BACKGROUND Ultrasound-guided peripherally inserted central catheter(PICC)placement is vital for cancer therapy,but lidocaine infiltration faces limitations like puncture pain and vasospasm.AIM To assess the clinical e...BACKGROUND Ultrasound-guided peripherally inserted central catheter(PICC)placement is vital for cancer therapy,but lidocaine infiltration faces limitations like puncture pain and vasospasm.AIM To assess the clinical efficacy of a no-pain intervention-combining compound lidocaine cream with warm compress-in reducing pain during ultrasound-guided PICC placement in cancer patients.METHODS A retrospective cohort study analyzed 88 cancer patients undergoing PICC placement(Shanghai Fourth People’s Hospital,2024).Patients were divided into control(lidocaine infiltration,n=44)and intervention(cream+warm compress,n=44)groups.Primary outcomes:Pain scores(numerical rating scale),procedural time,complications;secondary outcome:Satisfaction.RESULTS The intervention group showed significantly lower pain scores(1.2±0.4 vs 3.8±1.2,P=0.012)with comparable first-attempt success(95.5%vs 90.9%)and safety(P=0.672).Thermal activation of transient receptor potential vanilloid 1 channel enhanced drug penetration,achieving anesthesia within 8-10 minutes.Patient satisfaction reached 97.7%.CONCLUSION The combination of compound lidocaine cream with warm compress significantly alleviates procedural pain and enhances patient satisfaction during ultrasound-guided PICC placement in cancer patients,supporting its clinical application.展开更多
The warm compression tests were performed on the eutectoid steel to investigate the evolution of cementite morphology. Several processing parameters, such as temperature, strain rate and reduction, were changed to ana...The warm compression tests were performed on the eutectoid steel to investigate the evolution of cementite morphology. Several processing parameters, such as temperature, strain rate and reduction, were changed to analyze the effect of each parameter on spheroidization of cementite. The results showed that the warm compression promoted the fragmentize and the spheroidization of lamellar cementites. When the specimen was compressed with reduction of 50% at 700 ℃ and in the strain rate of 0.01 s-1, the excellent spheroidized cementite was obtained. The mechanism of fragmentation and spheroidization of lamellar cementites during compression was discussed by using transmission electron microscope. The formation of spheroidized cementite was related to the time of compression process. The fragmentize of lamellar cementites was due to the extension of sub-grain boundary in the cementite. The spheroidization of cementite depended on the diffusion of carbon atoms at the tip of bended and breakup cementite.展开更多
基金Supported by the Discipline Promotion Program of Shanghai Fourth People’s Hospital,No.SY-XKZT-2021-2006.
文摘BACKGROUND Ultrasound-guided peripherally inserted central catheter(PICC)placement is vital for cancer therapy,but lidocaine infiltration faces limitations like puncture pain and vasospasm.AIM To assess the clinical efficacy of a no-pain intervention-combining compound lidocaine cream with warm compress-in reducing pain during ultrasound-guided PICC placement in cancer patients.METHODS A retrospective cohort study analyzed 88 cancer patients undergoing PICC placement(Shanghai Fourth People’s Hospital,2024).Patients were divided into control(lidocaine infiltration,n=44)and intervention(cream+warm compress,n=44)groups.Primary outcomes:Pain scores(numerical rating scale),procedural time,complications;secondary outcome:Satisfaction.RESULTS The intervention group showed significantly lower pain scores(1.2±0.4 vs 3.8±1.2,P=0.012)with comparable first-attempt success(95.5%vs 90.9%)and safety(P=0.672).Thermal activation of transient receptor potential vanilloid 1 channel enhanced drug penetration,achieving anesthesia within 8-10 minutes.Patient satisfaction reached 97.7%.CONCLUSION The combination of compound lidocaine cream with warm compress significantly alleviates procedural pain and enhances patient satisfaction during ultrasound-guided PICC placement in cancer patients,supporting its clinical application.
基金Item Sponsored by National Natural Science Foundation of China(50271060)Natural Science Foundation of Hebei Province of China(503291)
文摘The warm compression tests were performed on the eutectoid steel to investigate the evolution of cementite morphology. Several processing parameters, such as temperature, strain rate and reduction, were changed to analyze the effect of each parameter on spheroidization of cementite. The results showed that the warm compression promoted the fragmentize and the spheroidization of lamellar cementites. When the specimen was compressed with reduction of 50% at 700 ℃ and in the strain rate of 0.01 s-1, the excellent spheroidized cementite was obtained. The mechanism of fragmentation and spheroidization of lamellar cementites during compression was discussed by using transmission electron microscope. The formation of spheroidized cementite was related to the time of compression process. The fragmentize of lamellar cementites was due to the extension of sub-grain boundary in the cementite. The spheroidization of cementite depended on the diffusion of carbon atoms at the tip of bended and breakup cementite.
