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TWEAK、KIM-1及RPR与系统性红斑狼疮患儿疾病活动程度、肾损伤的相关性分析
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作者 赵申 李俊杰 《中国免疫学杂志》 北大核心 2025年第3期675-679,共5页
目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另... 目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另收集同期40例健康体检新生儿作为对照组;将SLE患儿根据系统性红斑狼疮疾病活动指数(SLEDAI)评分分为(≤9分)24例和高疾病活动度组(>9分)18例,根据是否伴有肾脏损害分为LN组31例和非LN组11例。检测所有受试对象红细胞分布宽度(RDW)和血小板计数(PLT),并计算RPR;ELISA法检测血清TWEAK、KIM-1水平。结果:SLE组血清TWEAK、KIM-1及RPR水平均显著高于对照组(P<0.05);高疾病活动度组SLE患儿血清TWEAK、KIM-1及RPR水平均显著高于低疾病活动度组(P<0.05);LN组患儿血清TWEAK、KIM-1及RPR水平均显著高于非LN组(P<0.05)。相关性分析显示,RPR与SLEDAI评分呈显著正相关(P<0.05),TWEAK、KIM-1与24 h尿蛋白呈显著正相关(P<0.05)。RPR评估SLE高疾病活动度的AUC为0.744(95%CI 0.657~0.818),显著大于TWEAK、KIM-1评估的AUC分别为0.678(95%CI:0.588~0.760)和0.598(95%CI:0.505~0.686,P<0.05);TWEAK和KIM-1预测LN的AUC分别为0.847(95%CI:0.773~0.905)和0.773(95%CI:0.690~0.842),显著大于RPR预测的AUC为0.645(95%CI:0.555~0.727,P<0.05)。结论:SLE患儿存在TWEAK、KIM-1及RPR水平变化,其中RPR对SLE疾病活动度具有较高的诊断效能,而TWEAK和KIM-1对LN预测价值较高。 展开更多
关键词 系统性红斑狼疮 肿瘤坏死因素样凋亡微弱诱导剂 肾损伤因子1 红细胞分布宽度/血小板比值 疾病活动度 狼疮性肾炎
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ICU-acquired weakness in critically ill patients at risk of malnutrition: risk factors, biomarkers, and early enteral nutrition impact 被引量:3
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作者 Qingliu Zheng Changyun Liu +4 位作者 Lingying Le Qiqi Wu Zhihong Xu Jiyan Lin Qiuyun Chen 《World Journal of Emergency Medicine》 2025年第1期51-56,共6页
BACKGROUND: This study aimed to explore the risk factors associated with intensive care unitacquired weakness(ICU-AW) in critically ill patients at risk of malnutrition and to evaluate the efficacy of early enteral nu... BACKGROUND: This study aimed to explore the risk factors associated with intensive care unitacquired weakness(ICU-AW) in critically ill patients at risk of malnutrition and to evaluate the efficacy of early enteral nutrition(EEN) and the role of biomarkers in managing ICU-AW.METHODS: This retrospective, observational cohort study included 180 patients at risk of malnutrition admitted to the emergency intensive care unit of the First Affiliated Hospital of Xiamen University Hospital from January 2022 to December 2023. Patients were divided into ICU-AW group and non-ICU-AW group according to whether they developed ICU-AW, or categorized into EEN and parenteral nutrition(PN) groups according to nutritional support. ICU-AW was diagnosed using the Medical Research Council score. The primary outcome was the occurrence of ICU-AW.RESULTS: The significant factors associated with ICU-AW included age, sex, type of nutritional therapy, mechanical ventilation(MV), body mass index(BMI), blood urea nitrogen(BUN), and creatinine(Cr) levels(P<0.05). The PN group developed ICU-AW earlier than did the EEN group, with a significant difference observed(log-rank P<0.001). Among biomarkers for ICU-AW, the mean prealbumin(PAB)/C-reactive protein(CRP) ratio had the highest diagnostic accuracy(area under the curve [AUC] 0.928, 95% confidence interval [95% CI] 0.892–0.946), surpassing the mean Cr/BUN ratio(AUC 0.740, 95% CI 0.663–0.819) and mean transferrin levels(AUC 0.653, 95% CI 0.574–0.733).CONCLUSION: Independent risk factors for ICU-AW include female sex, advanced age, PN, MV, lower BMI, and elevated BUN and Cr levels. EEN may potentially delay ICU-AW onset, and the PAB/CRP ratio may be an effective diagnostic marker for this condition. 展开更多
关键词 Intensive care units Muscular weakness Hospital-acquired condition Enteral nutrition Biomarkers Risk factors
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Spatiotemporal characteristics and influencing factors of vegetation water use efficiency on the Tibetan Plateau in 2001-2020 被引量:2
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作者 HE Chenyang WANG Yanjiao +1 位作者 YAN Feng LU Qi 《Journal of Geographical Sciences》 2025年第1期39-64,共26页
Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosyste... Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosystems.However,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain unclear.This study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–2020.Results indicated an annual mean WUE of 0.8088 gC/mm·m^(2)across the plateau,with a spatial gradient reflecting decrease from the southeast toward the northwest.Areas manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,respectively.Remarkably,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of increase.Environmental factors accounted for 70.79%of the variability in WUE.The leaf area index and temperature served as the major driving forces of WUE variation. 展开更多
关键词 water use efficiency spatiotemporal characteristic influencing factor Tibetan Plateau
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A parameter-variant trochoidal-like tool path planning method for chatter-free and high-efficiency milling 被引量:1
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作者 Zhaoliang LI Jinbo NIU +1 位作者 Shuoxue SUN Yuwen SUN 《Chinese Journal of Aeronautics》 2025年第2期559-576,共18页
Trochoidal milling is known for its advantages in machining difficult-to-machine materials as it facilitates chip removal and tool cooling.However,the conventional trochoidal tool path presents challenges such as lowe... Trochoidal milling is known for its advantages in machining difficult-to-machine materials as it facilitates chip removal and tool cooling.However,the conventional trochoidal tool path presents challenges such as lower machining efficiency and longer machining time due to its time-varying cutter-workpiece engagement angle and a high percentage of non-cutting tool paths.To address these issues,this paper introduces a parameter-variant trochoidal-like(PVTR)tool path planning method for chatter-free and high-efficiency milling.This method ensures a constant engagement angle for each tool path period by adjusting the trochoidal radius and step.Initially,the nonlinear equation for the PVTR toolpath is established.Then,a segmented recurrence method is proposed to plan tool paths based on the desired engagement angle.The impact of trochoidal tool path parameters on the engagement angle is analyzed and coupled this information with the milling stability model based on spindle speed and engagement angle to determine the desired engagement angle throughout the machining process.Finally,several experimental tests are carried out using the bull-nose end mill to validate the feasibility and effectiveness of the proposed method. 展开更多
关键词 Trochoidal milling Milling stability Tool path planning Machining efficiency Bull-nose end mill
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Phase-change heterostructure with HfTe_(2)confinement sublayers for enhanced thermal efficiency and low-power operation through Joule heating localization 被引量:1
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作者 S.W.Park H.J.Lee +6 位作者 K.A.Nirmal T.H.Kim D.H.Kim J.Y.Choi J.S.Oh J.M.Joo T.G.Kim 《Journal of Materials Science & Technology》 2025年第1期104-114,共11页
Although phase-change random-access memory(PCRAM)is a promising next-generation nonvolatile memory technology,challenges remain in terms of reducing energy consumption.This is primarily be-cause the high thermal condu... Although phase-change random-access memory(PCRAM)is a promising next-generation nonvolatile memory technology,challenges remain in terms of reducing energy consumption.This is primarily be-cause the high thermal conductivities of phase-change materials(PCMs)promote Joule heating dissi-pation.Repeated phase transitions also induce long-range atomic diffusion,limiting the durability.To address these challenges,phase-change heterostructure(PCH)devices that incorporate confinement sub-layers based on transition-metal dichalcogenide materials have been developed.In this study,we engi-neered a PCH device by integrating HfTe_(2),which has low thermal conductivity and excellent stability,into the PCM to realize PCRAM with enhanced thermal efficiency and structural stability.HEAT sim-ulations were conducted to validate the superior heat confinement in the programming region of the HfTe_(2)-based PCH device.Moreover,electrical measurements of the device demonstrated its outstanding performance,which was characterized by a low RESET current(∼1.6 mA),stable two-order ON/OFF ratio,and exceptional cycling endurance(∼2×10^(7)).The structural integrity of the HfTe_(2)confinement sub-layer was confirmed using X-ray photoelectron spectroscopy and transmission electron microscopy.The material properties,including electrical conductivity,cohesive energy,and electronegativity,substantiated these findings.Collectively,these results revealed that the HfTe_(2)-based PCH device can achieve significant improvements in performance and reliability compared with conventional PCRAM devices. 展开更多
关键词 Phase-change random-access memory Phase-change heterostructure Thermal efficiency Thermal stability Low-power operation
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Application of a low-cost and high-efficiency polymer non-catalytic reduction technology for NO_(x) removal in waste-to-energy plant 被引量:1
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作者 Shuai Xiao Congbo Li +4 位作者 Xueyan Zheng Liya Li Jingzhong Si Xiuqi Shu Xianqiong Zeng 《Journal of Environmental Sciences》 2025年第12期112-125,共14页
Ultra-low emission of nitrogen oxide(NO_(x))is an irreversible trend for the development of waste-to-energy industry.But traditional approaches to remove NO_(x) face significant challenge s,such as low denitration eff... Ultra-low emission of nitrogen oxide(NO_(x))is an irreversible trend for the development of waste-to-energy industry.But traditional approaches to remove NO_(x) face significant challenge s,such as low denitration efficiency,complex denitration system,and high investment and operating cost.Here we put forward a novel polymer non-catalytic reduction(PNCR)technology that utilized a new type of polymer agent to remove NO_(x),and the proposed PNCR technology was applied to the existing waste-to-energy plant to test the denitration performance.The PNCR technology demonstrated excellent denitration performance with a NO_(x) emission concentration of<100 mg/Nm^(3) and high denitration efficiency of>75%at the temperature range of 800-900℃,which showed the application feasibility even on the complex and unstable industrial operating conditions.In addition,PNCR and hybrid polymer/selective non-catalytic reduction(PNCR/SNCR)technology possessed remarkable economic advantages including low investment fee and low operating cost of<10 CNY per ton of municipal solid waste(MSW)compared with selective catalytic reduction(SCR)technology.The excellent denitration performance of PNCR technology forebodes a broad industrial application prospect in the field of flue gas cleaning for waste-to-energy plants. 展开更多
关键词 Polymer non-catalytic reduction High denitration efficiency Low operating cost Waste-to-energy plant
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Dual‑Donor‑Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells
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作者 Anhai Liang Yuqing Sun +9 位作者 Sein Chung Jiyeong Shin Kangbo Sun Chaofeng Zhu Jingjing Zhao Zhenmin Zhao Yufei Zhong Guangye Zhang Kilwon Cho Zhipeng Kan 《Nano-Micro Letters》 SCIE EI CAS 2025年第3期376-388,共13页
Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains challengin... Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains challenging.Herein, wide bandgap polymer donor PTzBI-dF is demonstrated as an effectivemodulator for enhancing the crystallinity of the bulk heterojunction active layerscomposed of D18 derivatives blended with Y6, leading to dense and orderedmolecular packings, and thus, improves photoluminescence quenching properties.As a result, the photovoltaic devices exhibit reduced trap-assisted charge recombinationlosses, achieving an optimized power conversion efficiency of over 19%.Besides the efficiency enhancement, the devices comprised of PTzBI-dF as athird component simultaneously attain decreased current leakage, improved chargecarrier mobilities, and suppressed bimolecular charge recombination, leading toreduced energy losses. The advanced crystalline structures induced by PTzBI-dFand its characteristics, such as well-aligned energy level, and complementaryabsorption spectra, are ascribed to the promising performance improvements.Our findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providingguidelines for designing effective morphology modulators for high-performance organic solar cells. 展开更多
关键词 Trap-assisted charge recombination PHOTOLUMINESCENCE MISCIBILITY Current leakage Power conversion efficiency
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Split nitrogen application increases maize root growth,yield,and nitrogen use efficiency under soil warming conditions 被引量:2
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作者 Zhenqing Xia Yuxiang Gong +3 位作者 Xiangyue Lyu Junchen Lin Yi Yang Haidong Lu 《The Crop Journal》 2025年第2期565-575,共11页
The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use e... The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress. 展开更多
关键词 Maize(Zea mays L.) Soil warming Split nitrogen application Root growth Nitrogen use efficiency Grain yield
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An improved high efficiency low error substrate integrated waveguide wideband delay line
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作者 ZHANG Hongxi WANG Pei 《中国科学院大学学报(中英文)》 北大核心 2025年第5期677-685,共9页
In this paper,a wideband true time delay line for X-band is designed to overcome the beam dispersion problem in a high-resolution spaceborne synthetic aperture radar phased array antenna system.The delay line loads th... In this paper,a wideband true time delay line for X-band is designed to overcome the beam dispersion problem in a high-resolution spaceborne synthetic aperture radar phased array antenna system.The delay line loads the electromagnetic bandgap structure on the upper surface of the substrate integrated waveguide.This is equivalent to including an additional inductance-capacitance for energy storage,which realizes the slow-wave effect.A microstrip line-SIW tapered transition structure is introduced to achieve a low loss and a large bandwidth.In the frequency band between 8-12 GHz,the measured results show that the delay multiplier of the delay line reaches 4 times,i.e.,delay line’s delay time is 4 times larger than 50Ωmicrostrip line with same length.Furthermore,the delay fluctuation,i.e.,the difference between the maximum and minimum delay as a percentage of the standard delay is only 2.5%,the insertion loss is less than-2.5 dB,and the return loss is less than-15 dB.Compared with the existing delay lines,the proposed delay line has the advantages of high delay efficiency,low delay error,wide bandwidth and low loss,which has good practical value and application prospects. 展开更多
关键词 SIW EBG low error high efficiency WIDEBAND
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胃癌根治术病人术前血清sTWEAK、YKL-40水平对预后的影响 被引量:1
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作者 孙东跃 王旭青 《安徽医药》 2025年第4期729-732,共4页
目的探讨胃癌根治术病人术前血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、甲壳质酶蛋白40(YKL-40)表达水平及其对预后的影响。方法选取2017年10月至2019年12月在江苏大学附属医院接受诊治的122例胃癌根治术病人,并收集所有病人临... 目的探讨胃癌根治术病人术前血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、甲壳质酶蛋白40(YKL-40)表达水平及其对预后的影响。方法选取2017年10月至2019年12月在江苏大学附属医院接受诊治的122例胃癌根治术病人,并收集所有病人临床资料。采用酶联免疫吸附分析(ELISA)对胃癌根治术病人术前、术后血清sTWEAK、YKL-40水平进行检测;术后随访3年,根据术后生存状况分为预后良好组(n=70)和预后不良组(n=52)。比较各组间血清sTWEAK、YKL-40水平与基本资料;Cox回归分析胃癌根治术预后影响因素;受试者操作特征曲线(ROC曲线)分析sTWEAK、YKL-40对胃癌根治术预后的预测价值。结果胃癌根治术前病人血清sTWEAK(258.47±60.27)ng/L、YKL-40(106.41±30.47)μg/L水平显著高于术后(200.01±41.33)ng/L、(55.16±6.79)μg/L(P<0.05);与预后良好组相比,预后不良组术前血清sTWEAK、YKL-40水平显著升高(P<0.05);预后良好组与预后不良组在TNM分期、组织学类型上差异有统计学意义(P<0.05);TNM分期、组织学类型、sTWEAK、YKL-40为胃癌根治术预后的独立危险因素(P<0.05);ROC曲线结果显示术前sTWEAK、YKL-40单独评估胃癌根治术病人预后的AUC分别为0.74、0.74,灵敏度分别为64.0%、80.0%,特异度分别为36.2%、36.9%,两者联合评估的AUC为0.86,灵敏度、特异度分别为80.0%、60.6%。结论胃癌根治术后病人血清sTWEAK、YKL-40水平均显著降低,且术前血清sTWEAK、YKL-40是影响胃癌根治术病人预后的重要因素,因此sTWEAK、YKL-40在胃癌根治术病人血清中的表达水平可预测病人生存状况。 展开更多
关键词 胃肿瘤 胃切除术 肿瘤坏死因子样弱凋亡诱导物 甲壳质酶蛋白40(YKL-40) 预后
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Energy Efficiency Operating Indicator Forecasting and Speed Design Optimization for Polar Ice Class Merchant Vessels
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作者 LU Yu LI Chen−ran +3 位作者 ZHU Xiang−hang LI Shi−an GU Zhu−hao LIU She−wen 《船舶力学》 北大核心 2025年第6期901-911,共11页
In order to accurately forecast the main engine fuel consumption and reduce the Energy Efficiency Operational Indicator(EEOI)of merchant ships in polar ice areas,the energy transfer relationship between ship-machine-p... In order to accurately forecast the main engine fuel consumption and reduce the Energy Efficiency Operational Indicator(EEOI)of merchant ships in polar ice areas,the energy transfer relationship between ship-machine-propeller is studied by analyzing the complex force situation during ship navigation and building a MATLAB/Simulink simulation platform based on multi-environmental resistance,propeller efficiency,main engine power,fuel consumption,fuel consumption rate and EEOI calculation module.Considering the environmental factors of wind,wave and ice,the route is divided into sections,the calculation of main engine power,main engine fuel consumption and EEOI for each section is completed,and the speed design is optimized based on the simulation model for each section.Under the requirements of the voyage plan,the optimization results show that the energy efficiency operation index of the whole route is reduced by 3.114%and the fuel consumption is reduced by 9.17 t. 展开更多
关键词 Energy efficiency Operational Indicator ice-class ships segment division design optimization
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Improving Provider Efficiency at the Local Level
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作者 Ronald Lagoe Shelly Littau 《Case Reports in Clinical Medicine》 2025年第1期1-9,共9页
This study reviewed developments in provider utilization related to health care in the metropolitan area of the Syracuse hospitals between the twentieth century and the twenty first century with respect to major hospi... This study reviewed developments in provider utilization related to health care in the metropolitan area of the Syracuse hospitals between the twentieth century and the twenty first century with respect to major hospital services. In this study, a decline in the utilization of inpatient hospitals developed between 2020 and 2022. During this period, use of additional outpatient services such as ambulatory surgery, individual practitioners, outside hospitals, and the use of hospital emergency departments developed in the community. The study data demonstrated that between 2020 and 2022, the numbers of discharges from the combined hospitals declined for both adult medicine and adult surgery. Inpatient discharges declined by 2730 patients for adult medicine and 1961 patients for adult surgery. The data also demonstrated that between 2022 and 2024, the numbers of discharges increased by 1998 discharges for adult medicine and by 229 for adult surgery. As followup to this study, health care providers and payors should review approaches to efficiency in their communities and evaluate their impact on health care efficiency. 展开更多
关键词 Health Care efficiency Hospitals Ambulatory Care
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Global Ports Efficiency and Productivity Using DEA-MPI Approach
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作者 Calvin Elorm Atsunyo Bernard Kwei Tetteh 《Open Journal of Applied Sciences》 2025年第2期433-449,共17页
Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, P... Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, Port of Singapore, Rotterdam, Antwerp and Durban. The main objectives of this study are to determine the level of operational efficiency of the mentioned ports, measure and evaluate the ports’ productivity changes and lastly to investigate the factors influencing the productivity changes of the ports studied. To achieve these objectives, Data Envelopment Analysis (DEA-BCC) model was used to determine the technical and operational efficiencies of the ports and Malmquist productivity index was employed to calculate the various productivity levels. The results of the study can guide stakeholders to formulate their operational strategies for port efficiency and productivity. The study also has policy suggestions that are uniquely targeted to Africa’s issues and potential. 展开更多
关键词 efficiency PRODUCTIVITY Data Envelopment Analysis Malmquist Productivity Index
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Hcy与sTWEAK对前循环急性缺血性脑卒中患者脑白质病变的评估价值 被引量:1
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作者 宋庆云 吴文娟 +3 位作者 刘小娟 郭莹 刘春玲 王友明 《中国实用神经疾病杂志》 2025年第3期326-330,共5页
目的探究同型半胱氨酸(Hcy)及可溶性肿瘤坏死因子样弱凋亡诱导剂(sTWEAK)评估前循环急性缺血性脑卒中(AIS)患者脑白质病变(WML)的价值。方法回顾性分析2021-08—2023-08邯郸市人民医院收治的100例AIS患者资料,按是否并发WML将患者分为WM... 目的探究同型半胱氨酸(Hcy)及可溶性肿瘤坏死因子样弱凋亡诱导剂(sTWEAK)评估前循环急性缺血性脑卒中(AIS)患者脑白质病变(WML)的价值。方法回顾性分析2021-08—2023-08邯郸市人民医院收治的100例AIS患者资料,按是否并发WML将患者分为WML组(n=79)及非WML组(n=21),再按严重程度将WML患者分为轻度组(n=23)、中度组(n=30)及重度组(n=26)3个亚组。收集并比较WML组及非WML组基线资料及血清指标水平。采用Logistic回归分析AIS并发WML的危险因素。绘制ROC曲线分析血清Hcy及sTWEAK诊断AIS并发WML及评估WML严重程度的临床价值。结果WML组Hcy及sTWEAK水平高于非WML组(P<0.05)。三亚组Hcy及sTWEAK水平有统计学差异(P<0.05),血清Hcy及sTWEAK水平分布表现为轻度组<中度组<重度组(P<0.05)。高龄、合并高血压、高Hcy及高sTWEAK是AIS患者并发WML的独立危险因素(P<0.05)。Hcy联合sTWEAK诊断WML的AUC值(0.945)最大,高于Hcy(Z=2.989,P=0.003)及sTWEAK(Z=2.614,P=0.009)。Hcy联合sTWEAK诊断重度WML的AUC值最大(0.927),高于Hcy(Z=2.566,P=0.010)及sTWEAK(Z=1.537,P=0.124)。结论血清Hcy及sTWEAK能有效诊断AIS患者并发WML以及评估WML严重程度,血清Hcy及sTWEAK高表达是AIS患者并发WML的独立危险因素。 展开更多
关键词 急性缺血性脑卒中 前循环 脑白质病变 同型半胱氨酸 可溶性肿瘤坏死因子样弱凋亡诱导剂 血清 预测价值 危险因素
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Multiple Efforts to Improve Health Care Efficiency
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作者 Ronald Lagoe Shelly Littau 《Case Reports in Clinical Medicine》 2025年第2期98-105,共8页
This study reviewed a combination of health care programs in the metropolitan area of Syracuse, New York. They were designed to improve care, however a major purpose was to support efficiency. The study described a nu... This study reviewed a combination of health care programs in the metropolitan area of Syracuse, New York. They were designed to improve care, however a major purpose was to support efficiency. The study described a number of individual programs that were developed in order to improve the quality and the efficiency of care. These programs were implemented by a combination of local providers and payors. They included the development of outpatient services such as ambulatory surgery, as well as preventive care, case management, telemedicine, and mental health. The impact of these programs was a combination of these services, rather than individual efforts. The impact of these efforts was the product of a range of individual services, especially care management. Additional efforts should make it possible to extend these efforts among providers and payors in the Syracuse area. This approach should make it possible to extend the impact of health care efficiency further. 展开更多
关键词 Health Care efficiency Health Care Payors Health Care Providers
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Root morphological adaptation and leaf lipid remobilization drive differences in phosphorus use efficiency in rapeseed seedlings
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作者 Bingbing Zhang Xinxin Zhu +11 位作者 Pan Yuan Bei Han Tao Wu Ismail Din Chuang Wang John P.Hammond Sheliang Wang Guangda Ding Hongmei Cai Zhuqing Zhao Fangshen Xu Lei Shi 《The Crop Journal》 2025年第2期524-535,共12页
With the objective of investigating the basis of phosphorus(P)utilization efficiency(PUE),physiological and morphological traits,two P-efficient and two P-inefficient rapeseed(Brassica napus L.)cultivars were compared... With the objective of investigating the basis of phosphorus(P)utilization efficiency(PUE),physiological and morphological traits,two P-efficient and two P-inefficient rapeseed(Brassica napus L.)cultivars were compared at the seedling stage.P-efficient cultivars showed root morphological adaptation,high P uptake activity,and greater phospholipid degradation under low P stress.Improving root morphological adaptation and reducing lipid-P allocation could allow increasing PUE in rapeseed seedlings. 展开更多
关键词 Root morphology Root exudates Phosphorus acquisition efficiency Phosphorus utilization efficiency P fractions
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Knowledge Modeling and Institutional Memory at the University of Cape Coast: Examining Technology as a Mediator and Leadership Styles as a Moderator in Enhancing Administrative Efficiency
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作者 Harriette Nusrat Manu Eleanor Afua Onyame +2 位作者 Eunice Amoako Mensah Sarah Annim Sayibu Abdul-Gafaar 《Intelligent Information Management》 2025年第1期1-30,共30页
The integration of digital tools and effective knowledge management practices is critical for enhancing administrative efficiency and institutional continuity in higher education. This study investigates the relations... The integration of digital tools and effective knowledge management practices is critical for enhancing administrative efficiency and institutional continuity in higher education. This study investigates the relationships between knowledge modeling, institutional memory, leadership styles, technology, and administrative efficiency at the University of Cape Coast (UCC). The study sought to identify the challenges and opportunities in integrating digital tools into administrative processes and to provide actionable recommendations for improvement. A mixed-methods research design was employed, combining quantitative analysis using Partial Least Squares Structural Equation Modeling (PLS-SEM) with qualitative thematic analysis of interviews. The findings revealed key challenges, including resistance to change, fragmented knowledge repositories, and inadequate funding, alongside opportunities such as centralized knowledge systems, cost-effective open-source tools, and capacity-building initiatives. The study highlights the importance of strategic leadership, robust policies, and investments in digital infrastructure to enhance administrative practices. Policy implications include the need for clear digital transformation guidelines and leadership training to foster innovation and collaboration. Recommendations include investing in scalable digital tools, implementing comprehensive capacity-building programs, and promoting stakeholder engagement to drive successful digital integration. These insights provide a roadmap for UCC and similar institutions seeking to optimize administrative efficiency through digital transformation. 展开更多
关键词 Knowledge Management Institutional Memory Digital Integration Technology Adoption Administrative efficiency Leadership Styles Centralised Knowledge Repositories
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腹直肌TWEAK表达水平及其与胃癌患者生理指标的关系研究
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作者 和青森 钱国武 +2 位作者 张虎 孙晓林 史娟 《实用癌症杂志》 2025年第4期551-554,共4页
目的探讨胃癌患者腹直肌肿瘤坏死因子样弱凋亡诱导因子(TWEAK)的表达水平,及其与患者多项生理指标的相关性。方法选择80例胃癌患者设为观察组,选择80例行手术治疗的腹腔良性疾病患者设为对照组,术中均取0.1 g腹直肌的肌肉组织采用Wester... 目的探讨胃癌患者腹直肌肿瘤坏死因子样弱凋亡诱导因子(TWEAK)的表达水平,及其与患者多项生理指标的相关性。方法选择80例胃癌患者设为观察组,选择80例行手术治疗的腹腔良性疾病患者设为对照组,术中均取0.1 g腹直肌的肌肉组织采用Western blot法测定TWEAK表达水平。比较两组TWEAK表达水平,分析不同营养指标的胃癌患者腹直肌TWEAK表达差异及其相关性。结果观察组腹直肌TWEAK相对表达量为(0.20±0.06),高于对照组的(0.07±0.01),有统计学差异(t=19.116,P<0.001);以胃癌患者腹直肌TWEAK相对表达量中位数0.20为界,表达量高于0.20的52例患者纳入高表达组,≤0.20的28例患者纳入低表达组。腹直肌TWEAK表达升高与胃癌患者体质量指数、近半年体质量下降比例、预后营养指数(PNI)、血清血清白蛋白(ALB)、前白蛋白(PAB)、转铁蛋白和营养风险筛查2002(NRS 2002)评分有关(χ^(2)=8.137、4.216、20.247、24.759、13.410、32.919、3.970,P<0.05);Pearson分析显示,体质量指数、ALB、PAB、转铁蛋白与胃癌患者腹直肌TWEAK表达呈负相关(γ=-0.319、-0.556、-0.409、-0.641,P<0.05),近半年体质量下降比例、PNI、NRS 2002评分与胃癌患者腹直肌TWEAK表达呈正相关(γ=0.149、0.503、0.223,P<0.05)。结论胃癌患者腹直肌内TWEAK呈高表达,其表达高低与患者营养状况指标关系密切,可作为检测患者营养状况的重要指标,以指导临床治疗。 展开更多
关键词 胃癌 肿瘤坏死因子样弱凋亡诱导因子 腹直肌 营养状况
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Optimizing Efficiency and Performance in a Rankine Cycle Power Plant Analysis
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作者 Ramesh Kumar Abdullah Bin Queyam +2 位作者 Manish Kumar Singla Mohamed Louzazni Mishra Dipak Kumar 《Energy Engineering》 2025年第4期1373-1386,共14页
Enhancing the efficiency of Rankine cycles is crucial for improving the performance of thermal power plants,as it directly impacts operational costs and emissions in light of energy transition goals.This study sets it... Enhancing the efficiency of Rankine cycles is crucial for improving the performance of thermal power plants,as it directly impacts operational costs and emissions in light of energy transition goals.This study sets itself apart from existing research by applying a novel optimization technique to a basic ideal Rankine cycle,focusing on a specific power plant that has not been previously analyzed.Currently,this cycle operates at 41%efficiency and a steam quality of 76%,constrained by fixed operational parameters.The primary objectives are to increase thermal efficiency beyond 46%and raise steam quality above 85%,while adhering to operational limits:a boiler pressure not exceeding 15 MPa,condenser pressure not dropping below 10 kPa,and turbine temperature not surpassing 500℃.This study utilizes numerical simulations to model the effects of varying boiler pressure(Pb)and condenser pressure(Pc)within the ranges of 12MPa<Pb<15 MPa and 5 kPa<Pc<10 kPa.By systematically adjusting these parameters,the proposed aimto identify optimal conditions that maximize efficiency and performance within specified constraints.The findings will provide valuable insights for power plant operators seeking to optimize performance under real-world conditions,contributing to more efficient and sustainable power generation. 展开更多
关键词 Rankine cycle thermal efficiency steamquality boiler pressure condenser pressure cycle performance operational constraints efficiency improvement
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Tailoring a Back-Contact Barrier for a Self-Powered Broadband Kesterite Photodetector With Ultralow Dark Current Enabling Ultra-Weak-Light Detection
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作者 Qianfeng Wu Chuanhao Li +7 位作者 Shuo Chen Zhenghua Su Muhammad Abbas Chao Chen Qianqian Lin Jingting Luo Liming Ding Guangxing Liang 《Carbon Energy》 2025年第5期35-44,共10页
Visible and near-infrared photodetectors are widely used in intelligent driving,health monitoring,and other fields.However,the application of photodetectors in the near-infrared region is significantly impacted by hig... Visible and near-infrared photodetectors are widely used in intelligent driving,health monitoring,and other fields.However,the application of photodetectors in the near-infrared region is significantly impacted by high dark current,which can greatly reduce their performance and sensitivity,thereby limiting their effectiveness in certain applications.In this work,the introduction of a C60 back interface layer successfully mitigated back interface reactions to decrease the thickness of the Mo(S,Se)_(2)layer,tailoring the back-contact barrier and preventing reverse charge injection,resulting in a kesterite photodetector with an ultralow dark current density of 5.2×10^(-9)mA/cm^(2)and ultra-weak-light detection at levels as low as 25 pW/cm^(2).Besides,under a self-powered operation,it demonstrates outstanding performance,achieving a peak responsivity of 0.68 A/W,a wide response range spanning from 300 to 1600 nm,and an impressive detectivity of 5.27×10^(14)Jones.In addition,it offers exceptionally rapid response times,with rise and decay times of 70 and 650 ns,respectively.This research offers important insights for developing high-performance self-powered near-infrared photodetectors that have high responsivity,rapid response times,and ultralow dark current. 展开更多
关键词 DETECTIVITY KESTERITE PHOTODETECTOR thin film weak light detection
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