A big step forward to improve power system monitoring and performance, continued load growth without a corresponding increase in transmission resources has resulted in reduced operational margins for many power system...A big step forward to improve power system monitoring and performance, continued load growth without a corresponding increase in transmission resources has resulted in reduced operational margins for many power systems worldwide and has led to operation of power systems closer to their stability limits and to power exchange in new patterns. These issues, as well as the on-going worldwide trend towards deregulation of the entire industry on the one hand and the increased need for accurate and better network monitoring on the other hand, force power utilities exposed to this pressure to demand new solutions for wide area monitoring, protection and control. Wide-area monitoring, protection, and control require communicating the specific-node information to a remote station but all information should be time synchronized so that to neutralize the time difference between information. It gives a complete simultaneous snap shot of the power system. The conventional system is not able to satisfy the time-synchronized requirement of power system. Phasor Measurement Unit (PMU) is enabler of time-synchronized measurement, it communicate the synchronized local information to remote station.展开更多
The aim of this work is mathematical education through the knowledge system and mathematical modeling. A net model of formation of mathematical knowledge as a deductive theory is suggested here. Within this model the ...The aim of this work is mathematical education through the knowledge system and mathematical modeling. A net model of formation of mathematical knowledge as a deductive theory is suggested here. Within this model the formation of deductive theory is represented as the development of a certain informational space, the elements of which are structured in the form of the orientated semantic net. This net is properly metrized and characterized by a certain system of coverings. It allows injecting net optimization parameters, regulating qualitative aspects of knowledge system under consideration. To regulate the creative processes of the formation and realization of mathematical know- edge, stochastic model of formation deductive theory is suggested here in the form of branching Markovian process, which is realized in the corresponding informational space as a semantic net. According to this stochastic model we can get correct foundation of criterion of optimization creative processes that leads to “great main points” strategy (GMP-strategy) in the process of realization of the effective control in the research work in the sphere of mathematics and its applications.展开更多
This paper presents a closed-loop vector control structure based on adaptive Fuzzy Logic Sliding Mode Controller (FL-SMC) for a grid-connected Wave Energy Conversion System (WECS) driven Self-Excited Induction Generat...This paper presents a closed-loop vector control structure based on adaptive Fuzzy Logic Sliding Mode Controller (FL-SMC) for a grid-connected Wave Energy Conversion System (WECS) driven Self-Excited Induction Generator (SEIG). The aim of the developed control method is to automatically tune and optimize the scaling factors and the membership functions of the Fuzzy Logic Controllers (FLC) using Multi-Objective Genetic Algorithms (MOGA) and Multi-Objective Particle Swarm Optimization (MOPSO). Two Pulse Width Modulated voltage source PWM converters with a carrier-based Sinusoidal PWM modulation for both Generator- and Grid-side converters have been connected back to back between the generator terminals and utility grid via common DC link. The indirect vector control scheme is implemented to maintain balance between generated power and power supplied to the grid and maintain the terminal voltage of the generator and the DC bus voltage constant for variable rotor speed and load. Simulation study has been carried out using the MATLAB/Simulink environment to verify the robustness of the power electronics converters and the effectiveness of proposed control method under steady state and transient conditions and also machine parameters mismatches. The proposed control scheme has improved the voltage regulation and the transient performance of the wave energy scheme over a wide range of operating conditions.展开更多
Spider mites are significant pests in agricultural production.The increasing resistance of spider mites,along with environmental pollution and ecological imbalance caused by their control,is primarily attributed to th...Spider mites are significant pests in agricultural production.The increasing resistance of spider mites,along with environmental pollution and ecological imbalance caused by their control,is primarily attributed to the long-term use of chemical acaricides in agriculture.In contrast,bioactive substances of biological origin offer advantages such as wide availability,environmental friendliness,and low tendency to induce resistance,making them a research hotspot for spider mite control.This review summarizes recent advances in the use of plant-derived active compounds(exemplified by extracts from Veratrum rhizomes),RNA interference(RNAi)technology,and microorganism-derived active substances for controlling spider mites.These bioactive agents exert acaricidal effects by disrupting the nervous system,interfering with metabolic processes,or silencing key genes in mites,demonstrating favorable efficacy and considerable potential for development.However,challenges remain,including poor environmental stability,slow action,high production costs,and insufficient understanding of their effects on non-target organisms.Therefore,future research should focus on the screening and development of novel bioactive substances of biological origin,elucidation of their mechanisms of action,optimization of formulation technologies,and assessment of their ecological safety.These efforts will provide valuable insights for promoting the advancement of bioactive substances and supporting sustainable agricultural development.展开更多
Typically, active control systems either have a priori complete information about the boundary-value problem and damped waves before switching on, or get it during the measurement process or accumulate and update info...Typically, active control systems either have a priori complete information about the boundary-value problem and damped waves before switching on, or get it during the measurement process or accumulate and update information online (identification process in adaptive systems). In this case, the boundary problem is completely imprinted in the information arrays of the control system. However, very often complete information about a boundary-value problem is not available in principle or this info is changing in time faster than the process of its accumulation. The article considers examples of boundary control algorithms based almost without any information. The algorithms presented in the article cannot be obtained within the framework of the harmonic representation of the problem by complex amplitudes. And these algorithms carry out fast control in microstructured boundary problems. It is shown that in some cases it is possible to find simple solutions if we remove restrictions: 1) on the spatio-temporal resolution of controlling elements of a boundary-value problem;2) on the high-frequency radiation of the controlled boundary.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
Presented in this manuscript are conventional electrical engineering tools to model the earth as a rotating electrical machine. Calculations using known parameters of the earth and measured field data has resulted in ...Presented in this manuscript are conventional electrical engineering tools to model the earth as a rotating electrical machine. Calculations using known parameters of the earth and measured field data has resulted in new understanding of the earth’s electrical system and gyroscopic rotation. The material makeup of the inner earth is better understood based on derived permeability and permittivity constants. The planet has been modeled as simple coils and then as a parallel impedance circuit which has led to fundamental insight into planetary speed control and RLC combination for Schumann Resonance of 7.83 Hz. Torque and Voltage Constants and the inverse Speed Constant are calculated using three methods and all compare favorably with Newton’s Gravitational Constant. A helical resonator is referenced and Schumann’s Resonant ideal frequency is calculated and compared with others idealism. A new theory of gravity based on particle velocity selector at the poles is postulated. Two equations are presented as the needed links between Faraday’s electromagnetism and Newtonian physics. Acceleration and Deceleration of earth is explained as a centripetal governor. A new equation for planetary attraction and the attraction of atomic matter is theorized. Rotation of the earth’s electrical coil is explained in terms of the Richardson effect. Electric power transfer from the sun to the planets is proposed via Flux Transfer Events. The impact of this evolving science of electromagnetic modeling of planets will be magnified as the theory is proven, and found to be useful for future generations of engineers and scientists who seek to discover our world and other planets.展开更多
A narrative review of the data provided by Randomised Controlled clinical trials and meta-analyses was undertaken to assess how much reliance a clinician could place on these in selecting a treatment for patients with...A narrative review of the data provided by Randomised Controlled clinical trials and meta-analyses was undertaken to assess how much reliance a clinician could place on these in selecting a treatment for patients with disease of the Femoral artery. An attempt was made to detect and review every clinical trial and meta-analysis published on treatments relating to disease of the femoral artery but not relating to drug treatment. Disease of the femoral artery in >65 years age group occurs in approximately 20% of the population but symptomatology was present in 40%. In almost all trials the predominant (>90%) indication for treatment was intermittent claudication. In this setting, clinical benefit was limited and did not extend beyond 12 months. Mortality, from co-morbidities was high. The Basil Trial was the only one to examine intervention for critical limb ischemia. The results for Bypass surgery and Percutaneous transarterial balloon angioplasty (PTA) were equivalent. There is little evidence to support the use of PTA or stenting other than in the treatment of patients with critical limb ischemia.展开更多
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these...Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.展开更多
In this paper, we propose a H∞ robust observer-based control DC motor based on a photovoltaic pumping system. Maximum power point tracking is achieved via an algorithm using Perturb and Observe method, with array vol...In this paper, we propose a H∞ robust observer-based control DC motor based on a photovoltaic pumping system. Maximum power point tracking is achieved via an algorithm using Perturb and Observe method, with array voltage and current being used to generate the reference voltage which should be the PV panel’s operating voltage to get maximum available power. A Takagi-Sugeno (T-S) observer has been proposed and designed with non-measurable premise variables and the conditions of stability are given in terms of Linear Matrix Inequality (LMI). The simulation results show the effectiveness and robustness of the proposed method.展开更多
Several well-publicized cases of improper cleaning,disinfection or sterilization of contaminated reusable medical equipment that posed an increased risk of patientto-patient disease transmission were reported within t...Several well-publicized cases of improper cleaning,disinfection or sterilization of contaminated reusable medical equipment that posed an increased risk of patientto-patient disease transmission were reported within the past few years,resulting in the notification of approximately 20 000 patients.These medical errors,the specific infection-control standards they breached,and assessments of the risk of infection associated with each are discussed.Other topics discussed include the Food and Drug Administration’s(FDA)regulation of medical devices and infection-control products;the use of adulterated,misbranded,and investigational devices;consent decrees and associated Certificates of Medical Necessity;and informed patient consent.Focus is placed on liquid chemical sterilization,its history,and the FDA’s recent censure and discontinuation of a medical device labeled with this claim,namely,the STERIS System 1 processor.Recommendations are provided for healthcare facilities,regulatory agencies,manufacturers of reusable medical devices,and professional healthcare organizations and administrations to improve public health and prevent healthcareassociated infections.展开更多
Various optimal boundary control problems for linear infinite order distributed hyperbolic systems involving constant time lags are considered. Constraints on controls are imposed. Necessary and sufficient optimality ...Various optimal boundary control problems for linear infinite order distributed hyperbolic systems involving constant time lags are considered. Constraints on controls are imposed. Necessary and sufficient optimality conditions for the Neumann problem with the quadratic performance functional are derived.展开更多
This study highlights the importance of identifying and addressing risk factors associated with wound complications following transtibial amputation in diabetic patients.These amputations,often necessitated by severe ...This study highlights the importance of identifying and addressing risk factors associated with wound complications following transtibial amputation in diabetic patients.These amputations,often necessitated by severe diabetic foot ulcers,carry significant risks of postoperative complications such as infection and delayed wound healing.Elevated hemoglobin A1c levels,indicative of poor glycemic control,and a history of kidney transplantation,due to required immunosuppressive therapy,are key factors influencing these outcomes.This paper emphasizes the need for enhanced glycemic management and personalized postoperative care,particularly for immunocompromised individuals,to minimize complications and improve patient prognosis.Future research should focus on prospective studies to validate targeted interventions and optimize care strategies,ultimately aiming to reduce the healthcare burden associated with diabetic foot complications.展开更多
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.展开更多
The control problem of multiple-flexible-link manipulators( MFLMs) is studied in this paper.The dynamic model of MFLM is derived and separated into two-time scale by utilizing the singular perturbation technique. The ...The control problem of multiple-flexible-link manipulators( MFLMs) is studied in this paper.The dynamic model of MFLM is derived and separated into two-time scale by utilizing the singular perturbation technique. The active disturbance rejection control( ADRC) is adopted to the slow subsystem to track a desired trajectory. The proposed ADRC structure preshapes the desired trajectory by utilizing the tracking differentiator,estimates the disturbance and internal states with an extended state observer,and guarantees a robust performance by combining a feedback controller with a feedforward term. Two types of feedback controllers are designed,proportional derivative( PD) controller and nonlinear PD( NPD) controller. For the fast subsystem,a fast stabilizing control is designed according to the standard linear quadratic regulator approach. Simulations are performed to evaluate the proposed control scheme.Results show that,compared with the traditional PD controller,the ADRC structure based control scheme has smaller overshot and shorter settling time,suppresses vibration quickly,and is robust to the maneuver speed. In general,the control scheme utilizing ADRC structure and NPD feedback controller shows better performance.展开更多
This paper proposes a model-based control framework for vehicle platooning systems with secondorder nonlinear dynamics operating over switching signed networks,time-varying delays,and deception attacks.The study inclu...This paper proposes a model-based control framework for vehicle platooning systems with secondorder nonlinear dynamics operating over switching signed networks,time-varying delays,and deception attacks.The study includes two configurations:a leaderless structure using Finite-Time Non-Singular Terminal Bipartite Consensus(FNTBC)and Fixed-Time Bipartite Consensus(FXTBC),and a leader—follower structure ensuring structural balance and robustness against deceptive signals.In the leaderless model,a bipartite controller based on impulsive control theory,gauge transformation,and Markovian switching Lyapunov functions ensures mean-square stability and coordination under deception attacks and communication delays.The FNTBC achieves finite-time convergence depending on initial conditions,while the FXTBC guarantees fixed-time convergence independent of them,providing adaptability to different operating states.In the leader—follower case,a discontinuous impulsive control law synchronizes all followers with the leader despite deceptive attacks and switching topologies,maintaining robust coordination through nonlinear corrective mechanisms.To validate the approach,simulations are conducted on systems of five and seventeen vehicles in both leaderless and leader—follower configurations.The results demonstrate that the proposed framework achieves rapid consensus,strong robustness,and high resistance to deception attacks,offering a secure and scalable model-based control solution for modern vehicular communication networks.展开更多
Present day power scenarios demand a high quality uninterrupted power supply and needs environmental issues to be addressed. Both concerns can be dealt with by the introduction of the renewable sources to the existing...Present day power scenarios demand a high quality uninterrupted power supply and needs environmental issues to be addressed. Both concerns can be dealt with by the introduction of the renewable sources to the existing power system. Thus, automatic generation control(AGC) with diverse renewable sources and a modified-cascaded controller are presented in the paper.Also, a new hybrid scheme of the improved teaching learning based optimization-differential evolution(hITLBO-DE) algorithm is applied for providing optimization of controller parameters. A study of the system with a technique such as TLBO applied to a proportional integral derivative(PID), integral double derivative(IDD) and PIDD is compared to hITLBO-DE tuned cascaded controller with dynamic load change.The suggested methodology has been extensively applied to a 2-area system with a diverse source power system with various operation time non-linearities such as dead-band of, generation rate constraint and reheat thermal units. The multi-area system with reheat thermal plants, hydel plants and a unit of a wind-diesel combination is tested with the cascaded controller scheme with a different controller setting for each area. The variation of the load is taken within 1% to 5% of the connected load and robustness analysis is shown by modifying essential factors simultaneously by± 30%. Finally, the proposed scheme of controller and optimization technique is also tested with a 5-equal area thermal system with non-linearities. The simulation results demonstrate the superiority of the proposed controller and algorithm under a dynamically changing load.展开更多
Wind turbine technology is well known around the globe as an eco-friendly and eff ective renewable power source. However, this technology often faces reliability problems due to structural vibration. This study propos...Wind turbine technology is well known around the globe as an eco-friendly and eff ective renewable power source. However, this technology often faces reliability problems due to structural vibration. This study proposes a smart semi-active vibration control system using Magnetorheological (MR) dampers where feedback controllers are optimized with nature-inspired algorithms. Proportional integral derivative (PID) and Proportional integral (PI) controllers are designed to achieve the optimal desired force and current input for MR the damper. PID control parameters are optimized using an Ant colony optimization (ACO) algorithm. The eff ectiveness of the ACO algorithm is validated by comparing its performance with Ziegler-Nichols (Z-N) and particle swarm optimization (PSO). The placement of the MR damper on the tower is also investigated to ensure structural balance and optimal desired force from the MR damper. The simulation results show that the proposed semi-active PID-ACO control strategy can signifi cantly reduce vibration on the wind turbine tower under diff erent frequencies (i.e., 67%, 73%, 79% and 34.4% at 2 Hz, 3 Hz, 4.6 Hz and 6 Hz, respectively) and amplitudes (i.e. 50%, 58% and 67% for 50 N, 80 N, and 100 N, respectively). In this study, the simulation model is validated with an experimental study in terms of natural frequency, mode shape and uncontrolled response at the 1st mode. The proposed PID-ACO control strategy and optimal MR damper position is also implemented on a lab-scaled wind turbine tower model. The results show that the vibration reduction rate is 66% and 73% in the experimental and simulation study, respectively, at the 1st mode.展开更多
Maximizing the power capture is an important issue to the turbines that are installed in low wind speed area. In this paper, we focused on the modeling and control of variable speed wind turbine that is composed of tw...Maximizing the power capture is an important issue to the turbines that are installed in low wind speed area. In this paper, we focused on the modeling and control of variable speed wind turbine that is composed of two-mass drive train, a Squirrel Cage Induction Generator (SCIG), and voltage source converter control by Space Vector Pulse Width Modulation (SPVWM). To achieve Maximum Power Point Tracking (MPPT), the reference speed to the generator is searched via Extremum Seeking Control (ESC). ESC was designed for wind turbine region II operation based on dither-modulation scheme. ESC is a model-free method that has the ability to increase the captured power in real time under turbulent wind without any requirement for wind measurements. The controller is designed in two loops. In the outer loop, ESC is used to set a desired reference speed to PI controller to regulate the speed of the generator and extract the maximum electrical power. The inner control loop is based on Indirect Field Orientation Control (IFOC) to decouple the currents. Finally, Particle Swarm Optimization (PSO) is used to obtain the optimal PI parameters. Simulation and control of the system have been accomplished using MATLAB/Simulink 2014.展开更多
文摘A big step forward to improve power system monitoring and performance, continued load growth without a corresponding increase in transmission resources has resulted in reduced operational margins for many power systems worldwide and has led to operation of power systems closer to their stability limits and to power exchange in new patterns. These issues, as well as the on-going worldwide trend towards deregulation of the entire industry on the one hand and the increased need for accurate and better network monitoring on the other hand, force power utilities exposed to this pressure to demand new solutions for wide area monitoring, protection and control. Wide-area monitoring, protection, and control require communicating the specific-node information to a remote station but all information should be time synchronized so that to neutralize the time difference between information. It gives a complete simultaneous snap shot of the power system. The conventional system is not able to satisfy the time-synchronized requirement of power system. Phasor Measurement Unit (PMU) is enabler of time-synchronized measurement, it communicate the synchronized local information to remote station.
文摘The aim of this work is mathematical education through the knowledge system and mathematical modeling. A net model of formation of mathematical knowledge as a deductive theory is suggested here. Within this model the formation of deductive theory is represented as the development of a certain informational space, the elements of which are structured in the form of the orientated semantic net. This net is properly metrized and characterized by a certain system of coverings. It allows injecting net optimization parameters, regulating qualitative aspects of knowledge system under consideration. To regulate the creative processes of the formation and realization of mathematical know- edge, stochastic model of formation deductive theory is suggested here in the form of branching Markovian process, which is realized in the corresponding informational space as a semantic net. According to this stochastic model we can get correct foundation of criterion of optimization creative processes that leads to “great main points” strategy (GMP-strategy) in the process of realization of the effective control in the research work in the sphere of mathematics and its applications.
文摘This paper presents a closed-loop vector control structure based on adaptive Fuzzy Logic Sliding Mode Controller (FL-SMC) for a grid-connected Wave Energy Conversion System (WECS) driven Self-Excited Induction Generator (SEIG). The aim of the developed control method is to automatically tune and optimize the scaling factors and the membership functions of the Fuzzy Logic Controllers (FLC) using Multi-Objective Genetic Algorithms (MOGA) and Multi-Objective Particle Swarm Optimization (MOPSO). Two Pulse Width Modulated voltage source PWM converters with a carrier-based Sinusoidal PWM modulation for both Generator- and Grid-side converters have been connected back to back between the generator terminals and utility grid via common DC link. The indirect vector control scheme is implemented to maintain balance between generated power and power supplied to the grid and maintain the terminal voltage of the generator and the DC bus voltage constant for variable rotor speed and load. Simulation study has been carried out using the MATLAB/Simulink environment to verify the robustness of the power electronics converters and the effectiveness of proposed control method under steady state and transient conditions and also machine parameters mismatches. The proposed control scheme has improved the voltage regulation and the transient performance of the wave energy scheme over a wide range of operating conditions.
文摘Spider mites are significant pests in agricultural production.The increasing resistance of spider mites,along with environmental pollution and ecological imbalance caused by their control,is primarily attributed to the long-term use of chemical acaricides in agriculture.In contrast,bioactive substances of biological origin offer advantages such as wide availability,environmental friendliness,and low tendency to induce resistance,making them a research hotspot for spider mite control.This review summarizes recent advances in the use of plant-derived active compounds(exemplified by extracts from Veratrum rhizomes),RNA interference(RNAi)technology,and microorganism-derived active substances for controlling spider mites.These bioactive agents exert acaricidal effects by disrupting the nervous system,interfering with metabolic processes,or silencing key genes in mites,demonstrating favorable efficacy and considerable potential for development.However,challenges remain,including poor environmental stability,slow action,high production costs,and insufficient understanding of their effects on non-target organisms.Therefore,future research should focus on the screening and development of novel bioactive substances of biological origin,elucidation of their mechanisms of action,optimization of formulation technologies,and assessment of their ecological safety.These efforts will provide valuable insights for promoting the advancement of bioactive substances and supporting sustainable agricultural development.
文摘Typically, active control systems either have a priori complete information about the boundary-value problem and damped waves before switching on, or get it during the measurement process or accumulate and update information online (identification process in adaptive systems). In this case, the boundary problem is completely imprinted in the information arrays of the control system. However, very often complete information about a boundary-value problem is not available in principle or this info is changing in time faster than the process of its accumulation. The article considers examples of boundary control algorithms based almost without any information. The algorithms presented in the article cannot be obtained within the framework of the harmonic representation of the problem by complex amplitudes. And these algorithms carry out fast control in microstructured boundary problems. It is shown that in some cases it is possible to find simple solutions if we remove restrictions: 1) on the spatio-temporal resolution of controlling elements of a boundary-value problem;2) on the high-frequency radiation of the controlled boundary.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.
文摘Presented in this manuscript are conventional electrical engineering tools to model the earth as a rotating electrical machine. Calculations using known parameters of the earth and measured field data has resulted in new understanding of the earth’s electrical system and gyroscopic rotation. The material makeup of the inner earth is better understood based on derived permeability and permittivity constants. The planet has been modeled as simple coils and then as a parallel impedance circuit which has led to fundamental insight into planetary speed control and RLC combination for Schumann Resonance of 7.83 Hz. Torque and Voltage Constants and the inverse Speed Constant are calculated using three methods and all compare favorably with Newton’s Gravitational Constant. A helical resonator is referenced and Schumann’s Resonant ideal frequency is calculated and compared with others idealism. A new theory of gravity based on particle velocity selector at the poles is postulated. Two equations are presented as the needed links between Faraday’s electromagnetism and Newtonian physics. Acceleration and Deceleration of earth is explained as a centripetal governor. A new equation for planetary attraction and the attraction of atomic matter is theorized. Rotation of the earth’s electrical coil is explained in terms of the Richardson effect. Electric power transfer from the sun to the planets is proposed via Flux Transfer Events. The impact of this evolving science of electromagnetic modeling of planets will be magnified as the theory is proven, and found to be useful for future generations of engineers and scientists who seek to discover our world and other planets.
文摘A narrative review of the data provided by Randomised Controlled clinical trials and meta-analyses was undertaken to assess how much reliance a clinician could place on these in selecting a treatment for patients with disease of the Femoral artery. An attempt was made to detect and review every clinical trial and meta-analysis published on treatments relating to disease of the femoral artery but not relating to drug treatment. Disease of the femoral artery in >65 years age group occurs in approximately 20% of the population but symptomatology was present in 40%. In almost all trials the predominant (>90%) indication for treatment was intermittent claudication. In this setting, clinical benefit was limited and did not extend beyond 12 months. Mortality, from co-morbidities was high. The Basil Trial was the only one to examine intervention for critical limb ischemia. The results for Bypass surgery and Percutaneous transarterial balloon angioplasty (PTA) were equivalent. There is little evidence to support the use of PTA or stenting other than in the treatment of patients with critical limb ischemia.
基金supported by the Fundamental Research Funds for Central Public Welfare Research Institute,No.2020CZ-5(to WS and GS)the National Natural Science Foundation of China,No.31970970(to JSR)Fundamental Research Funds for the Central Universities,No.YWF-23-YG-QB-010(to JSR)。
文摘Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
文摘In this paper, we propose a H∞ robust observer-based control DC motor based on a photovoltaic pumping system. Maximum power point tracking is achieved via an algorithm using Perturb and Observe method, with array voltage and current being used to generate the reference voltage which should be the PV panel’s operating voltage to get maximum available power. A Takagi-Sugeno (T-S) observer has been proposed and designed with non-measurable premise variables and the conditions of stability are given in terms of Linear Matrix Inequality (LMI). The simulation results show the effectiveness and robustness of the proposed method.
文摘Several well-publicized cases of improper cleaning,disinfection or sterilization of contaminated reusable medical equipment that posed an increased risk of patientto-patient disease transmission were reported within the past few years,resulting in the notification of approximately 20 000 patients.These medical errors,the specific infection-control standards they breached,and assessments of the risk of infection associated with each are discussed.Other topics discussed include the Food and Drug Administration’s(FDA)regulation of medical devices and infection-control products;the use of adulterated,misbranded,and investigational devices;consent decrees and associated Certificates of Medical Necessity;and informed patient consent.Focus is placed on liquid chemical sterilization,its history,and the FDA’s recent censure and discontinuation of a medical device labeled with this claim,namely,the STERIS System 1 processor.Recommendations are provided for healthcare facilities,regulatory agencies,manufacturers of reusable medical devices,and professional healthcare organizations and administrations to improve public health and prevent healthcareassociated infections.
文摘Various optimal boundary control problems for linear infinite order distributed hyperbolic systems involving constant time lags are considered. Constraints on controls are imposed. Necessary and sufficient optimality conditions for the Neumann problem with the quadratic performance functional are derived.
基金Supported by Henan Province Key Research and Development Program,No.231111311000Henan Provincial Science and Technology Research Project,No.232102310411+2 种基金Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365Henan Province Medical Education Research Project,No.WJLX2023079Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.
文摘This study highlights the importance of identifying and addressing risk factors associated with wound complications following transtibial amputation in diabetic patients.These amputations,often necessitated by severe diabetic foot ulcers,carry significant risks of postoperative complications such as infection and delayed wound healing.Elevated hemoglobin A1c levels,indicative of poor glycemic control,and a history of kidney transplantation,due to required immunosuppressive therapy,are key factors influencing these outcomes.This paper emphasizes the need for enhanced glycemic management and personalized postoperative care,particularly for immunocompromised individuals,to minimize complications and improve patient prognosis.Future research should focus on prospective studies to validate targeted interventions and optimize care strategies,ultimately aiming to reduce the healthcare burden associated with diabetic foot complications.
基金supported by the National Natural Science Foundation of China(8210082163,81800343)the Fundamental Research Fund for the Central Universities(2042021kf0081)+1 种基金the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027)the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
文摘Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.
基金Sponsored by the China Postdoctoral Science Foundation(Grant No.2014M560255)the Open Research Fund of the State Key Laboratory of Robotics and System(HIT)(Grant No.SKLRS-2013-ZD-05)+1 种基金the Heilongjiang Postdoctoral Found(Grant No.LBH-Z14107)the Special Foundation of Heilongjiang Postdoctoral Science(Grant No.LBH-TZ1609)
文摘The control problem of multiple-flexible-link manipulators( MFLMs) is studied in this paper.The dynamic model of MFLM is derived and separated into two-time scale by utilizing the singular perturbation technique. The active disturbance rejection control( ADRC) is adopted to the slow subsystem to track a desired trajectory. The proposed ADRC structure preshapes the desired trajectory by utilizing the tracking differentiator,estimates the disturbance and internal states with an extended state observer,and guarantees a robust performance by combining a feedback controller with a feedforward term. Two types of feedback controllers are designed,proportional derivative( PD) controller and nonlinear PD( NPD) controller. For the fast subsystem,a fast stabilizing control is designed according to the standard linear quadratic regulator approach. Simulations are performed to evaluate the proposed control scheme.Results show that,compared with the traditional PD controller,the ADRC structure based control scheme has smaller overshot and shorter settling time,suppresses vibration quickly,and is robust to the maneuver speed. In general,the control scheme utilizing ADRC structure and NPD feedback controller shows better performance.
基金Deanship of Research and Graduate Studies at King Khalid University for funding this work through Large Research Project under grant number RGP.2/103/46”Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia for funding this research work through project number“NBU-FFR-2025-871-15”funding from Prince Sattam bin Abdulaziz University project number(PSAU/2025/R/1447).
文摘This paper proposes a model-based control framework for vehicle platooning systems with secondorder nonlinear dynamics operating over switching signed networks,time-varying delays,and deception attacks.The study includes two configurations:a leaderless structure using Finite-Time Non-Singular Terminal Bipartite Consensus(FNTBC)and Fixed-Time Bipartite Consensus(FXTBC),and a leader—follower structure ensuring structural balance and robustness against deceptive signals.In the leaderless model,a bipartite controller based on impulsive control theory,gauge transformation,and Markovian switching Lyapunov functions ensures mean-square stability and coordination under deception attacks and communication delays.The FNTBC achieves finite-time convergence depending on initial conditions,while the FXTBC guarantees fixed-time convergence independent of them,providing adaptability to different operating states.In the leader—follower case,a discontinuous impulsive control law synchronizes all followers with the leader despite deceptive attacks and switching topologies,maintaining robust coordination through nonlinear corrective mechanisms.To validate the approach,simulations are conducted on systems of five and seventeen vehicles in both leaderless and leader—follower configurations.The results demonstrate that the proposed framework achieves rapid consensus,strong robustness,and high resistance to deception attacks,offering a secure and scalable model-based control solution for modern vehicular communication networks.
文摘Present day power scenarios demand a high quality uninterrupted power supply and needs environmental issues to be addressed. Both concerns can be dealt with by the introduction of the renewable sources to the existing power system. Thus, automatic generation control(AGC) with diverse renewable sources and a modified-cascaded controller are presented in the paper.Also, a new hybrid scheme of the improved teaching learning based optimization-differential evolution(hITLBO-DE) algorithm is applied for providing optimization of controller parameters. A study of the system with a technique such as TLBO applied to a proportional integral derivative(PID), integral double derivative(IDD) and PIDD is compared to hITLBO-DE tuned cascaded controller with dynamic load change.The suggested methodology has been extensively applied to a 2-area system with a diverse source power system with various operation time non-linearities such as dead-band of, generation rate constraint and reheat thermal units. The multi-area system with reheat thermal plants, hydel plants and a unit of a wind-diesel combination is tested with the cascaded controller scheme with a different controller setting for each area. The variation of the load is taken within 1% to 5% of the connected load and robustness analysis is shown by modifying essential factors simultaneously by± 30%. Finally, the proposed scheme of controller and optimization technique is also tested with a 5-equal area thermal system with non-linearities. The simulation results demonstrate the superiority of the proposed controller and algorithm under a dynamically changing load.
基金University of Malaya Research under Grant No.RP013B-15SUS,Postgraduate Research Fund(PG098-2015A)
文摘Wind turbine technology is well known around the globe as an eco-friendly and eff ective renewable power source. However, this technology often faces reliability problems due to structural vibration. This study proposes a smart semi-active vibration control system using Magnetorheological (MR) dampers where feedback controllers are optimized with nature-inspired algorithms. Proportional integral derivative (PID) and Proportional integral (PI) controllers are designed to achieve the optimal desired force and current input for MR the damper. PID control parameters are optimized using an Ant colony optimization (ACO) algorithm. The eff ectiveness of the ACO algorithm is validated by comparing its performance with Ziegler-Nichols (Z-N) and particle swarm optimization (PSO). The placement of the MR damper on the tower is also investigated to ensure structural balance and optimal desired force from the MR damper. The simulation results show that the proposed semi-active PID-ACO control strategy can signifi cantly reduce vibration on the wind turbine tower under diff erent frequencies (i.e., 67%, 73%, 79% and 34.4% at 2 Hz, 3 Hz, 4.6 Hz and 6 Hz, respectively) and amplitudes (i.e. 50%, 58% and 67% for 50 N, 80 N, and 100 N, respectively). In this study, the simulation model is validated with an experimental study in terms of natural frequency, mode shape and uncontrolled response at the 1st mode. The proposed PID-ACO control strategy and optimal MR damper position is also implemented on a lab-scaled wind turbine tower model. The results show that the vibration reduction rate is 66% and 73% in the experimental and simulation study, respectively, at the 1st mode.
文摘Maximizing the power capture is an important issue to the turbines that are installed in low wind speed area. In this paper, we focused on the modeling and control of variable speed wind turbine that is composed of two-mass drive train, a Squirrel Cage Induction Generator (SCIG), and voltage source converter control by Space Vector Pulse Width Modulation (SPVWM). To achieve Maximum Power Point Tracking (MPPT), the reference speed to the generator is searched via Extremum Seeking Control (ESC). ESC was designed for wind turbine region II operation based on dither-modulation scheme. ESC is a model-free method that has the ability to increase the captured power in real time under turbulent wind without any requirement for wind measurements. The controller is designed in two loops. In the outer loop, ESC is used to set a desired reference speed to PI controller to regulate the speed of the generator and extract the maximum electrical power. The inner control loop is based on Indirect Field Orientation Control (IFOC) to decouple the currents. Finally, Particle Swarm Optimization (PSO) is used to obtain the optimal PI parameters. Simulation and control of the system have been accomplished using MATLAB/Simulink 2014.
