The role of autologous hematopoietic stem cell transplantation(auto-HSCT)following high-dose chemotherapy has been validated and accepted as a standard treatment for patients with relapsed diffuse large B-cell lymphom...The role of autologous hematopoietic stem cell transplantation(auto-HSCT)following high-dose chemotherapy has been validated and accepted as a standard treatment for patients with relapsed diffuse large B-cell lymphoma(DLBCL).However,its clinical efficacy as frontline therapy remains to be elucidated.This study aimed to examine the feasibility of frontline auto-HSCT for newly diagnosed intermediate/high-risk DLBCL patients.We retrospectively reviewed the data of 223 patients treated with frontline auto-HSCT or chemotherapy alone(year 2008-2014)from four hospitals.The median follow-up time was 29.4 months.Between the two treatment arms among the intermediate/high-risk DLBCL patients,the 3-year overall survival(OS)and progression-free survival(PFS)rates of patients given frontline auto-HSCT were 87.6%and 81.9%,respectively,and the chemotherapy-alone group showed 3-year OS and PFS rates of 64.9%and 59.59%,respectively.Compared with the chemotherapy-alone group,the frontline auto-HSCT could eliminate the adverse impact of non-germinal center B-cell(GCB)type.In addition,in the frontline auto-HSCT group,patients who achieved complete response(CR)at auto-HSCT had a longer survival time than those who did not achieve CR.Our results suggested that frontline auto-HSCT could improve the prognosis of intennediate/high-risk DLBCL patients.展开更多
On September 10th, 2007, the Ningbo Veken Group signed a cooperation contract with Japan KB Tsuzuki Co., Ltd on silk screen program, signing a big step into the top-class silk
Flexible supercapacitor electrodes with high mass loading are crucial for obtaining favorable electrochemical performance but still challenging due to sluggish electron and ion transport.Herein,rationally designed CNT...Flexible supercapacitor electrodes with high mass loading are crucial for obtaining favorable electrochemical performance but still challenging due to sluggish electron and ion transport.Herein,rationally designed CNT/MnO2/graphene-grafted carbon cloth electrodes are prepared by a“graft-deposit-coat”strategy.Due to the large surface area and good conductivity,graphene grafted on carbon cloth offers additional surface areas for the uniform deposition of MnO2(9.1 mg cm?2)and facilitates charge transfer.Meanwhile,the nanostructured MnO2 provides abundant electroactive sites and short ion transport distance,and CNT coated on MnO2 acts as interconnected conductive“highways”to accelerate the electron transport,significantly improving redox reaction kinetics.Benefiting from high mass loading of electroactive materials,favorable conductivity,and a porous structure,the electrode achieves large areal capacitances without compromising rate capability.The assembled asymmetric supercapacitor demonstrates a wide working voltage(2.2 V)and high energy density of 10.18 mWh cm?3.展开更多
The impact propylene copolymer （IPC） and isotactic polypropylene （iPP） were separately selected to prepare laminates with high density polyethylene （HDPE） by hot press. The peel forces of IPC/HDPE and iPP/HDPE l...The impact propylene copolymer （IPC） and isotactic polypropylene （iPP） were separately selected to prepare laminates with high density polyethylene （HDPE） by hot press. The peel forces of IPC/HDPE and iPP/HDPE laminates were examined, and it was found that the welded joint strength in IPC/HDPE laminate was dramatically higher than that of iPP/HDPE laminate. According to the special microstructure of IPC, the co-crystallization of the ethylene segments in ethylene-propylene block copolymer （EbP） component of IPC and the PE chain in HDPE was proposed to explain the high- strength welding. The DSC results indicated that there indeed existed some interaction between IPC and HDPE, and the crystallizable PE component in IPC could affect the crystallization of HDPE. The scanning electron microscope （SEM） observations of IPC/HDPE blends demonstrated that HDPE tended to stay with the PE-rich EbP chains to form the dispersed phase, indicating the good miscibility between HDPE and EbP components of IPC. According to the above results, the effect of co-crystallization of the PE components of the IPC and HDPE on the high weld strength of IPC/HDPE laminate was confirmed.展开更多
A theoretical model of flatband voltage （VFB） of metal/high-k/Si02/Si stack is proposed based on band alignment of entire gate stack, i.e., the VFB is obtained by simultaneously considering band alignments of metal/...A theoretical model of flatband voltage （VFB） of metal/high-k/Si02/Si stack is proposed based on band alignment of entire gate stack, i.e., the VFB is obtained by simultaneously considering band alignments of metal/high-k, high-k/SiO2 and SiO2/Si interfaces, and their interactions. Then the VFB of TiN/HfO2/SiO2/Si stack is experimentally obtained and theoretically investigated by this model. The theoretical calculations are in good agreement with the experimental results. Furthermore, both positive VFB shift of TiN/HfO2/SiO2/Si stack and Fermi level pinning are successfully interpreted and attributed to the dielectric contact induced gap states at TiN/HfO2 and HfO2/SiO2 interfaces.展开更多
In metal-gate/high-k stacks adopted by the 45 nm technology node, the fiat-band voltage （Vfb） shift remains one of the most critical challenges, particularly the flat-band voltage roll-off （Vfb roll-off） phenomeno...In metal-gate/high-k stacks adopted by the 45 nm technology node, the fiat-band voltage （Vfb） shift remains one of the most critical challenges, particularly the flat-band voltage roll-off （Vfb roll-off） phenomenon in p-channel metal- oxide-semiconductor （pMOS） devices with an ultrathin oxide layer. In this paper, recent progress on the investigation of the Vfb shift and the origin of the Vfb roll-off in the metal-gate/high-k pMOS stacks are reviewed. Methods that can alleviate the Vfb shift phenomenon are summarized and the future research trend is described.展开更多
In this paper the influences of the metal-gate and high-k/SiO 2 /Si stacked structure on the metal-oxide-semiconductor field-effect transistor（MOSFET） are investigated.The flat-band voltage is revised by considering...In this paper the influences of the metal-gate and high-k/SiO 2 /Si stacked structure on the metal-oxide-semiconductor field-effect transistor（MOSFET） are investigated.The flat-band voltage is revised by considering the influences of stacked structure and metal-semiconductor work function fluctuation.The two-dimensional Poisson＇s equation of potential distribution is presented.A threshold voltage analytical model for metal-gate/high-k/SiO 2 /Si stacked MOSFETs is developed by solving these Poisson＇s equations using the boundary conditions.The model is verified by a two-dimensional device simulator,which provides the basic design guidance for metal-gate/high-k/SiO 2 /Si stacked MOSFETs.展开更多
Necrotizing enterocolitis (NEC) in newborns is one of the life-threatening diseases. With the continuous advancement of perinatal medicine and neonatal intensive care technology, NEC has been on the rise year by year....Necrotizing enterocolitis (NEC) in newborns is one of the life-threatening diseases. With the continuous advancement of perinatal medicine and neonatal intensive care technology, NEC has been on the rise year by year. The etiology of NEC is not yet clear, and it may be the result of multiple risk factors working together, such as premature birth, infection, formula feeding, ischemia, hypoxia, dysbiosis of intestinal flora, and immune damage. Additionally, recent reports have documented factors such as immunoglobulin treatment for hemolytic jaundice, blood transfusion therapy, and rapid achievement of adequate feeding. This article comprehensively analyzes the current research progress on high-risk factors of NEC, and provides a reference for future prevention, diagnosis, and treatment directions.展开更多
基金the National Natural Science Foundation of China(No.82070208)the Technique Innovation and Applied Program of Chongqing(No.cstc2019jscx-msxmX0187)+2 种基金the Natural Science Key Foundation of Chongqing(No.cstc2019jcyj-zdxmX0023)the Science and Technology Innovation Promotion Project of Army Medical University(No.2019XLC3020)the Translational Research Program of National Clinical Research Center for Hematologic Diseases(Nos.2020ZKZC02,2021WWB05).
文摘The role of autologous hematopoietic stem cell transplantation(auto-HSCT)following high-dose chemotherapy has been validated and accepted as a standard treatment for patients with relapsed diffuse large B-cell lymphoma(DLBCL).However,its clinical efficacy as frontline therapy remains to be elucidated.This study aimed to examine the feasibility of frontline auto-HSCT for newly diagnosed intermediate/high-risk DLBCL patients.We retrospectively reviewed the data of 223 patients treated with frontline auto-HSCT or chemotherapy alone(year 2008-2014)from four hospitals.The median follow-up time was 29.4 months.Between the two treatment arms among the intermediate/high-risk DLBCL patients,the 3-year overall survival(OS)and progression-free survival(PFS)rates of patients given frontline auto-HSCT were 87.6%and 81.9%,respectively,and the chemotherapy-alone group showed 3-year OS and PFS rates of 64.9%and 59.59%,respectively.Compared with the chemotherapy-alone group,the frontline auto-HSCT could eliminate the adverse impact of non-germinal center B-cell(GCB)type.In addition,in the frontline auto-HSCT group,patients who achieved complete response(CR)at auto-HSCT had a longer survival time than those who did not achieve CR.Our results suggested that frontline auto-HSCT could improve the prognosis of intennediate/high-risk DLBCL patients.
文摘On September 10th, 2007, the Ningbo Veken Group signed a cooperation contract with Japan KB Tsuzuki Co., Ltd on silk screen program, signing a big step into the top-class silk
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF2018R1D1A1B07051249)Nano Material Technology Development Program(NRF-2015M3A7B6027970)of MSIP/NRF and Center for Integrated Smart Sensors funded by the Ministry of Science,ICTFuture Planning,Republic of Korea,as Global Frontier Project(CISS-2012M3A6A6054186).
文摘Flexible supercapacitor electrodes with high mass loading are crucial for obtaining favorable electrochemical performance but still challenging due to sluggish electron and ion transport.Herein,rationally designed CNT/MnO2/graphene-grafted carbon cloth electrodes are prepared by a“graft-deposit-coat”strategy.Due to the large surface area and good conductivity,graphene grafted on carbon cloth offers additional surface areas for the uniform deposition of MnO2(9.1 mg cm?2)and facilitates charge transfer.Meanwhile,the nanostructured MnO2 provides abundant electroactive sites and short ion transport distance,and CNT coated on MnO2 acts as interconnected conductive“highways”to accelerate the electron transport,significantly improving redox reaction kinetics.Benefiting from high mass loading of electroactive materials,favorable conductivity,and a porous structure,the electrode achieves large areal capacitances without compromising rate capability.The assembled asymmetric supercapacitor demonstrates a wide working voltage(2.2 V)and high energy density of 10.18 mWh cm?3.
基金supported by the National Basic Research Program of China(No.2005CB623800)the National Natural Science Foundation of China(No.50603023)the Joint Research Fund for Overseas Chinese Young Scholars (No.50728302)
文摘The impact propylene copolymer （IPC） and isotactic polypropylene （iPP） were separately selected to prepare laminates with high density polyethylene （HDPE） by hot press. The peel forces of IPC/HDPE and iPP/HDPE laminates were examined, and it was found that the welded joint strength in IPC/HDPE laminate was dramatically higher than that of iPP/HDPE laminate. According to the special microstructure of IPC, the co-crystallization of the ethylene segments in ethylene-propylene block copolymer （EbP） component of IPC and the PE chain in HDPE was proposed to explain the high- strength welding. The DSC results indicated that there indeed existed some interaction between IPC and HDPE, and the crystallizable PE component in IPC could affect the crystallization of HDPE. The scanning electron microscope （SEM） observations of IPC/HDPE blends demonstrated that HDPE tended to stay with the PE-rich EbP chains to form the dispersed phase, indicating the good miscibility between HDPE and EbP components of IPC. According to the above results, the effect of co-crystallization of the PE components of the IPC and HDPE on the high weld strength of IPC/HDPE laminate was confirmed.
基金supported by the National Natural Science of China(Grant Nos.61176091 and 50932001)
文摘A theoretical model of flatband voltage （VFB） of metal/high-k/Si02/Si stack is proposed based on band alignment of entire gate stack, i.e., the VFB is obtained by simultaneously considering band alignments of metal/high-k, high-k/SiO2 and SiO2/Si interfaces, and their interactions. Then the VFB of TiN/HfO2/SiO2/Si stack is experimentally obtained and theoretically investigated by this model. The theoretical calculations are in good agreement with the experimental results. Furthermore, both positive VFB shift of TiN/HfO2/SiO2/Si stack and Fermi level pinning are successfully interpreted and attributed to the dielectric contact induced gap states at TiN/HfO2 and HfO2/SiO2 interfaces.
基金Project supported by the National Natural Science Foundation of China (Grants Nos.50802005 and 11074020)the Program for New Century Excellent Talents in University,China (Grant No.NCET-08-0029)+1 种基金the Ph.D.Program Foundation of Ministry of Education of China (Grant No.200800061055)the Hong Kong Research Grants Council General Research Funds,China (Grant No.CityU112608)
文摘In metal-gate/high-k stacks adopted by the 45 nm technology node, the fiat-band voltage （Vfb） shift remains one of the most critical challenges, particularly the flat-band voltage roll-off （Vfb roll-off） phenomenon in p-channel metal- oxide-semiconductor （pMOS） devices with an ultrathin oxide layer. In this paper, recent progress on the investigation of the Vfb shift and the origin of the Vfb roll-off in the metal-gate/high-k pMOS stacks are reviewed. Methods that can alleviate the Vfb shift phenomenon are summarized and the future research trend is described.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 60936005 and 61076097)the Cultivation Fund of the Key Scientific and Technical Innovation Project,Ministry of Education of China (Grant No. 708083)the Fundamental Research Funds for the Central Universities (Grant No. 20110203110012)
文摘In this paper the influences of the metal-gate and high-k/SiO 2 /Si stacked structure on the metal-oxide-semiconductor field-effect transistor（MOSFET） are investigated.The flat-band voltage is revised by considering the influences of stacked structure and metal-semiconductor work function fluctuation.The two-dimensional Poisson＇s equation of potential distribution is presented.A threshold voltage analytical model for metal-gate/high-k/SiO 2 /Si stacked MOSFETs is developed by solving these Poisson＇s equations using the boundary conditions.The model is verified by a two-dimensional device simulator,which provides the basic design guidance for metal-gate/high-k/SiO 2 /Si stacked MOSFETs.
文摘Necrotizing enterocolitis (NEC) in newborns is one of the life-threatening diseases. With the continuous advancement of perinatal medicine and neonatal intensive care technology, NEC has been on the rise year by year. The etiology of NEC is not yet clear, and it may be the result of multiple risk factors working together, such as premature birth, infection, formula feeding, ischemia, hypoxia, dysbiosis of intestinal flora, and immune damage. Additionally, recent reports have documented factors such as immunoglobulin treatment for hemolytic jaundice, blood transfusion therapy, and rapid achievement of adequate feeding. This article comprehensively analyzes the current research progress on high-risk factors of NEC, and provides a reference for future prevention, diagnosis, and treatment directions.
