Detecting genotype-by-environment (GE) interaction effects or yield stability is one of the most important components for crop trial data analysis, especially in historical crop trial data. However, it is statisticall...Detecting genotype-by-environment (GE) interaction effects or yield stability is one of the most important components for crop trial data analysis, especially in historical crop trial data. However, it is statistically challenging to discover the GE interaction effects because many published data were just entry means under each environment rather than repeated field plot data. In this study, we propose a new methodology, which can be used to impute replicated trial data sets to reveal GE interactions from the original data. As a demonstration, we used a data set, which includes 28 potato genotypes and six environments with three replications to numerically evaluate the properties of this new imputation method. We compared the phenotypic means and predicted random effects from the imputed data with the results from the original data. The results from the imputed data were highly consistent with those from the original data set, indicating that imputed data from the method we proposed in this study can be used to reveal information including GE interaction effects harbored in the original data. Therefore, this study could pave a way to detect the GE interactions and other related information from historical crop trial reports when replications were not available.展开更多
The International Committee of Medical Journal Editors(ICMJE)believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves ...The International Committee of Medical Journal Editors(ICMJE)believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016.展开更多
AIM To develop a survey to help define the main problems in radiological clinical trials. METHODS Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academ...AIM To develop a survey to help define the main problems in radiological clinical trials. METHODS Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academic centres. We developed a preliminary questionnaire using a four-round Delphi approach to identify problems occurring in radiological clinical trials run at our centre. We investigated the recruitment experience, involvement of all multi-disciplinary team members and main obstacles to completing the projects. A final round of Delphi processes elucidated solutions to the identified problems.RESULTS Among 19/20(95%) respondents, 10(53%) were young physicians(under 35 years old), and the respondents included non-faculty members, fellows, residents, and undergraduate students. Ninety-four percent(18/19) of respondents showed interest in conducting clinical trials. On a scale of 1 to 10, the problems with higher/worse scores(8-9) were related to technical or communication problems. The most frequent problems across all studies were technical problems related to clinical trial equipment, insufficient willingness to participate, obstacles to understanding the design of electronic-case report form and extra work.CONCLUSION The developed questionnaire identified the main recurring problems in radiological clinical trials as perceived by endusers and helped define possible solutions that are mostly related to having dedicated clinical trial research staff.展开更多
Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the...Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials(RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research.展开更多
The deep learning models hold considerable potential for clinical applications, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently...The deep learning models hold considerable potential for clinical applications, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently only possible through multi-institutional cooperation. Building large central repositories is one strategy for multi-institution studies. However, this is hampered by issues regarding data sharing, including patient privacy, data de-identification, regulation, intellectual property, and data storage. These difficulties have lessened the impracticality of central data storage. In this survey, we will look at 24 research publications that concentrate on machine learning approaches linked to privacy preservation techniques for multi-institutional data, highlighting the multiple shortcomings of the existing methodologies. Researching different approaches will be made simpler in this case based on a number of factors, such as performance measures, year of publication and journals, achievements of the strategies in numerical assessments, and other factors. A technique analysis that considers the benefits and drawbacks of the strategies is additionally provided. The article also looks at some potential areas for future research as well as the challenges associated with increasing the accuracy of privacy protection techniques. The comparative evaluation of the approaches offers a thorough justification for the research’s purpose.展开更多
文摘Detecting genotype-by-environment (GE) interaction effects or yield stability is one of the most important components for crop trial data analysis, especially in historical crop trial data. However, it is statistically challenging to discover the GE interaction effects because many published data were just entry means under each environment rather than repeated field plot data. In this study, we propose a new methodology, which can be used to impute replicated trial data sets to reveal GE interactions from the original data. As a demonstration, we used a data set, which includes 28 potato genotypes and six environments with three replications to numerically evaluate the properties of this new imputation method. We compared the phenotypic means and predicted random effects from the imputed data with the results from the original data. The results from the imputed data were highly consistent with those from the original data set, indicating that imputed data from the method we proposed in this study can be used to reveal information including GE interaction effects harbored in the original data. Therefore, this study could pave a way to detect the GE interactions and other related information from historical crop trial reports when replications were not available.
文摘The International Committee of Medical Journal Editors(ICMJE)believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016.
文摘AIM To develop a survey to help define the main problems in radiological clinical trials. METHODS Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academic centres. We developed a preliminary questionnaire using a four-round Delphi approach to identify problems occurring in radiological clinical trials run at our centre. We investigated the recruitment experience, involvement of all multi-disciplinary team members and main obstacles to completing the projects. A final round of Delphi processes elucidated solutions to the identified problems.RESULTS Among 19/20(95%) respondents, 10(53%) were young physicians(under 35 years old), and the respondents included non-faculty members, fellows, residents, and undergraduate students. Ninety-four percent(18/19) of respondents showed interest in conducting clinical trials. On a scale of 1 to 10, the problems with higher/worse scores(8-9) were related to technical or communication problems. The most frequent problems across all studies were technical problems related to clinical trial equipment, insufficient willingness to participate, obstacles to understanding the design of electronic-case report form and extra work.CONCLUSION The developed questionnaire identified the main recurring problems in radiological clinical trials as perceived by endusers and helped define possible solutions that are mostly related to having dedicated clinical trial research staff.
基金supported by Fundamental Research Funds of State Key Laboratory of Ophthalmology (Grant No.2015QN01)Young Teacher Top-Support project of Sun Yat-sen University(Grant No.2015ykzd11)+4 种基金the Cultivation Projects for Young Teaching Staff of Sun Yat-sen University(Grant No.12ykpy61) from the Fundamental Research Funds for the Central Universitiesthe Pearl River Science and Technology New Star(Grant No.2014J2200060)Project of Guangzhou City,the Guangdong Provincial Natural Science Foundation for Distinguished Young Scholars of China(Grant No. 2014A030306030)Youth Science and Technology Innovation Talents Funds in Special Support Plan for High Level Talents in Guangdong Province(Grant No. 2014TQ01R573)Key Research Plan for National Natural Science Foundation of China in Cultivation Project (No.91546101)
文摘Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials(RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research.
文摘The deep learning models hold considerable potential for clinical applications, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently only possible through multi-institutional cooperation. Building large central repositories is one strategy for multi-institution studies. However, this is hampered by issues regarding data sharing, including patient privacy, data de-identification, regulation, intellectual property, and data storage. These difficulties have lessened the impracticality of central data storage. In this survey, we will look at 24 research publications that concentrate on machine learning approaches linked to privacy preservation techniques for multi-institutional data, highlighting the multiple shortcomings of the existing methodologies. Researching different approaches will be made simpler in this case based on a number of factors, such as performance measures, year of publication and journals, achievements of the strategies in numerical assessments, and other factors. A technique analysis that considers the benefits and drawbacks of the strategies is additionally provided. The article also looks at some potential areas for future research as well as the challenges associated with increasing the accuracy of privacy protection techniques. The comparative evaluation of the approaches offers a thorough justification for the research’s purpose.
