A route to the total synthesis of koumine has been suggested.Five 4-substituted 1,2- dihydropyridine derivatives,which are supposed to be a conjugated diene of Diels-Alder reaction to produce the isoquinuclidine ring ...A route to the total synthesis of koumine has been suggested.Five 4-substituted 1,2- dihydropyridine derivatives,which are supposed to be a conjugated diene of Diels-Alder reaction to produce the isoquinuclidine ring of koumine,have been synthesized.Only two of them were found to be able to undergo the Diels-Alder reaction.The stereochemistry of the reaction product has also been examined.展开更多
文摘A route to the total synthesis of koumine has been suggested.Five 4-substituted 1,2- dihydropyridine derivatives,which are supposed to be a conjugated diene of Diels-Alder reaction to produce the isoquinuclidine ring of koumine,have been synthesized.Only two of them were found to be able to undergo the Diels-Alder reaction.The stereochemistry of the reaction product has also been examined.
