Fluid dynamics simulation is often repeated under varying conditions.This leads to a generation of large amounts of results,which are difficult to compare.To compare results under different conditions,it is effective ...Fluid dynamics simulation is often repeated under varying conditions.This leads to a generation of large amounts of results,which are difficult to compare.To compare results under different conditions,it is effective to overlap the streamlines generated from each condition in a single three-dimensional space.Streamline is a curved line,which represents a wind flow.This paper presents a technique to automatically select and visualize important streamlines that are suitable for the comparison of the simulation results.Additionally,we present an implementation to observe the flow fields in virtual reality spaces.展开更多
In order to realize visualization of three-dimensional data field （TDDF） in instrument, two methods of visualization of TDDF and the usual manner of quick graphic and image processing are analyzed. And how to use Op...In order to realize visualization of three-dimensional data field （TDDF） in instrument, two methods of visualization of TDDF and the usual manner of quick graphic and image processing are analyzed. And how to use OpenGL technique and the characteristic of analyzed data to construct a TDDF, the ways of reality processing and interactive processing are described. Then the medium geometric element and a related realistic model are constructed by means of the first algorithm. Models obtained for attaching the third dimension in three-dimensional data field are presented. An example for TDDF realization of machine measuring is provided. The analysis of resultant graphic indicates that the three-dimensional graphics built by the method developed is featured by good reality, fast processing and strong interaction展开更多
AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary ne...AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary nerve fiber layer(pRNFL)and ganglion cell complex(GCC).METHODS:This prospective longitudinal observational study included patients with chiasmal compression due to sellar region mass scheduled for decompressive surgery.Generalized estimating equations were used to compare retinal vessel density and retinal layer thickness preand post-operatively and with healthy controls.Logistic regression models were used to assess the relationship between preoperative GCC,pRNFL,SRCP,and RPC parameters and visual field recovery after surgery.RESULTS:The study included 43 eyes of 24 patients and 48 eyes of 24 healthy controls.Preoperative RPC and SRCP vessel density and pRNFL and GCC thickness were lower than healthy controls and higher than postoperative values.The best predictive GCC and pRNFL models were based on the superior GCC[area under the curve(AUC)=0.866]and the tempo-inferior pRNFL(AUC=0.824),and the best predictive SRCP and RPC models were based on the nasal SRCP(AUC=0.718)and tempo-inferior RPC(AUC=0.825).There was no statistical difference in the predictive value of the superior GCC,tempo-inferior pRNFL,and tempo-inferior RPC(all P>0.05).CONCLUSION:Compression of the optic chiasm by tumors in the saddle area can reduce retinal thickness and blood perfusion.This reduction persists despite the recovery of the visual field after decompression surgery.GCC,pRNFL,and RPC can be used as sensitive predictors of visual field recovery after decompression surgery.展开更多
AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced glaucoma.METHODS:T...AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced glaucoma.METHODS:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were included.The relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were determined.Patients with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were assessed.RESULTS:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without CVFDs.The area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal eyes.CONCLUSION:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.展开更多
Aims:To explore the point-wise correlations between 10-2 visual field(VF)metrics and macular vessel density,as measured by optical coherence tomography angiography(OCTA),in patients with early open-angle glaucoma(OAG)...Aims:To explore the point-wise correlations between 10-2 visual field(VF)metrics and macular vessel density,as measured by optical coherence tomography angiography(OCTA),in patients with early open-angle glaucoma(OAG)and healthy controls.Methods:This is a cross-sectional study that retrospectively analyzed data from 54 participants(18 early OAG patients and 36 healthy controls)from the Zhongshan Ophthalmic Center.All participants underwent comprehensive ophthalmic examinations,10-2 VF,and macular OCTA imaging.The correlation between capillary density(CD)in macular subregions and light sensitivity(LS)at corresponding VF test points was analyzed using Pearson's correlation coefficients.Results:The analysis revealed a significant reduction in CD within the inferior macular regions of glaucomatous eyes.Notably,there were strong point-wise correlations between CD and 10-2 VF,particularly in the inferior region of outer ring(peak r=0.534,P<0.001).Conclusion:The point-wise correlation between 10-2 VF and macular CD demonstrates the potential for using CD to predict central VF damage in glaucoma,emphasizing the importance of macular microcirculation in early disease screening.展开更多
Transparent flow field visualization techniques play a critical role in engineering and scientific applications.They provide a clear and intuitive means to understand fluid dynamics and its complex phenomena,such as l...Transparent flow field visualization techniques play a critical role in engineering and scientific applications.They provide a clear and intuitive means to understand fluid dynamics and its complex phenomena,such as laminar flow,turbulence,and vortices.However,achieving fully two-dimensional quantitative visualization of transparent flow fields under non-invasive conditions remains a significant challenge.Here,we present an approach for achieving flow field visualization by harnessing the synergistic effects of a dielectric metasurface array endowed with photonic spindecoupled capability.This approach enables the simultaneous acquisition of light-field images containing flow field information in two orthogonal dimensions,which allows for the real-time and quantitative derivation of multiple physical parameters.As a proof-of-concept,we experimentally demonstrate the applicability of the proposed visualization technique to various scenarios,including temperature field mapping,gas leak detection,visualization of various fluid physical phenomena,and 3D morphological reconstruction of transparent phase objects.This technique not only establishes an exceptional platform for advancing research in fluid physics,but also exhibits significant potential for broad applications in industrial design and vision.展开更多
AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients...AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients with acute NAION(<30d of visual acuity loss)were enrolled and given intravitreal TA(IVTA)once.Visual field(VF),best corrected visual acuity(BCVA),retinal nerve fiber layer(RNFL)thickness,ganglion cell complex(GCC)thickness,radial peripapillary capillary(RPC)density,and intraocular pressure(IOP)were evaluated at baseline and 7d,1,3,and 6mo after IVTA.RESULTS:VF and BCVA were significant improved during the follow-up according to the mean deviation(MD),visual field index(VFI),and Early Treatment Diabetic Retinopathy Study(ETDRS)scores(all P<0.001).There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset.The RNFL thickness,GCC thickness and RPC density were significantly decreased(all P<0.001).Temporary ocular hypertension was present in five eyes.CONCLUSION:Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage.However,optic nerve atrophy still existed.展开更多
For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low.Nevertheless,there is always some potential for ...For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low.Nevertheless,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticity.Neuroplasticity refers to the ability of the brain to change its own functional architecture by modulating synaptic efficacy.It is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing neuroplasticity.In ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current stimulation.Treatment with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the brain.Electroencephalography and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their networks.The future of low vision is optimistic because vision loss is indeed,partially reversible.展开更多
AIM: To investigate the influencing factors of visual field improvement after trans-sphenoidal resection of pituitary macroadenomas. METHODS: This retrospective cohort study included 201 patients (366 eyes) with visua...AIM: To investigate the influencing factors of visual field improvement after trans-sphenoidal resection of pituitary macroadenomas. METHODS: This retrospective cohort study included 201 patients (366 eyes) with visual field defect induced by pituitary macroadenomas. All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation, best -corrected visual acuity (BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, visual field defect index mean deviation (MD), duration of symptoms, age, sex, and volume of tumors were compared. Expression of vascular endothelial growth factor (VEGF) and Ki-67 of tumor tissue were detected by immunohistochemical technique. RESULTS: The mean age of patients was 44.23 +/- 1.29y. Ninety -three patients were female and 108 were male. The mean tumor volume was 14.36 +/- 6.23 cm(3). The mean duration of preoperative symptoms was 11.50 +/- 0.88mo. Mean preoperative MD was -17.50 +/- 0.82 dB. Mean Preoperative visual acuity was 0.64 +/- 0.04. Postoperative visual field improved in 270 (73.77%) eyes, unchanged in 96 (26.23%) eyes. Multivariate logistic regression displayed that the factors independently influencing visual field improvement were young age (OR=1.71, 95%CI: 1.325-2.387, P=0.013), low preoperative MD absolute value (OR=1.277, 95%CI: 1.205-1.355, P<0.001), small volume of tumor (OR=1.458, 95%CI: 1.060-4.289, P<0.001), low expression of VEGF in tumor tissue (OR=1.554, 95%CI: 1.089-2.457, P=0.022), and low expression of Ki-67 in tumor tissue (OR=1.552, 95%CI: 1.161-2.847, P=0.026). CONCLUSION: After pituitary macroadenomas trans sphenoidal resection, the independent influencing factors of the visual fields recovery were low preoperative MD absolute value, young age, small volume of tumor, and expression levels of VEGF/Ki-67.展开更多
AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) patients.METHODS: Correlations of MDs with the visual...AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) patients.METHODS: Correlations of MDs with the visual acuity and retinal pigmentation were analyzed in 928 RP patients. MD decreasing rate in 10 y and potential influences of gender, age, family history and retinal pigmentation on the rate were explored in 201 RP patients. RESULTS: In the 928 patients, average MD and visual acuity were-14.44±8.61 dB and 0.79±0.35 respectively and when MD was lower than-9.18 dB the visual acuity would be below 1.0(20/20). The average MD medium between eyes with or without retinal pigmentation was-14.82 dB. In 123 non-pigmented eyes, the average MD were lower than the medium but in 153 pigmented eyes it was higher than that. In the 201 patients, the average decreasing value of MD in 10 years’ period was-8.01±3.66 dB and the value were correlated to retinal pigmentation but not to gender, age or RP family history. CONCLUSION: The rate of MD decline in RP eyes is significantly related to retinal pigmentation. Our study demonstrates the quantitative rate of MD decline in RP patients and the value of MD could well reflect the severity of RP.展开更多
Texture-based visualization method is a common method in the visualization of vector field data.Aiming at adding color mapping to the texture of ocean vector field and solving the ambiguity of vector direction in text...Texture-based visualization method is a common method in the visualization of vector field data.Aiming at adding color mapping to the texture of ocean vector field and solving the ambiguity of vector direction in texture image,a new color texture enhancement algorithm based on the Line Integral Convolution(LIC)for the vector field data is proposed,which combines the HSV color mapping and cumulative distribution function calculation of vector field data.This algorithm can be summarized as follows:firstly,the vector field data is convoluted twice by line integration to get the gray texture image.Secondly,the method of mapping vector data to each component of the HSV color space is established.And then,the vector field data is mapped into HSV color space and converted from HSV to RGB values to get the color image.Thirdly,the cumulative distribution function of the RGB color components of the gray texture image and the color image is constructed to enhance the gray texture and RGB color values.Finally,both the gray texture image and the color image are fused to get the color texture.The experimental results show that the proposed LIC color texture enhancement algorithm is capable of generating a better display of vector field data.Furthermore,the ambiguity of vector direction in the texture images is solved and the direction information of the vector field is expressed more accurately.展开更多
AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients ...AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients with well-controlled Goldmann applanation tonometer（GAT） who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled.GAT and ORA parameters including corneal compensated intraocular pressure（lOPcc）,Goldmann estimated intraocular pressure（lOPg）,corneal hysteresis（CH）,corneal resistance factor（CRF） were recorded.VF was tested by Swedish interactive threshold algorithm（SITA）-standard 30-2 fields.All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up.Patients were divided into four groups according to VF change over 3y,and ORA findings were compared between the upper 25th percentile group（slow progression group） and the lower 25th percentile group（rapid progression group）.RESULTS：Eighty-two eyes of 56 patients were studied.There were 21 eyes（21 patients） each in rapid and slow progression groups respectively.GAT,lOPcc,lOPg,CH,CRF were 12.1＋1.4 mm Hg,15.8±1.8 mm Hg,12.8±2.0 mm Hg,8.4±1.1 mm Hg,7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg,13.5±2.1 mm Hg,11.2±1.6 mm Hg,9.3±1.1 mm Hg,8.2±0.9 mm Hg respectively in slow progression group（P=0.214,〈0.001,0.007,0.017,0.413,respectively）.In bivariate correlation analysis,lOPcc,lOPcc-GAT and CH were significant correlated with m△MD（r =-0.292,-0.312,0.228 respectively,P =0.008,0.004,0.039 respectively）.CONCLUSION：Relatively rapid VF progression occurred in NTG patients whose lOPcc are rather high,CH are rather low and the difference between lOPcc and GAT are relatively large.Higher lOPcc and lower CH are associated with VF progression in NTG patients.This study suggests that GAT measures might underestimate the IOP in such patients.展开更多
AIM:To compare visual field defects using the Swedish Interactive Thresholding Algorithm(SITA)Fast strategy with SITA Faster strategy,a newly developed time-saving threshold visual field strategy.METHODS:Ninety-three ...AIM:To compare visual field defects using the Swedish Interactive Thresholding Algorithm(SITA)Fast strategy with SITA Faster strategy,a newly developed time-saving threshold visual field strategy.METHODS:Ninety-three participants(60 glaucoma patients and 33 normal controls)were enrolled.One eye from each participant was selected randomly for the study.SITA Fast and SITA Faster were performed using the 24-2 default mode for each test.The differences of visual field defects between the two strategies were compared using the test duration,false-positive response errors,mean deviation(MD),visual field index(VFI)and the numbers of depressed test points at the significant levels of P<5%,<2%,<1%,and<0.5%in probability plots.The correlation between strategies was analyzed.The agreement between strategies was acquired by Bland-Altman analysis.RESULTS:Mean test durations were 246.0±60.9 s for SITA Fast,and 156.3±46.3 s for SITA Faster(P<0.001).The test duration of SITA Faster was 36.5%shorter than SITA Fast.The MD,VFI and numbers of depressed points at P<5%,<2%,<1%,and<0.5%in probability plots showed no statistically significant difference between two strategies(P>0.05).Correlation analysis showed a high correlation for MD(r=0.986,P<0.001)and VFI(r=0.986,P<0.001)between the two strategies.Bland-Altman analysis showed great agreement between the two strategies.CONCLUSION:SITA Faster,which saves considerable test time,has a great test quality comparing to SITA Fast,but may be not directly interchangeable.展开更多
AIM：To determine the Bruch＇s membrane opening-minimum rim width（BMO-MRW） tipping point where corresponding visual field（VF） damages become detectable.METHODS：A total of 85 normal subjects and 83 glaucoma patie...AIM：To determine the Bruch＇s membrane opening-minimum rim width（BMO-MRW） tipping point where corresponding visual field（VF） damages become detectable.METHODS：A total of 85 normal subjects and 83 glaucoma patients（one eye per participant） were recruited for the study.All of the patients had VF examinations and spectral-domain optical coherence tomography to measure the BMO-MRW.Total deviation values for 52 VF points were allocated to the corresponding sector according to the Garway-Heath distribution map.To evaluate the relationship between VF loss and BMOMRW measurements,a ＂broken-stick＂ statistical model was used.The tipping point where the VF values started to sharply decrease as a function of BMO-MRW measurements was estimated and the slopes above and below this tipping point were compared.RESULTS：A 25.9% global BMO-MRW loss from normative value was required for the VF loss to be detectable.Sectorally,substantial BMO-MRW thinning in inferotemporal sector（33.1%） and relatively less BMO-MRW thinning in the superotemporal sector（8.9%） were necessary for the detection of the VF loss.Beyond the tipping point,the slopes were close to zero throughout all of the sectors and the VF loss was unrelated to the BMO-MRW loss.The VF loss was related to the BMO-MRW loss below the tipping point.The difference between the two slopes was statistically significant（P≤0.002）.CONCLUSION：Substantial BMO-MRW loss appears to be necessary for VF loss to be detectable in patients with open angle glaucoma with standard achromatic perimetry.展开更多
AIM:To validate the ability of the Heidelberg Edge Perimeter(HEP)in detecting glaucomatous visual field(VF)defects compared to the Octopus Visual Field(OVF)Analyzer and to determine the test-retest repeatability of bo...AIM:To validate the ability of the Heidelberg Edge Perimeter(HEP)in detecting glaucomatous visual field(VF)defects compared to the Octopus Visual Field(OVF)Analyzer and to determine the test-retest repeatability of both modalities.METHODS:This prospective,cross-sectional study was conducted at Wills Eye Hospital,Philadelphia,PA.Glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP)Ⅲ30-2 Adaptive Staircase Thresholding Algorithm(ASTA)FAST protocol and OVF G-TOP white-on-white strategy.Testing order was randomized.Pearson's correlation coefficient was calculated for both mean deviation(MD)and pattern standard deviation/square root of loss of variance(PSD/s LV).Receiver operating characteristic(ROC)curves were used to determine the diagnostic abilities of both modalities.Glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs)were calculated to assess test-retest repeatability.RESULTS:Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled.HEP and OVF were significantly correlated for both MD(r=-0.84;P<0.01)and PSD/s LV(r=0.79;P<0.01).Areas under the ROC curves(AUCs)were also comparable between HEP and OVF for both MD(0.74 and 0.79,respectively;P=0.26)and PSD/sL V(0.74 and 0.82;P=0.08).ICC was high for both HEP(0.96 for MD,0.95 for PSD/s LV)and OVF(0.82 and 0.88,respectively).Mean test duration(min)was significantly shorter for OVF(2.63)compared to HEP(5.15;P<0.01).CONCLUSION:HEP and OVF show strong correlation for both MD and PSD/s LV,and have similar validity for detecting glaucoma.The test-retest repeatability is high for both HEP and OVF,however the average testing duration of HEP is significantly longer than that of OVF.展开更多
AIM:To evaluate the driving performance in young and middle-aged Chinese glaucoma patients with mild to severe visual field loss compared to those without glaucoma by using a driving simulation test.METHODS:Twenty-nin...AIM:To evaluate the driving performance in young and middle-aged Chinese glaucoma patients with mild to severe visual field loss compared to those without glaucoma by using a driving simulation test.METHODS:Twenty-nine participants were included in this study:nine patients with glaucoma but pass the binocular Esterman visual field test,ten patients with glaucoma and fail the binocular Esterman visual field test,and ten age-matched healthy controls.A driving simulation test was designed as a frequency-based analysis of a lanekeeping task.The total performance error,the controlresponse amplitude and delay were calculated.RESULTS:Esterman visual field test fail group showed the longest delay of control-response among three groups(P=0.02).And the delay in lane-keeping task was significantly associated with inferior field of better-eye(r=0.51,P=0.004)and integrated visual field(r=0.55,P=0.002).CONCLUSION:Young and middle-aged glaucoma patients with binocular visual field loss suffered from a longer delay of response in driving simulation test,while inferior visual field having more impact than superior visual field.展开更多
AIM: To assess the association between buried optic disc drusen(BODD) location using spectral-domain optical coherence tomography(SD-OCT) and the location of associated visual field defects(VFD) using the Garway-Heath...AIM: To assess the association between buried optic disc drusen(BODD) location using spectral-domain optical coherence tomography(SD-OCT) and the location of associated visual field defects(VFD) using the Garway-Heath mapping.METHODS: This monocentric retrospective crosssectional study was led at the authors’ institution. Adult patients diagnosed with BODD who had complete records with a reliable Humphrey? 24-2 visual field, macular, and papillary OCT were enrolled. Fisher’s exact test was used to measure the association between BODD location and VFD distribution according to Garway-Heath’s mapping.RESULTS: Totally 20 eyes of 15 patients were included(60% females). The median age(interquartile range) was 63(43)y and the median best corrected visual acuity(BCVA) was-0.08(0.08) log MAR. BODD were mostly located in zones A, E, and F. The minimal rim width(MRW) was globally preserved. The retinal nerve fiber layer(RNFL) was predominantly altered in zones D, E, and F. There was a significant correlation between BODD location and that of RNFL alterations in zones D(P=0.03) and E(P=0.025);Moreover, the presence of BODD in the E zone was significantly related to damaged RNFL in the neighbouring sectors D and F(P=0.012;P=0.02 respectively). Sixty-three percent(12/19) of visual fields were abnormal and there was a significant match(Phi=0.7, P=0.009) between drusen location and VFD only in zone D.CONCLUSION: BODD do not only affect young patients and can be more harmful than usually expected, as we found VFD in 63% of cases. There is a correspondence between BODD location, RNFL damage, and VFD distributions. The presence of BODD induces the overestimation of MRW,thereby disrupting its sensitivity as an early indicator of ganglion fibers damage.展开更多
AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations a...AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations and their diagnostic ability in glaucomatous eyes.METHODS:The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were tested.We investigated the correlations of mean deviation,pattern standard deviation,visual field index,and the sensitivity.RESULTS:Measurements of mean deviation(r=0.886,P<0.001),pattern standard deviation(r=0.814,P<0.001),and visual field index(r=0.871,P<0.001)in both perimeters were strongly and positively correlated.The sensitivities in the imo perimeter were 80.5%for mean deviation,81.2%for pattern standard deviation,and 80.5%in visual field index;those in the HFA were 63.3%for mean deviation,74.5%for pattern standard deviation,and 80.5%for visual field index.Both perimeters demonstrated high diagnostic ability.CONCLUSION:The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity,specificity,and diagnostic ability.However,the difference between imo and HFA results increases with the increase in visual field disturbance.展开更多
文摘Fluid dynamics simulation is often repeated under varying conditions.This leads to a generation of large amounts of results,which are difficult to compare.To compare results under different conditions,it is effective to overlap the streamlines generated from each condition in a single three-dimensional space.Streamline is a curved line,which represents a wind flow.This paper presents a technique to automatically select and visualize important streamlines that are suitable for the comparison of the simulation results.Additionally,we present an implementation to observe the flow fields in virtual reality spaces.
基金This project is supported by National Natural Science Foundation of China (No.50405009)
文摘In order to realize visualization of three-dimensional data field （TDDF） in instrument, two methods of visualization of TDDF and the usual manner of quick graphic and image processing are analyzed. And how to use OpenGL technique and the characteristic of analyzed data to construct a TDDF, the ways of reality processing and interactive processing are described. Then the medium geometric element and a related realistic model are constructed by means of the first algorithm. Models obtained for attaching the third dimension in three-dimensional data field are presented. An example for TDDF realization of machine measuring is provided. The analysis of resultant graphic indicates that the three-dimensional graphics built by the method developed is featured by good reality, fast processing and strong interaction
文摘AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary nerve fiber layer(pRNFL)and ganglion cell complex(GCC).METHODS:This prospective longitudinal observational study included patients with chiasmal compression due to sellar region mass scheduled for decompressive surgery.Generalized estimating equations were used to compare retinal vessel density and retinal layer thickness preand post-operatively and with healthy controls.Logistic regression models were used to assess the relationship between preoperative GCC,pRNFL,SRCP,and RPC parameters and visual field recovery after surgery.RESULTS:The study included 43 eyes of 24 patients and 48 eyes of 24 healthy controls.Preoperative RPC and SRCP vessel density and pRNFL and GCC thickness were lower than healthy controls and higher than postoperative values.The best predictive GCC and pRNFL models were based on the superior GCC[area under the curve(AUC)=0.866]and the tempo-inferior pRNFL(AUC=0.824),and the best predictive SRCP and RPC models were based on the nasal SRCP(AUC=0.718)and tempo-inferior RPC(AUC=0.825).There was no statistical difference in the predictive value of the superior GCC,tempo-inferior pRNFL,and tempo-inferior RPC(all P>0.05).CONCLUSION:Compression of the optic chiasm by tumors in the saddle area can reduce retinal thickness and blood perfusion.This reduction persists despite the recovery of the visual field after decompression surgery.GCC,pRNFL,and RPC can be used as sensitive predictors of visual field recovery after decompression surgery.
基金National Natural Science Foundation of China(No.81860170).
文摘AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced glaucoma.METHODS:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were included.The relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were determined.Patients with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were assessed.RESULTS:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without CVFDs.The area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal eyes.CONCLUSION:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.
基金supported by the National Key Research and Development Program of China(2022YFC2502800)the National Natural Science Foundation of China(82070955)the Science and Technology Program of Guangzhou,China(2024A03J0250).
文摘Aims:To explore the point-wise correlations between 10-2 visual field(VF)metrics and macular vessel density,as measured by optical coherence tomography angiography(OCTA),in patients with early open-angle glaucoma(OAG)and healthy controls.Methods:This is a cross-sectional study that retrospectively analyzed data from 54 participants(18 early OAG patients and 36 healthy controls)from the Zhongshan Ophthalmic Center.All participants underwent comprehensive ophthalmic examinations,10-2 VF,and macular OCTA imaging.The correlation between capillary density(CD)in macular subregions and light sensitivity(LS)at corresponding VF test points was analyzed using Pearson's correlation coefficients.Results:The analysis revealed a significant reduction in CD within the inferior macular regions of glaucomatous eyes.Notably,there were strong point-wise correlations between CD and 10-2 VF,particularly in the inferior region of outer ring(peak r=0.534,P<0.001).Conclusion:The point-wise correlation between 10-2 VF and macular CD demonstrates the potential for using CD to predict central VF damage in glaucoma,emphasizing the importance of macular microcirculation in early disease screening.
基金support from the Key Research and Development Program of the Ministry of Science and Technology of China(2022YFA1205000)the National Natural Science Foundation of China(12274217,12104225)+2 种基金the Natural Science Foundation of Jiangsu Province(BK20220068)Fundamental Research Funds for the Central UniversitiesThe authors acknowledge the technique support from the microfabrication center of the National Laboratory of Solid-State Microstructures.
文摘Transparent flow field visualization techniques play a critical role in engineering and scientific applications.They provide a clear and intuitive means to understand fluid dynamics and its complex phenomena,such as laminar flow,turbulence,and vortices.However,achieving fully two-dimensional quantitative visualization of transparent flow fields under non-invasive conditions remains a significant challenge.Here,we present an approach for achieving flow field visualization by harnessing the synergistic effects of a dielectric metasurface array endowed with photonic spindecoupled capability.This approach enables the simultaneous acquisition of light-field images containing flow field information in two orthogonal dimensions,which allows for the real-time and quantitative derivation of multiple physical parameters.As a proof-of-concept,we experimentally demonstrate the applicability of the proposed visualization technique to various scenarios,including temperature field mapping,gas leak detection,visualization of various fluid physical phenomena,and 3D morphological reconstruction of transparent phase objects.This technique not only establishes an exceptional platform for advancing research in fluid physics,but also exhibits significant potential for broad applications in industrial design and vision.
基金Supported by the National Key R&D Program of China(No.2016YFC0904800,No.2019YFC0840607)the National Science and Technology Major Project of China(No.2017ZX09304010)the Clinical Research Innovation Plan of Shanghai General Hospital(No.CTCCR-2018BP04).
文摘AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients with acute NAION(<30d of visual acuity loss)were enrolled and given intravitreal TA(IVTA)once.Visual field(VF),best corrected visual acuity(BCVA),retinal nerve fiber layer(RNFL)thickness,ganglion cell complex(GCC)thickness,radial peripapillary capillary(RPC)density,and intraocular pressure(IOP)were evaluated at baseline and 7d,1,3,and 6mo after IVTA.RESULTS:VF and BCVA were significant improved during the follow-up according to the mean deviation(MD),visual field index(VFI),and Early Treatment Diabetic Retinopathy Study(ETDRS)scores(all P<0.001).There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset.The RNFL thickness,GCC thickness and RPC density were significantly decreased(all P<0.001).Temporary ocular hypertension was present in five eyes.CONCLUSION:Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage.However,optic nerve atrophy still existed.
文摘For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low.Nevertheless,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticity.Neuroplasticity refers to the ability of the brain to change its own functional architecture by modulating synaptic efficacy.It is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing neuroplasticity.In ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current stimulation.Treatment with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the brain.Electroencephalography and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their networks.The future of low vision is optimistic because vision loss is indeed,partially reversible.
文摘AIM: To investigate the influencing factors of visual field improvement after trans-sphenoidal resection of pituitary macroadenomas. METHODS: This retrospective cohort study included 201 patients (366 eyes) with visual field defect induced by pituitary macroadenomas. All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation, best -corrected visual acuity (BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, visual field defect index mean deviation (MD), duration of symptoms, age, sex, and volume of tumors were compared. Expression of vascular endothelial growth factor (VEGF) and Ki-67 of tumor tissue were detected by immunohistochemical technique. RESULTS: The mean age of patients was 44.23 +/- 1.29y. Ninety -three patients were female and 108 were male. The mean tumor volume was 14.36 +/- 6.23 cm(3). The mean duration of preoperative symptoms was 11.50 +/- 0.88mo. Mean preoperative MD was -17.50 +/- 0.82 dB. Mean Preoperative visual acuity was 0.64 +/- 0.04. Postoperative visual field improved in 270 (73.77%) eyes, unchanged in 96 (26.23%) eyes. Multivariate logistic regression displayed that the factors independently influencing visual field improvement were young age (OR=1.71, 95%CI: 1.325-2.387, P=0.013), low preoperative MD absolute value (OR=1.277, 95%CI: 1.205-1.355, P<0.001), small volume of tumor (OR=1.458, 95%CI: 1.060-4.289, P<0.001), low expression of VEGF in tumor tissue (OR=1.554, 95%CI: 1.089-2.457, P=0.022), and low expression of Ki-67 in tumor tissue (OR=1.552, 95%CI: 1.161-2.847, P=0.026). CONCLUSION: After pituitary macroadenomas trans sphenoidal resection, the independent influencing factors of the visual fields recovery were low preoperative MD absolute value, young age, small volume of tumor, and expression levels of VEGF/Ki-67.
文摘AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) patients.METHODS: Correlations of MDs with the visual acuity and retinal pigmentation were analyzed in 928 RP patients. MD decreasing rate in 10 y and potential influences of gender, age, family history and retinal pigmentation on the rate were explored in 201 RP patients. RESULTS: In the 928 patients, average MD and visual acuity were-14.44±8.61 dB and 0.79±0.35 respectively and when MD was lower than-9.18 dB the visual acuity would be below 1.0(20/20). The average MD medium between eyes with or without retinal pigmentation was-14.82 dB. In 123 non-pigmented eyes, the average MD were lower than the medium but in 153 pigmented eyes it was higher than that. In the 201 patients, the average decreasing value of MD in 10 years’ period was-8.01±3.66 dB and the value were correlated to retinal pigmentation but not to gender, age or RP family history. CONCLUSION: The rate of MD decline in RP eyes is significantly related to retinal pigmentation. Our study demonstrates the quantitative rate of MD decline in RP patients and the value of MD could well reflect the severity of RP.
基金The National Natural Science Foundation of China under contract Nos 61702455,61672462 and 61902350the Natural Science Foundation of Zhejiang Province,China under contract No.LY20F020025。
文摘Texture-based visualization method is a common method in the visualization of vector field data.Aiming at adding color mapping to the texture of ocean vector field and solving the ambiguity of vector direction in texture image,a new color texture enhancement algorithm based on the Line Integral Convolution(LIC)for the vector field data is proposed,which combines the HSV color mapping and cumulative distribution function calculation of vector field data.This algorithm can be summarized as follows:firstly,the vector field data is convoluted twice by line integration to get the gray texture image.Secondly,the method of mapping vector data to each component of the HSV color space is established.And then,the vector field data is mapped into HSV color space and converted from HSV to RGB values to get the color image.Thirdly,the cumulative distribution function of the RGB color components of the gray texture image and the color image is constructed to enhance the gray texture and RGB color values.Finally,both the gray texture image and the color image are fused to get the color texture.The experimental results show that the proposed LIC color texture enhancement algorithm is capable of generating a better display of vector field data.Furthermore,the ambiguity of vector direction in the texture images is solved and the direction information of the vector field is expressed more accurately.
文摘AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients with well-controlled Goldmann applanation tonometer（GAT） who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled.GAT and ORA parameters including corneal compensated intraocular pressure（lOPcc）,Goldmann estimated intraocular pressure（lOPg）,corneal hysteresis（CH）,corneal resistance factor（CRF） were recorded.VF was tested by Swedish interactive threshold algorithm（SITA）-standard 30-2 fields.All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up.Patients were divided into four groups according to VF change over 3y,and ORA findings were compared between the upper 25th percentile group（slow progression group） and the lower 25th percentile group（rapid progression group）.RESULTS：Eighty-two eyes of 56 patients were studied.There were 21 eyes（21 patients） each in rapid and slow progression groups respectively.GAT,lOPcc,lOPg,CH,CRF were 12.1＋1.4 mm Hg,15.8±1.8 mm Hg,12.8±2.0 mm Hg,8.4±1.1 mm Hg,7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg,13.5±2.1 mm Hg,11.2±1.6 mm Hg,9.3±1.1 mm Hg,8.2±0.9 mm Hg respectively in slow progression group（P=0.214,〈0.001,0.007,0.017,0.413,respectively）.In bivariate correlation analysis,lOPcc,lOPcc-GAT and CH were significant correlated with m△MD（r =-0.292,-0.312,0.228 respectively,P =0.008,0.004,0.039 respectively）.CONCLUSION：Relatively rapid VF progression occurred in NTG patients whose lOPcc are rather high,CH are rather low and the difference between lOPcc and GAT are relatively large.Higher lOPcc and lower CH are associated with VF progression in NTG patients.This study suggests that GAT measures might underestimate the IOP in such patients.
文摘AIM:To compare visual field defects using the Swedish Interactive Thresholding Algorithm(SITA)Fast strategy with SITA Faster strategy,a newly developed time-saving threshold visual field strategy.METHODS:Ninety-three participants(60 glaucoma patients and 33 normal controls)were enrolled.One eye from each participant was selected randomly for the study.SITA Fast and SITA Faster were performed using the 24-2 default mode for each test.The differences of visual field defects between the two strategies were compared using the test duration,false-positive response errors,mean deviation(MD),visual field index(VFI)and the numbers of depressed test points at the significant levels of P<5%,<2%,<1%,and<0.5%in probability plots.The correlation between strategies was analyzed.The agreement between strategies was acquired by Bland-Altman analysis.RESULTS:Mean test durations were 246.0±60.9 s for SITA Fast,and 156.3±46.3 s for SITA Faster(P<0.001).The test duration of SITA Faster was 36.5%shorter than SITA Fast.The MD,VFI and numbers of depressed points at P<5%,<2%,<1%,and<0.5%in probability plots showed no statistically significant difference between two strategies(P>0.05).Correlation analysis showed a high correlation for MD(r=0.986,P<0.001)and VFI(r=0.986,P<0.001)between the two strategies.Bland-Altman analysis showed great agreement between the two strategies.CONCLUSION:SITA Faster,which saves considerable test time,has a great test quality comparing to SITA Fast,but may be not directly interchangeable.
文摘AIM：To determine the Bruch＇s membrane opening-minimum rim width（BMO-MRW） tipping point where corresponding visual field（VF） damages become detectable.METHODS：A total of 85 normal subjects and 83 glaucoma patients（one eye per participant） were recruited for the study.All of the patients had VF examinations and spectral-domain optical coherence tomography to measure the BMO-MRW.Total deviation values for 52 VF points were allocated to the corresponding sector according to the Garway-Heath distribution map.To evaluate the relationship between VF loss and BMOMRW measurements,a ＂broken-stick＂ statistical model was used.The tipping point where the VF values started to sharply decrease as a function of BMO-MRW measurements was estimated and the slopes above and below this tipping point were compared.RESULTS：A 25.9% global BMO-MRW loss from normative value was required for the VF loss to be detectable.Sectorally,substantial BMO-MRW thinning in inferotemporal sector（33.1%） and relatively less BMO-MRW thinning in the superotemporal sector（8.9%） were necessary for the detection of the VF loss.Beyond the tipping point,the slopes were close to zero throughout all of the sectors and the VF loss was unrelated to the BMO-MRW loss.The VF loss was related to the BMO-MRW loss below the tipping point.The difference between the two slopes was statistically significant（P≤0.002）.CONCLUSION：Substantial BMO-MRW loss appears to be necessary for VF loss to be detectable in patients with open angle glaucoma with standard achromatic perimetry.
基金Supported by Wills Eye Innovation Grant#WEF15064
文摘AIM:To validate the ability of the Heidelberg Edge Perimeter(HEP)in detecting glaucomatous visual field(VF)defects compared to the Octopus Visual Field(OVF)Analyzer and to determine the test-retest repeatability of both modalities.METHODS:This prospective,cross-sectional study was conducted at Wills Eye Hospital,Philadelphia,PA.Glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP)Ⅲ30-2 Adaptive Staircase Thresholding Algorithm(ASTA)FAST protocol and OVF G-TOP white-on-white strategy.Testing order was randomized.Pearson's correlation coefficient was calculated for both mean deviation(MD)and pattern standard deviation/square root of loss of variance(PSD/s LV).Receiver operating characteristic(ROC)curves were used to determine the diagnostic abilities of both modalities.Glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs)were calculated to assess test-retest repeatability.RESULTS:Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled.HEP and OVF were significantly correlated for both MD(r=-0.84;P<0.01)and PSD/s LV(r=0.79;P<0.01).Areas under the ROC curves(AUCs)were also comparable between HEP and OVF for both MD(0.74 and 0.79,respectively;P=0.26)and PSD/sL V(0.74 and 0.82;P=0.08).ICC was high for both HEP(0.96 for MD,0.95 for PSD/s LV)and OVF(0.82 and 0.88,respectively).Mean test duration(min)was significantly shorter for OVF(2.63)compared to HEP(5.15;P<0.01).CONCLUSION:HEP and OVF show strong correlation for both MD and PSD/s LV,and have similar validity for detecting glaucoma.The test-retest repeatability is high for both HEP and OVF,however the average testing duration of HEP is significantly longer than that of OVF.
基金Supported by State Key Program of National Natural Science Foundation of China(No.81430007)National Natural Science Foundation of China(No.81790641,No.81401533)Natural Science Foundation of Shanghai(No.18ZR1406000)。
文摘AIM:To evaluate the driving performance in young and middle-aged Chinese glaucoma patients with mild to severe visual field loss compared to those without glaucoma by using a driving simulation test.METHODS:Twenty-nine participants were included in this study:nine patients with glaucoma but pass the binocular Esterman visual field test,ten patients with glaucoma and fail the binocular Esterman visual field test,and ten age-matched healthy controls.A driving simulation test was designed as a frequency-based analysis of a lanekeeping task.The total performance error,the controlresponse amplitude and delay were calculated.RESULTS:Esterman visual field test fail group showed the longest delay of control-response among three groups(P=0.02).And the delay in lane-keeping task was significantly associated with inferior field of better-eye(r=0.51,P=0.004)and integrated visual field(r=0.55,P=0.002).CONCLUSION:Young and middle-aged glaucoma patients with binocular visual field loss suffered from a longer delay of response in driving simulation test,while inferior visual field having more impact than superior visual field.
文摘AIM: To assess the association between buried optic disc drusen(BODD) location using spectral-domain optical coherence tomography(SD-OCT) and the location of associated visual field defects(VFD) using the Garway-Heath mapping.METHODS: This monocentric retrospective crosssectional study was led at the authors’ institution. Adult patients diagnosed with BODD who had complete records with a reliable Humphrey? 24-2 visual field, macular, and papillary OCT were enrolled. Fisher’s exact test was used to measure the association between BODD location and VFD distribution according to Garway-Heath’s mapping.RESULTS: Totally 20 eyes of 15 patients were included(60% females). The median age(interquartile range) was 63(43)y and the median best corrected visual acuity(BCVA) was-0.08(0.08) log MAR. BODD were mostly located in zones A, E, and F. The minimal rim width(MRW) was globally preserved. The retinal nerve fiber layer(RNFL) was predominantly altered in zones D, E, and F. There was a significant correlation between BODD location and that of RNFL alterations in zones D(P=0.03) and E(P=0.025);Moreover, the presence of BODD in the E zone was significantly related to damaged RNFL in the neighbouring sectors D and F(P=0.012;P=0.02 respectively). Sixty-three percent(12/19) of visual fields were abnormal and there was a significant match(Phi=0.7, P=0.009) between drusen location and VFD only in zone D.CONCLUSION: BODD do not only affect young patients and can be more harmful than usually expected, as we found VFD in 63% of cases. There is a correspondence between BODD location, RNFL damage, and VFD distributions. The presence of BODD induces the overestimation of MRW,thereby disrupting its sensitivity as an early indicator of ganglion fibers damage.
文摘AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations and their diagnostic ability in glaucomatous eyes.METHODS:The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were tested.We investigated the correlations of mean deviation,pattern standard deviation,visual field index,and the sensitivity.RESULTS:Measurements of mean deviation(r=0.886,P<0.001),pattern standard deviation(r=0.814,P<0.001),and visual field index(r=0.871,P<0.001)in both perimeters were strongly and positively correlated.The sensitivities in the imo perimeter were 80.5%for mean deviation,81.2%for pattern standard deviation,and 80.5%in visual field index;those in the HFA were 63.3%for mean deviation,74.5%for pattern standard deviation,and 80.5%for visual field index.Both perimeters demonstrated high diagnostic ability.CONCLUSION:The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity,specificity,and diagnostic ability.However,the difference between imo and HFA results increases with the increase in visual field disturbance.
