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A time-space network based international transportation scheduling problem incorporating CO_2 emission levels
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作者 Takashi IROHARA 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2010年第12期927-932,共6页
Environmental problems have received a great deal of attention in recent years.In particular,CO2 emissions worsen global warming and other environmental problems.The transport sector accounts for 20% of the total CO2 ... Environmental problems have received a great deal of attention in recent years.In particular,CO2 emissions worsen global warming and other environmental problems.The transport sector accounts for 20% of the total CO2 emissions.Therefore,the CO2 emission reduction of the transport sector is of great importance.In order to reduce emissions effectively,it is necessary to change the distribution and transportation processes.The purpose of this study is to minimize both the transportation costs and CO2 emissions during transportation.Our model considers a transportation scheduling problem in which loads are transported from an overseas production base to three domestic demand centers.The need for time-space networks arises naturally to improve the model.It is possible to know the distance carriers are moving,and also consider the timetables of carriers during transportation.Carrier choice,less-than carrier load,and domestic transportation among demand centers are considered as the three target areas to reduce CO2 emissions during the distribution process.The research model was formulated as a mixed integer programming (MIP) problem.It achieves cost reduction,and will contribute to improvement of the natural environment. 展开更多
关键词 time-space network TIMETABLE Transportation scheduling problem Mixed integer programming (MIP) problem Less-than carrier load
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A time-space network-based model for transportation service optimization of China Railway Express
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作者 Weichuan Yin Wenhu Hu +2 位作者 Xueting Yan Bo Peng Xiaoling Yang 《High-Speed Railway》 2024年第3期153-163,共11页
This paper describes the development and optimization plans for the China Railway Express(CR Express).As a new type of international land transport organization,CR Express has emerged with the continuous expansion of ... This paper describes the development and optimization plans for the China Railway Express(CR Express).As a new type of international land transport organization,CR Express has emerged with the continuous expansion of China toward European investment and trade,and in particular,has expanded with the continuous progress of the One Belt and One Road(OBOR)initiative.In addition to improving the service quality of CR Express,the operating costs must be reduced for developing“smart railways”that serve“smart cities”.We propose a dualobjective-based function mathematical optimization model;the satisfaction of the cargo owner is considered,and the timeliness,transportation capacity,and goods category constraints of CR Express transportation are designed.Moreover,we present the normalized equivalent method of the two-objective function of the model.Finally,a case study is conducted against the background of certain trains in the western corridor of CR Express to validate the effectiveness of the model and research methods proposed in this study. 展开更多
关键词 One Belt and One Road China Railway Express Transportation service Mathematical optimization time-space network
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Shrinking India:Visualizing time-space implication of introduction of semihigh-speed trains in India
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作者 Vimal Kumar Arulmozhi Shreyas P.Bharule 《High-Speed Railway》 2025年第2期93-104,共12页
Indian Railways have been the largest people moving transport infrastructure in India.Over the years the systems and trains have been upgraded resulting in both better passenger amenities and reduction in travel time.... Indian Railways have been the largest people moving transport infrastructure in India.Over the years the systems and trains have been upgraded resulting in both better passenger amenities and reduction in travel time.The newest addition is the Vande Bharat Express,a semi-high-speed train that was introduced in India in 2019.The train currently runs between 10 routes and has brought significant changes to India’s railway network.This article explores the introduction of Vande Bharat Express trains in India and its effects on the country’s interstation time-space shrinkage using cartographic techniques.The cartographic techniques like stepwise multidimensional scaling and interpolation using the distance cartogram plugin in QGIS are mainly used for generating the time-space maps for various speeds.The limitations of these techniques and the methods to overcome those limitations are also explored in this article. 展开更多
关键词 Vande Bharat trains Multidimensional scaling INTERPOLATION time-space Map distortion
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SPREADING SPEED FOR A TIME-SPACE PERIODIC EPIDEMIC MODEL IN DISCRETE MEDIA
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作者 Haiqin ZHAO 《Acta Mathematica Scientia》 2025年第3期1005-1018,共14页
This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward... This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward spreading speeds for the infective individuals, which can be used to estimate how fast the disease spreads. To overcome the difficulty arising from the lack of comparison principle for such time-space periodic nonmonotone systems, our proof is mainly based on constructing a series of scalar time-space periodic equations, establishing the spreading speeds for such auxiliary equations and using comparison methods. It may be the first work to study the spreading speed for time-space periodic non-monotone systems. 展开更多
关键词 spreading speed epidemic models time-space periodic habitats
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A traffic model of optical networks based on time-space complexity and traffic grooming
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作者 赵永利 《High Technology Letters》 EI CAS 2009年第2期198-202,共5页
This paper researched the traffic of optical networks in time-space complexity,proposed a novel traf-fic model for complex optical networks based on traffic grooming,designed a traffic generator GTS(gener-ator based o... This paper researched the traffic of optical networks in time-space complexity,proposed a novel traf-fic model for complex optical networks based on traffic grooming,designed a traffic generator GTS(gener-ator based on time and space)with 'centralized+distributed' idea,and then made a simulation in Clanguage.Experiments results show that GTS can produce the virtual network topology which can changedynamically with the characteristic of scaling-free network.GTS can also groom the different traffic andtrigger them under real-time or scheduling mechanisms,generating different optical connections.Thistraffic model is convenient for the simulation of optical networks considering the traffic complexity. 展开更多
关键词 optical networks traffic model time-space complexity scaling-free SELF-SIMILARITY traffic grooming
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Effective pure qP-wave equation and its numerical implementation in the time-space domain for 3D complicated anisotropic media
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作者 Shi-Gang Xu Xing-Guo Huang Li Han 《Petroleum Science》 2025年第4期1534-1547,共14页
Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic... Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic anisotropy(OA)are two typical categories of anisotropic media in exploration geophysics.In comparison of the elastic wave equations in both TI and OA media,pseudo-acoustic wave equations(PWEs)based on the acoustic assumption can markedly reduce computational cost and complexity.However,the presently available PWEs may experience SV-wave contamination and instability when anisotropic parameters cannot satisfy the approximated condition.Exploiting pure-mode wave equations can effectively resolve the above-mentioned issues and generate pure P-wave events without any artifacts.To further improve the computational accuracy and efficiency,we develop two novel pure qP-wave equations(PPEs)and illustrate the corresponding numerical solutions in the timespace domain for 3D tilted TI(TTI)and tilted OA(TOA)media.First,the rational polynomials are adopted to estimate the exact pure qP-wave dispersion relations,which contain complicated pseudo-differential operators with irrational forms.The polynomial coefficients are produced by applying a linear optimization algorithm to minimize the objective function difference between the expansion formula and the exact one.Then,the developed optimized PPEs are efficiently implemented using the finite-difference(FD)method in the time-space domain by introducing a scalar operator,which can help avoid the problem of spectral-based algorithms and other calculation burdens.Structures of the new equations are concise and corresponding implementation processes are straightforward.Phase velocity analyses indicate that our proposed optimized equations can lead to reliable approximation results.3D synthetic examples demonstrate that our proposed FD-based PPEs can produce accurate and stable P-wave responses,and effectively describe the wavefield features in complicated TTI and TOA media. 展开更多
关键词 Anisotropic media Wavefield extrapolation Pure qP-wave equation Optimization algorithm Finite-difference method time-space domain
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Joint Optimization of Routing and Resource Allocation in Decentralized UAV Networks Based on DDQN and GNN
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作者 Nawaf Q.H.Othman YANG Qinghai JIANG Xinpei 《电讯技术》 北大核心 2026年第1期1-10,共10页
Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combinin... Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks. 展开更多
关键词 decentralized UAV network resource allocation routing algorithm GNN DDQN DRL
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Exploring the material basis and mechanisms of the action of Hibiscus mutabilis L. for its anti-inflammatory effects based on network pharmacology and cell experiments
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作者 Wenyuan Chen Xiaolan Chen +2 位作者 Jing Wan Qin Deng Yong Gao 《日用化学工业(中英文)》 北大核心 2026年第1期55-64,共10页
To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review a... To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review and SwissADME platform.Genes related to the inflammation were collected using Genecards and OMIM databases,and the intersection genes were submitted on STRING and DAVID websites.Then,the protein interaction network(PPI),gene ontology(GO)and pathway(KEGG)were analyzed.Cytoscape 3.7.2 software was used to construct the“Hibiscus mutabilis L.-active ingredient-target-inflammation”network diagram,and AutoDockTools-1.5.6 software was used for the molecular docking verification.The antiinflammatory effect of Hibiscus mutabilis L.active ingredient was verified by the RAW264.7 inflammatory cell model.The results showed that 11 active components and 94 potential targets,1029 inflammatory targets and 24 intersection targets were obtained from Hibiscus mutabilis L..The key anti-inflammatory active ingredients of Hibiscus mutabilis L.are quercetin,apigenin and luteolin.Its action pathway is mainly related to NF-κB,cancer pathway and TNF signaling pathway.Cell experiments showed that total flavonoids of Hibiscus mutabilis L.could effectively inhibit the expression of tumor necrosis factor(TNF-α),interleukin 8(IL-8)and epidermal growth factor receptor(EGFR)in LPS-induced RAW 264.7 inflammatory cells.It also downregulates the phosphorylation of human nuclear factor ĸB inhibitory protein α(IĸBα)and NF-κB p65 subunit protein(p65).Overall,the anti-inflammatory effect of Hibiscus mutabilis L.is related to many active components,many signal pathways and targets,which provides a theoretical basis for its further development and application. 展开更多
关键词 Hibiscus mutabilis L. INFLAMMATION network pharmacology molecular docking cell validation
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HGS-ATD:A Hybrid Graph Convolutional Network-GraphSAGE Model for Anomaly Traffic Detection
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作者 Zhian Cui Hailong Li Xieyang Shen 《Journal of Harbin Institute of Technology(New Series)》 2026年第1期33-50,共18页
With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a ... With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a promising Deep Learning(DL)approach,has proven to be highly effective in identifying intricate patterns in graph⁃structured data and has already found wide applications in the field of network security.In this paper,we propose a hybrid Graph Convolutional Network(GCN)⁃GraphSAGE model for Anomaly Traffic Detection,namely HGS⁃ATD,which aims to improve the accuracy of anomaly traffic detection by leveraging edge feature learning to better capture the relationships between network entities.We validate the HGS⁃ATD model on four publicly available datasets,including NF⁃UNSW⁃NB15⁃v2.The experimental results show that the enhanced hybrid model is 5.71%to 10.25%higher than the baseline model in terms of accuracy,and the F1⁃score is 5.53%to 11.63%higher than the baseline model,proving that the model can effectively distinguish normal traffic from attack traffic and accurately classify various types of attacks. 展开更多
关键词 anomaly traffic detection graph neural network deep learning graph convolutional network
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Conditional Generative Adversarial Network-Based Travel Route Recommendation
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作者 Sunbin Shin Luong Vuong Nguyen +3 位作者 Grzegorz J.Nalepa Paulo Novais Xuan Hau Pham Jason J.Jung 《Computers, Materials & Continua》 2026年第1期1178-1217,共40页
Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of... Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of user preferences.To address this,we propose a Conditional Generative Adversarial Network(CGAN)that generates diverse and highly relevant itineraries.Our approach begins by constructing a conditional vector that encapsulates a user’s profile.This vector uniquely fuses embeddings from a Heterogeneous Information Network(HIN)to model complex user-place-route relationships,a Recurrent Neural Network(RNN)to capture sequential path dynamics,and Neural Collaborative Filtering(NCF)to incorporate collaborative signals from the wider user base.This comprehensive condition,further enhanced with features representing user interaction confidence and uncertainty,steers a CGAN stabilized by spectral normalization to generate high-fidelity latent route representations,effectively mitigating the data sparsity problem.Recommendations are then formulated using an Anchor-and-Expand algorithm,which selects relevant starting Points of Interest(POI)based on user history,then expands routes through latent similarity matching and geographic coherence optimization,culminating in Traveling Salesman Problem(TSP)-based route optimization for practical travel distances.Experiments on a real-world check-in dataset validate our model’s unique generative capability,achieving F1 scores ranging from 0.163 to 0.305,and near-zero pairs−F1 scores between 0.002 and 0.022.These results confirm the model’s success in generating novel travel routes by recommending new locations and sequences rather than replicating users’past itineraries.This work provides a robust solution for personalized travel planning,capable of generating novel and compelling routes for both new and existing users by learning from collective travel intelligence. 展开更多
关键词 Travel route recommendation conditional generative adversarial network heterogeneous information network anchor-and-expand algorithm
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Artificial Intelligence (AI)-Enabled Unmanned Aerial Vehicle (UAV) Systems for Optimizing User Connectivity in Sixth-Generation (6G) Ubiquitous Networks
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作者 Zeeshan Ali Haider Inam Ullah +2 位作者 Ahmad Abu Shareha Rashid Nasimov Sufyan Ali Memon 《Computers, Materials & Continua》 2026年第1期534-549,共16页
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener... The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment. 展开更多
关键词 6G networks UAV-based communication cooperative reinforcement learning network optimization user connectivity energy efficiency
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Analysis of DC Aging Characteristics of Stable ZnO Varistors Based on Voronoi Network and Finite Element Simulation Model
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作者 ZHANG Ping LU Mingtai +1 位作者 LU Tiantian YUE Yinghu 《材料导报》 北大核心 2026年第2期20-28,共9页
In modern ZnO varistors,traditional aging mechanisms based on increased power consumption are no longer relevant due to reduced power consumption during DC aging.Prolonged exposure to both AC and DC voltages results i... In modern ZnO varistors,traditional aging mechanisms based on increased power consumption are no longer relevant due to reduced power consumption during DC aging.Prolonged exposure to both AC and DC voltages results in increased leakage current,decreased breakdown voltage,and lower nonlinearity,ultimately compromising their protective performance.To investigate the evolution in electrical properties during DC aging,this work developed a finite element model based on Voronoi networks and conducted accelerated aging tests on commercial varistors.Throughout the aging process,current-voltage characteristics and Schottky barrier parameters were measured and analyzed.The results indicate that when subjected to constant voltage,current flows through regions with larger grain sizes,forming discharge channels.As aging progresses,the current focus increases on these channels,leading to a decline in the varistor’s overall performance.Furthermore,analysis of the Schottky barrier parameters shows that the changes in electrical performance during aging are non-monotonic.These findings offer theoretical support for understanding the aging mechanisms and condition assessment of modern stable ZnO varistors. 展开更多
关键词 ZnO varistors Voronoi network DC aging finite element method(FEM) current distribution double Schottky barrier theory
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Blockchain-Enabled Trusted Virtual Network Embedding in Intelligent Cyber-Physical Systems
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作者 Zhu Hailong Huang Tao +2 位作者 Zhang Yi Chen Ning Zhang Peiying 《China Communications》 2026年第1期175-188,共14页
With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Further... With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Furthermore,given the open environment and a multitude of devices,enhancing the security of ICPS is an urgent concern.To address these issues,this paper proposes a novel trusted virtual network embedding(T-VNE)approach for ICPS based combining blockchain and edge computing technologies.Additionally,the proposed algorithm leverages a deep reinforcement learning(DRL)model to optimize decision-making processes.It employs the policygradient-based agent to compute candidate embedding nodes and utilizes a breadth-first search(BFS)algorithm to determine the optimal embedding paths.Finally,through simulation experiments,the efficacy of the proposed method was validated,demonstrating outstanding performance in terms of security,revenue generation,and virtual network request(VNR)acceptance rate. 展开更多
关键词 blockchain cyber-physical system trusted embedding virtual network
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Artificial Neural Network Model for Thermal Conductivity Estimation of Metal Oxide Water-Based Nanofluids
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作者 Nikhil S.Mane Sheetal Kumar Dewangan +3 位作者 Sayantan Mukherjee Pradnyavati Mane Deepak Kumar Singh Ravindra Singh Saluja 《Computers, Materials & Continua》 2026年第1期316-331,共16页
The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a n... The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a necessary step before their practical application.As these investigations are time and resource-consuming undertakings,an effective prediction model can significantly improve the efficiency of research operations.In this work,an Artificial Neural Network(ANN)model is developed to predict the thermal conductivity of metal oxide water-based nanofluid.For this,a comprehensive set of 691 data points was collected from the literature.This dataset is split into training(70%),validation(15%),and testing(15%)and used to train the ANN model.The developed model is a backpropagation artificial neural network with a 4–12–1 architecture.The performance of the developed model shows high accuracy with R values above 0.90 and rapid convergence.It shows that the developed ANN model accurately predicts the thermal conductivity of nanofluids. 展开更多
关键词 Artificial neural networks nanofluids thermal conductivity PREDICTION
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Recurrent MAPPO for Joint UAV Trajectory and Traffic Offloading in Space-Air-Ground Integrated Networks
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作者 Zheyuan Jia Fenglin Jin +1 位作者 Jun Xie Yuan He 《Computers, Materials & Continua》 2026年第1期447-461,共15页
This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential g... This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential growth of mobile devices and data traffic has substantially increased network congestion,particularly in urban areas and regions with limited terrestrial infrastructure.Our approach jointly optimizes unmanned aerial vehicle(UAV)trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput,minimize energy consumption,and maintain equitable resource distribution.The proposed RMAPPO framework incorporates recurrent neural networks(RNNs)to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent reinforcement learning architecture to reduce communication overhead while improving system robustness.The proposed RMAPPO algorithm was evaluated through simulation experiments,with the results indicating that it significantly enhances the cumulative traffic offloading rate of nodes and reduces the energy consumption of UAVs. 展开更多
关键词 Space-air-ground integrated networks UAV traffic offloading reinforcement learning
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Research Progress and Network Pharmacological Analysis of Single Herb Improvement of Functional Dyspepsia by Jineijin Shanzha(Galli Gigerii Endothelium Corneum and Crataegi Fructus)Traditional Chinese Medicine Patch
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作者 Yingbing HE Tianbao ZHANG Quan SHI 《Medicinal Plant》 2026年第1期10-19,共10页
[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD... [Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9. 展开更多
关键词 Medicinal plant Functional dyspepsia Action mechanism network pharmacology
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Investigating the potential mechanisms of Wenqing Yin against atopic dermatitis based on network pharmacology,experimental pharmacology,and molecular docking
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作者 Yi Wang Zhen Liu +3 位作者 Si-Man Li Lin Lin Wei Dai Meng-Yue Ren 《Traditional Medicine Research》 2026年第2期1-11,共11页
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o... Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses. 展开更多
关键词 Wenqing Yin atopic dermatitis mouse model UPLC-Orbitrap-MS/MS network pharmacology
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Graph Attention Networks for Skin Lesion Classification with CNN-Driven Node Features
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作者 Ghadah Naif Alwakid Samabia Tehsin +3 位作者 Mamoona Humayun Asad Farooq Ibrahim Alrashdi Amjad Alsirhani 《Computers, Materials & Continua》 2026年第1期1964-1984,共21页
Skin diseases affect millions worldwide.Early detection is key to preventing disfigurement,lifelong disability,or death.Dermoscopic images acquired in primary-care settings show high intra-class visual similarity and ... Skin diseases affect millions worldwide.Early detection is key to preventing disfigurement,lifelong disability,or death.Dermoscopic images acquired in primary-care settings show high intra-class visual similarity and severe class imbalance,and occasional imaging artifacts can create ambiguity for state-of-the-art convolutional neural networks(CNNs).We frame skin lesion recognition as graph-based reasoning and,to ensure fair evaluation and avoid data leakage,adopt a strict lesion-level partitioning strategy.Each image is first over-segmented using SLIC(Simple Linear Iterative Clustering)to produce perceptually homogeneous superpixels.These superpixels form the nodes of a region-adjacency graph whose edges encode spatial continuity.Node attributes are 1280-dimensional embeddings extracted with a lightweight yet expressive EfficientNet-B0 backbone,providing strong representational power at modest computational cost.The resulting graphs are processed by a five-layer Graph Attention Network(GAT)that learns to weight inter-node relationships dynamically and aggregates multi-hop context before classifying lesions into seven classes with a log-softmax output.Extensive experiments on the DermaMNIST benchmark show the proposed pipeline achieves 88.35%accuracy and 98.04%AUC,outperforming contemporary CNNs,AutoML approaches,and alternative graph neural networks.An ablation study indicates EfficientNet-B0 produces superior node descriptors compared with ResNet-18 and DenseNet,and that roughly five GAT layers strike a good balance between being too shallow and over-deep while avoiding oversmoothing.The method requires no data augmentation or external metadata,making it a drop-in upgrade for clinical computer-aided diagnosis systems. 展开更多
关键词 Graph neural network image classification DermaMNIST dataset graph representation
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5G Advanced Network Supporting LEO Satellite with User Plane Function
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作者 Wang Hucheng Liu Liang +3 位作者 Chen Shanzhi Ji Junwei Xu Hui 《China Communications》 2026年第1期140-153,共14页
As investigated by 3GPP,support of UPF(user plane function)onboard satellite can reduce the latency of communications via satellite,and then it becomes a key enhancement in 5G network integrating with satellite commun... As investigated by 3GPP,support of UPF(user plane function)onboard satellite can reduce the latency of communications via satellite,and then it becomes a key enhancement in 5G network integrating with satellite communication.However,current 5G system cannot support UPF onboard LEO(low earth orbit)satellites,as it would face challenges like UPF mobility handling,synchronization between mobile network and satellite network,and condition of activating local data switching.To solve such challenges,this paper proposes a solution to support UPF onboard LEO satellite,which consists of enhanced network architecture,I-UPF(intermediate UPF)based local data switching scheme and communication latency based data path selection.We subsequently develop analytic models for performance evaluation and conduct simulations using the constellation configuration of iridium II.The simulation results show that the data switching via I-UPF onboard LEO satellite can reduce E2E(end to end)packet delivery latency and E2E packet loss ratio significantly compared with that of routing the data back to 5GC on the ground.The proposed scheme yet has increased signaling cost for handling UPF mobility.els,compared with existing similar companding algorithms. 展开更多
关键词 data switching 5G network LEO satellite UPF mobility
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A Dual-Attention CNN-BiLSTM Model for Network Intrusion Detection
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作者 Zheng Zhang Jie Hao +2 位作者 Liquan Chen Tianhao Hou Yanan Liu 《Computers, Materials & Continua》 2026年第1期1119-1140,共22页
With the increasing severity of network security threats,Network Intrusion Detection(NID)has become a key technology to ensure network security.To address the problem of low detection rate of traditional intrusion det... With the increasing severity of network security threats,Network Intrusion Detection(NID)has become a key technology to ensure network security.To address the problem of low detection rate of traditional intrusion detection models,this paper proposes a Dual-Attention model for NID,which combines Convolutional Neural Network(CNN)and Bidirectional Long Short-Term Memory(BiLSTM)to design two modules:the FocusConV and the TempoNet module.The FocusConV module,which automatically adjusts and weights CNN extracted local features,focuses on local features that are more important for intrusion detection.The TempoNet module focuses on global information,identifies more important features in time steps or sequences,and filters and weights the information globally to further improve the accuracy and robustness of NID.Meanwhile,in order to solve the class imbalance problem in the dataset,the EQL v2 method is used to compute the class weights of each class and to use them in the loss computation,which optimizes the performance of the model on the class imbalance problem.Extensive experiments were conducted on the NSL-KDD,UNSW-NB15,and CIC-DDos2019 datasets,achieving average accuracy rates of 99.66%,87.47%,and 99.39%,respectively,demonstrating excellent detection accuracy and robustness.The model also improves the detection performance of minority classes in the datasets.On the UNSW-NB15 dataset,the detection rates for Analysis,Exploits,and Shellcode attacks increased by 7%,7%,and 10%,respectively,demonstrating the Dual-Attention CNN-BiLSTM model’s excellent performance in NID. 展开更多
关键词 network intrusion detection class imbalance problem deep learning
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