Network Intrusion Detection System(NIDS)detection of minority class attacks is always a difficult task when dealing with attacks in complex network environments.To improve the detection capability of minority-class at...Network Intrusion Detection System(NIDS)detection of minority class attacks is always a difficult task when dealing with attacks in complex network environments.To improve the detection capability of minority-class attacks,this study proposes an intrusion detection method based on a two-layer structure.The first layer employs a CNN-BiLSTM model incorporating an attention mechanism to classify network traffic into normal traffic,majority class attacks,and merged minority class attacks.The second layer further segments the minority class attacks through Stacking ensemble learning.The datasets are selected from the generic network dataset CIC-IDS2017,NSL-KDD,and the industrial network dataset Mississippi Gas Pipeline dataset to enhance the generalization and practical applicability of the model.Experimental results show that the proposed model achieves an overall detection accuracy of 99%,99%,and 95%on the CIC-IDS2017,NSL-KDD,and industrial network datasets,respectively.It also significantly outperforms traditional methods in terms of detection accuracy and recall rate for minority class attacks.Compared with the single-layer deep learning model,the two-layer structure effectively reduces the false alarm rate while improving the minority-class attack detection performance.The research in this paper not only improves the adaptability of NIDS to complex network environments but also provides a new solution for minority-class attack detection in industrial network security.展开更多
The mutual coupling between neurons in a realistic neuronal system is much complex, and a two-layer neuronal network is designed to investigate the transition of electric activities of neurons. The Hindmarsh–Rose neu...The mutual coupling between neurons in a realistic neuronal system is much complex, and a two-layer neuronal network is designed to investigate the transition of electric activities of neurons. The Hindmarsh–Rose neuron model is used to describe the local dynamics of each neuron, and neurons in the two-layer networks are coupled in dislocated type. The coupling intensity between two-layer networks, and the coupling ratio(Pro), which defines the percentage involved in the coupling in each layer, are changed to observe the synchronization transition of collective behaviors in the two-layer networks. It is found that the two-layer networks of neurons becomes synchronized with increasing the coupling intensity and coupling ratio(Pro) beyond certain thresholds. An ordered wave in the first layer is useful to wake up the rest state in the second layer, or suppress the spatiotemporal state in the second layer under coupling by generating target wave or spiral waves. And the scheme of dislocation coupling can be used to suppress spatiotemporal chaos and excite quiescent neurons.展开更多
An image-reconstruction approach for optical tomography is presented,in which a two-layered BP neural network is used to distinguish the tumor location.The inverse problem is solved as optimization problem by Femlab s...An image-reconstruction approach for optical tomography is presented,in which a two-layered BP neural network is used to distinguish the tumor location.The inverse problem is solved as optimization problem by Femlab software and Levenberg–Marquardt algorithm.The concept of the average optical coefficient is proposed in this paper,which is helpful to understand the distribution of the scattering photon from tumor.The reconstructive¯µs by the trained network is reasonable for showing the changes of photon number transporting inside tumor tissue.It realized the fast reconstruction of tissue optical properties and provided optical OT with a new method.展开更多
Multilayer network is a frontier direction of network science research. In this paper, the cluster ring network is extended to a two-layer network model, and the inner structures of the cluster blocks are random, smal...Multilayer network is a frontier direction of network science research. In this paper, the cluster ring network is extended to a two-layer network model, and the inner structures of the cluster blocks are random, small world or scale-free. We study the influence of network scale, the interlayer linking weight and interlayer linking fraction on synchronizability. It is found that the synchronizability of the two-layer cluster ring network decreases with the increase of network size. There is an optimum value of the interlayer linking weight in the two-layer cluster ring network, which makes the synchronizability of the network reach the optimum. When the interlayer linking weight and the interlayer linking fraction are very small, the change of them will affect the synchronizability.展开更多
In recent years,discrete neuron and discrete neural network models have played an important role in the development of neural dynamics.This paper reviews the theoretical advantages of well-known discrete neuron models...In recent years,discrete neuron and discrete neural network models have played an important role in the development of neural dynamics.This paper reviews the theoretical advantages of well-known discrete neuron models,some existing discretized continuous neuron models,and discrete neural networks in simulating complex neural dynamics.It places particular emphasis on the importance of memristors in the composition of neural networks,especially their unique memory and nonlinear characteristics.The integration of memristors into discrete neural networks,including Hopfield networks and their fractional-order variants,cellular neural networks and discrete neuron models has enabled the study and construction of various neural models with memory.These models exhibit complex dynamic behaviors,including superchaotic attractors,hidden attractors,multistability,and synchronization transitions.Furthermore,the present paper undertakes an analysis of more complex dynamical properties,including synchronization,speckle patterns,and chimera states in discrete coupled neural networks.This research provides new theoretical foundations and potential applications in the fields of brain-inspired computing,artificial intelligence,image encryption,and biological modeling.展开更多
Neuronal soma segmentation plays a crucial role in neuroscience applications.However,the fine structure,such as boundaries,small-volume neuronal somata and fibers,are commonly present in cell images,which pose a chall...Neuronal soma segmentation plays a crucial role in neuroscience applications.However,the fine structure,such as boundaries,small-volume neuronal somata and fibers,are commonly present in cell images,which pose a challenge for accurate segmentation.In this paper,we propose a 3D semantic segmentation network for neuronal soma segmentation to address this issue.Using an encoding-decoding structure,we introduce a Multi-Scale feature extraction and Adaptive Weighting fusion module(MSAW)after each encoding block.The MSAW module can not only emphasize the fine structures via an upsampling strategy,but also provide pixel-wise weights to measure the importance of the multi-scale features.Additionally,a dynamic convolution instead of normal convolution is employed to better adapt the network to input data with different distributions.The proposed MSAW-based semantic segmentation network(MSAW-Net)was evaluated on three neuronal soma images from mouse brain and one neuronal soma image from macaque brain,demonstrating the efficiency of the proposed method.It achieved an F1 score of 91.8%on Fezf2-2A-CreER dataset,97.1%on LSL-H2B-GFP dataset,82.8%on Thy1-EGFP-Mline dataset,and 86.9%on macaque dataset,achieving improvements over the 3D U-Net model by 3.1%,3.3%,3.9%,and 2.3%,respectively.展开更多
We study the target inactivation and recovery in two-layer networks. Five kinds of strategies are chosen to attack the two-layer networks and to recover the activity of the networks by increasing the inter-layer coupl...We study the target inactivation and recovery in two-layer networks. Five kinds of strategies are chosen to attack the two-layer networks and to recover the activity of the networks by increasing the inter-layer coupling strength. The results show that we can easily control the dying state effectively by a randomly attacked situation. We then investigate the recovery activity of the networks by increasing the inter-layer coupled strength. The optimal values of the inter-layer coupled strengths are found, which could provide a more effective range to recovery activity of complex networks. As the multilayer systems composed of active and inactive elements raise important and interesting problems, our results on the target inactivation and recovery in two-layer networks would be extended to different studies.展开更多
An evolutionary prisoner＇s dilemma game is investigated on two-layered complex networks respectively representing interaction and learning networks in one and two dimensions. A parameter q is introduced to denote the...An evolutionary prisoner＇s dilemma game is investigated on two-layered complex networks respectively representing interaction and learning networks in one and two dimensions. A parameter q is introduced to denote the correlation degree between the two-layered networks. Using Monte Carlo simulations we studied the effects of the correlation degree on cooperative behaviour and found that the cooperator density nontrivially changes with q for different payoff parameter values depending on the detailed strategy updating and network dimension. An explanation for the obtained results is provided.展开更多
In Information Centric Networking(ICN)where content is the object of exchange,in-network caching is a unique functional feature with the ability to handle data storage and distribution in remote sensing satellite netw...In Information Centric Networking(ICN)where content is the object of exchange,in-network caching is a unique functional feature with the ability to handle data storage and distribution in remote sensing satellite networks.Setting up cache space at any node enables users to access data nearby,thus relieving the processing pressure on the servers.However,the existing caching strategies still suffer from the lack of global planning of cache contents and low utilization of cache resources due to the lack of fine-grained division of cache contents.To address the issues mentioned,a cooperative caching strategy(CSTL)for remote sensing satellite networks based on a two-layer caching model is proposed.The two-layer caching model is constructed by setting up separate cache spaces in the satellite network and the ground station.Probabilistic caching of popular contents in the region at the ground station to reduce the access delay of users.A content classification method based on hierarchical division is proposed in the satellite network,and differential probabilistic caching is employed for different levels of content.The cached content is also dynamically adjusted by analyzing the subsequent changes in the popularity of the cached content.In the two-layer caching model,ground stations and satellite networks collaboratively cache to achieve global planning of cache contents,rationalize the utilization of cache resources,and reduce the propagation delay of remote sensing data.Simulation results show that the CSTL strategy not only has a high cache hit ratio compared with other caching strategies but also effectively reduces user request delay and server load,which satisfies the timeliness requirement of remote sensing data transmission.展开更多
Overlay multicast has become one of the most promising multicast solutions for IP network,and Neutral Network(NN) has been a good candidate for searching optimal solutions to the constrained shortest routing path in v...Overlay multicast has become one of the most promising multicast solutions for IP network,and Neutral Network(NN) has been a good candidate for searching optimal solutions to the constrained shortest routing path in virtue of its powerful capacity for parallel computation. Though traditional Hopfield NN can tackle the optimization problem,it is incapable of dealing with large scale networks due to the large number of neurons. In this paper,a neural network for overlay multicast tree com-putation is presented to reliably implement routing algorithm in real time. The neural network is constructed as a two-layer recurrent architecture,which is comprised of Independent Variable Neurons(IDVN) and Dependent Variable Neurons(DVN) ,according to the independence of the decision variables associated with the edges in directed graph. Compared with the heuristic routing algorithms,it is characterized as shorter computational time,fewer neurons,and better precision.展开更多
Effective small object detection is crucial in various applications including urban intelligent transportation and pedestrian detection.However,small objects are difficult to detect accurately because they contain les...Effective small object detection is crucial in various applications including urban intelligent transportation and pedestrian detection.However,small objects are difficult to detect accurately because they contain less information.Many current methods,particularly those based on Feature Pyramid Network(FPN),address this challenge by leveraging multi-scale feature fusion.However,existing FPN-based methods often suffer from inadequate feature fusion due to varying resolutions across different layers,leading to suboptimal small object detection.To address this problem,we propose the Two-layerAttention Feature Pyramid Network(TA-FPN),featuring two key modules:the Two-layer Attention Module(TAM)and the Small Object Detail Enhancement Module(SODEM).TAM uses the attention module to make the network more focused on the semantic information of the object and fuse it to the lower layer,so that each layer contains similar semantic information,to alleviate the problem of small object information being submerged due to semantic gaps between different layers.At the same time,SODEM is introduced to strengthen the local features of the object,suppress background noise,enhance the information details of the small object,and fuse the enhanced features to other feature layers to ensure that each layer is rich in small object information,to improve small object detection accuracy.Our extensive experiments on challenging datasets such as Microsoft Common Objects inContext(MSCOCO)and Pattern Analysis Statistical Modelling and Computational Learning,Visual Object Classes(PASCAL VOC)demonstrate the validity of the proposedmethod.Experimental results show a significant improvement in small object detection accuracy compared to state-of-theart detectors.展开更多
We study evolutionary games in two-layer networks by introducing the correlation between two layers through the C-dominance or the D-dominance. We assume that individuals play prisoner＇s dilemma game （PDG） in one l...We study evolutionary games in two-layer networks by introducing the correlation between two layers through the C-dominance or the D-dominance. We assume that individuals play prisoner＇s dilemma game （PDG） in one layer and snowdrift game （SDG） in the other. We explore the dependences of the fraction of the strategy cooperation in different layers on the game parameter and initial conditions. The results on two-layer square lattices show that, when cooperation is the dominant strategy, initial conditions strongly influence cooperation in the PDG layer while have no impact in the SDG layer. Moreover, in contrast to the result for PDG in single-layer square lattices, the parameter regime where cooperation could be maintained expands significantly in the PDG layer. We also investigate the effects of mutation and network topology. We find that different mutation rates do not change the cooperation behaviors. Moreover, similar behaviors on cooperation could be found in two-layer random networks.展开更多
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction.展开更多
Synchronous firing of neurons is thought to be important for information communication in neuronal networks. This paper investigates the complete and phase synchronization in a heterogeneous small-world chaotic Hindma...Synchronous firing of neurons is thought to be important for information communication in neuronal networks. This paper investigates the complete and phase synchronization in a heterogeneous small-world chaotic Hindmarsh Rose neuronal network. The effects of various network parameters on synchronization behaviour are discussed with some biological explanations. Complete synchronization of small-world neuronal networks is studied theoretically by the master stability function method. It is shown that the coupling strength necessary for complete or phase synchronization decreases with the neuron number, the node degree and the connection density are increased. The effect of heterogeneity of neuronal networks is also considered and it is found that the network heterogeneity has an adverse effect on synchrony.展开更多
In forest variety registration, visual traits of the plants appearance are widely used to discern different tree species. The new recognition system of leaf image strategy which based on neural network established to ...In forest variety registration, visual traits of the plants appearance are widely used to discern different tree species. The new recognition system of leaf image strategy which based on neural network established to administrate a hierarchical list of leaf images, some sorts of edge detection can be performed to identify the individual tokens of every image and the frame of the leaf can be got to differentiate the tree species. An approach based on back-propagation neuronal network is proposed and the programming language for the implementation is also Riven by using Java. The numerical simulations results have shown that the proposed leaf strategt is effective and feasible.展开更多
Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and is considered an independent risk factor for later dementia.However,given its inherent complexity,few animal models of delir...Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and is considered an independent risk factor for later dementia.However,given its inherent complexity,few animal models of delirium have been established and the mechanism underlying the onset of delirium remains elusive.Here,we conducted a comparison of three mouse models of delirium induced by clinically relevant risk factors,including anesthesia with surgery(AS),systemic inflammation,and neurotransmission modulation.We found that both bacterial lipopolysaccharide(LPS)and cholinergic receptor antagonist scopolamine(Scop)induction reduced neuronal activities in the delirium-related brain network,with the latter presenting a similar pattern of reduction as found in delirium patients.Consistently,Scop injection resulted in reversible cognitive impairment with hyperactive behavior.No loss of cholinergic neurons was found with treatment,but hippocampal synaptic functions were affected.These findings provide further clues regarding the mechanism underlying delirium onset and demonstrate the successful application of the Scop injection model in mimicking delirium-like phenotypes in mice.展开更多
The stochastic resonance in paced time-delayed scale-free FitzHugh--Nagumo （FHN） neuronal networks is investigated. We show that an intermediate intensity of additive noise is able to optimally assist the pacemaker ...The stochastic resonance in paced time-delayed scale-free FitzHugh--Nagumo （FHN） neuronal networks is investigated. We show that an intermediate intensity of additive noise is able to optimally assist the pacemaker in imposing its rhythm on the whole ensemble. Furthermore, we reveal that appropriately tuned delays can induce stochastic multiresonances, appearing at every integer multiple of the pacemaker＇s oscillation period. We conclude that fine-tuned delay lengths and locally acting pacemakers are vital for ensuring optimal conditions for stochastic resonance on complex neuronal networks.展开更多
Some recent research reports that a dendritic neuron model(DNM)can achieve better performance than traditional artificial neuron networks(ANNs)on classification,prediction,and other problems when its parameters are we...Some recent research reports that a dendritic neuron model(DNM)can achieve better performance than traditional artificial neuron networks(ANNs)on classification,prediction,and other problems when its parameters are well-tuned by a learning algorithm.However,the back-propagation algorithm(BP),as a mostly used learning algorithm,intrinsically suffers from defects of slow convergence and easily dropping into local minima.Therefore,more and more research adopts non-BP learning algorithms to train ANNs.In this paper,a dynamic scale-free network-based differential evolution(DSNDE)is developed by considering the demands of convergent speed and the ability to jump out of local minima.The performance of a DSNDE trained DNM is tested on 14 benchmark datasets and a photovoltaic power forecasting problem.Nine meta-heuristic algorithms are applied into comparison,including the champion of the 2017 IEEE Congress on Evolutionary Computation(CEC2017)benchmark competition effective butterfly optimizer with covariance matrix adapted retreat phase(EBOwithCMAR).The experimental results reveal that DSNDE achieves better performance than its peers.展开更多
Spatial coherence resonance in a two-dimensional neuronal network induced by additive Gaussian coloured noise and parameter diversity is studied. We focus on the ability of additive Gaussian coloured noise and paramet...Spatial coherence resonance in a two-dimensional neuronal network induced by additive Gaussian coloured noise and parameter diversity is studied. We focus on the ability of additive Gaussian coloured noise and parameter diversity to extract a particular spatial frequency （wave number） of excitatory waves in the excitable medium of this network. We show that there exists an intermediate noise level of the coloured noise and a particular value of diversity, where a characteristic spatial frequency of the system comes forth. Hereby, it is verified that spatial coherence resonance occurs in the studied model. Furthermore, we show that the optimal noise intensity for spatial coherence resonance decays exponentially with respect to the noise correlation time. Some explanations of the observed nonlinear phenomena are also presented.展开更多
Diversity in the neurons and noise are inevitable in the real neuronal network.In this paper,parameter diversity induced spiral waves and multiple spatial coherence resonances in a two-dimensional neuronal network wit...Diversity in the neurons and noise are inevitable in the real neuronal network.In this paper,parameter diversity induced spiral waves and multiple spatial coherence resonances in a two-dimensional neuronal network without or with noise are simulated.The relationship between the multiple resonances and the multiple transitions between patterns of spiral waves are identified.The coherence degrees induced by the diversity are suppressed when noise is introduced and noise density is increased.The results suggest that natural nervous system might profit from both parameter diversity and noise,provided a possible approach to control formation and transition of spiral wave by the cooperation between the diversity and noise.展开更多
基金supported by the Institute of Information&Communications Technology Planning&Evaluation(IITP)—Innovative Human Resource Development for Local Intellectualization program grant funded by the Korea government(MSIT)(IITP-2025-RS-2022-00156334)in part by Liaoning Province Nature Fund Project(2024-BSLH-214).
文摘Network Intrusion Detection System(NIDS)detection of minority class attacks is always a difficult task when dealing with attacks in complex network environments.To improve the detection capability of minority-class attacks,this study proposes an intrusion detection method based on a two-layer structure.The first layer employs a CNN-BiLSTM model incorporating an attention mechanism to classify network traffic into normal traffic,majority class attacks,and merged minority class attacks.The second layer further segments the minority class attacks through Stacking ensemble learning.The datasets are selected from the generic network dataset CIC-IDS2017,NSL-KDD,and the industrial network dataset Mississippi Gas Pipeline dataset to enhance the generalization and practical applicability of the model.Experimental results show that the proposed model achieves an overall detection accuracy of 99%,99%,and 95%on the CIC-IDS2017,NSL-KDD,and industrial network datasets,respectively.It also significantly outperforms traditional methods in terms of detection accuracy and recall rate for minority class attacks.Compared with the single-layer deep learning model,the two-layer structure effectively reduces the false alarm rate while improving the minority-class attack detection performance.The research in this paper not only improves the adaptability of NIDS to complex network environments but also provides a new solution for minority-class attack detection in industrial network security.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11265008,11372122,and 11365014
文摘The mutual coupling between neurons in a realistic neuronal system is much complex, and a two-layer neuronal network is designed to investigate the transition of electric activities of neurons. The Hindmarsh–Rose neuron model is used to describe the local dynamics of each neuron, and neurons in the two-layer networks are coupled in dislocated type. The coupling intensity between two-layer networks, and the coupling ratio(Pro), which defines the percentage involved in the coupling in each layer, are changed to observe the synchronization transition of collective behaviors in the two-layer networks. It is found that the two-layer networks of neurons becomes synchronized with increasing the coupling intensity and coupling ratio(Pro) beyond certain thresholds. An ordered wave in the first layer is useful to wake up the rest state in the second layer, or suppress the spatiotemporal state in the second layer under coupling by generating target wave or spiral waves. And the scheme of dislocation coupling can be used to suppress spatiotemporal chaos and excite quiescent neurons.
基金National Nature Sci-ence Foundation of China(Grant No.30671997).
文摘An image-reconstruction approach for optical tomography is presented,in which a two-layered BP neural network is used to distinguish the tumor location.The inverse problem is solved as optimization problem by Femlab software and Levenberg–Marquardt algorithm.The concept of the average optical coefficient is proposed in this paper,which is helpful to understand the distribution of the scattering photon from tumor.The reconstructive¯µs by the trained network is reasonable for showing the changes of photon number transporting inside tumor tissue.It realized the fast reconstruction of tissue optical properties and provided optical OT with a new method.
文摘Multilayer network is a frontier direction of network science research. In this paper, the cluster ring network is extended to a two-layer network model, and the inner structures of the cluster blocks are random, small world or scale-free. We study the influence of network scale, the interlayer linking weight and interlayer linking fraction on synchronizability. It is found that the synchronizability of the two-layer cluster ring network decreases with the increase of network size. There is an optimum value of the interlayer linking weight in the two-layer cluster ring network, which makes the synchronizability of the network reach the optimum. When the interlayer linking weight and the interlayer linking fraction are very small, the change of them will affect the synchronizability.
基金supported by the Natural Science Foundation of Hunan Province(Grant No.2025JJ50368)the Scientific Research Fund of Hunan Provincial Education Department(Grant No.24A0248)the Guiding Science and Technology Plan Project of Changsha City(Grant No.kzd2501129)。
文摘In recent years,discrete neuron and discrete neural network models have played an important role in the development of neural dynamics.This paper reviews the theoretical advantages of well-known discrete neuron models,some existing discretized continuous neuron models,and discrete neural networks in simulating complex neural dynamics.It places particular emphasis on the importance of memristors in the composition of neural networks,especially their unique memory and nonlinear characteristics.The integration of memristors into discrete neural networks,including Hopfield networks and their fractional-order variants,cellular neural networks and discrete neuron models has enabled the study and construction of various neural models with memory.These models exhibit complex dynamic behaviors,including superchaotic attractors,hidden attractors,multistability,and synchronization transitions.Furthermore,the present paper undertakes an analysis of more complex dynamical properties,including synchronization,speckle patterns,and chimera states in discrete coupled neural networks.This research provides new theoretical foundations and potential applications in the fields of brain-inspired computing,artificial intelligence,image encryption,and biological modeling.
基金supported by the STI2030-Major-Projects(No.2021ZD0200104)the National Natural Science Foundations of China under Grant 61771437.
文摘Neuronal soma segmentation plays a crucial role in neuroscience applications.However,the fine structure,such as boundaries,small-volume neuronal somata and fibers,are commonly present in cell images,which pose a challenge for accurate segmentation.In this paper,we propose a 3D semantic segmentation network for neuronal soma segmentation to address this issue.Using an encoding-decoding structure,we introduce a Multi-Scale feature extraction and Adaptive Weighting fusion module(MSAW)after each encoding block.The MSAW module can not only emphasize the fine structures via an upsampling strategy,but also provide pixel-wise weights to measure the importance of the multi-scale features.Additionally,a dynamic convolution instead of normal convolution is employed to better adapt the network to input data with different distributions.The proposed MSAW-based semantic segmentation network(MSAW-Net)was evaluated on three neuronal soma images from mouse brain and one neuronal soma image from macaque brain,demonstrating the efficiency of the proposed method.It achieved an F1 score of 91.8%on Fezf2-2A-CreER dataset,97.1%on LSL-H2B-GFP dataset,82.8%on Thy1-EGFP-Mline dataset,and 86.9%on macaque dataset,achieving improvements over the 3D U-Net model by 3.1%,3.3%,3.9%,and 2.3%,respectively.
基金Supported by the National Basic Research Program of China under Grant Nos 2013CBA01502,2011CB921503 and 2013CB834100the National Natural Science Foundation of China under Grant Nos 11374040 and 11274051
文摘We study the target inactivation and recovery in two-layer networks. Five kinds of strategies are chosen to attack the two-layer networks and to recover the activity of the networks by increasing the inter-layer coupling strength. The results show that we can easily control the dying state effectively by a randomly attacked situation. We then investigate the recovery activity of the networks by increasing the inter-layer coupled strength. The optimal values of the inter-layer coupled strengths are found, which could provide a more effective range to recovery activity of complex networks. As the multilayer systems composed of active and inactive elements raise important and interesting problems, our results on the target inactivation and recovery in two-layer networks would be extended to different studies.
基金supported by the National Natural Science Foundation of China (Grant No. 10775060)
文摘An evolutionary prisoner＇s dilemma game is investigated on two-layered complex networks respectively representing interaction and learning networks in one and two dimensions. A parameter q is introduced to denote the correlation degree between the two-layered networks. Using Monte Carlo simulations we studied the effects of the correlation degree on cooperative behaviour and found that the cooperator density nontrivially changes with q for different payoff parameter values depending on the detailed strategy updating and network dimension. An explanation for the obtained results is provided.
基金This research was funded by the National Natural Science Foundation of China(No.U21A20451)the Science and Technology Planning Project of Jilin Province(No.20200401105GX)the China University Industry University Research Innovation Fund(No.2021FNA01003).
文摘In Information Centric Networking(ICN)where content is the object of exchange,in-network caching is a unique functional feature with the ability to handle data storage and distribution in remote sensing satellite networks.Setting up cache space at any node enables users to access data nearby,thus relieving the processing pressure on the servers.However,the existing caching strategies still suffer from the lack of global planning of cache contents and low utilization of cache resources due to the lack of fine-grained division of cache contents.To address the issues mentioned,a cooperative caching strategy(CSTL)for remote sensing satellite networks based on a two-layer caching model is proposed.The two-layer caching model is constructed by setting up separate cache spaces in the satellite network and the ground station.Probabilistic caching of popular contents in the region at the ground station to reduce the access delay of users.A content classification method based on hierarchical division is proposed in the satellite network,and differential probabilistic caching is employed for different levels of content.The cached content is also dynamically adjusted by analyzing the subsequent changes in the popularity of the cached content.In the two-layer caching model,ground stations and satellite networks collaboratively cache to achieve global planning of cache contents,rationalize the utilization of cache resources,and reduce the propagation delay of remote sensing data.Simulation results show that the CSTL strategy not only has a high cache hit ratio compared with other caching strategies but also effectively reduces user request delay and server load,which satisfies the timeliness requirement of remote sensing data transmission.
基金the High-tech Project of Jiangsu Province (No.BG2003001).
文摘Overlay multicast has become one of the most promising multicast solutions for IP network,and Neutral Network(NN) has been a good candidate for searching optimal solutions to the constrained shortest routing path in virtue of its powerful capacity for parallel computation. Though traditional Hopfield NN can tackle the optimization problem,it is incapable of dealing with large scale networks due to the large number of neurons. In this paper,a neural network for overlay multicast tree com-putation is presented to reliably implement routing algorithm in real time. The neural network is constructed as a two-layer recurrent architecture,which is comprised of Independent Variable Neurons(IDVN) and Dependent Variable Neurons(DVN) ,according to the independence of the decision variables associated with the edges in directed graph. Compared with the heuristic routing algorithms,it is characterized as shorter computational time,fewer neurons,and better precision.
文摘Effective small object detection is crucial in various applications including urban intelligent transportation and pedestrian detection.However,small objects are difficult to detect accurately because they contain less information.Many current methods,particularly those based on Feature Pyramid Network(FPN),address this challenge by leveraging multi-scale feature fusion.However,existing FPN-based methods often suffer from inadequate feature fusion due to varying resolutions across different layers,leading to suboptimal small object detection.To address this problem,we propose the Two-layerAttention Feature Pyramid Network(TA-FPN),featuring two key modules:the Two-layer Attention Module(TAM)and the Small Object Detail Enhancement Module(SODEM).TAM uses the attention module to make the network more focused on the semantic information of the object and fuse it to the lower layer,so that each layer contains similar semantic information,to alleviate the problem of small object information being submerged due to semantic gaps between different layers.At the same time,SODEM is introduced to strengthen the local features of the object,suppress background noise,enhance the information details of the small object,and fuse the enhanced features to other feature layers to ensure that each layer is rich in small object information,to improve small object detection accuracy.Our extensive experiments on challenging datasets such as Microsoft Common Objects inContext(MSCOCO)and Pattern Analysis Statistical Modelling and Computational Learning,Visual Object Classes(PASCAL VOC)demonstrate the validity of the proposedmethod.Experimental results show a significant improvement in small object detection accuracy compared to state-of-theart detectors.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11575036,71301012,and 11505016
文摘We study evolutionary games in two-layer networks by introducing the correlation between two layers through the C-dominance or the D-dominance. We assume that individuals play prisoner＇s dilemma game （PDG） in one layer and snowdrift game （SDG） in the other. We explore the dependences of the fraction of the strategy cooperation in different layers on the game parameter and initial conditions. The results on two-layer square lattices show that, when cooperation is the dominant strategy, initial conditions strongly influence cooperation in the PDG layer while have no impact in the SDG layer. Moreover, in contrast to the result for PDG in single-layer square lattices, the parameter regime where cooperation could be maintained expands significantly in the PDG layer. We also investigate the effects of mutation and network topology. We find that different mutation rates do not change the cooperation behaviors. Moreover, similar behaviors on cooperation could be found in two-layer random networks.
基金supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW)the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW)+3 种基金the Shanghai Rising-Star Program,No. 23QA1407700 (to CW)the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW)the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL)the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
文摘Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction.
基金supported by the National Natural Science Foundation of China (Grant No 10872014)
文摘Synchronous firing of neurons is thought to be important for information communication in neuronal networks. This paper investigates the complete and phase synchronization in a heterogeneous small-world chaotic Hindmarsh Rose neuronal network. The effects of various network parameters on synchronization behaviour are discussed with some biological explanations. Complete synchronization of small-world neuronal networks is studied theoretically by the master stability function method. It is shown that the coupling strength necessary for complete or phase synchronization decreases with the neuron number, the node degree and the connection density are increased. The effect of heterogeneity of neuronal networks is also considered and it is found that the network heterogeneity has an adverse effect on synchrony.
基金Foundation project： This paper was supported by National Natural Science Foundation of China （No. 30371126）.
文摘In forest variety registration, visual traits of the plants appearance are widely used to discern different tree species. The new recognition system of leaf image strategy which based on neural network established to administrate a hierarchical list of leaf images, some sorts of edge detection can be performed to identify the individual tokens of every image and the frame of the leaf can be got to differentiate the tree species. An approach based on back-propagation neuronal network is proposed and the programming language for the implementation is also Riven by using Java. The numerical simulations results have shown that the proposed leaf strategt is effective and feasible.
基金supported by the National Natural Science Foundation of China(82071191,82001129)Natural Science Foundation of Sichuan Province(2022NSFSC1509)+1 种基金National Clinical Research Center for Geriatrics of West China Hospital(Z2021LC001)West China Hospital 1.3.5 Project for Disciplines of Excellence(ZYYC20009)。
文摘Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and is considered an independent risk factor for later dementia.However,given its inherent complexity,few animal models of delirium have been established and the mechanism underlying the onset of delirium remains elusive.Here,we conducted a comparison of three mouse models of delirium induced by clinically relevant risk factors,including anesthesia with surgery(AS),systemic inflammation,and neurotransmission modulation.We found that both bacterial lipopolysaccharide(LPS)and cholinergic receptor antagonist scopolamine(Scop)induction reduced neuronal activities in the delirium-related brain network,with the latter presenting a similar pattern of reduction as found in delirium patients.Consistently,Scop injection resulted in reversible cognitive impairment with hyperactive behavior.No loss of cholinergic neurons was found with treatment,but hippocampal synaptic functions were affected.These findings provide further clues regarding the mechanism underlying delirium onset and demonstrate the successful application of the Scop injection model in mimicking delirium-like phenotypes in mice.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 10672140,10972001 and 10832006)Matjaz Perc individually acknowledges the Support from the Slovenian Research Agency (Grant Nos. Z1-9629 and Z1-2032-2547)
文摘The stochastic resonance in paced time-delayed scale-free FitzHugh--Nagumo （FHN） neuronal networks is investigated. We show that an intermediate intensity of additive noise is able to optimally assist the pacemaker in imposing its rhythm on the whole ensemble. Furthermore, we reveal that appropriately tuned delays can induce stochastic multiresonances, appearing at every integer multiple of the pacemaker＇s oscillation period. We conclude that fine-tuned delay lengths and locally acting pacemakers are vital for ensuring optimal conditions for stochastic resonance on complex neuronal networks.
基金This work was partially supported by the National Natural Science Foundation of China(62073173,61833011)the Natural Science Foundation of Jiangsu Province,China(BK20191376)the Nanjing University of Posts and Telecommunications(NY220193,NY220145)。
文摘Some recent research reports that a dendritic neuron model(DNM)can achieve better performance than traditional artificial neuron networks(ANNs)on classification,prediction,and other problems when its parameters are well-tuned by a learning algorithm.However,the back-propagation algorithm(BP),as a mostly used learning algorithm,intrinsically suffers from defects of slow convergence and easily dropping into local minima.Therefore,more and more research adopts non-BP learning algorithms to train ANNs.In this paper,a dynamic scale-free network-based differential evolution(DSNDE)is developed by considering the demands of convergent speed and the ability to jump out of local minima.The performance of a DSNDE trained DNM is tested on 14 benchmark datasets and a photovoltaic power forecasting problem.Nine meta-heuristic algorithms are applied into comparison,including the champion of the 2017 IEEE Congress on Evolutionary Computation(CEC2017)benchmark competition effective butterfly optimizer with covariance matrix adapted retreat phase(EBOwithCMAR).The experimental results reveal that DSNDE achieves better performance than its peers.
基金Project supported by the National Natural Science Foundation of China (Grant No. 10872014)
文摘Spatial coherence resonance in a two-dimensional neuronal network induced by additive Gaussian coloured noise and parameter diversity is studied. We focus on the ability of additive Gaussian coloured noise and parameter diversity to extract a particular spatial frequency （wave number） of excitatory waves in the excitable medium of this network. We show that there exists an intermediate noise level of the coloured noise and a particular value of diversity, where a characteristic spatial frequency of the system comes forth. Hereby, it is verified that spatial coherence resonance occurs in the studied model. Furthermore, we show that the optimal noise intensity for spatial coherence resonance decays exponentially with respect to the noise correlation time. Some explanations of the observed nonlinear phenomena are also presented.
基金Supported by National Natural Science Foundation of China under Grant Nos.11072135 and 10772101the Fundamental Research Funds for the Central Universities under Grant No.GK200902025
文摘Diversity in the neurons and noise are inevitable in the real neuronal network.In this paper,parameter diversity induced spiral waves and multiple spatial coherence resonances in a two-dimensional neuronal network without or with noise are simulated.The relationship between the multiple resonances and the multiple transitions between patterns of spiral waves are identified.The coherence degrees induced by the diversity are suppressed when noise is introduced and noise density is increased.The results suggest that natural nervous system might profit from both parameter diversity and noise,provided a possible approach to control formation and transition of spiral wave by the cooperation between the diversity and noise.
