Objective To analyze the correlative factors of peptic ulcer recurrence in the elderly.Methods From January to December 2009,169 elderly patients(≥60 years old)with peptic ulcer delected by edoscopy were enrolled,who...Objective To analyze the correlative factors of peptic ulcer recurrence in the elderly.Methods From January to December 2009,169 elderly patients(≥60 years old)with peptic ulcer delected by edoscopy were enrolled,whose treatment and usage of medication were analyzed.Data of treatment and recurrence in 3-year follow-up were recorded.Mann-Whitney rank sum test展开更多
An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pyl...An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pylori(H.pylori).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric ulcer.Though cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but H.pylori was undetectable.This is the first case of recurrent Candida-associated gastric ulcer in the world.Detected in both the original and recurrent lesions in an H.pylori-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.展开更多
Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work r...Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.展开更多
Objective: To observe the curative effects of Yiqing granule and Zhibai Dihuang pill combined with Oralpolin gel on recurrent aphthous ulcer. Methods: 150 patients with mild recurrent aphthous ulcer were classified as...Objective: To observe the curative effects of Yiqing granule and Zhibai Dihuang pill combined with Oralpolin gel on recurrent aphthous ulcer. Methods: 150 patients with mild recurrent aphthous ulcer were classified as excessive internal heat type and deficiency internal heat type by traditional Chinese medicine theory. Then, they were randomly divided into the positive control group (thalidomide group), the trial group (Yiqing granule group/Zhibai Dihuang pill group), and the negative control group (topical medication group). All the patients in every group used Oralpolin gel. Additionally, the patients in the positive control group took thalidomide tablets orally and those in the trial group orally took proprietary Chinese medicine (Yiqing granule/Zhibai Dihuang pill). The treatment lasted for 4 weeks. The curative effects were all evaluated according to the “RAU Efficacy Evaluation Trial Standard” which was formulated by the Professional Committee of Mucosal Diseases of Chinese Stomatological Association. Results: Of all the 150 patients involved in this medical experiment, 146 cases finished it, including 66 ones in the trial group, 36 ones in the positive control group, and 44 ones in the negative control group. The total drop-out rate was 2.7%. For the excessive internal heat type, the effective rates in the thalidomide group, the Yiqing granule group and the local medication group were 91.7%, 52.6% and 52.9% respectively in order. For the deficiency internal heat type, the effective rates in the thalidomide group, the Zhibai Dihuang pill group and the local medication group were 87.5%, 71.4% and 40% respectively in order. The clinical efficacy of the Zhibai Dihuang pill group was better than that of the local medication group and similar to that of the thalidomide group (P Conclusion: Zhibai Dihuang pill is significantly effective in the treatment for mild recurrent aphthous ulcer of deficiency internal heat type without severe adverse reactions.展开更多
Recurrent oral ulceration,which is small but not easy to cure,seriously affects the quality of life of the patients.This paper analyzes professor Wang Xiaoyan's application of Yinhuotanghuacai to treat oral ulcer ...Recurrent oral ulceration,which is small but not easy to cure,seriously affects the quality of life of the patients.This paper analyzes professor Wang Xiaoyan's application of Yinhuotanghuacai to treat oral ulcer with floating of yang in deficiency condition,which can significantly improve the clinical symptoms of patients and improve the quality of life of patients.展开更多
Based on Mongolian medical theory and modern pharmacology,literature on the main components and action mechanism of Hatageqi-7 in the treatment of recurrent aphthous ulcer is collected,sorted and summarized.The resear...Based on Mongolian medical theory and modern pharmacology,literature on the main components and action mechanism of Hatageqi-7 in the treatment of recurrent aphthous ulcer is collected,sorted and summarized.The research hopes to provide certain basis for its clinical efficacy from theory.展开更多
Objective: to explore the clinical treatment effect of banxia xiexin decoction combined with Wucornus officinalis sticking Yongquan point in patients with recurrent oral ulcer. Methods: 104 patients with recurrent ora...Objective: to explore the clinical treatment effect of banxia xiexin decoction combined with Wucornus officinalis sticking Yongquan point in patients with recurrent oral ulcer. Methods: 104 patients with recurrent oral ulcer in outpatient department were selected to participate in the study, and divided into two groups by simple random method: control group, western medicine vitamin treatment, observation group, banxia xiexin decoction plus or minus combined with Wucornus sticking Yongquan point treatment. Each group had 52 cases. The control group was treated with Western medicine, the observation group was treated with traditional Chinese medicine, and the therapeutic effects of the two groups were compared. Results: the total effective rate of observation group was significantly higher than that of control group, data comparison between groups: P < 0.05. Conclusion: banxia xiexin decoction combined with Wucornus sticking Yongquan point can achieve ideal therapeutic effect in the treatment of recurrent oral ulcer.展开更多
Objective: to investigate the correlation between psychological factors and the incidence of recurrent oral ulcer among college students in Mudanjiang area. Methods: 80 cases of recurrent oral ulcer were randomly sele...Objective: to investigate the correlation between psychological factors and the incidence of recurrent oral ulcer among college students in Mudanjiang area. Methods: 80 cases of recurrent oral ulcer were randomly selected from full-time college students in Mudanjiang area, the incidence of recurrent oral ulcer in college students was investigated by questionnaire, the psychological factors affecting the occurrence of the disease were evaluated, and the appropriate psychological intervention was carried out to compare the effects before and after the intervention. Results: 98.75% of the students had different stress events in the course of disease, among which learning pressure was the dominant one. After the intervention, the score of symptom scale was lower than that before the intervention, P < 0.05. Before and after the intervention, there was no difference in P psychosis and L dissimulation tendency, P > 0.05. After the intervention, N neuroticism was lower than before, and E inside and outside tendency was higher than before, P < 0.05. Conclusion: psychological factors are closely related to the occurrence of recurrent oral ulcer, and effective psychological intervention should be taken for college students in Mudanjiang area to reduce the incidence of recurrent oral ulcer.展开更多
Objective: To analyze the clinical effect of kangfuxin liquid and iodine glycerin in the treatment of recurrent oral ulcer. Methods: A total of 120 patients with recurrent oral ulcer treated in our hospital from Decem...Objective: To analyze the clinical effect of kangfuxin liquid and iodine glycerin in the treatment of recurrent oral ulcer. Methods: A total of 120 patients with recurrent oral ulcer treated in our hospital from December 2019 to December 2020 were selected as the research objects. The patients were divided into control group and observation group according to random number grouping method, with 60 patients in each group. The control group was treated with iodine glycerin, and the observation group was treated with kangfuxin solution. The clinical therapeutic effects of the two groups were compared. Results: There was no significant difference in VAS score between the two groups before treatment (P>0.05), but 1 day, 1 week and 1 month after treatment, VAS score of the observation group was significantly better than that of the control group, and pain symptoms were better improved, the difference was statistically significant (P<0.05). The time of ulcer disappearance in the observation group was faster than that in the control group, and the total effective rate in the observation group was 96.67%, which was higher than that in the observation group (83.33%), the difference was statistically significant (P<0.05). Conclusion: The use of kangfuxin solution for the treatment of recurrent oral ulcer patients can obtain better therapeutic effect, effectively relieve the pain of patients with ulcer, in a shorter time to let the ulcer disappear, and has a higher therapeutic effectiveness, reduce the recurrence of the disease, should be popularized in clinical application.展开更多
Objective: to discuss the curative effect of combined traditional Chinese and western medicine on recurrent oral ulcer. Methods: the data of 92 patients with recurrent oral ulcer were reviewed and randomly divided int...Objective: to discuss the curative effect of combined traditional Chinese and western medicine on recurrent oral ulcer. Methods: the data of 92 patients with recurrent oral ulcer were reviewed and randomly divided into two groups. Different treatment methods were used to compare the clinical effects. Results: the indexes of the study group were better than those of the control group (P < 0.05). Conclusion: combination of traditional Chinese and western medicine has significant effect on recurrent oral ulcer.展开更多
文摘Objective To analyze the correlative factors of peptic ulcer recurrence in the elderly.Methods From January to December 2009,169 elderly patients(≥60 years old)with peptic ulcer delected by edoscopy were enrolled,whose treatment and usage of medication were analyzed.Data of treatment and recurrence in 3-year follow-up were recorded.Mann-Whitney rank sum test
文摘An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pylori(H.pylori).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric ulcer.Though cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but H.pylori was undetectable.This is the first case of recurrent Candida-associated gastric ulcer in the world.Detected in both the original and recurrent lesions in an H.pylori-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.
基金the National Natural Science Foundation of China(Nos.62003023,32071407,52073138,52003018 and 52003019)Beijing Natural Science Foundation(No.7212204)Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University.
文摘Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.
文摘Objective: To observe the curative effects of Yiqing granule and Zhibai Dihuang pill combined with Oralpolin gel on recurrent aphthous ulcer. Methods: 150 patients with mild recurrent aphthous ulcer were classified as excessive internal heat type and deficiency internal heat type by traditional Chinese medicine theory. Then, they were randomly divided into the positive control group (thalidomide group), the trial group (Yiqing granule group/Zhibai Dihuang pill group), and the negative control group (topical medication group). All the patients in every group used Oralpolin gel. Additionally, the patients in the positive control group took thalidomide tablets orally and those in the trial group orally took proprietary Chinese medicine (Yiqing granule/Zhibai Dihuang pill). The treatment lasted for 4 weeks. The curative effects were all evaluated according to the “RAU Efficacy Evaluation Trial Standard” which was formulated by the Professional Committee of Mucosal Diseases of Chinese Stomatological Association. Results: Of all the 150 patients involved in this medical experiment, 146 cases finished it, including 66 ones in the trial group, 36 ones in the positive control group, and 44 ones in the negative control group. The total drop-out rate was 2.7%. For the excessive internal heat type, the effective rates in the thalidomide group, the Yiqing granule group and the local medication group were 91.7%, 52.6% and 52.9% respectively in order. For the deficiency internal heat type, the effective rates in the thalidomide group, the Zhibai Dihuang pill group and the local medication group were 87.5%, 71.4% and 40% respectively in order. The clinical efficacy of the Zhibai Dihuang pill group was better than that of the local medication group and similar to that of the thalidomide group (P Conclusion: Zhibai Dihuang pill is significantly effective in the treatment for mild recurrent aphthous ulcer of deficiency internal heat type without severe adverse reactions.
文摘Recurrent oral ulceration,which is small but not easy to cure,seriously affects the quality of life of the patients.This paper analyzes professor Wang Xiaoyan's application of Yinhuotanghuacai to treat oral ulcer with floating of yang in deficiency condition,which can significantly improve the clinical symptoms of patients and improve the quality of life of patients.
文摘Based on Mongolian medical theory and modern pharmacology,literature on the main components and action mechanism of Hatageqi-7 in the treatment of recurrent aphthous ulcer is collected,sorted and summarized.The research hopes to provide certain basis for its clinical efficacy from theory.
文摘Objective: to explore the clinical treatment effect of banxia xiexin decoction combined with Wucornus officinalis sticking Yongquan point in patients with recurrent oral ulcer. Methods: 104 patients with recurrent oral ulcer in outpatient department were selected to participate in the study, and divided into two groups by simple random method: control group, western medicine vitamin treatment, observation group, banxia xiexin decoction plus or minus combined with Wucornus sticking Yongquan point treatment. Each group had 52 cases. The control group was treated with Western medicine, the observation group was treated with traditional Chinese medicine, and the therapeutic effects of the two groups were compared. Results: the total effective rate of observation group was significantly higher than that of control group, data comparison between groups: P < 0.05. Conclusion: banxia xiexin decoction combined with Wucornus sticking Yongquan point can achieve ideal therapeutic effect in the treatment of recurrent oral ulcer.
文摘Objective: to investigate the correlation between psychological factors and the incidence of recurrent oral ulcer among college students in Mudanjiang area. Methods: 80 cases of recurrent oral ulcer were randomly selected from full-time college students in Mudanjiang area, the incidence of recurrent oral ulcer in college students was investigated by questionnaire, the psychological factors affecting the occurrence of the disease were evaluated, and the appropriate psychological intervention was carried out to compare the effects before and after the intervention. Results: 98.75% of the students had different stress events in the course of disease, among which learning pressure was the dominant one. After the intervention, the score of symptom scale was lower than that before the intervention, P < 0.05. Before and after the intervention, there was no difference in P psychosis and L dissimulation tendency, P > 0.05. After the intervention, N neuroticism was lower than before, and E inside and outside tendency was higher than before, P < 0.05. Conclusion: psychological factors are closely related to the occurrence of recurrent oral ulcer, and effective psychological intervention should be taken for college students in Mudanjiang area to reduce the incidence of recurrent oral ulcer.
文摘Objective: To analyze the clinical effect of kangfuxin liquid and iodine glycerin in the treatment of recurrent oral ulcer. Methods: A total of 120 patients with recurrent oral ulcer treated in our hospital from December 2019 to December 2020 were selected as the research objects. The patients were divided into control group and observation group according to random number grouping method, with 60 patients in each group. The control group was treated with iodine glycerin, and the observation group was treated with kangfuxin solution. The clinical therapeutic effects of the two groups were compared. Results: There was no significant difference in VAS score between the two groups before treatment (P>0.05), but 1 day, 1 week and 1 month after treatment, VAS score of the observation group was significantly better than that of the control group, and pain symptoms were better improved, the difference was statistically significant (P<0.05). The time of ulcer disappearance in the observation group was faster than that in the control group, and the total effective rate in the observation group was 96.67%, which was higher than that in the observation group (83.33%), the difference was statistically significant (P<0.05). Conclusion: The use of kangfuxin solution for the treatment of recurrent oral ulcer patients can obtain better therapeutic effect, effectively relieve the pain of patients with ulcer, in a shorter time to let the ulcer disappear, and has a higher therapeutic effectiveness, reduce the recurrence of the disease, should be popularized in clinical application.
文摘Objective: to discuss the curative effect of combined traditional Chinese and western medicine on recurrent oral ulcer. Methods: the data of 92 patients with recurrent oral ulcer were reviewed and randomly divided into two groups. Different treatment methods were used to compare the clinical effects. Results: the indexes of the study group were better than those of the control group (P < 0.05). Conclusion: combination of traditional Chinese and western medicine has significant effect on recurrent oral ulcer.
