Thermal radiation of accretion disks around a charged Hayward black hole
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作者 Munisa Boltatoshova Bakhtiyor Narzilloev Bobomurat Ahmedov 《Communications in Theoretical Physics》 2025年第8期117-128,共12页
This study explores the dynamics of charged Hayward black holes,focusing on the effects of electric charge and the length factor on accretion disk characteristics.Our results show that increasing both parameters reduc... This study explores the dynamics of charged Hayward black holes,focusing on the effects of electric charge and the length factor on accretion disk characteristics.Our results show that increasing both parameters reduces the size of the event horizon and innermost stable circular orbits(ISCO)radius,with the electric charge exerting a more pronounced influence.Additionally,the length factor and electric charge can effectively replicate the spin of a Kerr black hole.Both parameters also affect the electromagnetic radiation emitted from the accretion disk,increasing the flux,temperature,and radiative efficiency.The peak radiation occurs in the soft x-ray band,with higher values of electric charge and length factor enhancing disk luminosity and shifting the peak to higher frequencies.These findings can offer valuable insights into the accretion processes around black holes and their observable signatures,particularly in x-ray astronomy. 展开更多
关键词 black hole dark matter accretion disk general relativity
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Heat Transfer and Flow Dynamics of Ternary Hybrid Nanofluid over a Permeable Disk underMagnetic Field and Joule Heating Effects
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作者 Umi Nadrah Hussein Najiyah Safwa Khashi’ie +1 位作者 Norihan Md Arifin Ioan Pop 《Frontiers in Heat and Mass Transfer》 2025年第2期383-395,共13页
This study investigates the heat transfer and flow dynamics of a ternary hybrid nanofluid comprising alumina,copper,and silica/titania nanoparticles dispersed in water.The analysis considers the effects of suction,mag... This study investigates the heat transfer and flow dynamics of a ternary hybrid nanofluid comprising alumina,copper,and silica/titania nanoparticles dispersed in water.The analysis considers the effects of suction,magnetic field,and Joule heating over a permeable shrinking disk.Amathematicalmodel is developed and converted to a systemof differential equations using similarity transformation which then,solved numerically using the bvp4c solver in Matlab software.The study introduces a novel comparative analysis of alumina-copper-silica and alumina-coppertitania nanofluids,revealing distinct thermal conductivity behaviors and identifying critical suction values necessary for flow stabilization.Dual solutions are found within a specific range of parameters such that the minimum required suction values for flow stability,with S_(c)=1.2457 for alumina-copper-silica/water and S_(c)=1.2351 for alumina-coppertitania/water.The results indicate that increasing suction by 1%enhances the skin friction coefficient by up to 4.17%and improves heat transfer efficiency by approximately 1%,highlighting its crucial role in stabilizing the opposing flow induced by the shrinking disk.Additionally,the inclusion of 1%silica nanoparticles reduces both skin friction and heat transfer rate by approximately 0.28%and 0.85%,respectively,while 1%titania concentration increases skin friction by 3.02%but results in a slight heat transfer loss of up to 0.61%.These findings confirm the superior thermal performance of alumina-copper-titania/water,making it a promising candidate for enhanced cooling systems,energy-efficient heat exchangers,and industrial thermal management applications. 展开更多
关键词 Dual solutions Joule heating magnetic field shrinking disk suction ternary hybrid nanofluid
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Radiative Flow of Ag-Fe_(3)O_(4)/Water Hybrid Nanofluids Induced by a Shrinking/Stretching Disk with Influence of Velocity and Thermal Slip Conditions
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作者 Muhammad Zubair Mustafa Sumera Dero +2 位作者 Liaquat Ali Lund Mehboob Ul Hassan Umair Khan 《Computer Modeling in Engineering & Sciences》 2025年第4期499-513,共15页
This paper discusses the model of the boundary layer(BL)flow and the heat transfer characteristics of hybrid nanofluid(HNF)over shrinking/stretching disks.In addition,the thermal radiation and the impact of velocity a... This paper discusses the model of the boundary layer(BL)flow and the heat transfer characteristics of hybrid nanofluid(HNF)over shrinking/stretching disks.In addition,the thermal radiation and the impact of velocity and thermal slip boundary conditions are also examined.The considered hybrid nano-fluid contains silver(Ag)and iron oxide(Fe_(3)O_(4))nanoparticles dispersed in the water to prepare the Ag-Fe_(3)O_(4)/water-based hybrid nanofluid.The requisite posited partial differential equations model is converted to ordinary differential equations using similarity transformations.For a numerical solution,the shooting method in Maple is employed.Moreover,the duality in solutions is achieved for both cases of the disk(stretching(λ>0)and shrinking(λ<0)).At the same time,a unique solution is observed for λ=0.No solution is found for them at λ<λ_(c),whereas the solutions are split at the λ=λ_(c).Besides,the value of the λ_(c) is dependent on the φ_(hnf).Meanwhile,the values of f″(0)and -θ′(0)intensified with increasing φ_(hnf).Stability analysis has been applied using bvp4c in MATLAB software due to a dual solution.Furthermore,analysis shows that the first solution is stable and feasible physically.For the slip parameters,an increase in the velocity slip parameter increases the velocity and shear stress profiles while increasing the temperature profile in the first solutions.While the rise in thermal slip parameter reduces the temperature profile nanoparticle volume fractions increase it. 展开更多
关键词 Dual solutions slip and radiation hybrid nanofluid shrinking/stretching disk stability analysis
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The Fate of Stars Embedded in AGN Disks is Determined by an Internal Mixing Threshold
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作者 Zheng-Hao Xu 《Research in Astronomy and Astrophysics》 2025年第11期174-181,共8页
Stars can form and evolve within gaseous disks around active galactic nuclei(AGNs).In the sub-parsec region of disks around~10~8M_(☉)black holes,stars accrete rapidly,reaching■200 M_(☉)and settling into a quasi-ste... Stars can form and evolve within gaseous disks around active galactic nuclei(AGNs).In the sub-parsec region of disks around~10~8M_(☉)black holes,stars accrete rapidly,reaching■200 M_(☉)and settling into a quasi-steady state in which accretion balances wind-driven mass loss.Within this environment,their ultimate fate depends critically on the radiative-zone diffusion coefficient(Dmix),which encapsulates various mixing processes and governs chemical transport between surface and core.Using the MESA stellar evolution code,we simulate AGN stars across a range of mixing efficiencies.We find a critical threshold floor value D_(mix,min)≈1010 cm~2 s^(-1)that separates two distinct fates:1."Immortal stars"—when mixing is over-efficient(D_(mix,min)■10^(10)cm~2 s^(-1)),rapid hydrogen replenishment sustains core hydrogen burning,maintains main-sequence equilibrium,rendering the star effectively“immortal.”2."Metamorphic stars"—when mixing is merely efficient(D_(mix,min)<1010 cm~2 s^(-1)),stars exhaust core hydrogen,evolve off-main-sequence,shed mass to≈15 M_(☉),and produce super-solar a-abundances consistent with AGN observations.We conclude that maintaining a mixing floor below this threshold is sufficient to avoid immortality,as flux-induced extra mixing can be effectively modeled via constant floor values.Our estimates provide a foundation for future work on disk enrichment and stellar evolution. 展开更多
关键词 stars:massive stars:evolution galaxies:active ACCRETION accretion disks galaxies:abundances
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A Biomimetic Stress Field Modulation Strategy Inspired by Scorpion Compound Slit Sensilla Enabled High-Accuracy and Low-Power Positioning Sensor for Identifying the Load Incident Angles
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作者 Junqiu Zhang Yu Chen +11 位作者 Haoran Li Jiqi Gao Xiangbo Gu Jiachao Wu Xiaojing Qin Kejun Wang Bin Zhu Daobing Chen Tao Sun Jianhua Fan Zhiwu Han Luquan Ren 《Journal of Bionic Engineering》 2025年第2期727-738,共12页
Numerous arthropods evolve and optimize sensory systems, enabling them to effectively adapt complex and competitive habitats. Typically, scorpions can precisely perceive the prey location with the lowest metabolic rat... Numerous arthropods evolve and optimize sensory systems, enabling them to effectively adapt complex and competitive habitats. Typically, scorpions can precisely perceive the prey location with the lowest metabolic rate among invertebrates. This biological phenomenon contrasts sharply with engineered systems, which generally associates high accuracy with substantial energy consumption. Inspired by the Scorpion Compound Slit Sensilla (SCSS) with a stress field modulation strategy, a bionic positioning sensor with superior precision and minimal power consumption is developed for the first time, which utilizes the particular Minimum Positioning Units (MPUs) to efficiently locate vibration signals. The single MPU of the SCSS can recognize the direction of collinear loads by regulating the stress field distribution and further, the coupling action of three MPUs can realize all-angle vibration monitoring in plane. Experiments demonstrate that the bionic positioning sensor achieves 1.43 degrees of angle-error-free accuracy without additional energy supply. As a proof of concept, two bionic positioning sensors and machine learning algorithm are integrated to provide centimeter (cm)-accuracy target localization, ideally suited for the man-machine interaction. The novel design offers a new mechanism for the design of traditional positioning devices, improving precision and efficiency in both the meta-universe and real-world Internet-connected systems. 展开更多
关键词 Scorpion Compound slit Sensilla(SCSS) Vibration Source Stress Field Modulation Strategy High-accuracy and low-power Positioning Sensor Minimum Positioning Unit(MPU)
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SLIT-ROBO Rho GTPase激活蛋白2在肌萎缩侧索硬化症运动神经元退变中的作用
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作者 王晨晨 张雪 +5 位作者 高学帅 白雪 闫秋鹏 王雪枚 刘金梦 陈燕春 《解剖学报》 2025年第4期413-420,共8页
目的 探讨SLIT-ROBO Rho GTPase激活蛋白2(srGAP2)在肌萎缩侧索硬化症(ALS)转基因小鼠脊髓运动神经元退变中的作用。方法 应用生物信息学分析srGAP2在人超氧化物歧化酶1(hSOD1)突变型ALS转基因小鼠脊髓中的表达变化。选取hSOD1G93A突变... 目的 探讨SLIT-ROBO Rho GTPase激活蛋白2(srGAP2)在肌萎缩侧索硬化症(ALS)转基因小鼠脊髓运动神经元退变中的作用。方法 应用生物信息学分析srGAP2在人超氧化物歧化酶1(hSOD1)突变型ALS转基因小鼠脊髓中的表达变化。选取hSOD1G93A突变型ALS转基因小鼠进行实验验证,以同窝野生型(WT)小鼠为对照组,分为发病前期、早期、中期和晚期4组共36对,应用Real-time PCR、Western blotting和免疫荧光双标染色检测小鼠脊髓内srGAP2的表达变化及细胞定位。建立hSOD1G93A突变型NSC34运动神经元样细胞模型,体外实验检测srGAP2的表达变化,检测过表达srGAP2对hSOD1G93A突变型NSC34细胞活力的影响和细胞突起生长的影响。结果 生物信息学分析发现,srGAP2在hSOD1突变型ALS转基因小鼠脊髓中异常低表达。动物实验验证发现,与WT小鼠相比,在发病早期、中期和晚期hSOD1G93A突变型ALS转基因小鼠脊髓中srGAP2的mRNA水平和蛋白水平表达均降低。相较于WT小鼠,hSOD1G93A突变型ALS转基因小鼠脊髓前角srGAP2+/NeuN+双阳性细胞中srGAP2积分吸光度(IA)值降低,srGAP2+/GFAP+双阳性细胞中srGAP2 IA值升高;与hSOD1WTNSC34细胞相比,hSOD1G93A突变型NSC34细胞中srGAP2的mRNA和蛋白表达均降低。过表达srGAP2可升高hSOD1G93A突变型NSC34细胞的活力,上调突起相关蛋白βⅢ-tubulin、生长相关联蛋白43(GAP43)的表达。结论 srGAP2低表达与ALS疾病进展密切相关,过表达srGAP2可促进突起生长,对ALS脊髓运动神经元具有保护作用。 展开更多
关键词 slit-ROBO Rho GTPase激活蛋白2 肌萎缩侧索硬化症 脊髓 NSC34细胞 免疫印迹法 转基因小鼠
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电针对局灶性脑梗死大鼠皮质Slit2/Robo1表达的影响 被引量:18
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作者 吕凯 李凤 +3 位作者 龚标 代恩泽 汪莹 曾志华 《针刺研究》 CAS CSCD 北大核心 2013年第4期265-270,共6页
目的:观察局灶性脑梗死大鼠皮质Slit 2/Robo 1的表达及电针干预对其表达的影响,探讨Slit2/Robo 1在电针对脑梗死后神经可塑性影响中的作用。方法:雄性SD大鼠随机分为正常组、模型组和电针组,后两组再根据缺血时间随机分为1、3、7、14d4... 目的:观察局灶性脑梗死大鼠皮质Slit 2/Robo 1的表达及电针干预对其表达的影响,探讨Slit2/Robo 1在电针对脑梗死后神经可塑性影响中的作用。方法:雄性SD大鼠随机分为正常组、模型组和电针组,后两组再根据缺血时间随机分为1、3、7、14d4个亚组,每组各10只。用线栓法制作大脑中动脉闭塞模型。电针组取"内关""足三里",留针30min,每日治疗1次。在第1、3、7、14天分别利用免疫组织化学法和免疫印迹法检测缺血侧大脑皮质Slit 2和Robo 1的表达。结果:免疫组化和免疫印迹法检测结果显示,与正常组相比,模型组Slit 2表达水平在术后1d即开始上升(P<0.05,P<0.01),3d时升高达高峰(P<0.01),14d时回落到基础水平(P>0.05);电针组与模型组同时间点相比均呈现高表达(P<0.05,P<0.01),电针组Slit 2高峰出现在术后7d。与正常组相比,模型组Robo 1表达水平在术后1d即开始上升(P<0.05,P<0.01),3d时升高达高峰(P<0.01),免疫印迹结果显示14d时仍高于基础水平(P<0.01);电针组与模型组相比,1、7、14d时呈现更高表达(P<0.01,P<0.05)。结论:局灶性脑梗死后大鼠皮质Slit 2/Robo 1表达明显上调,给予电针干预后可提高其表达峰值并延长高表达时间,这可能是电针促进脑梗死后神经功能恢复的机制之一。 展开更多
关键词 脑缺血再灌注 电针 脑皮质 slit 2 ROBO 1
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开槽盘式异步磁力耦合器电磁振动与噪声分析
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作者 杨超君 朱志成 +2 位作者 王凯旋 郭亚飞 张意雯 《机械传动》 北大核心 2026年第1期40-49,共10页
【目的】磁场交替变换会引起机械部件的振动,从而产生噪声。电磁激振力与电磁转矩的波动是造成电磁振动噪声的主要原因。为了分析电磁激振力与电磁转矩波动的产生机制与作用规律,针对一台9对极16槽的开槽盘式异步磁力耦合器,进行了电磁... 【目的】磁场交替变换会引起机械部件的振动,从而产生噪声。电磁激振力与电磁转矩的波动是造成电磁振动噪声的主要原因。为了分析电磁激振力与电磁转矩波动的产生机制与作用规律,针对一台9对极16槽的开槽盘式异步磁力耦合器,进行了电磁振动噪声分析。【方法】首先,运用磁势磁导法与麦克斯韦应力张量法,推导出气隙磁密和电磁激振力的理论公式;并结合有限元仿真,得到了气隙磁密和电磁激振力傅里叶分解后的各谐波阶次幅值。其次,基于能量法,推导出齿槽转矩的表达式;运用有限元仿真,得到了磁力耦合器运行时产生的齿槽转矩及电磁转矩波动。再次,建立了电磁-结构-声学多物理场耦合模型;运用模态叠加法,得到了磁力耦合器稳定运行时产生的振动加速度与振动位移,并分析了其电磁噪声特征。最后,搭建磁力耦合器试验平台,测试了磁力耦合器稳定运行时的电磁噪声;将试验结果与仿真结果进行比较,以验证理论分析的正确性。【结果】结果表明,低阶电磁激振力是造成磁力耦合器振动的主要原因,且当电磁激振力频率与磁力耦合器固有频率相近时会产生较大振动。对比仿真结果,通过磁力耦合器试验平台得到的试验结果证明了理论分析的正确性。 展开更多
关键词 开槽盘式异步磁力耦合器 振动噪声 傅里叶分解 多物理场耦合
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神经轴突导向分子Slit的功能及其分子作用机制研究进展 被引量:9
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作者 于奇 周启升 +1 位作者 赵晓 刘庆信 《生理学报》 CAS CSCD 北大核心 2012年第2期220-230,共11页
神经轴突导向分子Slit是一种在进化上高度保守的分泌型糖蛋白,Slit对神经轴突导向、神经细胞迁移、神经细胞形态分化、肿瘤转移、血管生成、心脏形态发生等多种生命活动具有调节作用。Slit功能的实现主要是通过其LRR-2结构域与受体Round... 神经轴突导向分子Slit是一种在进化上高度保守的分泌型糖蛋白,Slit对神经轴突导向、神经细胞迁移、神经细胞形态分化、肿瘤转移、血管生成、心脏形态发生等多种生命活动具有调节作用。Slit功能的实现主要是通过其LRR-2结构域与受体Roundabout(Robo)的Ig1结构域相结合而实现的,另外硫酸肝素蛋白多糖(heparan sulfate proteoglycans,HSPGs)、GTP酶激活蛋白(GTPase-activating proteins,GAPs)、酪氨酸激酶Abelson、Ca2+、MicroRNA-218和其它轴突导向分子等多种信号分子也参与了Slit功能的实现。slit基因受到Single-minded、Irx4和Midline等转录因子的调控,另外,转录后水平的选择性剪接使slit基因存在多种亚型。Slit导向机制的研究有助于揭示生物神经发育和再生过程中神经网络形成的内在分子基础,同时,也将为预防和治疗人类神经疾病、抑制癌细胞转移等提供理论参考。 展开更多
关键词 slit基因 robo基因 神经轴突导向 细胞迁移 分子作用机制 基因表达调控
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大鼠坐骨神经横断后脊髓、背根神经节及坐骨神经 Slit 2表达的变化 被引量:5
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作者 易西南 郑林丰 +2 位作者 许愿忠 张建伟 罗学港 《解剖学杂志》 CAS CSCD 北大核心 2006年第1期85-88,共4页
目的:观察 Slit 2在大鼠坐骨神经横断模型中的表达变化,为进一步研究 Slit/Robo 在周围神经再生中的作用提供实验依据。方法:SD 大鼠坐骨神经横断后用原位杂交及免疫组织化学方法检测 Slit 2在脊髓、背根神经节(DRG)和横断神经近、远... 目的:观察 Slit 2在大鼠坐骨神经横断模型中的表达变化,为进一步研究 Slit/Robo 在周围神经再生中的作用提供实验依据。方法:SD 大鼠坐骨神经横断后用原位杂交及免疫组织化学方法检测 Slit 2在脊髓、背根神经节(DRG)和横断神经近、远端内的表达变化,图像分析方法测定阳性细胞数及平均积分光密度值。结果:正常脊髓前角运动神经元、DRG 和神经干内 Slit 2有一定的基础表达。损伤后近端神经胶质瘤、神经远端 Slit 2表达增高;DRG 内的 Slit 2表达呈现一定的时间变化,7 d 为表达高峰,14 d 下降。结论:Slit 2存在于正常成年大鼠周围神经系统,损伤可致其表达改变,Slit 2可能在周围神经再生中发挥重要作用。 展开更多
关键词 slit 周围神经 原位杂交 免疫组化 大鼠
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