BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side effects.This case report explores the novel us...BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side effects.This case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA repair.CASE SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain control.The patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without complications.By preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular surgeries.CONCLUSION Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.展开更多
For a simple graph G,let A(G)and D(G)be the adjacency matrix and the diagonal degree matrix of G,respectively.[Appl.Anal.Discrete Math.,2017,11(1):81-107]defined the matrix A_(α)(G)of G as A_(α)(G)=αD(G)(1-α)A(G)...For a simple graph G,let A(G)and D(G)be the adjacency matrix and the diagonal degree matrix of G,respectively.[Appl.Anal.Discrete Math.,2017,11(1):81-107]defined the matrix A_(α)(G)of G as A_(α)(G)=αD(G)(1-α)A(G),α∈[0,1].The Aa-spectral radius is the largest eigenvalue of A_(α)(G).Let G_(n,β) be the set graphs with order n and dissociation numberβ.In this paper,we identify the b with maximal A_(α)-spectral radius among all graphs in G_(n,β).展开更多
This paper explores the recovery of block sparse signals in frame-based settings using the l_(2)/l_(q)-synthesis technique(0<q≤1).We propose a new null space property,referred to as block D-NSP_(q),which is based ...This paper explores the recovery of block sparse signals in frame-based settings using the l_(2)/l_(q)-synthesis technique(0<q≤1).We propose a new null space property,referred to as block D-NSP_(q),which is based on the dictionary D.We establish that matrices adhering to the block D-NSP_(q)condition are both necessary and sufficient for the exact recovery of block sparse signals via l_(2)/l_(q)-synthesis.Additionally,this condition is essential for the stable recovery of signals that are block-compressible with respect to D.This D-NSP_(q)property is identified as the first complete condition for successful signal recovery using l_(2)/l_(q)-synthesis.Furthermore,we assess the theoretical efficacy of the l2/lq-synthesis method under conditions of measurement noise.展开更多
A nonlinear multi-scale interaction(NMI)model was proposed and developed by the first author for nearly 30 years to represent the evolution of atmospheric blocking.In this review paper,we first review the creation and...A nonlinear multi-scale interaction(NMI)model was proposed and developed by the first author for nearly 30 years to represent the evolution of atmospheric blocking.In this review paper,we first review the creation and development of the NMI model and then emphasize that the NMI model represents a new tool for identifying the basic physics of how climate change influences mid-to-high latitude weather extremes.The building of the NMI model took place over three main periods.In the 1990s,a nonlinear Schr?dinger(NLS)equation model was presented to describe atmospheric blocking as a wave packet;however,it could not depict the lifetime(10-20 days)of atmospheric blocking.In the 2000s,we proposed an NMI model of atmospheric blocking in a uniform basic flow by making a scale-separation assumption and deriving an eddyforced NLS equation.This model succeeded in describing the life cycle of atmospheric blocking.In the 2020s,the NMI model was extended to include the impact of a changing climate mainly by altering the basic zonal winds and the magnitude of the meridional background potential vorticity gradient(PVy).Model results show that when PVy is smaller,blocking has a weaker dispersion and a stronger nonlinearity,so blocking can be more persistent and have a larger zonal scale and weaker eastward movement,thus favoring stronger weather extremes.However,when PVy is much smaller and below a critical threshold under much stronger winter Arctic warming of global warming,atmospheric blocking becomes locally less persistent and shows a much stronger westward movement,which acts to inhibit local cold extremes.Such a case does not happen in summer under global warming because PVy fails to fall below the critical threshold.Thus,our theory indicates that global warming can render summer-blocking anticyclones and mid-to-high latitude heatwaves more persistent,intense,and widespread.展开更多
Ballet is one of the finalists of the block cipher project in the 2019 National Cryptographic Algorithm Design Competition.This study aims to conduct a comprehensive security evaluation of Ballet from the perspective ...Ballet is one of the finalists of the block cipher project in the 2019 National Cryptographic Algorithm Design Competition.This study aims to conduct a comprehensive security evaluation of Ballet from the perspective of differential-linear(DL)cryptanalysis.Specifically,we present an automated search for the DL distinguishers of Ballet based on MILP/MIQCP.For the versions with block sizes of 128 and 256 bits,we obtain 16 and 22 rounds distinguishers with estimated correlations of 2^(-59.89)and 2^(-116.80),both of which are the publicly longest distinguishers.In addition,this study incorporates the complexity information of key-recovery attacks into the automated model,to search for the optimal key-recovery attack structures based on DL distinguishers.As a result,we mount the key-recovery attacks on 16-round Ballet-128/128,17-round Ballet-128/256,and 21-round Ballet-256/256.The data/time complexities for these attacks are 2^(108.36)/2^(120.36),2^(115.90)/2^(192),and 2^(227.62)/2^(240.67),respectively.展开更多
With the continuous development of artificial intelligence and machine learning techniques,there have been effective methods supporting the work of dermatologist in the field of skin cancer detection.However,object si...With the continuous development of artificial intelligence and machine learning techniques,there have been effective methods supporting the work of dermatologist in the field of skin cancer detection.However,object significant challenges have been presented in accurately segmenting melanomas in dermoscopic images due to the objects that could interfere human observations,such as bubbles and scales.To address these challenges,we propose a dual U-Net network framework for skin melanoma segmentation.In our proposed architecture,we introduce several innovative components that aim to enhance the performance and capabilities of the traditional U-Net.First,we establish a novel framework that links two simplified U-Nets,enabling more comprehensive information exchange and feature integration throughout the network.Second,after cascading the second U-Net,we introduce a skip connection between the decoder and encoder networks,and incorporate a modified receptive field block(MRFB),which is designed to capture multi-scale spatial information.Third,to further enhance the feature representation capabilities,we add a multi-path convolution block attention module(MCBAM)to the first two layers of the first U-Net encoding,and integrate a new squeeze-and-excitation(SE)mechanism with residual connections in the second U-Net.To illustrate the performance of our proposed model,we conducted comprehensive experiments on widely recognized skin datasets.On the ISIC-2017 dataset,the IoU value of our proposed model increased from 0.6406 to 0.6819 and the Dice coefficient increased from 0.7625 to 0.8023.On the ISIC-2018 dataset,the IoU value of proposed model also improved from 0.7138 to 0.7709,while the Dice coefficient increased from 0.8285 to 0.8665.Furthermore,the generalization experiments conducted on the jaw cyst dataset from Quzhou People’s Hospital further verified the outstanding segmentation performance of the proposed model.These findings collectively affirm the potential of our approach as a valuable tool in supporting clinical decision-making in the field of skin cancer detection,as well as advancing research in medical image analysis.展开更多
Accurate identification and effective support of key blocks are crucial for ensuring the stability and safety of rock slopes.The number of structural planes and rock blocks were reduced in previous studies.This impair...Accurate identification and effective support of key blocks are crucial for ensuring the stability and safety of rock slopes.The number of structural planes and rock blocks were reduced in previous studies.This impairs the ability to characterize complex rock slopes accurately and inhibits the identification of key blocks.In this paper,a knowledge-data dually driven paradigm for accurate identification of key blocks in complex rock slopes is proposed.Our basic idea is to integrate key block theory into data-driven models based on finely characterizing structural features to identify key blocks in complex rock slopes accurately.The proposed novel paradigm consists of(1)representing rock slopes as graph-structured data based on complex systems theory,(2)identifying key nodes in the graph-structured data using graph deep learning,and(3)mapping the key nodes of graph-structured data to corresponding key blocks in the rock slope.Verification experiments and real-case applications are conducted by the proposed method.The verification results demonstrate excellent model performance,strong generalization capability,and effective classification results.Moreover,the real case application is conducted on the northern slope of the Yanqianshan Iron Mine.The results show that the proposed method can accurately identify key blocks in complex rock slopes,which can provide a decision-making basis and rational recommendations for effective support and instability prevention of rock slopes,thereby ensuring the stability of rock engineering and the safety of life and property.展开更多
Dear Editor,The latest Visian implantable collamer lens(ICL)with a central port design(Aquaport;model V4c)obviates the necessity for preoperative laser iridotomy or intraoperative iridectomy by allowing the free flow ...Dear Editor,The latest Visian implantable collamer lens(ICL)with a central port design(Aquaport;model V4c)obviates the necessity for preoperative laser iridotomy or intraoperative iridectomy by allowing the free flow of the aqueous humor between the sides of the intraocular lens.The design of Aquaport can also eliminate the complications associated with iridotomy and iridectomy.Therefore,the V4c ICL has the potential to significantly reduce the risk of pupillary block compared to its predecessors.展开更多
The Bijigou intrusion is one of the largest and most well-differentiated Fe–Ti oxide-bearing layered intrusions in the Hannan massif located in the northwestern margin of the Yangtze Block,South China.Besides the min...The Bijigou intrusion is one of the largest and most well-differentiated Fe–Ti oxide-bearing layered intrusions in the Hannan massif located in the northwestern margin of the Yangtze Block,South China.Besides the mineralization-related mafic-ultramafic rocks,the intermediate-acid intrusive rocks are also exposed in the mining area,which is of great significance for the understanding the Neoproterozoic tectonic evolution of the Yangtze Block,but studies on these intermediate-acid rocks are scarce.The Bijigou mafic-ultramafic layered intrusion is surrounded by granite and cut by syenite veins.Here,we report new zircon U-Pb ages,Lu-Hf isotope composition and bulk rock geochemical data of the Bijigou syenite vein and wall-rock granite in the northwestern margin of the Yangtze Block.Laser ablation inductively coupled plasma mass spectrometry(LAICP-MS)zircon U-Pb dating results show that the Bijigou syenite vein and wall-rock granite formed at 770±3.5 Ma(MSWD=0.17,n=28)and 810±4 Ma(MSWD=0.84,n=26),respectively.The zirconεHf(t)values of the syenite veins range from+1.52 to+5.33(average of+3.05),combined with its high potassium contents,negative Nb–Ta anomalies and positive Pb anomalies,suggesting that they may have originated from mantle-derived basaltic magma,which was modified by materials from subducting oceanic slab.The zirconεHf(t)and T_(DM2)ages of the wall-rock granite range from+0.71 to+5.71(average+3.06)and 1344 to 1659 Ma(average 1519 Ma),respectively,indicating that the granite was produced by partial melting of juvenile crust.The geochemical characteristics of the Bijigou syenite and granite indicate that they were formed in a continental margin arc setting.Thus,combined with previous studies,it suggests that there was a major subduction system along the northwestern margin of the Yangtze Block during 824-720 Ma,and the magmatism in the Hannan massif was divided into two episodes:(1)early magmatism(824-790 Ma),such as the Bijigou,Hongmiaozhen and Huangguanzhen granitoids,was derived from partial melting of the juvenile or pre-existing crust in a continental arc setting;(2)later magmatism(789-718 Ma),including Bijigou syenite,Wudumen,Erliba and Zushidian granitoids,formed in a subduction-related back-arc extensional environment.The long-term subduction system along the northwestern margin of the Yangtze Block during 824-720 Ma suggests that the Yangtze Block was previously located at the periphery of the Rodinia supercontinent.展开更多
A significant challenge in developing block copolymer photonic crystals is constructing low-symmetric ordered phases,which are essential for achieving a complete photonic band gap.Here,we propose a promising strategy ...A significant challenge in developing block copolymer photonic crystals is constructing low-symmetric ordered phases,which are essential for achieving a complete photonic band gap.Here,we propose a promising strategy to create low-symmetric ordered morphologies by incorporating shape-anisotropic rod-like side chains into block copolymers.Using dissipative particle dynamics simulations,we demonstrate that block copolymers with longer rod-like side chains can self-assemble into a hexagonally packed columnar phase characterized by a low-symmetric rectangular cross-section.Photonic band structure calculations reveal that this low-symmetric columnar phase can exhibit a complete photonic band gap,with the gap size dependent on the aspect ratio of the rectangular cross-sections of the columns.Our findings suggest an effective approach to constructing low-symmetric photonic crystals through the self-assembly of block copolymers with shape-anisotropic segments.展开更多
Multiple instances of the Late Cretaceous granodiorites within the Anglonggangri region of the northwestern Lhasa Block were identified,their petrogenesis were explored and mineralization potential were assessed.The z...Multiple instances of the Late Cretaceous granodiorites within the Anglonggangri region of the northwestern Lhasa Block were identified,their petrogenesis were explored and mineralization potential were assessed.The zircon U-Pb dating of the Anglonggangri granodiorites revealed ages of 82.8 and 80.8 Ma.Granodiorite samples have SiO2 contents of 64.36-68.33 wt%,with high Sr/Y(55-95)and A/CNK ratios(0.99-1.06).Zirconε_(Hf)(t)values range from−0.3 to+16.2.Two granodiorite samples have(^(87)Sr/^(86)Sr)i values of 0.7034 and 0.7043 and positiveɛNd(t)values of 3.51 and 3.83.These geochemical properties indicate that they are adakitic rocks formed by partial melting of the juvenile thickened lower crust,slightly contaminated with material from the mantle due to the small-scale delamination of the lower crust.The zircons in the granodiorites have moderate Ce/Nd(2.5-43),logfO2(−20.0 to−9.6),andΔFMQ(−1.28 to+4.00)values;low(Ce/Nd)/Y(0.001-0.049)ratios;and high Dy/Yb(0.17-1.16)ratios,which indicate that these granodiorites exhibit moderate oxygen fugacity and lower magma water content than the Miocene Gangdese porphyry copper deposits associated with high-Sr/Y granites.Their ability to create porphyry-type copper deposits could have been hampered by their low magma water content and moderate oxygen fugacity.展开更多
BACKGROUND The dexmedetomidine(DEX)plus ropivacaine treatment enables a transversus abdominis plane block(TAPB)of the peripheral nerves in patients undergoing radical resection for colorectal cancer(CRC)that can provi...BACKGROUND The dexmedetomidine(DEX)plus ropivacaine treatment enables a transversus abdominis plane block(TAPB)of the peripheral nerves in patients undergoing radical resection for colorectal cancer(CRC)that can provide clinical data for improving the postoperative analgesic effect,reducing the risk of cognitive impairment,and decreasing the circulating levels of serum inflammatory factors and stress hormones.AIM To assess the impact of DEX plus ropivacaine-enabled TAPB on pain,postoperative cognitive dysfunction(POCD),and inflammatory/stress factors.METHODS Our patient cohort was randomly divided into control and observation groups(60/group).The observation group used a DEX plus ropivacaine-enabled TAPB,while the control group employed a ropivacaine-enabled TAPB.The pain score[Visual Analogy Scale(VAS),Montreal Cognitive Assessment(MoCA)],serum inflammatory factor level(C-reactive protein,interleukin-6 and tumor necrosis factor-α),serum stress hormone levels(cortisol and adrenaline)and postoperative adverse reactions were compared between the two groups.RESULTS The observation group VAS scores were lower than those of the control group(better analgesic effect,P<0.05).The MoCA and POCD scores decreased post-surgery in the observation group(P<0.05).In the elderly,the overall VAS and MoCA scores were significantly reduced compared with the young group.The C-reactive protein,interleukin-6,tumor necrosis factor-α,cortisol and adrenaline levels were lower in the observation group compared with the control group post-surgery(P<0.05).There was no significant difference in adverse reactions between the two groups post-surgery,but the incidence of adverse reactions in the observation group was still lower.DEX continuously inhibited p65-phosphorylation levels in the nuclear factorκB pathway at multiple time points,and its inhibitory effect became more significant over time.CONCLUSION DEX plus ropivacaine-enabled TAPB reduces POCD and inflammatory/stress hormone levels,and significantly improves the postoperative analgesic effect of patients undergoing radical resection for colorectal cancer.展开更多
Polymerization-induced self-assembly(PISA)has become one of the most versatile approaches for scalable preparation of linear block copolymer nanoparticles with various morphologies.However,the controlled introduction ...Polymerization-induced self-assembly(PISA)has become one of the most versatile approaches for scalable preparation of linear block copolymer nanoparticles with various morphologies.However,the controlled introduction of branching into the core-forming block and the effect on the morphologies of block copolymer nanoparticles under PISA conditions have rarely been explored.Herein,a series of multifunctional macromolecular chain transfer agents(macro-CTAs)were first synthesized by a two-step green light-activated photoiniferter polymerization using two types of chain transfer monomers(CTMs).These macro-CTAs were then used to mediate reversible addition-fragmentation chain transfer(RAFT)dispersion polymerization of styrene(St)to prepare block copolymers with different core-forming block structures and the assemblies.The effect of the core-forming block structure on the morphology of block copolymer nanoparticles was investigated in detail.Transmission electron microscopy(TEM)analysis indicated that the brush-like core-forming block structure facilitated the formation of higher-order morphologies,while the branched core-forming block structure favored the formation of lower-order morphologies.Moreover,it was found that using macroCTAs with a shorter length also promoted the formation of higher-order morphologies.Finally,structures of block copolymers and the assemblies were further controlled by changing the structure of macro-CTA or using a binary mixture of two different macro-CTAs.We expect that this work not only sheds light on the synthesis of block copolymer nanoparticles but also provide important mechanistic insights into PISA of nonlinear block copolymers.展开更多
基金Supported by the Taichung Veterans General Hospital,No.TCVGH-1125401B.
文摘BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side effects.This case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA repair.CASE SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain control.The patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without complications.By preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular surgeries.CONCLUSION Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.
基金Supported by NSFC (Nos.12171089,12271235)NSF of Jiangsu (No.BK20190919)NSF of Fujian (No.2021J02048)。
文摘For a simple graph G,let A(G)and D(G)be the adjacency matrix and the diagonal degree matrix of G,respectively.[Appl.Anal.Discrete Math.,2017,11(1):81-107]defined the matrix A_(α)(G)of G as A_(α)(G)=αD(G)(1-α)A(G),α∈[0,1].The Aa-spectral radius is the largest eigenvalue of A_(α)(G).Let G_(n,β) be the set graphs with order n and dissociation numberβ.In this paper,we identify the b with maximal A_(α)-spectral radius among all graphs in G_(n,β).
基金Supported by The Featured Innovation Projects of the General University of Guangdong Province(2023KTSCX096)The Special Projects in Key Areas of Guangdong Province(ZDZX1088)Research Team Project of Guangdong University of Education(2024KYCXTD018)。
文摘This paper explores the recovery of block sparse signals in frame-based settings using the l_(2)/l_(q)-synthesis technique(0<q≤1).We propose a new null space property,referred to as block D-NSP_(q),which is based on the dictionary D.We establish that matrices adhering to the block D-NSP_(q)condition are both necessary and sufficient for the exact recovery of block sparse signals via l_(2)/l_(q)-synthesis.Additionally,this condition is essential for the stable recovery of signals that are block-compressible with respect to D.This D-NSP_(q)property is identified as the first complete condition for successful signal recovery using l_(2)/l_(q)-synthesis.Furthermore,we assess the theoretical efficacy of the l2/lq-synthesis method under conditions of measurement noise.
基金supported by the National Natural Science Foundation of China(Grant Nos.42150204 and 2288101)supported by the China National Postdoctoral Program for Innovative Talents(BX20230045)the China Postdoctoral Science Foundation(2023M730279)。
文摘A nonlinear multi-scale interaction(NMI)model was proposed and developed by the first author for nearly 30 years to represent the evolution of atmospheric blocking.In this review paper,we first review the creation and development of the NMI model and then emphasize that the NMI model represents a new tool for identifying the basic physics of how climate change influences mid-to-high latitude weather extremes.The building of the NMI model took place over three main periods.In the 1990s,a nonlinear Schr?dinger(NLS)equation model was presented to describe atmospheric blocking as a wave packet;however,it could not depict the lifetime(10-20 days)of atmospheric blocking.In the 2000s,we proposed an NMI model of atmospheric blocking in a uniform basic flow by making a scale-separation assumption and deriving an eddyforced NLS equation.This model succeeded in describing the life cycle of atmospheric blocking.In the 2020s,the NMI model was extended to include the impact of a changing climate mainly by altering the basic zonal winds and the magnitude of the meridional background potential vorticity gradient(PVy).Model results show that when PVy is smaller,blocking has a weaker dispersion and a stronger nonlinearity,so blocking can be more persistent and have a larger zonal scale and weaker eastward movement,thus favoring stronger weather extremes.However,when PVy is much smaller and below a critical threshold under much stronger winter Arctic warming of global warming,atmospheric blocking becomes locally less persistent and shows a much stronger westward movement,which acts to inhibit local cold extremes.Such a case does not happen in summer under global warming because PVy fails to fall below the critical threshold.Thus,our theory indicates that global warming can render summer-blocking anticyclones and mid-to-high latitude heatwaves more persistent,intense,and widespread.
基金National Natural Science Foundation of China(62272147,12471492,62072161,12401687)Shandong Provincial Natural Science Foundation(ZR2024QA205)+1 种基金Science and Technology on Communication Security Laboratory Foundation(6142103012207)Innovation Group Project of the Natural Science Foundation of Hubei Province of China(2023AFA021)。
文摘Ballet is one of the finalists of the block cipher project in the 2019 National Cryptographic Algorithm Design Competition.This study aims to conduct a comprehensive security evaluation of Ballet from the perspective of differential-linear(DL)cryptanalysis.Specifically,we present an automated search for the DL distinguishers of Ballet based on MILP/MIQCP.For the versions with block sizes of 128 and 256 bits,we obtain 16 and 22 rounds distinguishers with estimated correlations of 2^(-59.89)and 2^(-116.80),both of which are the publicly longest distinguishers.In addition,this study incorporates the complexity information of key-recovery attacks into the automated model,to search for the optimal key-recovery attack structures based on DL distinguishers.As a result,we mount the key-recovery attacks on 16-round Ballet-128/128,17-round Ballet-128/256,and 21-round Ballet-256/256.The data/time complexities for these attacks are 2^(108.36)/2^(120.36),2^(115.90)/2^(192),and 2^(227.62)/2^(240.67),respectively.
基金funded by Zhejiang Basic Public Welfare Research Project,grant number LZY24E060001supported by Guangzhou Development Zone Science and Technology(2021GH10,2020GH10,2023GH02)+1 种基金the University of Macao(MYRG2022-00271-FST)the Science and Technology Development Fund(FDCT)of Macao(0032/2022/A).
文摘With the continuous development of artificial intelligence and machine learning techniques,there have been effective methods supporting the work of dermatologist in the field of skin cancer detection.However,object significant challenges have been presented in accurately segmenting melanomas in dermoscopic images due to the objects that could interfere human observations,such as bubbles and scales.To address these challenges,we propose a dual U-Net network framework for skin melanoma segmentation.In our proposed architecture,we introduce several innovative components that aim to enhance the performance and capabilities of the traditional U-Net.First,we establish a novel framework that links two simplified U-Nets,enabling more comprehensive information exchange and feature integration throughout the network.Second,after cascading the second U-Net,we introduce a skip connection between the decoder and encoder networks,and incorporate a modified receptive field block(MRFB),which is designed to capture multi-scale spatial information.Third,to further enhance the feature representation capabilities,we add a multi-path convolution block attention module(MCBAM)to the first two layers of the first U-Net encoding,and integrate a new squeeze-and-excitation(SE)mechanism with residual connections in the second U-Net.To illustrate the performance of our proposed model,we conducted comprehensive experiments on widely recognized skin datasets.On the ISIC-2017 dataset,the IoU value of our proposed model increased from 0.6406 to 0.6819 and the Dice coefficient increased from 0.7625 to 0.8023.On the ISIC-2018 dataset,the IoU value of proposed model also improved from 0.7138 to 0.7709,while the Dice coefficient increased from 0.8285 to 0.8665.Furthermore,the generalization experiments conducted on the jaw cyst dataset from Quzhou People’s Hospital further verified the outstanding segmentation performance of the proposed model.These findings collectively affirm the potential of our approach as a valuable tool in supporting clinical decision-making in the field of skin cancer detection,as well as advancing research in medical image analysis.
基金supported by the National Natural Science Foundation of China(Grant Nos.42277161,42230709).
文摘Accurate identification and effective support of key blocks are crucial for ensuring the stability and safety of rock slopes.The number of structural planes and rock blocks were reduced in previous studies.This impairs the ability to characterize complex rock slopes accurately and inhibits the identification of key blocks.In this paper,a knowledge-data dually driven paradigm for accurate identification of key blocks in complex rock slopes is proposed.Our basic idea is to integrate key block theory into data-driven models based on finely characterizing structural features to identify key blocks in complex rock slopes accurately.The proposed novel paradigm consists of(1)representing rock slopes as graph-structured data based on complex systems theory,(2)identifying key nodes in the graph-structured data using graph deep learning,and(3)mapping the key nodes of graph-structured data to corresponding key blocks in the rock slope.Verification experiments and real-case applications are conducted by the proposed method.The verification results demonstrate excellent model performance,strong generalization capability,and effective classification results.Moreover,the real case application is conducted on the northern slope of the Yanqianshan Iron Mine.The results show that the proposed method can accurately identify key blocks in complex rock slopes,which can provide a decision-making basis and rational recommendations for effective support and instability prevention of rock slopes,thereby ensuring the stability of rock engineering and the safety of life and property.
基金Supported by the National Key Research and Development Program(No.2019YFC1710200)the Shandong Province Pharmaceutical Technology Development Project(No.202107020970).
文摘Dear Editor,The latest Visian implantable collamer lens(ICL)with a central port design(Aquaport;model V4c)obviates the necessity for preoperative laser iridotomy or intraoperative iridectomy by allowing the free flow of the aqueous humor between the sides of the intraocular lens.The design of Aquaport can also eliminate the complications associated with iridotomy and iridectomy.Therefore,the V4c ICL has the potential to significantly reduce the risk of pupillary block compared to its predecessors.
基金jointly supported financially by the National Natural Science Foundation of China(No.41603040)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2023-JC-YB-239)Fundamental Research Funds for the Central Universities(S202310710204)。
文摘The Bijigou intrusion is one of the largest and most well-differentiated Fe–Ti oxide-bearing layered intrusions in the Hannan massif located in the northwestern margin of the Yangtze Block,South China.Besides the mineralization-related mafic-ultramafic rocks,the intermediate-acid intrusive rocks are also exposed in the mining area,which is of great significance for the understanding the Neoproterozoic tectonic evolution of the Yangtze Block,but studies on these intermediate-acid rocks are scarce.The Bijigou mafic-ultramafic layered intrusion is surrounded by granite and cut by syenite veins.Here,we report new zircon U-Pb ages,Lu-Hf isotope composition and bulk rock geochemical data of the Bijigou syenite vein and wall-rock granite in the northwestern margin of the Yangtze Block.Laser ablation inductively coupled plasma mass spectrometry(LAICP-MS)zircon U-Pb dating results show that the Bijigou syenite vein and wall-rock granite formed at 770±3.5 Ma(MSWD=0.17,n=28)and 810±4 Ma(MSWD=0.84,n=26),respectively.The zirconεHf(t)values of the syenite veins range from+1.52 to+5.33(average of+3.05),combined with its high potassium contents,negative Nb–Ta anomalies and positive Pb anomalies,suggesting that they may have originated from mantle-derived basaltic magma,which was modified by materials from subducting oceanic slab.The zirconεHf(t)and T_(DM2)ages of the wall-rock granite range from+0.71 to+5.71(average+3.06)and 1344 to 1659 Ma(average 1519 Ma),respectively,indicating that the granite was produced by partial melting of juvenile crust.The geochemical characteristics of the Bijigou syenite and granite indicate that they were formed in a continental margin arc setting.Thus,combined with previous studies,it suggests that there was a major subduction system along the northwestern margin of the Yangtze Block during 824-720 Ma,and the magmatism in the Hannan massif was divided into two episodes:(1)early magmatism(824-790 Ma),such as the Bijigou,Hongmiaozhen and Huangguanzhen granitoids,was derived from partial melting of the juvenile or pre-existing crust in a continental arc setting;(2)later magmatism(789-718 Ma),including Bijigou syenite,Wudumen,Erliba and Zushidian granitoids,formed in a subduction-related back-arc extensional environment.The long-term subduction system along the northwestern margin of the Yangtze Block during 824-720 Ma suggests that the Yangtze Block was previously located at the periphery of the Rodinia supercontinent.
基金financially supported by the National Key R&D Program of China(No.2022YFB3707300)the National Natural Science Foundation of China(Nos.22133002,22373089)the support from the Excellent Youth Foundation of Henan Scientific Committee(No.242300421032).
文摘A significant challenge in developing block copolymer photonic crystals is constructing low-symmetric ordered phases,which are essential for achieving a complete photonic band gap.Here,we propose a promising strategy to create low-symmetric ordered morphologies by incorporating shape-anisotropic rod-like side chains into block copolymers.Using dissipative particle dynamics simulations,we demonstrate that block copolymers with longer rod-like side chains can self-assemble into a hexagonally packed columnar phase characterized by a low-symmetric rectangular cross-section.Photonic band structure calculations reveal that this low-symmetric columnar phase can exhibit a complete photonic band gap,with the gap size dependent on the aspect ratio of the rectangular cross-sections of the columns.Our findings suggest an effective approach to constructing low-symmetric photonic crystals through the self-assembly of block copolymers with shape-anisotropic segments.
基金jointly supported by the National Key Research&Development Program of China(2021YFC2900100)the Basic Research Fund of the Chinese Academy of Geological Sciences(KK2306)+1 种基金the Geological Survey Project(DD20230360,DD20243483)the Sichuan Provincial Natural Science Foundation(2023NSFSC0798).
文摘Multiple instances of the Late Cretaceous granodiorites within the Anglonggangri region of the northwestern Lhasa Block were identified,their petrogenesis were explored and mineralization potential were assessed.The zircon U-Pb dating of the Anglonggangri granodiorites revealed ages of 82.8 and 80.8 Ma.Granodiorite samples have SiO2 contents of 64.36-68.33 wt%,with high Sr/Y(55-95)and A/CNK ratios(0.99-1.06).Zirconε_(Hf)(t)values range from−0.3 to+16.2.Two granodiorite samples have(^(87)Sr/^(86)Sr)i values of 0.7034 and 0.7043 and positiveɛNd(t)values of 3.51 and 3.83.These geochemical properties indicate that they are adakitic rocks formed by partial melting of the juvenile thickened lower crust,slightly contaminated with material from the mantle due to the small-scale delamination of the lower crust.The zircons in the granodiorites have moderate Ce/Nd(2.5-43),logfO2(−20.0 to−9.6),andΔFMQ(−1.28 to+4.00)values;low(Ce/Nd)/Y(0.001-0.049)ratios;and high Dy/Yb(0.17-1.16)ratios,which indicate that these granodiorites exhibit moderate oxygen fugacity and lower magma water content than the Miocene Gangdese porphyry copper deposits associated with high-Sr/Y granites.Their ability to create porphyry-type copper deposits could have been hampered by their low magma water content and moderate oxygen fugacity.
文摘BACKGROUND The dexmedetomidine(DEX)plus ropivacaine treatment enables a transversus abdominis plane block(TAPB)of the peripheral nerves in patients undergoing radical resection for colorectal cancer(CRC)that can provide clinical data for improving the postoperative analgesic effect,reducing the risk of cognitive impairment,and decreasing the circulating levels of serum inflammatory factors and stress hormones.AIM To assess the impact of DEX plus ropivacaine-enabled TAPB on pain,postoperative cognitive dysfunction(POCD),and inflammatory/stress factors.METHODS Our patient cohort was randomly divided into control and observation groups(60/group).The observation group used a DEX plus ropivacaine-enabled TAPB,while the control group employed a ropivacaine-enabled TAPB.The pain score[Visual Analogy Scale(VAS),Montreal Cognitive Assessment(MoCA)],serum inflammatory factor level(C-reactive protein,interleukin-6 and tumor necrosis factor-α),serum stress hormone levels(cortisol and adrenaline)and postoperative adverse reactions were compared between the two groups.RESULTS The observation group VAS scores were lower than those of the control group(better analgesic effect,P<0.05).The MoCA and POCD scores decreased post-surgery in the observation group(P<0.05).In the elderly,the overall VAS and MoCA scores were significantly reduced compared with the young group.The C-reactive protein,interleukin-6,tumor necrosis factor-α,cortisol and adrenaline levels were lower in the observation group compared with the control group post-surgery(P<0.05).There was no significant difference in adverse reactions between the two groups post-surgery,but the incidence of adverse reactions in the observation group was still lower.DEX continuously inhibited p65-phosphorylation levels in the nuclear factorκB pathway at multiple time points,and its inhibitory effect became more significant over time.CONCLUSION DEX plus ropivacaine-enabled TAPB reduces POCD and inflammatory/stress hormone levels,and significantly improves the postoperative analgesic effect of patients undergoing radical resection for colorectal cancer.
基金financially supported by the National Natural Science Foundation of China(Nos.22171055 and 52222301)the Guangdong Natural Science Foundation for Distinguished Young Scholar(No.2022B1515020078)the Science and Technology Program of Guangzhou(No.2024A04J2821)。
文摘Polymerization-induced self-assembly(PISA)has become one of the most versatile approaches for scalable preparation of linear block copolymer nanoparticles with various morphologies.However,the controlled introduction of branching into the core-forming block and the effect on the morphologies of block copolymer nanoparticles under PISA conditions have rarely been explored.Herein,a series of multifunctional macromolecular chain transfer agents(macro-CTAs)were first synthesized by a two-step green light-activated photoiniferter polymerization using two types of chain transfer monomers(CTMs).These macro-CTAs were then used to mediate reversible addition-fragmentation chain transfer(RAFT)dispersion polymerization of styrene(St)to prepare block copolymers with different core-forming block structures and the assemblies.The effect of the core-forming block structure on the morphology of block copolymer nanoparticles was investigated in detail.Transmission electron microscopy(TEM)analysis indicated that the brush-like core-forming block structure facilitated the formation of higher-order morphologies,while the branched core-forming block structure favored the formation of lower-order morphologies.Moreover,it was found that using macroCTAs with a shorter length also promoted the formation of higher-order morphologies.Finally,structures of block copolymers and the assemblies were further controlled by changing the structure of macro-CTA or using a binary mixture of two different macro-CTAs.We expect that this work not only sheds light on the synthesis of block copolymer nanoparticles but also provide important mechanistic insights into PISA of nonlinear block copolymers.
