As emerging two-dimensional(2D)materials,carbides and nitrides(MXenes)could be solid solutions or organized structures made up of multi-atomic layers.With remarkable and adjustable electrical,optical,mechanical,and el...As emerging two-dimensional(2D)materials,carbides and nitrides(MXenes)could be solid solutions or organized structures made up of multi-atomic layers.With remarkable and adjustable electrical,optical,mechanical,and electrochemical characteristics,MXenes have shown great potential in brain-inspired neuromorphic computing electronics,including neuromorphic gas sensors,pressure sensors and photodetectors.This paper provides a forward-looking review of the research progress regarding MXenes in the neuromorphic sensing domain and discussed the critical challenges that need to be resolved.Key bottlenecks such as insufficient long-term stability under environmental exposure,high costs,scalability limitations in large-scale production,and mechanical mismatch in wearable integration hinder their practical deployment.Furthermore,unresolved issues like interfacial compatibility in heterostructures and energy inefficiency in neu-romorphic signal conversion demand urgent attention.The review offers insights into future research directions enhance the fundamental understanding of MXene properties and promote further integration into neuromorphic computing applications through the convergence with various emerging technologies.展开更多
Two-dimensional(2D)multilayer kagome materials hold significant research value for regulating kagome-related physical properties and exploring quantum effects.However,their development is hindered by the scarcity of a...Two-dimensional(2D)multilayer kagome materials hold significant research value for regulating kagome-related physical properties and exploring quantum effects.However,their development is hindered by the scarcity of available material systems,making the identification of novel 2D multilayer kagome candidates particularly important.In this work,three types of 2D materials with trilayer kagome lattices,namely Sc_(6)S_(5)X_(6)(X=Cl,Br,I),are predicted based on first-principles calculations.These 2D materials feature two kagome lattices composed of Sc atoms and one kagome lattice composed of S atoms.Stability analysis indicates that these materials can exist as free-standing 2D materials.Electronic structure calculations reveal that Sc_(6)S_(5)X_(6)are narrow-bandgap semiconductors(0.76–0.95 e V),with their band structures exhibiting flat bands contributed by Sc-based kagome lattices and Dirac band gaps resulting from symmetry breaking.The sulfur-based kagome lattice in the central layer contributes an independent flat band below the Fermi level.Additionally,Sc_(6)S_(5)X_(6)exhibit high carrier mobility,with hole and electron mobilities reaching up to 10^(3)cm^(2)·V^(-1)·s^(-1),indicating potential applications in low-dimensional electronic devices.This work provides an excellent example for the development of novel multilayer 2D kagome materials.展开更多
Gas Turbines are among the most important energy systems for aviation and thermal-based power generation.The performance of gas turbine intakes with S-shaped diffusers is vulnerable to flow separation,reversal flow,an...Gas Turbines are among the most important energy systems for aviation and thermal-based power generation.The performance of gas turbine intakes with S-shaped diffusers is vulnerable to flow separation,reversal flow,and pressure distortion,mainly in aggressive S-shaped diffusers.Severalmethods,including vortex generators and energy promoters,have been proposed and investigated both experimentally and numerically.This paper compiles a review of experimental investigations that have been performed and reported to mitigate flow separation and restore system performance.The operational principles,classifications,design geometries,and performance parameters of Sshaped diffusers are presented to facilitate the analysis and understanding of the influence of each mitigation method on flowenhancement in S-shaped diffusers.Theinfluencing design parameters on the performance of the S-shaped diffuser and the findings achieved by various experimental investigations are discussed and compared.The review concludes that reducing the intake length reduces the size and weight of the gas turbine,leading to a higher power-to-weight ratio.However,the main challenge in shortening the S-shaped diffusers is the flow separation in the high-curvature section,which must be prevented to maintain high performance.Prevention can be achieved through flow control methods,which are categorized into passive and aggressive methods.The static pressure recovery coefficient,total pressure loss coefficient,ideal static pressure coefficient,distortion coefficient,and skin friction coefficient are the primary performance evaluation and comparison parameters between the experimentally investigated mitigation methods.The new trend in S-shaped diffuser studies includes the integration of computational and data-driven methods.展开更多
AIM:To investigate the clinical characteristics and treatment outcomes,including visual function and overall survival(OS)of patients with ocular adnexal diffuse large B-cell lymphoma(OA-DLBCL).METHODS:This retrospecti...AIM:To investigate the clinical characteristics and treatment outcomes,including visual function and overall survival(OS)of patients with ocular adnexal diffuse large B-cell lymphoma(OA-DLBCL).METHODS:This retrospective cohort study enrolled 29 patients diagnosed with OA-DLBCL based on histopathological biopsy between 2006 and 2023.Patients were stratified into two subgroups:primary OA-DLBCL(no prior history of lymphoma)and secondary OA-DLBCL(history of DLBCL at non-ocular adnexal sites).OS was defined as the time interval from OA-DLBCL diagnosis to death from any cause.Survival analysis was performed using the Kaplan–Meier method,and prognostic factors affecting OS were identified using multivariate Cox proportional hazards regression with a stepwise selection approach.RESULTS:The cohort included 24 patients with primary OA-DLBCL(13 males,11 females;mean age:61.36±18.29y)and 5 patients with secondary OA-DLBCL(2 males,3 females;mean age:50.94±18.17y).Among the primary OA-DLBCL subgroup,12 patients(50%)presented with advanced disease(Ann Arbor stage IIIE–IV),and 16 patients(66%)were classified as T4 disease according to the tumor-node-metastasis(TNM)staging system.The mean final visual acuity was 1.72±1.10 in the primary group and 0.90±1.18 in the secondary group.The 5-year OS rate for the entire cohort was 27.7%.Multivariate analysis identified five factors significantly associated with poor survival outcomes:epiphora[adjusted hazard ratio(aHR),36.95],atherosclerotic cardiovascular disease(aHR,10.08),human immunodeficiency virus(HIV)infection(aHR,12.47),M1 stage(aHR,6.99),and secondary OA-DLBCL(aHR,6.03;all P<0.05).The median OS was 1.68y for primary OA-DLBCL and 1.12y for secondary OA-DLBCL.CONCLUSION:A substantial proportion of patients with primary OA-DLBCL present with advanced-stage disease at diagnosis.Epiphora,atherosclerotic cardiovascular disease,HIV infection,M1 stage,and secondary OA-DLBCL are independent prognostic factors for poor survival outcomes.These findings emphasize the urgent need for optimized therapeutic strategies and early screening protocols to improve the management of OA-DLBCL,particularly in developing countries.展开更多
Objectives:B-cell lymphoma 6(BCL6)is a transcriptional repressor whose overexpression is closely linked to the progression of diffuse large B-cell lymphoma(DLBCL),making it a promising therapeutic target.This study ai...Objectives:B-cell lymphoma 6(BCL6)is a transcriptional repressor whose overexpression is closely linked to the progression of diffuse large B-cell lymphoma(DLBCL),making it a promising therapeutic target.This study aims to identify a novel small molecule,synthesized via proteolysis-targeting chimeras(PROTACs),capable of degrading BCL6,thereby inhibiting DLBCL growth and providing a foundation for future preclinical studies.Methods:The expression of BCL6 in DLBCL was analyzed using The Cancer Genome Atlas(TCGA)database and the Human Protein Atlas.Western blotting assays confirmed BCL6 expression in tumor cell lines,leading to the identification of the small molecule compound DZ-865B.To evaluate DZ-865B’s in vitro efficacy,multiple assays were performed,including protein immunoblotting,immunofluorescence,reverse transcription quantitative PCR,EDU proliferation,and soft agar cloning assays.Results:TCGA analysis revealed significant overexpression of BCL6 in DLBCL(p<0.05),corroborated by immunohistological staining and western blotting.DZ-865B induced BCL6 degradation in DLBCL cell lines(OCI-LY-1 and SU-DHL-4)in a concentration-and time-dependent manner,and induced the degradation of nuclear BCL6 through the ubiquitin-proteasome pathway.Notably,DZ-865B did not alter BCL6 mRNA levels but modulated downstream gene expression,leading to the activation of apoptosis pathway proteins and inhibition of DNA synthesis,effectively suppressing DLBCL cell growth.Conclusion:This study demonstrates that the small molecule DZ-865B targets and degrades BCL6 in DLBCL cells,promoting apoptosis and inhibiting cellular proliferation.These findings highlight DZ-865B as a potential therapeutic agent for diffuse large B-cell lymphoma.展开更多
A turbulent separation-rcattachment flow in a two-dimensional asymmetrical curved-wall diffuser is studied by a two-dimensional laser doppler velocimeter.The turbulent boundary layer separates on the lower curved wall...A turbulent separation-rcattachment flow in a two-dimensional asymmetrical curved-wall diffuser is studied by a two-dimensional laser doppler velocimeter.The turbulent boundary layer separates on the lower curved wall under strong pressure gradient and then reattaches on a parallel channel.At the inlet of the diffuser,Reynolds number based on the diffuser height is 1.2×10~5 and the velocity is 25.2m/s.The re- sults of experiments are presented and analyzed in new defined streamline-aligned coordinates.The experiment shows that after Transitory Detachment Reynolds shear stress is negative in the near-wall backflow region. Their characteristics are approximately the same as in simple turbulent shear layers near the maximum Reynolds shear stress.A scale is formed using the maximum Reynolds shear stresses.It is found that a Reynolds shear stress similarity exists from separation to reattachment and the Schofield-Perry velocity law ex- ists in the forward shear flow.Both profiles are used in the experimental work that leads to the design of a new eddy-viscosity model.The length scale is taken from that developed by Schofield and Perry.The composite velocity scale is formed by the maximum Reynolds shear stress and the Schofield Perry velocity scale as well as the edge velocity of the boundary layer.The results of these experiments are presented in this paper展开更多
To consider the reliability and performance of electronic devices based on polyimide derivatives, dynamic water sorption and diffusion behavior in a polyimide derivative： poly（4＇4 oxydiphenylene pyromellitimide） ...To consider the reliability and performance of electronic devices based on polyimide derivatives, dynamic water sorption and diffusion behavior in a polyimide derivative： poly（4＇4 oxydiphenylene pyromellitimide） （PMDA-ODA）/silica nanocomposite was investigated by two-dimensional ATR-FTIR spectroscopy, by which three states of water molecules owning different H-bonding strength were distinguished. The amounts and strength of H-bonding also played a significant role in determining the diffusion rate of the different states of water molecules. The type of aggregated water molecules which also formed H-bonding with silicic acid （residues） or polyimide system was the last one diffusing to the polymer side in contact with the ATR crystal element because the polymeric matrix blocked their diffusion to a great extent. The diffusion coefficient was also estimated to gain the information of the dynamic diffusion behavior.展开更多
In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-d...In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results.展开更多
Fractional diffusion equations have been the focus of modeling problems in hydrology, biology, viscoelasticity, physics, engineering, and other areas of applications. In this paper, a meshfree method based on the movi...Fractional diffusion equations have been the focus of modeling problems in hydrology, biology, viscoelasticity, physics, engineering, and other areas of applications. In this paper, a meshfree method based on the moving Kriging inter- polation is developed for a two-dimensional time-fractional diffusion equation. The shape function and its derivatives are obtained by the moving Kriging interpolation technique. For possessing the Kronecker delta property, this technique is very efficient in imposing the essential boundary conditions. The governing time-fractional diffusion equations are transformed into a standard weak formulation by the Galerkin method. It is then discretized into a meshfree system of time-dependent equations, which are solved by the standard central difference method. Numerical examples illustrating the applicability and effectiveness of the proposed method are presented and discussed in detail.展开更多
The combination of dual-main-phase(DMP)(Nd,Ce)-Fe-B magnets and grain boundary diffusion process(GBDP)is currently a research topic for obtaining high-cost performance materials in rare earth permanent magnet fields.T...The combination of dual-main-phase(DMP)(Nd,Ce)-Fe-B magnets and grain boundary diffusion process(GBDP)is currently a research topic for obtaining high-cost performance materials in rare earth permanent magnet fields.The novel structural features of GBDP(Nd,Ce)-Fe-B magnets give a version of different domain reversal processes from those of non-diffused magnets.In this work,the in-situ magnetic domain evolution of the DMP magnets was observed at elevated temperatures,and the temperature demagnetization and coercivity mechanism of the GBDP dual-main-phase(Nd,Ce)-Fe-B magnets are discussed.The results show that the shell composition of different types of grains in DMP magnets is similar,while the magnetic microstructure results indicate the Ce-rich grains tend to demagnetize first.Dy-rich shell with a high anisotropic field caused by GBDP leads to an increase in the nucleation field,which enhances the coercivity.It is found that much more grains exhibit single domain characteristics in the remanent state for GBDP dual-main-phase(Nd,Ce)-Fe-B magnets.In addition,the grains that undergo demagnetization first are Ce-rich or Nd-rich grains,which is different from that of non-diffused magnets.These results were not found in previous studies but can be intuitively characterized from the perspective of magnetic domains in this work,providing a new perspective and understanding of the performance improvement of magnetic materials.展开更多
The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an over...The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an overwhelming tendency,providing powerful tools for remote health monitoring and personal health management.Among many candidates,two-dimensional(2D)materials stand out due to several exotic mechanical,electrical,optical,and chemical properties that can be efficiently integrated into atomic-thin films.While previous reviews on 2D materials for biodevices primarily focus on conventional configurations and materials like graphene,the rapid development of new 2D materials with exotic properties has opened up novel applications,particularly in smart interaction and integrated functionalities.This review aims to consolidate recent progress,highlight the unique advantages of 2D materials,and guide future research by discussing existing challenges and opportunities in applying 2D materials for smart wearable biodevices.We begin with an in-depth analysis of the advantages,sensing mechanisms,and potential applications of 2D materials in wearable biodevice fabrication.Following this,we systematically discuss state-of-the-art biodevices based on 2D materials for monitoring various physiological signals within the human body.Special attention is given to showcasing the integration of multi-functionality in 2D smart devices,mainly including self-power supply,integrated diagnosis/treatment,and human–machine interaction.Finally,the review concludes with a concise summary of existing challenges and prospective solutions concerning the utilization of2D materials for advanced biodevices.展开更多
BACKGROUND Diffuse panbronchiolitis(DPB)is a rare,chronic inflammatory lung disease mar-ked by chronic cough,breathlessness,and preceding sinusitis.Symptoms often persist for years and can be misdiagnosed as asthma,pa...BACKGROUND Diffuse panbronchiolitis(DPB)is a rare,chronic inflammatory lung disease mar-ked by chronic cough,breathlessness,and preceding sinusitis.Symptoms often persist for years and can be misdiagnosed as asthma,particularly in children.This report describes a DPB case resolved with long-term azithromycin therapy,em-phasizing the need for a timely and accurate diagnosis.CASE SUMMARY A 12-year-old girl,diagnosed with asthma at age five and managed with inhaled corticosteroids and long-acting beta-2 agonists,developed a history of chronic productive cough and chronic sinusitis for a year.On examination,she exhibited wheezing and coarse crackles.Despite receiving treatment for an asthma exacer-bation,her symptoms did not improve.A chest X-ray revealed reticulonodular infiltration in both lower lungs,prompting further evaluation with high-resolu-tion computed tomography(HRCT).The HRCT confirmed centrilobular nodule opacities,a'tree-in-bud'pattern,and non-tapering bronchi,suggesting DPB.Elevated cold hemagglutinin titers at 128 further supported the diagnosis.Her cough and sinusitis resolved within a month after starting azithromycin therapy,chosen for its anti-inflammatory and immunomodulatory effects.Follow-up HRCT scans after 1 year of continuous treatment showed complete normalization.CONCLUSION This case highlights the importance of early diagnosis and prompt treatment in achieving favorable outcomes for DPB.展开更多
The present paper is concerned with the investigation of disturbances in＇a homogeneous, isotropic elastic medium with generalized thermoelastic diffusion, when a moving source is acting along one of the co-ordinate a...The present paper is concerned with the investigation of disturbances in＇a homogeneous, isotropic elastic medium with generalized thermoelastic diffusion, when a moving source is acting along one of the co-ordinate axis on the boundary of the medium. Eigen value approach is applied to study the disturbance in Laplace-Fourier transform domain for a two dimensional problem. The analytical expressions for displacement components, stresses, temperature field, concentration and chemical potential are obtained in the physical domain by using a numerical technique for the inversion of Laplace transform based on Fourier expansion techniques. These expressions are calculated numerically for a copper like material and depicted graphically. As special cases, the results in generalized thermoelastic and elastic media are obtained. Effect of presence of diffusion is analyzed theoretically and numerically.展开更多
Intracellular diffusion is critical for molecule translocation in cytoplasm and mediates many important cellular processes.Meanwhile,the diffusion dynamics is affected by the heterogeneous cytoplasm.Previous studies o...Intracellular diffusion is critical for molecule translocation in cytoplasm and mediates many important cellular processes.Meanwhile,the diffusion dynamics is affected by the heterogeneous cytoplasm.Previous studies on intracellular diffusion are mainly based on two-dimensional(2 D)measurements under the assumption that the three-dimensional(3 D)diffusion is isotropic.However,the real behaviors of 3 D diffusion of molecules in cytoplasm are still unclear.Here,we have built a 3 D single-particle tracking(SPT)microscopy and studied the 3 D diffusion of quantum dots(QDs)in adherent A549 cells.Notably,we found that the intracellular diffusion of QDs is quasi-2 D,with the axial motion being severely confined.Further investigations demonstrated that disrupting the cytoskeleton component or endoplasmic reticulum(ER)does not alter the quasi-2 D diffusion pattern,although ER reduces the diffusion rates and slightly relieves the constraint in the axial diffusion.The preferred quasi-2 D diffusion is quite robust and attributed to the complex cytoarchitectures in the flat adherent cells.With the aid of 3 D SPT method,the quasi-2 D diffusion in cells was revealed,shedding new light on the physical nature of cytoplasm.展开更多
A molecular dynamical simulation method is used to investigate the diffusion of the two-dimensional magnetized dusty plasmas. The effects of charge and mass of the particles, as well as the external magnetic field are...A molecular dynamical simulation method is used to investigate the diffusion of the two-dimensional magnetized dusty plasmas. The effects of charge and mass of the particles, as well as the external magnetic field are discussed in detail It is shown that, relative to the mass of particulate, the charge and magnetic field have a more considerable effect on the diffusion process, particularly on the resulting structure of the system. The dependence of diffusion coecient on the temperature is shown to be linearly changed over a wide range of temperature.展开更多
A functional interlayer based on two-dimensional(2D)porous modified vermiculite nanosheets(PVS)was obtained by acid-etching vermiculite nanosheets.The as-obtained 2D porous nanosheets exhibited a high specific surface...A functional interlayer based on two-dimensional(2D)porous modified vermiculite nanosheets(PVS)was obtained by acid-etching vermiculite nanosheets.The as-obtained 2D porous nanosheets exhibited a high specific surface area of 427 m^(2)·g^(-1)and rich surface active sites,which help restrain polysulfides(LiPSs)through good physi-cal and chemical adsorption,while simultaneously accelerating the nucleation and dissolution kinetics of Li_(2)S,effec-tively suppressing the shuttle effect.The assembled lithium-sulfur batteries(LSBs)employing the PVS-based inter-layer delivered a high initial discharge capacity of 1386 mAh·g^(-1)at 0.1C(167.5 mAh·g^(-1)),long-term cycling stabil-ity,and good rate property.展开更多
This paper investigates ruin,capital injection,and dividends for a two-dimensional risk model.The model posits that surplus levels of insurance companies are governed by a perturbed composite Poisson risk model.This m...This paper investigates ruin,capital injection,and dividends for a two-dimensional risk model.The model posits that surplus levels of insurance companies are governed by a perturbed composite Poisson risk model.This model introduces a dependence between the two surplus levels,present in both the associated perturbations and the claims resulting from common shocks.Critical levels of capital injection and dividends are established for each of the two risks.The surplus levels are observed discretely at fixed intervals,guiding decisions on capital injection,dividends,and ruin at these junctures.This study employs a two-dimensional Fourier cosine series expansion method to approximate the finite time expected discounted operating cost until ruin.The ensuing approximation error is also quantified.The validity and accuracy of the method are corroborated through numerical examples.Furthermore,the research delves into the optimal capital allocation problem.展开更多
In this article, we consider a two-dimensional symmetric space-fractional diffusion equation in which the space fractional derivatives are defined in Riesz potential sense. The well-posed feature is guaranteed by ener...In this article, we consider a two-dimensional symmetric space-fractional diffusion equation in which the space fractional derivatives are defined in Riesz potential sense. The well-posed feature is guaranteed by energy inequality. To solve the diffusion equation, a fully discrete form is established by employing Crank-Nicolson technique in time and Galerkin finite element method in space. The stability and convergence are proved and the stiffness matrix is given analytically. Three numerical examples are given to confirm our theoretical analysis in which we find that even with the same initial condition, the classical and fractional diffusion equations perform differently but tend to be uniform diffusion at last.展开更多
Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported previously.However,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its int...Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported previously.However,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully understood.Methods:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups.Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL.Furthermore,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide treatment.Results:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in DLBCL.Notably,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression analysis.Additionally,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 expression.This effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide treatment.In vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.展开更多
基金supported by the NSFC(12474071)Natural Science Foundation of Shandong Province(ZR2024YQ051,ZR2025QB50)+6 种基金Guangdong Basic and Applied Basic Research Foundation(2025A1515011191)the Shanghai Sailing Program(23YF1402200,23YF1402400)funded by Basic Research Program of Jiangsu(BK20240424)Open Research Fund of State Key Laboratory of Crystal Materials(KF2406)Taishan Scholar Foundation of Shandong Province(tsqn202408006,tsqn202507058)Young Talent of Lifting engineering for Science and Technology in Shandong,China(SDAST2024QTB002)the Qilu Young Scholar Program of Shandong University。
文摘As emerging two-dimensional(2D)materials,carbides and nitrides(MXenes)could be solid solutions or organized structures made up of multi-atomic layers.With remarkable and adjustable electrical,optical,mechanical,and electrochemical characteristics,MXenes have shown great potential in brain-inspired neuromorphic computing electronics,including neuromorphic gas sensors,pressure sensors and photodetectors.This paper provides a forward-looking review of the research progress regarding MXenes in the neuromorphic sensing domain and discussed the critical challenges that need to be resolved.Key bottlenecks such as insufficient long-term stability under environmental exposure,high costs,scalability limitations in large-scale production,and mechanical mismatch in wearable integration hinder their practical deployment.Furthermore,unresolved issues like interfacial compatibility in heterostructures and energy inefficiency in neu-romorphic signal conversion demand urgent attention.The review offers insights into future research directions enhance the fundamental understanding of MXene properties and promote further integration into neuromorphic computing applications through the convergence with various emerging technologies.
基金supported by the Fundamental Research Funds for the Central Universities(WUT:2024IVA052 and Grant No.104972025KFYjc0089)。
文摘Two-dimensional(2D)multilayer kagome materials hold significant research value for regulating kagome-related physical properties and exploring quantum effects.However,their development is hindered by the scarcity of available material systems,making the identification of novel 2D multilayer kagome candidates particularly important.In this work,three types of 2D materials with trilayer kagome lattices,namely Sc_(6)S_(5)X_(6)(X=Cl,Br,I),are predicted based on first-principles calculations.These 2D materials feature two kagome lattices composed of Sc atoms and one kagome lattice composed of S atoms.Stability analysis indicates that these materials can exist as free-standing 2D materials.Electronic structure calculations reveal that Sc_(6)S_(5)X_(6)are narrow-bandgap semiconductors(0.76–0.95 e V),with their band structures exhibiting flat bands contributed by Sc-based kagome lattices and Dirac band gaps resulting from symmetry breaking.The sulfur-based kagome lattice in the central layer contributes an independent flat band below the Fermi level.Additionally,Sc_(6)S_(5)X_(6)exhibit high carrier mobility,with hole and electron mobilities reaching up to 10^(3)cm^(2)·V^(-1)·s^(-1),indicating potential applications in low-dimensional electronic devices.This work provides an excellent example for the development of novel multilayer 2D kagome materials.
文摘Gas Turbines are among the most important energy systems for aviation and thermal-based power generation.The performance of gas turbine intakes with S-shaped diffusers is vulnerable to flow separation,reversal flow,and pressure distortion,mainly in aggressive S-shaped diffusers.Severalmethods,including vortex generators and energy promoters,have been proposed and investigated both experimentally and numerically.This paper compiles a review of experimental investigations that have been performed and reported to mitigate flow separation and restore system performance.The operational principles,classifications,design geometries,and performance parameters of Sshaped diffusers are presented to facilitate the analysis and understanding of the influence of each mitigation method on flowenhancement in S-shaped diffusers.Theinfluencing design parameters on the performance of the S-shaped diffuser and the findings achieved by various experimental investigations are discussed and compared.The review concludes that reducing the intake length reduces the size and weight of the gas turbine,leading to a higher power-to-weight ratio.However,the main challenge in shortening the S-shaped diffusers is the flow separation in the high-curvature section,which must be prevented to maintain high performance.Prevention can be achieved through flow control methods,which are categorized into passive and aggressive methods.The static pressure recovery coefficient,total pressure loss coefficient,ideal static pressure coefficient,distortion coefficient,and skin friction coefficient are the primary performance evaluation and comparison parameters between the experimentally investigated mitigation methods.The new trend in S-shaped diffuser studies includes the integration of computational and data-driven methods.
基金Supported by the Faculty of Medicine,Prince of Songkla University.Wainipitapong S has received grants from the Faculty of Medicine,Prince of Songkla University。
文摘AIM:To investigate the clinical characteristics and treatment outcomes,including visual function and overall survival(OS)of patients with ocular adnexal diffuse large B-cell lymphoma(OA-DLBCL).METHODS:This retrospective cohort study enrolled 29 patients diagnosed with OA-DLBCL based on histopathological biopsy between 2006 and 2023.Patients were stratified into two subgroups:primary OA-DLBCL(no prior history of lymphoma)and secondary OA-DLBCL(history of DLBCL at non-ocular adnexal sites).OS was defined as the time interval from OA-DLBCL diagnosis to death from any cause.Survival analysis was performed using the Kaplan–Meier method,and prognostic factors affecting OS were identified using multivariate Cox proportional hazards regression with a stepwise selection approach.RESULTS:The cohort included 24 patients with primary OA-DLBCL(13 males,11 females;mean age:61.36±18.29y)and 5 patients with secondary OA-DLBCL(2 males,3 females;mean age:50.94±18.17y).Among the primary OA-DLBCL subgroup,12 patients(50%)presented with advanced disease(Ann Arbor stage IIIE–IV),and 16 patients(66%)were classified as T4 disease according to the tumor-node-metastasis(TNM)staging system.The mean final visual acuity was 1.72±1.10 in the primary group and 0.90±1.18 in the secondary group.The 5-year OS rate for the entire cohort was 27.7%.Multivariate analysis identified five factors significantly associated with poor survival outcomes:epiphora[adjusted hazard ratio(aHR),36.95],atherosclerotic cardiovascular disease(aHR,10.08),human immunodeficiency virus(HIV)infection(aHR,12.47),M1 stage(aHR,6.99),and secondary OA-DLBCL(aHR,6.03;all P<0.05).The median OS was 1.68y for primary OA-DLBCL and 1.12y for secondary OA-DLBCL.CONCLUSION:A substantial proportion of patients with primary OA-DLBCL present with advanced-stage disease at diagnosis.Epiphora,atherosclerotic cardiovascular disease,HIV infection,M1 stage,and secondary OA-DLBCL are independent prognostic factors for poor survival outcomes.These findings emphasize the urgent need for optimized therapeutic strategies and early screening protocols to improve the management of OA-DLBCL,particularly in developing countries.
基金supported by the National Natural Science Foundation of China(82260716)the Key Research and Development Program of Ningxia(2023BEG02010).
文摘Objectives:B-cell lymphoma 6(BCL6)is a transcriptional repressor whose overexpression is closely linked to the progression of diffuse large B-cell lymphoma(DLBCL),making it a promising therapeutic target.This study aims to identify a novel small molecule,synthesized via proteolysis-targeting chimeras(PROTACs),capable of degrading BCL6,thereby inhibiting DLBCL growth and providing a foundation for future preclinical studies.Methods:The expression of BCL6 in DLBCL was analyzed using The Cancer Genome Atlas(TCGA)database and the Human Protein Atlas.Western blotting assays confirmed BCL6 expression in tumor cell lines,leading to the identification of the small molecule compound DZ-865B.To evaluate DZ-865B’s in vitro efficacy,multiple assays were performed,including protein immunoblotting,immunofluorescence,reverse transcription quantitative PCR,EDU proliferation,and soft agar cloning assays.Results:TCGA analysis revealed significant overexpression of BCL6 in DLBCL(p<0.05),corroborated by immunohistological staining and western blotting.DZ-865B induced BCL6 degradation in DLBCL cell lines(OCI-LY-1 and SU-DHL-4)in a concentration-and time-dependent manner,and induced the degradation of nuclear BCL6 through the ubiquitin-proteasome pathway.Notably,DZ-865B did not alter BCL6 mRNA levels but modulated downstream gene expression,leading to the activation of apoptosis pathway proteins and inhibition of DNA synthesis,effectively suppressing DLBCL cell growth.Conclusion:This study demonstrates that the small molecule DZ-865B targets and degrades BCL6 in DLBCL cells,promoting apoptosis and inhibiting cellular proliferation.These findings highlight DZ-865B as a potential therapeutic agent for diffuse large B-cell lymphoma.
文摘A turbulent separation-rcattachment flow in a two-dimensional asymmetrical curved-wall diffuser is studied by a two-dimensional laser doppler velocimeter.The turbulent boundary layer separates on the lower curved wall under strong pressure gradient and then reattaches on a parallel channel.At the inlet of the diffuser,Reynolds number based on the diffuser height is 1.2×10~5 and the velocity is 25.2m/s.The re- sults of experiments are presented and analyzed in new defined streamline-aligned coordinates.The experiment shows that after Transitory Detachment Reynolds shear stress is negative in the near-wall backflow region. Their characteristics are approximately the same as in simple turbulent shear layers near the maximum Reynolds shear stress.A scale is formed using the maximum Reynolds shear stresses.It is found that a Reynolds shear stress similarity exists from separation to reattachment and the Schofield-Perry velocity law ex- ists in the forward shear flow.Both profiles are used in the experimental work that leads to the design of a new eddy-viscosity model.The length scale is taken from that developed by Schofield and Perry.The composite velocity scale is formed by the maximum Reynolds shear stress and the Schofield Perry velocity scale as well as the edge velocity of the boundary layer.The results of these experiments are presented in this paper
基金supported by the National Natural Science Foundation of China(No.20573022,No.20425415)the National Basic Research Pro-gram of China(2005CB623800),the PHD Program of M0E(20050246010)the"Qimingxing"Project(No.04QM1402)of Shanghai Municipal Science and Technology Commission,and the"Shuguang"Project(No.01SG05)of the Shanghai Municipal Education Commission and Shanghai Education Development Foundation.
文摘To consider the reliability and performance of electronic devices based on polyimide derivatives, dynamic water sorption and diffusion behavior in a polyimide derivative： poly（4＇4 oxydiphenylene pyromellitimide） （PMDA-ODA）/silica nanocomposite was investigated by two-dimensional ATR-FTIR spectroscopy, by which three states of water molecules owning different H-bonding strength were distinguished. The amounts and strength of H-bonding also played a significant role in determining the diffusion rate of the different states of water molecules. The type of aggregated water molecules which also formed H-bonding with silicic acid （residues） or polyimide system was the last one diffusing to the polymer side in contact with the ATR crystal element because the polymeric matrix blocked their diffusion to a great extent. The diffusion coefficient was also estimated to gain the information of the dynamic diffusion behavior.
基金the National Natural Science Fund(11661058,11761053)Natural Science Fund of Inner Mongolia Autonomous Region(2016MS0102,2017MS0107)+1 种基金Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT-17-A07)National Undergraduate Innovative Training Project of Inner Mongolia University(201710126026).
文摘In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results.
基金Project supported by the National Natural Science Foundation of China(Grant No.11072117)the Natural Science Foundation of Ningbo City,China(GrantNo.2013A610103)+2 种基金the Natural Science Foundation of Zhejiang Province,China(Grant No.Y6090131)the Disciplinary Project of Ningbo City,China(GrantNo.SZXL1067)the K.C.Wong Magna Fund in Ningbo University,China
文摘Fractional diffusion equations have been the focus of modeling problems in hydrology, biology, viscoelasticity, physics, engineering, and other areas of applications. In this paper, a meshfree method based on the moving Kriging inter- polation is developed for a two-dimensional time-fractional diffusion equation. The shape function and its derivatives are obtained by the moving Kriging interpolation technique. For possessing the Kronecker delta property, this technique is very efficient in imposing the essential boundary conditions. The governing time-fractional diffusion equations are transformed into a standard weak formulation by the Galerkin method. It is then discretized into a meshfree system of time-dependent equations, which are solved by the standard central difference method. Numerical examples illustrating the applicability and effectiveness of the proposed method are presented and discussed in detail.
基金supported by the National Key Research and Development Program of China(Nos.2021YFB3503003,2021YFB3503100,and 2022YFB3505401).
文摘The combination of dual-main-phase(DMP)(Nd,Ce)-Fe-B magnets and grain boundary diffusion process(GBDP)is currently a research topic for obtaining high-cost performance materials in rare earth permanent magnet fields.The novel structural features of GBDP(Nd,Ce)-Fe-B magnets give a version of different domain reversal processes from those of non-diffused magnets.In this work,the in-situ magnetic domain evolution of the DMP magnets was observed at elevated temperatures,and the temperature demagnetization and coercivity mechanism of the GBDP dual-main-phase(Nd,Ce)-Fe-B magnets are discussed.The results show that the shell composition of different types of grains in DMP magnets is similar,while the magnetic microstructure results indicate the Ce-rich grains tend to demagnetize first.Dy-rich shell with a high anisotropic field caused by GBDP leads to an increase in the nucleation field,which enhances the coercivity.It is found that much more grains exhibit single domain characteristics in the remanent state for GBDP dual-main-phase(Nd,Ce)-Fe-B magnets.In addition,the grains that undergo demagnetization first are Ce-rich or Nd-rich grains,which is different from that of non-diffused magnets.These results were not found in previous studies but can be intuitively characterized from the perspective of magnetic domains in this work,providing a new perspective and understanding of the performance improvement of magnetic materials.
基金the support from the National Natural Science Foundation of China(22272004,62272041)the Fundamental Research Funds for the Central Universities(YWF-22-L-1256)+1 种基金the National Key R&D Program of China(2023YFC3402600)the Beijing Institute of Technology Research Fund Program for Young Scholars(No.1870011182126)。
文摘The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an overwhelming tendency,providing powerful tools for remote health monitoring and personal health management.Among many candidates,two-dimensional(2D)materials stand out due to several exotic mechanical,electrical,optical,and chemical properties that can be efficiently integrated into atomic-thin films.While previous reviews on 2D materials for biodevices primarily focus on conventional configurations and materials like graphene,the rapid development of new 2D materials with exotic properties has opened up novel applications,particularly in smart interaction and integrated functionalities.This review aims to consolidate recent progress,highlight the unique advantages of 2D materials,and guide future research by discussing existing challenges and opportunities in applying 2D materials for smart wearable biodevices.We begin with an in-depth analysis of the advantages,sensing mechanisms,and potential applications of 2D materials in wearable biodevice fabrication.Following this,we systematically discuss state-of-the-art biodevices based on 2D materials for monitoring various physiological signals within the human body.Special attention is given to showcasing the integration of multi-functionality in 2D smart devices,mainly including self-power supply,integrated diagnosis/treatment,and human–machine interaction.Finally,the review concludes with a concise summary of existing challenges and prospective solutions concerning the utilization of2D materials for advanced biodevices.
文摘BACKGROUND Diffuse panbronchiolitis(DPB)is a rare,chronic inflammatory lung disease mar-ked by chronic cough,breathlessness,and preceding sinusitis.Symptoms often persist for years and can be misdiagnosed as asthma,particularly in children.This report describes a DPB case resolved with long-term azithromycin therapy,em-phasizing the need for a timely and accurate diagnosis.CASE SUMMARY A 12-year-old girl,diagnosed with asthma at age five and managed with inhaled corticosteroids and long-acting beta-2 agonists,developed a history of chronic productive cough and chronic sinusitis for a year.On examination,she exhibited wheezing and coarse crackles.Despite receiving treatment for an asthma exacer-bation,her symptoms did not improve.A chest X-ray revealed reticulonodular infiltration in both lower lungs,prompting further evaluation with high-resolu-tion computed tomography(HRCT).The HRCT confirmed centrilobular nodule opacities,a'tree-in-bud'pattern,and non-tapering bronchi,suggesting DPB.Elevated cold hemagglutinin titers at 128 further supported the diagnosis.Her cough and sinusitis resolved within a month after starting azithromycin therapy,chosen for its anti-inflammatory and immunomodulatory effects.Follow-up HRCT scans after 1 year of continuous treatment showed complete normalization.CONCLUSION This case highlights the importance of early diagnosis and prompt treatment in achieving favorable outcomes for DPB.
文摘The present paper is concerned with the investigation of disturbances in＇a homogeneous, isotropic elastic medium with generalized thermoelastic diffusion, when a moving source is acting along one of the co-ordinate axis on the boundary of the medium. Eigen value approach is applied to study the disturbance in Laplace-Fourier transform domain for a two dimensional problem. The analytical expressions for displacement components, stresses, temperature field, concentration and chemical potential are obtained in the physical domain by using a numerical technique for the inversion of Laplace transform based on Fourier expansion techniques. These expressions are calculated numerically for a copper like material and depicted graphically. As special cases, the results in generalized thermoelastic and elastic media are obtained. Effect of presence of diffusion is analyzed theoretically and numerically.
基金supported by the National Natural Science Foundation of China(Grant Nos.11674383,11874415,21991133,11774407)the National Key Research and Development Program(Grant No.2016YFA0301500)+1 种基金the Youth Innovation Promotion Association of CAS(Grant No.2019006)the Fundamental Research Funds for the Central Universities(Grant No.2019NTST26)。
文摘Intracellular diffusion is critical for molecule translocation in cytoplasm and mediates many important cellular processes.Meanwhile,the diffusion dynamics is affected by the heterogeneous cytoplasm.Previous studies on intracellular diffusion are mainly based on two-dimensional(2 D)measurements under the assumption that the three-dimensional(3 D)diffusion is isotropic.However,the real behaviors of 3 D diffusion of molecules in cytoplasm are still unclear.Here,we have built a 3 D single-particle tracking(SPT)microscopy and studied the 3 D diffusion of quantum dots(QDs)in adherent A549 cells.Notably,we found that the intracellular diffusion of QDs is quasi-2 D,with the axial motion being severely confined.Further investigations demonstrated that disrupting the cytoskeleton component or endoplasmic reticulum(ER)does not alter the quasi-2 D diffusion pattern,although ER reduces the diffusion rates and slightly relieves the constraint in the axial diffusion.The preferred quasi-2 D diffusion is quite robust and attributed to the complex cytoarchitectures in the flat adherent cells.With the aid of 3 D SPT method,the quasi-2 D diffusion in cells was revealed,shedding new light on the physical nature of cytoplasm.
基金Supported by National Magnetic Confinement Fusion Science Program under Grant No.2013GB111005the Foundation of Civil Aviation University of China under Grant No.08QD07X
文摘A molecular dynamical simulation method is used to investigate the diffusion of the two-dimensional magnetized dusty plasmas. The effects of charge and mass of the particles, as well as the external magnetic field are discussed in detail It is shown that, relative to the mass of particulate, the charge and magnetic field have a more considerable effect on the diffusion process, particularly on the resulting structure of the system. The dependence of diffusion coecient on the temperature is shown to be linearly changed over a wide range of temperature.
文摘A functional interlayer based on two-dimensional(2D)porous modified vermiculite nanosheets(PVS)was obtained by acid-etching vermiculite nanosheets.The as-obtained 2D porous nanosheets exhibited a high specific surface area of 427 m^(2)·g^(-1)and rich surface active sites,which help restrain polysulfides(LiPSs)through good physi-cal and chemical adsorption,while simultaneously accelerating the nucleation and dissolution kinetics of Li_(2)S,effec-tively suppressing the shuttle effect.The assembled lithium-sulfur batteries(LSBs)employing the PVS-based inter-layer delivered a high initial discharge capacity of 1386 mAh·g^(-1)at 0.1C(167.5 mAh·g^(-1)),long-term cycling stabil-ity,and good rate property.
基金supported by the Shihezi University High-Level Talents Research Startup Project(Project No.RCZK202521)the National Natural Science Foundation of China(Grant Nos.12271066,11871121,12171405)+1 种基金the Chongqing Natural Science Foundation Joint Fund for Innovation and Development Project(Project No.CSTB2024NSCQLZX0085)the Chongqing Normal University Foundation(Grant No.23XLB018).
文摘This paper investigates ruin,capital injection,and dividends for a two-dimensional risk model.The model posits that surplus levels of insurance companies are governed by a perturbed composite Poisson risk model.This model introduces a dependence between the two surplus levels,present in both the associated perturbations and the claims resulting from common shocks.Critical levels of capital injection and dividends are established for each of the two risks.The surplus levels are observed discretely at fixed intervals,guiding decisions on capital injection,dividends,and ruin at these junctures.This study employs a two-dimensional Fourier cosine series expansion method to approximate the finite time expected discounted operating cost until ruin.The ensuing approximation error is also quantified.The validity and accuracy of the method are corroborated through numerical examples.Furthermore,the research delves into the optimal capital allocation problem.
文摘In this article, we consider a two-dimensional symmetric space-fractional diffusion equation in which the space fractional derivatives are defined in Riesz potential sense. The well-posed feature is guaranteed by energy inequality. To solve the diffusion equation, a fully discrete form is established by employing Crank-Nicolson technique in time and Galerkin finite element method in space. The stability and convergence are proved and the stiffness matrix is given analytically. Three numerical examples are given to confirm our theoretical analysis in which we find that even with the same initial condition, the classical and fractional diffusion equations perform differently but tend to be uniform diffusion at last.
基金supported by the Key Research and Development Program of Science and Technology Department of Guizhou Province(No.20204Y147).
文摘Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported previously.However,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully understood.Methods:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups.Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL.Furthermore,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide treatment.Results:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in DLBCL.Notably,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression analysis.Additionally,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 expression.This effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide treatment.In vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.
