Environmental problems have received a great deal of attention in recent years.In particular,CO2 emissions worsen global warming and other environmental problems.The transport sector accounts for 20% of the total CO2 ...Environmental problems have received a great deal of attention in recent years.In particular,CO2 emissions worsen global warming and other environmental problems.The transport sector accounts for 20% of the total CO2 emissions.Therefore,the CO2 emission reduction of the transport sector is of great importance.In order to reduce emissions effectively,it is necessary to change the distribution and transportation processes.The purpose of this study is to minimize both the transportation costs and CO2 emissions during transportation.Our model considers a transportation scheduling problem in which loads are transported from an overseas production base to three domestic demand centers.The need for time-space networks arises naturally to improve the model.It is possible to know the distance carriers are moving,and also consider the timetables of carriers during transportation.Carrier choice,less-than carrier load,and domestic transportation among demand centers are considered as the three target areas to reduce CO2 emissions during the distribution process.The research model was formulated as a mixed integer programming (MIP) problem.It achieves cost reduction,and will contribute to improvement of the natural environment.展开更多
This paper describes the development and optimization plans for the China Railway Express(CR Express).As a new type of international land transport organization,CR Express has emerged with the continuous expansion of ...This paper describes the development and optimization plans for the China Railway Express(CR Express).As a new type of international land transport organization,CR Express has emerged with the continuous expansion of China toward European investment and trade,and in particular,has expanded with the continuous progress of the One Belt and One Road(OBOR)initiative.In addition to improving the service quality of CR Express,the operating costs must be reduced for developing“smart railways”that serve“smart cities”.We propose a dualobjective-based function mathematical optimization model;the satisfaction of the cargo owner is considered,and the timeliness,transportation capacity,and goods category constraints of CR Express transportation are designed.Moreover,we present the normalized equivalent method of the two-objective function of the model.Finally,a case study is conducted against the background of certain trains in the western corridor of CR Express to validate the effectiveness of the model and research methods proposed in this study.展开更多
Indian Railways have been the largest people moving transport infrastructure in India.Over the years the systems and trains have been upgraded resulting in both better passenger amenities and reduction in travel time....Indian Railways have been the largest people moving transport infrastructure in India.Over the years the systems and trains have been upgraded resulting in both better passenger amenities and reduction in travel time.The newest addition is the Vande Bharat Express,a semi-high-speed train that was introduced in India in 2019.The train currently runs between 10 routes and has brought significant changes to India’s railway network.This article explores the introduction of Vande Bharat Express trains in India and its effects on the country’s interstation time-space shrinkage using cartographic techniques.The cartographic techniques like stepwise multidimensional scaling and interpolation using the distance cartogram plugin in QGIS are mainly used for generating the time-space maps for various speeds.The limitations of these techniques and the methods to overcome those limitations are also explored in this article.展开更多
This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward...This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward spreading speeds for the infective individuals, which can be used to estimate how fast the disease spreads. To overcome the difficulty arising from the lack of comparison principle for such time-space periodic nonmonotone systems, our proof is mainly based on constructing a series of scalar time-space periodic equations, establishing the spreading speeds for such auxiliary equations and using comparison methods. It may be the first work to study the spreading speed for time-space periodic non-monotone systems.展开更多
This paper researched the traffic of optical networks in time-space complexity,proposed a novel traf-fic model for complex optical networks based on traffic grooming,designed a traffic generator GTS(gener-ator based o...This paper researched the traffic of optical networks in time-space complexity,proposed a novel traf-fic model for complex optical networks based on traffic grooming,designed a traffic generator GTS(gener-ator based on time and space)with 'centralized+distributed' idea,and then made a simulation in Clanguage.Experiments results show that GTS can produce the virtual network topology which can changedynamically with the characteristic of scaling-free network.GTS can also groom the different traffic andtrigger them under real-time or scheduling mechanisms,generating different optical connections.Thistraffic model is convenient for the simulation of optical networks considering the traffic complexity.展开更多
Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic...Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic anisotropy(OA)are two typical categories of anisotropic media in exploration geophysics.In comparison of the elastic wave equations in both TI and OA media,pseudo-acoustic wave equations(PWEs)based on the acoustic assumption can markedly reduce computational cost and complexity.However,the presently available PWEs may experience SV-wave contamination and instability when anisotropic parameters cannot satisfy the approximated condition.Exploiting pure-mode wave equations can effectively resolve the above-mentioned issues and generate pure P-wave events without any artifacts.To further improve the computational accuracy and efficiency,we develop two novel pure qP-wave equations(PPEs)and illustrate the corresponding numerical solutions in the timespace domain for 3D tilted TI(TTI)and tilted OA(TOA)media.First,the rational polynomials are adopted to estimate the exact pure qP-wave dispersion relations,which contain complicated pseudo-differential operators with irrational forms.The polynomial coefficients are produced by applying a linear optimization algorithm to minimize the objective function difference between the expansion formula and the exact one.Then,the developed optimized PPEs are efficiently implemented using the finite-difference(FD)method in the time-space domain by introducing a scalar operator,which can help avoid the problem of spectral-based algorithms and other calculation burdens.Structures of the new equations are concise and corresponding implementation processes are straightforward.Phase velocity analyses indicate that our proposed optimized equations can lead to reliable approximation results.3D synthetic examples demonstrate that our proposed FD-based PPEs can produce accurate and stable P-wave responses,and effectively describe the wavefield features in complicated TTI and TOA media.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
The transformation between time and space is discussed. To improve real-time response speed of intelligent measuring system, the concept of exchanging program execution time with more circuitry is presented working in...The transformation between time and space is discussed. To improve real-time response speed of intelligent measuring system, the concept of exchanging program execution time with more circuitry is presented working in cycle mode. Displacement measuring by magnification is achieved with period measurement by magnification. To change the condition that traditional precision measurement depends on machining precision greatly, the concept of measuring space with time and theory of time-space coordinate transformation are proposed. Guided by the idea of measuring space with time, differential frequency measurement system and time grating displacement sensor are developed based on the proposed novel methods. And high-precision measurement is achieved without high-precision manufacture, which embeds the remarkable characteristics of low cost but high precision to the devices. Experiment and test results conform the validity of the proposed time-space concept.展开更多
Collocated multiple input multiple output(MIMO)radar,which has agile multi-beam working mode,can offer enhanced multiple targets tracking(MTT)ability.In detail,it can illuminate different targets simultaneously with m...Collocated multiple input multiple output(MIMO)radar,which has agile multi-beam working mode,can offer enhanced multiple targets tracking(MTT)ability.In detail,it can illuminate different targets simultaneously with multi-beam or one wide beam among multi-beam,providing greater degree of freedom in system resource control.An adaptive time-space resource and waveform control optimization model for the collocated MIMO radar with simultaneous multi-beam is proposed in this paper.The aim of the proposed scheme is to improve the overall tracking accuracy and meanwhile minimize the resource consumption under the guarantee of effective targets detection.A resource and waveform control algorithm which integrates the genetic algorithm(GA)is proposed to solve the optimization problem.The optimal transmitting waveform parameters,system sampling period,sub-array number,binary radar tracking parameterχ_i(t_k),transmitting energy and multi-beam direction vector combination are chosen adaptively,where the first one realizes the waveform control and the latter five realize the timespace resource allocation.Simulation results demonstrate the effectiveness of the proposed control method.展开更多
Compared with the traditional phased array radar, the co-located multiple-input multiple-output(MIMO) radar is able to transmit orthogonal waveforms to form different illuminating modes, providing a larger freedom deg...Compared with the traditional phased array radar, the co-located multiple-input multiple-output(MIMO) radar is able to transmit orthogonal waveforms to form different illuminating modes, providing a larger freedom degree in radar resource management. In order to implement the effective resource management for the co-located MIMO radar in multi-target tracking,this paper proposes a resource management optimization model,where the system resource consumption and the tracking accuracy requirements are considered comprehensively. An adaptive resource management algorithm for the co-located MIMO radar is obtained based on the proposed model, where the sub-array number, sampling period, transmitting energy, beam direction and working mode are adaptively controlled to realize the time-space resource joint allocation. Simulation results demonstrate the superiority of the proposed algorithm. Furthermore, the co-located MIMO radar using the proposed algorithm can satisfy the predetermined tracking accuracy requirements with less comprehensive cost compared with the phased array radar.展开更多
Recently,Non-Terrestrial Satellite Networks(NTSTs)have gained more and more attentions due to global coverage,low latency,and high-speed communications.The routing scheme is one of the primary challenges for NTSNs,due...Recently,Non-Terrestrial Satellite Networks(NTSTs)have gained more and more attentions due to global coverage,low latency,and high-speed communications.The routing scheme is one of the primary challenges for NTSNs,due to the mega scale of an NTSN constellation and the dynamic topology feature.To solve many pressing problems,a Compass time-space Model-based Virtual IP(CMVIP)routing scheme is proposed in this paper.In order to compensate for discontinuities in existing topology models,a compass-shaped time-space model is proposed.It can be adapted with Inter-Satellite-Link(ISL)and Ground-Satellite-Link(GSL)transmissions.A distributed algorithm with multiple optimization objectives and multiple constraints is applied for routing path discovery.To more realistically verify the specific scheme,a traffic model that supports two different services is proposed.Access and bearer services are the two main applications of an NTSN.Experimental results demonstrate that the proposed scheme achieves superior Qualityof-Service(QoS)performance.In addition,comparison results demonstrate that the CMVIP routing scheme is superior to the Virtual-Topology-based Shortest Path(VT-SP)routing algorithm.展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
We present one family of general analytical solutions for the generalized nonlinear Schr?dinger equation with time-space modulation via the method of a combination of the Darboux transformation and similarity transfor...We present one family of general analytical solutions for the generalized nonlinear Schr?dinger equation with time-space modulation via the method of a combination of the Darboux transformation and similarity transformation. Nonlinear waves on different localized and periodic backgrounds depending on the corresponding nonlinearity modulations are obtained. In particular, we demonstrate the existence and property of localized modes on a doubleperiodic background under a special designed optical lattice potential. Our results may raise the possibility of related experiments and potential applications in nonlinear optics and Bose–Einstein condensates.展开更多
In this paper we discuss a parallel sorting algorithm on a hypercube. Its time complexity is O(n logn/p) +O(n). Here, P is the number of processors available and n, the amount of items to be sorted. Take the problem o...In this paper we discuss a parallel sorting algorithm on a hypercube. Its time complexity is O(n logn/p) +O(n). Here, P is the number of processors available and n, the amount of items to be sorted. Take the problem of time-space optimization into consideration, when P≤ O(log n), this algorithm is both timespace optimal and cost optimization. But this means only speedup is O(P) and it is not linear speedup. Therefore, we further discuss relevant parallel efficiency problems.展开更多
Following the fractional cable equation established in the letter [B.I. Henry, T.A.M. Langlands, and S.L.Wearne, Phys. Rev. Lett. 100(2008) 128103], we present the time-space fractional cable equation which describes ...Following the fractional cable equation established in the letter [B.I. Henry, T.A.M. Langlands, and S.L.Wearne, Phys. Rev. Lett. 100(2008) 128103], we present the time-space fractional cable equation which describes the anomalous transport of electrodiffusion in nerve cells. The derivation is based on the generalized fractional Ohm's law;and the temporal memory effects and spatial-nonlocality are involved in the time-space fractional model. With the help of integral transform method we derive the analytical solutions expressed by the Green's function; the corresponding fractional moments are calculated; and their asymptotic behaviors are discussed. In addition, the explicit solutions of the considered model with two different external current injections are also presented.展开更多
Artificially ground freezing (AGF) is one of the main methods to establish temporary support for shaft sinking in unstable water bearing strata. Domde (1915) formula based on frozen soil strength has widely been used ...Artificially ground freezing (AGF) is one of the main methods to establish temporary support for shaft sinking in unstable water bearing strata. Domde (1915) formula based on frozen soil strength has widely been used for designing freezing wall thickness. However, it can not ensure the stability of freezing wall, nor guarantee the safety of shaft construction as frozen depth increases in unstable water bearing strata. F A. Auld (1985, 1988)[1,2] presented a design method of freezing wall, which is on the basis of strength and stability, together with deformation of freezing wall. This paper, according to the practice in China, describes a "time -space" related design method for deep freezing wall. The method is based on "time-space" concept, which includes influence of excavation rate of advance, unsupported length of freezing wall and the sump state on inward deformation of freezing wall, and the allowable pipe deformation caused by inward deformation of freezing wall. Finally, successful application of this method to the large scale coal mine-Jining No. 2 Mine[3] in Shandong Province of China is presented. It saved much investment compared with F. A. Auld’s design for the same mine.展开更多
文摘Environmental problems have received a great deal of attention in recent years.In particular,CO2 emissions worsen global warming and other environmental problems.The transport sector accounts for 20% of the total CO2 emissions.Therefore,the CO2 emission reduction of the transport sector is of great importance.In order to reduce emissions effectively,it is necessary to change the distribution and transportation processes.The purpose of this study is to minimize both the transportation costs and CO2 emissions during transportation.Our model considers a transportation scheduling problem in which loads are transported from an overseas production base to three domestic demand centers.The need for time-space networks arises naturally to improve the model.It is possible to know the distance carriers are moving,and also consider the timetables of carriers during transportation.Carrier choice,less-than carrier load,and domestic transportation among demand centers are considered as the three target areas to reduce CO2 emissions during the distribution process.The research model was formulated as a mixed integer programming (MIP) problem.It achieves cost reduction,and will contribute to improvement of the natural environment.
基金supported by the National Natural Science Foundation of China(Grant No.62102032)the R&D Program of Beijing Municipal Education Commission(Grant No.KM202211417010).
文摘This paper describes the development and optimization plans for the China Railway Express(CR Express).As a new type of international land transport organization,CR Express has emerged with the continuous expansion of China toward European investment and trade,and in particular,has expanded with the continuous progress of the One Belt and One Road(OBOR)initiative.In addition to improving the service quality of CR Express,the operating costs must be reduced for developing“smart railways”that serve“smart cities”.We propose a dualobjective-based function mathematical optimization model;the satisfaction of the cargo owner is considered,and the timeliness,transportation capacity,and goods category constraints of CR Express transportation are designed.Moreover,we present the normalized equivalent method of the two-objective function of the model.Finally,a case study is conducted against the background of certain trains in the western corridor of CR Express to validate the effectiveness of the model and research methods proposed in this study.
文摘Indian Railways have been the largest people moving transport infrastructure in India.Over the years the systems and trains have been upgraded resulting in both better passenger amenities and reduction in travel time.The newest addition is the Vande Bharat Express,a semi-high-speed train that was introduced in India in 2019.The train currently runs between 10 routes and has brought significant changes to India’s railway network.This article explores the introduction of Vande Bharat Express trains in India and its effects on the country’s interstation time-space shrinkage using cartographic techniques.The cartographic techniques like stepwise multidimensional scaling and interpolation using the distance cartogram plugin in QGIS are mainly used for generating the time-space maps for various speeds.The limitations of these techniques and the methods to overcome those limitations are also explored in this article.
基金supported by the Natural Science Basic Research Program of Shanxi(Grant No.2024JC-YBMS-025)the Innovation Capability Support Program of Shanxi(Grant No.2024RS-CXTD-88)。
文摘This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward spreading speeds for the infective individuals, which can be used to estimate how fast the disease spreads. To overcome the difficulty arising from the lack of comparison principle for such time-space periodic nonmonotone systems, our proof is mainly based on constructing a series of scalar time-space periodic equations, establishing the spreading speeds for such auxiliary equations and using comparison methods. It may be the first work to study the spreading speed for time-space periodic non-monotone systems.
基金Supported by the High Technology Research and Development Programme of China (No. 2008AA01A328)the National Natural Science Foundation of China (No. 60772022)+2 种基金the Program for New Century Excellent Talents in University (No. NCET-05-0112)the Program for Changjiang Scholars and Innovative Research Team in University of MOE, China (No. IRT0609)111 Project (No. B07005)
文摘This paper researched the traffic of optical networks in time-space complexity,proposed a novel traf-fic model for complex optical networks based on traffic grooming,designed a traffic generator GTS(gener-ator based on time and space)with 'centralized+distributed' idea,and then made a simulation in Clanguage.Experiments results show that GTS can produce the virtual network topology which can changedynamically with the characteristic of scaling-free network.GTS can also groom the different traffic andtrigger them under real-time or scheduling mechanisms,generating different optical connections.Thistraffic model is convenient for the simulation of optical networks considering the traffic complexity.
基金supported by the National Key R&D Program of China(2021YFA0716902)National Natural Science Foundation of China(NSFC)under contract number 42374149 and 42004119National Science and Technology Major Project(2024ZD1002907)。
文摘Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic anisotropy(OA)are two typical categories of anisotropic media in exploration geophysics.In comparison of the elastic wave equations in both TI and OA media,pseudo-acoustic wave equations(PWEs)based on the acoustic assumption can markedly reduce computational cost and complexity.However,the presently available PWEs may experience SV-wave contamination and instability when anisotropic parameters cannot satisfy the approximated condition.Exploiting pure-mode wave equations can effectively resolve the above-mentioned issues and generate pure P-wave events without any artifacts.To further improve the computational accuracy and efficiency,we develop two novel pure qP-wave equations(PPEs)and illustrate the corresponding numerical solutions in the timespace domain for 3D tilted TI(TTI)and tilted OA(TOA)media.First,the rational polynomials are adopted to estimate the exact pure qP-wave dispersion relations,which contain complicated pseudo-differential operators with irrational forms.The polynomial coefficients are produced by applying a linear optimization algorithm to minimize the objective function difference between the expansion formula and the exact one.Then,the developed optimized PPEs are efficiently implemented using the finite-difference(FD)method in the time-space domain by introducing a scalar operator,which can help avoid the problem of spectral-based algorithms and other calculation burdens.Structures of the new equations are concise and corresponding implementation processes are straightforward.Phase velocity analyses indicate that our proposed optimized equations can lead to reliable approximation results.3D synthetic examples demonstrate that our proposed FD-based PPEs can produce accurate and stable P-wave responses,and effectively describe the wavefield features in complicated TTI and TOA media.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金National Natural Science Foundation of China(No.59575095,No.59675089,No.50075091,No.50575235)
文摘The transformation between time and space is discussed. To improve real-time response speed of intelligent measuring system, the concept of exchanging program execution time with more circuitry is presented working in cycle mode. Displacement measuring by magnification is achieved with period measurement by magnification. To change the condition that traditional precision measurement depends on machining precision greatly, the concept of measuring space with time and theory of time-space coordinate transformation are proposed. Guided by the idea of measuring space with time, differential frequency measurement system and time grating displacement sensor are developed based on the proposed novel methods. And high-precision measurement is achieved without high-precision manufacture, which embeds the remarkable characteristics of low cost but high precision to the devices. Experiment and test results conform the validity of the proposed time-space concept.
基金supported by the National Natural Science Foundation of China(61671137)。
文摘Collocated multiple input multiple output(MIMO)radar,which has agile multi-beam working mode,can offer enhanced multiple targets tracking(MTT)ability.In detail,it can illuminate different targets simultaneously with multi-beam or one wide beam among multi-beam,providing greater degree of freedom in system resource control.An adaptive time-space resource and waveform control optimization model for the collocated MIMO radar with simultaneous multi-beam is proposed in this paper.The aim of the proposed scheme is to improve the overall tracking accuracy and meanwhile minimize the resource consumption under the guarantee of effective targets detection.A resource and waveform control algorithm which integrates the genetic algorithm(GA)is proposed to solve the optimization problem.The optimal transmitting waveform parameters,system sampling period,sub-array number,binary radar tracking parameterχ_i(t_k),transmitting energy and multi-beam direction vector combination are chosen adaptively,where the first one realizes the waveform control and the latter five realize the timespace resource allocation.Simulation results demonstrate the effectiveness of the proposed control method.
基金supported by the National Natural Science Fundation of China (61671137)。
文摘Compared with the traditional phased array radar, the co-located multiple-input multiple-output(MIMO) radar is able to transmit orthogonal waveforms to form different illuminating modes, providing a larger freedom degree in radar resource management. In order to implement the effective resource management for the co-located MIMO radar in multi-target tracking,this paper proposes a resource management optimization model,where the system resource consumption and the tracking accuracy requirements are considered comprehensively. An adaptive resource management algorithm for the co-located MIMO radar is obtained based on the proposed model, where the sub-array number, sampling period, transmitting energy, beam direction and working mode are adaptively controlled to realize the time-space resource joint allocation. Simulation results demonstrate the superiority of the proposed algorithm. Furthermore, the co-located MIMO radar using the proposed algorithm can satisfy the predetermined tracking accuracy requirements with less comprehensive cost compared with the phased array radar.
基金This research was funded by the China State Key Laboratory of Robotics(No.19Z1240010018)the office of the Military and Civilian Integration Development Committee of Shanghai,China(No.2019-jmrh1-kj3).
文摘Recently,Non-Terrestrial Satellite Networks(NTSTs)have gained more and more attentions due to global coverage,low latency,and high-speed communications.The routing scheme is one of the primary challenges for NTSNs,due to the mega scale of an NTSN constellation and the dynamic topology feature.To solve many pressing problems,a Compass time-space Model-based Virtual IP(CMVIP)routing scheme is proposed in this paper.In order to compensate for discontinuities in existing topology models,a compass-shaped time-space model is proposed.It can be adapted with Inter-Satellite-Link(ISL)and Ground-Satellite-Link(GSL)transmissions.A distributed algorithm with multiple optimization objectives and multiple constraints is applied for routing path discovery.To more realistically verify the specific scheme,a traffic model that supports two different services is proposed.Access and bearer services are the two main applications of an NTSN.Experimental results demonstrate that the proposed scheme achieves superior Qualityof-Service(QoS)performance.In addition,comparison results demonstrate that the CMVIP routing scheme is superior to the Virtual-Topology-based Shortest Path(VT-SP)routing algorithm.
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11475135 and 11547302
文摘We present one family of general analytical solutions for the generalized nonlinear Schr?dinger equation with time-space modulation via the method of a combination of the Darboux transformation and similarity transformation. Nonlinear waves on different localized and periodic backgrounds depending on the corresponding nonlinearity modulations are obtained. In particular, we demonstrate the existence and property of localized modes on a doubleperiodic background under a special designed optical lattice potential. Our results may raise the possibility of related experiments and potential applications in nonlinear optics and Bose–Einstein condensates.
文摘In this paper we discuss a parallel sorting algorithm on a hypercube. Its time complexity is O(n logn/p) +O(n). Here, P is the number of processors available and n, the amount of items to be sorted. Take the problem of time-space optimization into consideration, when P≤ O(log n), this algorithm is both timespace optimal and cost optimization. But this means only speedup is O(P) and it is not linear speedup. Therefore, we further discuss relevant parallel efficiency problems.
基金Supported by the Program for New Century Excellent Talents in University under Grant No.NCET-09-0438the National Natural Science Foundation of China under Grant No.11271173+2 种基金the training Program of the Major Research Plan of the National Natural Science Foundation of China under Grant No.91120014the Starting Research Foundation from the Xi’an University of Technology under GrantNo.108-211206the Scientific Research Foundation of the Education Department of Shaanxi Province under Grant No.2013JK0581
文摘Following the fractional cable equation established in the letter [B.I. Henry, T.A.M. Langlands, and S.L.Wearne, Phys. Rev. Lett. 100(2008) 128103], we present the time-space fractional cable equation which describes the anomalous transport of electrodiffusion in nerve cells. The derivation is based on the generalized fractional Ohm's law;and the temporal memory effects and spatial-nonlocality are involved in the time-space fractional model. With the help of integral transform method we derive the analytical solutions expressed by the Green's function; the corresponding fractional moments are calculated; and their asymptotic behaviors are discussed. In addition, the explicit solutions of the considered model with two different external current injections are also presented.
文摘Artificially ground freezing (AGF) is one of the main methods to establish temporary support for shaft sinking in unstable water bearing strata. Domde (1915) formula based on frozen soil strength has widely been used for designing freezing wall thickness. However, it can not ensure the stability of freezing wall, nor guarantee the safety of shaft construction as frozen depth increases in unstable water bearing strata. F A. Auld (1985, 1988)[1,2] presented a design method of freezing wall, which is on the basis of strength and stability, together with deformation of freezing wall. This paper, according to the practice in China, describes a "time -space" related design method for deep freezing wall. The method is based on "time-space" concept, which includes influence of excavation rate of advance, unsupported length of freezing wall and the sump state on inward deformation of freezing wall, and the allowable pipe deformation caused by inward deformation of freezing wall. Finally, successful application of this method to the large scale coal mine-Jining No. 2 Mine[3] in Shandong Province of China is presented. It saved much investment compared with F. A. Auld’s design for the same mine.
