Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart...Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart failure,rheumatic heart disease,coronary heart disease,hypotension,shock and other diseases.However,it also contains the main ingredients that produce toxic effects and are highly toxic to the cardiovascular system,nervous system,digestive system,reproductive system,embryos,and livers and kidneys.In this study,we analyzed the toxicity-reducing and efficacy-enhancing effects of the compatibility of Radix Aconiti Lateralis Praeparata with with single herbs Glycyrrhiza uralensis Fisch.,Panax ginseng C.A.Meyer,Zingiber ojjicinale Rosc.and Rheum palmatum L.,aiming to provide references for further exploring the appropriate compatibility conditions of traditional Chinese medicine in the future and improving the safety of the clinical application of Radix Aconiti Lateralis Praeparata.展开更多
The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn...The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome.Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.展开更多
Since 1968 when the first successful hematopoietic stem cell transplantation(HSCT) was performed, transplant technique has developed rapidly for more than 50 years. In the past 20 years, the significant breakthroughs ...Since 1968 when the first successful hematopoietic stem cell transplantation(HSCT) was performed, transplant technique has developed rapidly for more than 50 years. In the past 20 years, the significant breakthroughs and widely use of haploidentical-related donor HSCT(e.g. Beijing Protocol) make everyone can have a donor(1), and the novel, reduced-toxicity transplant regimens help elderly patients receive HSCT safely(2).展开更多
Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergisti...Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergistic advantage.However,current research focuses more on the efficacy enhancing of drugs,while ignoring the toxicity reducing effects.Here,we established two drug synergy patterns based on the different situations of drugs and targets,in order to better illuminate the synergistic mechanism of drugs.展开更多
Objective: to analyze the clinical effect of goiter with exuberant heart-fire syndrome in reducing toxicity and increasing efficacy. Methods: a total of 60 newly diagnosed goiter patients who were admitted to our hosp...Objective: to analyze the clinical effect of goiter with exuberant heart-fire syndrome in reducing toxicity and increasing efficacy. Methods: a total of 60 newly diagnosed goiter patients who were admitted to our hospital in recent years were randomly divided into the control group and observation group A, observation group B, a total of three groups, 20 cases in each group. The therapeutic drug of the control group was methimazole. The observation groups A and B were mainly based on the control group combined with Xiehuo Xiaoying Decoction with the effects of 3 times /d and 1 time /d, respectively. The therapeutic effects and side effects of the experimental subjects in the three groups were compared. Results: the total effective rates of patients in observation group A and group B were higher than that in control group, and there was significant difference between groups (P < 0.05), but the difference between observation group A and group B was not significant (P > 0.05). The incidence rate of adverse reactions in the control group was higher than those in the observation groups A and B, and the incidence rate in the observation group A was higher than that in the observation group B. There was a statistical significance in the difference (P < 0.05). Conclusion: the observation protocol plays an important role in improving the clinical efficacy of patients with goiter of heart-liver fire hyperactivity syndrome and reducing toxic and side effects.展开更多
基金Guangxi Key Laboratory of Zhuang and Yao Medicines(GKJZ[2014]32)Guangxi"2011 Collaborative Innovation Center"-Collaborative Innovation Center for Zhuang and Yao Medicines(GJKY[2013]20)+2 种基金Guangxi First-class Discipline:Chinese Pharmacy(0501802815)National Natural Science Foundation of China(82060695)National Medicine Resources and Application Engineering Research Center of Guangxi Zhuang Autonomous Region(GFGGJH[2020]2605).
文摘Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart failure,rheumatic heart disease,coronary heart disease,hypotension,shock and other diseases.However,it also contains the main ingredients that produce toxic effects and are highly toxic to the cardiovascular system,nervous system,digestive system,reproductive system,embryos,and livers and kidneys.In this study,we analyzed the toxicity-reducing and efficacy-enhancing effects of the compatibility of Radix Aconiti Lateralis Praeparata with with single herbs Glycyrrhiza uralensis Fisch.,Panax ginseng C.A.Meyer,Zingiber ojjicinale Rosc.and Rheum palmatum L.,aiming to provide references for further exploring the appropriate compatibility conditions of traditional Chinese medicine in the future and improving the safety of the clinical application of Radix Aconiti Lateralis Praeparata.
基金financially supported by the National Natural Science Foundation of China(Nos.22161009 and 82060641)the Thousands of Young and Middle-aged Backbone Teachers Training Project of Guangxi Colleges and Universities(No.Gui-Jiao 2020-58)+2 种基金Guangxi University of Chinese Medicine"Qihuang Project"High-level Talent Team Cultivation Programme(No.202408)Gui Style Xinglin Top Talent Funding Project of Guangxi University of Chinese Medicine(Nos.2022C014 and 2022C005)the Innovation Project of Guangxi Graduate Education(No.YCSW2022342)。
文摘The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome.Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.
文摘Since 1968 when the first successful hematopoietic stem cell transplantation(HSCT) was performed, transplant technique has developed rapidly for more than 50 years. In the past 20 years, the significant breakthroughs and widely use of haploidentical-related donor HSCT(e.g. Beijing Protocol) make everyone can have a donor(1), and the novel, reduced-toxicity transplant regimens help elderly patients receive HSCT safely(2).
基金This work was supported by the National Natural Science Foundation of China(No.82003982,82274313,82204746).
文摘Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergistic advantage.However,current research focuses more on the efficacy enhancing of drugs,while ignoring the toxicity reducing effects.Here,we established two drug synergy patterns based on the different situations of drugs and targets,in order to better illuminate the synergistic mechanism of drugs.
文摘Objective: to analyze the clinical effect of goiter with exuberant heart-fire syndrome in reducing toxicity and increasing efficacy. Methods: a total of 60 newly diagnosed goiter patients who were admitted to our hospital in recent years were randomly divided into the control group and observation group A, observation group B, a total of three groups, 20 cases in each group. The therapeutic drug of the control group was methimazole. The observation groups A and B were mainly based on the control group combined with Xiehuo Xiaoying Decoction with the effects of 3 times /d and 1 time /d, respectively. The therapeutic effects and side effects of the experimental subjects in the three groups were compared. Results: the total effective rates of patients in observation group A and group B were higher than that in control group, and there was significant difference between groups (P < 0.05), but the difference between observation group A and group B was not significant (P > 0.05). The incidence rate of adverse reactions in the control group was higher than those in the observation groups A and B, and the incidence rate in the observation group A was higher than that in the observation group B. There was a statistical significance in the difference (P < 0.05). Conclusion: the observation protocol plays an important role in improving the clinical efficacy of patients with goiter of heart-liver fire hyperactivity syndrome and reducing toxic and side effects.
