期刊文献+
共找到30,920篇文章
< 1 2 250 >
每页显示 20 50 100
Empathetic Response Generation Based on Topic Shifting
1
作者 Lili Yin Xiaoqiang Du Hengwen Gu 《Journal of Harbin Institute of Technology(New Series)》 2025年第5期65-73,共9页
The current dialogue system can be sensitive to the emotions in the user's words,generating an empathetic response to help calm the user's emotions.But in some cases,eliciting empathetic responses may not adeq... The current dialogue system can be sensitive to the emotions in the user's words,generating an empathetic response to help calm the user's emotions.But in some cases,eliciting empathetic responses may not adequately mitigate the adverse effects that the current conversation topic is having on users.The dialogue system will continue the conversation with the user under this uncomfortable topic,which will lead to a worse chat situation or even an impasse.To solve this problem,a dialogue system that can change the topic autonomously according to the user's emotions is proposed in this paper.Specifically,the dialogue system first collects the emotional semantic information of the users and then detects it according to the emotion classification module.Once the detection results show that the user is in a bad mood,the topic change module selects a new topic from the context to shift to and generates a response.This not only helps to calm the user's mood but also move the conversation to a new area,steering the user away from the uncomfortable topic.The experimental results show that the proposed method incurs less cost in terms of content quality,but improves the emotional perception ability.Additionally,it endows the dialogue system with the ability to change the topic,and improves the user's dialogue experience. 展开更多
关键词 topic shifting empathetic response emotion classification
在线阅读 下载PDF
Research on the Impact of Conception Vessel Dredging Therapy Based on the Theory of Shifting Essence and Changing Qi in Inner Canon of Huangdi on Physical and Mental Health
2
作者 Yizhou Shen Fengrun Liu 《Journal of Clinical and Nursing Research》 2025年第5期152-158,共7页
This study,based on the theory of shifting essence and changing Qi in Inner Canon of Huangdi,deeply explores the theoretical basis,operation method of Conception Vessel Dredging Therapy and its influence on human heal... This study,based on the theory of shifting essence and changing Qi in Inner Canon of Huangdi,deeply explores the theoretical basis,operation method of Conception Vessel Dredging Therapy and its influence on human health.Through case analysis and the statistical analysis of medical records during the pandemic,it reveals the remarkable effects of this method in regulating the endocrine system,improving metabolism,and relieving physical and mental diseases.It provides a theoretical and practical basis for the application of traditional Chinese medicine anti-aging therapy in the modern health field,and helps to explore new ways to delay aging and improve physical and mental health. 展开更多
关键词 shifting essence and changing Qi Conception vessel dredging therapy Inner canon of Huangdi Endocrine regulation Metabolic improvement Anti-aging Mental health
暂未订购
Matching actions to needs: shifting policy responses to the changing health needs of Chinese children and adolescents 被引量:2
3
作者 Tian-Jiao Chen 《四川生理科学杂志》 2024年第4期866-866,共1页
China is home to the second largest population of children and adolescents in the world.Yet demographic shifts mean that the government must manage the challenge of fewer children with the needs of an ageing populatio... China is home to the second largest population of children and adolescents in the world.Yet demographic shifts mean that the government must manage the challenge of fewer children with the needs of an ageing population,while considering the delicate tension between economic growth and environmental sustainability.We mapped the health problems and risks of contemporary school-aged children and adolescents in China against current national health policies.We involved multidisciplinary experts,including young people,with the aim of identifying actionable strategies and specific recommendations to promote child and adolescent health and wellbeing.Notwithstanding major improvements in their health over the past few decades,contemporary Chinese children and adolescents face distinct social challenges,including high academic pressures and youth unemployment,and new health concerns including obesity,mental health issues,and sexually transmitted infections.Inequality by gender,geography,and ethnicity remains a feature of health risks and outcomes.We identified a mismatch between current health determinants,risks and outcomes,and government policies. 展开更多
关键词 POLICY children shifting
暂未订购
THE PERSISTENCE OF SOLUTIONS IN A NONLOCAL PREDATOR-PREY SYSTEM WITH A SHIFTING HABITAT
4
作者 赵敏 袁荣 《Acta Mathematica Scientia》 SCIE CSCD 2024年第3期1096-1114,共19页
In this paper,we mainly study the propagation properties of a nonlocal dispersal predator-prey system in a shifting environment.It is known that Choi et al.[J Differ Equ,2021,302:807-853]studied the persistence or ext... In this paper,we mainly study the propagation properties of a nonlocal dispersal predator-prey system in a shifting environment.It is known that Choi et al.[J Differ Equ,2021,302:807-853]studied the persistence or extinction of the prey and of the predator separately in various moving frames.In particular,they achieved a complete picture in the local diffusion case.However,the question of the persistence of the prey and of the predator in some intermediate moving frames in the nonlocal diffusion case was left open in Choi et al.'s paper.By using some a prior estimates,the Arzelà-Ascoli theorem and a diagonal extraction process,we can extend and improve the main results of Choi et al.to achieve a complete picture in the nonlocal diffusion case. 展开更多
关键词 predator-prey system PERSISTENCE nonlocal dispersal shifting environment
在线阅读 下载PDF
Propagation Dynamics of Forced Pulsating Waves for a Time Periodic Lotka-Volterra Cooperative System with Nonlocal Effects in Shifting Habitats
5
作者 Zewen Gong 《Journal of Applied Mathematics and Physics》 2024年第10期3402-3421,共20页
In this paper, we will concern the existence, asymptotic behaviors and stability of forced pulsating waves for a Lotka-Volterra cooperative system with nonlocal effects under shifting habitats. By using the alternativ... In this paper, we will concern the existence, asymptotic behaviors and stability of forced pulsating waves for a Lotka-Volterra cooperative system with nonlocal effects under shifting habitats. By using the alternatively-coupling upper-lower solution method, we establish the existence of forced pulsating waves, as long as the shifting speed falls in a finite interval where the endpoints are obtained from KPP-Fisher speeds. The asymptotic behaviors of the forced pulsating waves are derived. Finally, with proper initial, the stability of the forced pulsating waves is studied by the squeezing technique based on the comparison principle. 展开更多
关键词 Nonlocal Effects Time Periodic Lotka-Volterra System Forced Pulsating Waves shifting Habitats
在线阅读 下载PDF
The modern textile factory:Charting the impact of a shifting textile supply chain landscape
6
《China Textile》 2024年第1期42-43,共2页
Smartex is at the forefront of transforming the textile industry through the integration of Artificial Intelligence,focusing specifically on achieving zero waste and traceability in Tier 2,the most impactful step of t... Smartex is at the forefront of transforming the textile industry through the integration of Artificial Intelligence,focusing specifically on achieving zero waste and traceability in Tier 2,the most impactful step of the textile supply chain.They are part of a larger movement involving dynamic technology companies,forward-thinking factories,pioneering brands,and influential policy-makers all actively addressing challenges within the supply chain. 展开更多
关键词 impact LANDSCAPE shifting
在线阅读 下载PDF
Isotope shifts due to the 1s^(2)2s^(2)S_(1/2)→1s^(2)2p^(2)P_(1/2,3/2)transitions of Li-like Th^(87)+ions
7
作者 Huqiang Lu Bingbing Li +8 位作者 Mingye Yang Lin Dong Yanmin Wang Maijuan Li Lei Wu Jiguang Li Jun Jiang Chenzhong Dong Denghong Zhang 《Chinese Physics B》 2025年第7期290-295,共6页
The transition energies of the 1s^(2)2s^(2)S_(1/2)→1s^(2)2p^(2)p_(1/2,3/2)transitions in Li-like Th87+ions were calculated by combining the multi-configuration Dirac-Hartree-Fock(MCDHF)method with the model-quantum e... The transition energies of the 1s^(2)2s^(2)S_(1/2)→1s^(2)2p^(2)p_(1/2,3/2)transitions in Li-like Th87+ions were calculated by combining the multi-configuration Dirac-Hartree-Fock(MCDHF)method with the model-quantum electrodynamics(modelQED)approach.The effects of electron correlation,Breit interaction,and QED effects were analyzed in detail.The isotope shifts,including the mass shifts and field shifts,due to the 2s2S_(1/2)→2p^(2)P_(1/2,3/2)transitions were then calculated using two different methods,namely,the MCDHF method and the finite-field method.The results show that these two methods are in excellent agreement. 展开更多
关键词 isotope shift MCDHF method finite-field method QED effect
原文传递
Shift in Translation:A Case Study of Translating NFPA 1 Fire Code into Chinese
8
作者 Fang Chen Xinlu Xing Huili Wang 《Journal of Contemporary Educational Research》 2025年第2期1-15,共15页
National Fire codes,mandated by government authorities to tackle technical challenges in fire prevention and control,establish fundamental standards for construction practices.International collaboration in fire prote... National Fire codes,mandated by government authorities to tackle technical challenges in fire prevention and control,establish fundamental standards for construction practices.International collaboration in fire protection technologies has opened avenues for China to access a wealth of documents and codes,which are crucial in crafting regulations and developing a robust,scientific framework for fire code formulation.However,the translation of these codes into Chinese has been inadequate,thereby diminishing the benefits of technological exchange and collaborative learning.This underscores the necessity for comprehensive research into code translation,striving for higher-quality translations guided by established translation theories.In this study,we translated the initial segment of the NFPA 1 Fire Code into Chinese and examined both the source text and target text through the lens of Translation Shift Theory,a concept introduced by Catford.The conclusion culminated in identifying four key shifts across various linguistic levels:lexis,sentences,and groups,to ensure an accurate and precise translation of fire codes.This study offers a through and lucid explanation of how the translator integrates Catford’s theories to solve technical challenges in NFPA 1 Fire Code translation,and establish essential standards for construction translation practices. 展开更多
关键词 Fire code Code document JC Catford Translation shift theory
在线阅读 下载PDF
Paradigm Shift:Construction of the “One-on- One” Teaching Model in Nursing Education for Neurology Nursing Students
9
作者 Youxian Tan Yu Huang +1 位作者 Li Mo Xianying Tang 《Journal of Clinical and Nursing Research》 2025年第9期81-87,共7页
With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neu... With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology.This paper focuses on nursing education for neurology nursing students and explores the construction of the“one-on-one”teaching model,aiming to achieve a paradigm shift in nursing education.By analyzing the current status of neurology nursing education,this paper identifies the problems in traditional teaching models.Combining the advantages of the“one-on-one”teaching model,it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors,the design of teaching content,the innovation of teaching methods,and the improvement of the teaching evaluation system.The research shows that the“one-on-one”teaching model can significantly enhance nursing students’mastery of professional knowledge,clinical operation skills,communication skills,and emergency response capabilities,as well as strengthen their professional identity and sense of responsibility.It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education. 展开更多
关键词 NEUROLOGY Nursing students One-on-one teaching model Nursing education Paradigm shift
在线阅读 下载PDF
Unifying the Nepal height system and China height system based on gravity frequency shift approach
10
作者 K.C.Shanker Ziyu Shen Wenbin Shen 《Geodesy and Geodynamics》 2025年第2期193-202,共10页
Highly accurate international height reference frames with long-term stability,global consistency,and homogeneity are crucial for monitoring sea level variations,understanding climate change,managing disasters,and sup... Highly accurate international height reference frames with long-term stability,global consistency,and homogeneity are crucial for monitoring sea level variations,understanding climate change,managing disasters,and supporting other applications that benefit scientific research and societal well-being.Currently,there are over 100 local height reference systems worldwide.Unifying these systems is a pivotal step toward constructing international height reference frames.The method introduced in this study-the gravity frequency shift via Satellite Frequency Signal Transfer(SFST)-represents a groundbreaking relativistic geodetic approach,demonstrating its potential to surpass the constraints of conventional techniques.The advent of high-precision optical atomic clocks(OAC)with an accuracy level of 1×10^(-18) has facilitated this method's implementation.The International Association of Geodesy(IAG)has established the International Height Reference System(IHRS)and its practical realization,the International Height Reference Frame(IHRF).Our study focuses on two neighbouring height systems:the China Height System(CHS)and the Nepal Height System(NHS),separated by the Himalayas and the Xizang plateau.We aim to unify these two systems by determining the geopotential and orthometric height differences between their respective height datum stations:the Qingdao Height Datum Station(QHDS)and the Madar Height Datum Station(MHDS)using a simulation experiment with the method mentioned above.Using an OAC with an accuracy of 1×10^(-18),we identified a geopotential difference of-8.348±0.464 m^(2)s^(-2) and an orthometric height difference of 0.786±0.047 m between QHDS and MHDS.These results suggest that the introduced method could unify any two height systems with fewcentimeter-level precision,emphasizing its significance in contributing to the construction of the IHRS/IHRF with today's required precision.In summary,the SFST technique is a novel geodetic method that offers an alternative for height system unification,delivering centimeter-level precision,surpassing traditional methods,and supporting the development of the IHRF. 展开更多
关键词 Vertical reference system Gravity frequency shift SFST IHRF Height system unification
原文传递
New interaction solutions in Mel’nikov equation obtained by modulating the phase shift
11
作者 Mi Chen Zhen Wang 《Chinese Physics B》 2025年第4期229-236,共8页
The degradation and nonlinear interactions of a two-breather solution of the Mel’nikov equation are analyzed.By modulating the phase shift and limit method,we prove that in different regions near the non-singular bou... The degradation and nonlinear interactions of a two-breather solution of the Mel’nikov equation are analyzed.By modulating the phase shift and limit method,we prove that in different regions near the non-singular boundaries,there are four kinds of solutions with repulsive interaction or attractive interaction in addition to the two-breather solution.They are the interaction solution between soliton and breather,the two-soliton solution,and the two-breather solution with small amplitude,which all exhibit repulsive interactions;and the two-breather solution with small amplitude,which exhibits attractive interaction.Interestingly,a new breather acts as a messenger to transfer energy during the interaction between two breather solutions with small amplitude. 展开更多
关键词 Mel’nikov equation breather solution phase shift
原文传递
Analysis of Conceptual Metonymy of Verbal-to-Nominal Shift in English and Chinese
12
作者 LI Guo-ao GAO Wen-cheng 《Journal of Literature and Art Studies》 2025年第10期775-780,共6页
The phenomenon of verbal-to-nominal shift(hereafter referred to as“V-N shift”)exists in both English and Chinese.It reflects both the universal conceptual metonymic thinking and the principle of linguistic economy.F... The phenomenon of verbal-to-nominal shift(hereafter referred to as“V-N shift”)exists in both English and Chinese.It reflects both the universal conceptual metonymic thinking and the principle of linguistic economy.Focusing on conceptual metonymy theory and combined with the Event Idealized Cognitive Model(ICM),this paper systematically compares the V-N shift phenomenon in English and Chinese.The study shows that English and Chinese V-N shifts share the core cognitive mechanism of“conceptual proximity within the Event ICM”,while significant differences exist in type distribution and usage frequency.This analysis not only helps deepen the understanding of the cognitive logic behind English and Chinese V-N shifts but also provides a new perspective for the study of word-class conversion and the relationship between language and thinking. 展开更多
关键词 English-Chinese verbal-to-nominal shift conceptual metonymy Event ICM Model
在线阅读 下载PDF
Precision calculation of^(4,6,8)He isotope shifts
13
作者 Xiao-Qiu Qi Xing-Han Dong +4 位作者 Fang-Fei Wu Zong-Chao Yan Li-Yan Tang Zhen-Xiang Zhong Ting-Yun Shi 《Chinese Physics B》 2025年第11期162-168,共7页
Standard perturbation theory is employed to calculate the mass shifts of the 2^(1)S_(0)-^(3)S_(1)and 2^(3)S_(1)-2^(3)P_(J)transitions for^(4,6,8)He.High-precision results are obtained for the mass shifts in the isotop... Standard perturbation theory is employed to calculate the mass shifts of the 2^(1)S_(0)-^(3)S_(1)and 2^(3)S_(1)-2^(3)P_(J)transitions for^(4,6,8)He.High-precision results are obtained for the mass shifts in the isotope pairs 6He-4He and 8He-4He,with uncertainties below 1 part per million(ppm).Our analysis provides a complete set of isotope-shift results and systematically examines their sensitivity to nuclear charge-radius differences.Once experimental measurements reach a precision comparable to that of the calculated mass shifts,the squared differences of nuclear charge radii can be determined with an accuracy of approximately 0.4%-0.6%,representing an order-of-magnitude improvement over current values. 展开更多
关键词 isotope shifts nuclear charge radius atomic spectroscopy quantum electrodynamic
原文传递
Chinese provincial-level new records for 96 resident bird species reveal poleward range shifts
14
作者 Shengxi Chen Zhehao Chen +3 位作者 Hongtao Lin Haoting Duan Jiehua Yu Jiekun He 《Avian Research》 2025年第4期610-617,共8页
Anthropogenic climate change is altering species distributions globally.While species distributions are expected to shift to higher latitudes and elevations under global warming,empirical evidence on distribution shif... Anthropogenic climate change is altering species distributions globally.While species distributions are expected to shift to higher latitudes and elevations under global warming,empirical evidence on distribution shifts is mixed,and factors mediating the direction and magnitude of range shifts remain unclear.Using a dataset of 132new provincial records for 96 resident bird species from 2000 to 2023,we measured geographic distance,latitudinal shift,and temperature shift from each new record to the historical range for each species to test for poleward shifts.We assessed taxonomic variation in the magnitude of range shifts and used phylogenetic generalized linear mixed models to quantify relationships between species traits and the extent of range shifts.Our results revealed that new records occurred at a mean geographic distance of 420 km from historical ranges,with mean latitudinal shifts of+1.68°(poleward)and temperature shifts of-1.33℃(toward colder climates).The magnitude of geographic range shifts was strongly constrained by phylogenetic relatedness.Habitat breadth,habitat openness,and centroid latitude of historical ranges emerged as significant predictors of range shifts.Our results suggest that resident bird species'geographic ranges in China are shifting poleward,but the magnitude of these shifts is non-random across lineages.Species with broader habitat preferences and those from warmer climates are more likely to shift farther from their historical ranges and toward higher latitudes.This study emphasizes taxonomic variation in species range shifts and highlights the need for species-and site-specific conservation strategies under global warming. 展开更多
关键词 China Climate change Geographic distribution New records Phylogenetic analysis Range shifts
在线阅读 下载PDF
The Blue Pivot China’s marine economy shifts from quantity to quality
15
作者 Wang Yan 《China Report ASEAN》 2025年第11期18-21,共4页
According to the 2024 China Marine Economy Statistical Bulletin(hereinafter“the Bulletin”),China’s marine economy surpassed the 10 trillion yuan(US$1.38 trillion)mark for the first time in 2024,0.9 percentage point... According to the 2024 China Marine Economy Statistical Bulletin(hereinafter“the Bulletin”),China’s marine economy surpassed the 10 trillion yuan(US$1.38 trillion)mark for the first time in 2024,0.9 percentage points higher than the growth rate of the national GDP. 展开更多
关键词 growth rate marine economy national GDP trillion yuan quality shift
在线阅读 下载PDF
A Global⁃Local Part⁃Shift Network for Gait Recognition
16
作者 Guizhi Li Weiwei Fang 《Journal of Harbin Institute of Technology(New Series)》 2025年第5期86-93,共8页
Gait recognition,a promising biometric technology,relies on analyzing individuals' walking patterns and offers a non-intrusive and convenient approach to identity verification.However,gait recognition accuracy is ... Gait recognition,a promising biometric technology,relies on analyzing individuals' walking patterns and offers a non-intrusive and convenient approach to identity verification.However,gait recognition accuracy is often compromised by external factors such as changes in viewpoint and attire,which present substantial challenges in practical applications.To enhance gait recognition performance under diverse viewpoints and complex conditions,a global-local part-shift network is proposed in this paper.This framework integrates two novel modules:the part-shift feature extractor and the dynamic feature aggregator.The part-shift feature extractor strategically shifts body parts to capture the intrinsic relationships between non-adjacent regions,enriching the recognition process with both global and local spatial features.The dynamic feature aggregator addresses long-range dependency issues by incorporating multi-range temporal modeling,effectively aggregating information across parts and time steps to achieve a more robust recognition outcome.Comprehensive experiments on the CASIA-B dataset demonstrate that the proposed global-local part-shift network delivers superior performance compared with state-of-the-art methods,highlighting its potential for practical deployment. 展开更多
关键词 gait recognition global⁃local feature part⁃shift
在线阅读 下载PDF
Frequency shifts of high-order harmonics from ZnO crystals by chirped laser pulses
17
作者 Yu Zhao Xiao-Jin Liu +3 位作者 Shuang Wang Xiao-Xin Huo Yun-He Xing Jun Zhang 《Chinese Physics B》 2025年第3期340-346,共7页
We investigate theoretically the effects of chirped laser pulses on high-order harmonic generation(HHG)from solids.We find that the harmonic spectra display redshifts for the driving laser pulses with negative chirp a... We investigate theoretically the effects of chirped laser pulses on high-order harmonic generation(HHG)from solids.We find that the harmonic spectra display redshifts for the driving laser pulses with negative chirp and blueshifts for those with positive chirp,which is due to the change in the instantaneous frequency of the driving laser for different chirped pulses.The analysis of crystal-momentum-resolved(k-resolved)HHG reveals that the frequency shifts are equal for the harmonics generated by different crystal momentum channels.The frequency shifts in the cutoff region are larger than those in the plateau region.With the increase of the absolute value of the chirp parameters,the frequency shifts of HHG become more significant,leading to the shifts from odd-to even-order harmonics.We also demonstrate that the frequency shifts of harmonic spectra are related to the duration of the chirped laser field,but are insensitive to the laser intensity and dephasing time. 展开更多
关键词 high-order harmonic generation ZnO crystal chirped laser pulse spectral shift
原文传递
Carboniferous-Permian provenance shift in the southeastern Ordos Basin:Tracing early-stage uplift-erosion history of the western Qinling-Dabie orogen
18
作者 Chuang Yang Jiaopeng Sun +4 位作者 Zonglin Li Yukun Qi Kai Ye Junxiang Zhang Zhigang Wang 《Acta Geochimica》 2025年第5期945-961,共17页
An enhanced understanding of the history of the western Qinling-Dabie orogen is pivotal in reconstructing geological processes of the east Asian mainland.However,less attention has been paid to its early-stage uplift-... An enhanced understanding of the history of the western Qinling-Dabie orogen is pivotal in reconstructing geological processes of the east Asian mainland.However,less attention has been paid to its early-stage uplift-erosion history after closure of surrounding oceanic basins at the mid-Paleozoic.In this study,we undertook a comprehensive study including paleocurrent reconstruction,sandstone petrology,and detrital zircon U-Pb dating on Late Carboniferous to Early Permian successions in the southern Ordos neighboring the northern Qinling-Dabie.New provenance data reveal a significant provenance shift at the Carboniferous-Permian transition.The older Benxi Formation was sourced southerly from the North Qinling Terrane that provided detritus mostly of Neoproterozoic and Early Paleozoic ages.In contrast,Early Permian samples yield age relation dominated by Neoarchean,Paleoproterozoic,Early Paleozoic,and Late Paleozoic age populations,with a significant gap of ca.1600-550 Ma,implying a sediment derivation from the Inner Mongolia Continental Arc.This shift is further verified by paleocurrent transition from south to north then.We suggest that the North Qinling Terrane experienced a significant uplift history from ca.500 Ma and remained as a highland until end-Carboniferous.From Early Permian,the North Qinling Terrane was submerged,covered by widespread deltaic sedimentation there.Northerly source from the Inner Mongolia Continental Arc began to be accumulated in the northern flank of the North Qinling Terrane,before termination approximately along the southern North Qinling Terrane,where shallow-water carbonate shelf sedimentation sustained from Devonian to Triassic.This new finding indicates that uplift of the North Qinling Terrane lasted about 150 Ma after the Proto-Tethys Ocean closure. 展开更多
关键词 Carboniferous-Permian transition Provenance shift Southern Ordos Uplift history Western Qinling-Dabie orogen
在线阅读 下载PDF
Near-infrared fluorescent probe with large Stokes shift and long emission wavelength for rapid diagnosis of lung cancer via aerosol inhalation delivery
19
作者 Wenping Dong Mo Ma +4 位作者 Jingkang Li Lanlan Xu Dejiang Gao Pinyi Ma Daqian Song 《Chinese Chemical Letters》 2025年第5期532-535,共4页
The aggressive nature and high mortality rate of lung cancer underscore the imperative need for early diagnosis of the disease.Thus,aminopeptidase N(APN),a potential biomarker for lung cancer,should be thoroughly inve... The aggressive nature and high mortality rate of lung cancer underscore the imperative need for early diagnosis of the disease.Thus,aminopeptidase N(APN),a potential biomarker for lung cancer,should be thoroughly investigated in this context.This report describes the development of HA-apn,a novel near-infrared fluorescent probe,specifically engineered for the sensitive detection of endogenous APN.Characterized by its high selectivity,straightforward molecular architecture,and suitable optical properties,including a long-wavelength emission at 835 nm and a large Stokes shift of 285 nm,HA-apn had high efficacy in identifying overexpressed APN in tumor cells,which shows its potential in pinpointing malignancies.To further validate its applicability and effectiveness in facilitating the direct and enhanced visualization of pulmonary alterations,an in situ lung cancer mouse model was employed.Notably,HAapn was applied for in vivo imaging of APN activity in the lung cancer mouse model receiving the probe through aerosol inhalation,and rapid and precise diagnostic results were achieved within 30min postadministration.Overall,HA-apn can be applied as an effective,non-intrusive tool for the rapid and accurate detection of pulmonary conditions. 展开更多
关键词 NEAR-INFRARED Fluorescent probe Large Stokes shift In situ lung cancer Rapid diagnosis
原文传递
Westward shift of western North Pacific tropical cyclones in CMIP6-High Res MIP models
20
作者 Zhuoying Li Wen Zhou 《Atmospheric and Oceanic Science Letters》 2025年第2期86-93,共8页
Against the backdrop of climate change,the activity of tropical cyclones(TCs)has captured widespread attention.Observational datasets indicate a declining trend in the genesis longitude of western North Pacific(WNP)TC... Against the backdrop of climate change,the activity of tropical cyclones(TCs)has captured widespread attention.Observational datasets indicate a declining trend in the genesis longitude of western North Pacific(WNP)TCs.This study investigates the zonal changes of WNP TCs with CMIP6-HighResMIP models.These models capture the genesis density of WNP TCs fairly well.The results reveal a westward shift in TC genesis longitude.This trend is associated with the significant reduction in the TC frequency over the southeastern WNP.The study also discusses changes in large-scale circulation patterns and the impact of the strengthening Pacific Walker circulation. 展开更多
关键词 Tropical cyclones Westward shift CMIP6-HighResMIP models Pacific walker circulation
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部