Metal-organic frameworks(MOFs)attract broad interests in mercury(Hg)ion adsorption field,while unreasonable distribution of active groups commonly restricts their utilization efficiency.In this work,we constructed a n...Metal-organic frameworks(MOFs)attract broad interests in mercury(Hg)ion adsorption field,while unreasonable distribution of active groups commonly restricts their utilization efficiency.In this work,we constructed a new MOF(TYUST-6)with dense thiol-rich traps in the 1D pore wall.This accessible channel and rational distribution of thiols allow the smooth diffusion of Hg ions and thereby result in a high Langmuir adsorption capacity of 1347.6 mg/g,almost reaching the theoretical maximum(1444.3 mg/g).Adsorption equilibrium needs 10 and 30 min at the initial concentrations of 10 and 100 mg/L,respectively.Common co-existing ions and solution pH show almost negligible interferences on the adsorption,and adsorbent regeneration can be well achieved.Combining experimental characterizations and theoretical calculations,the thiol groups in the pore wall are proved to be the dominant interaction sites.Thus,this work reports a novel high-capacity adsorbent for Hg^(2+),and proposes a feasible guideline for designing effective adsorbents.展开更多
Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this...Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this study, we evaluate the relationship between genetic, demographic, social, environmental, and health factors and redox imbalance biomarkers in a group of children and adolescents environmentally exposed to atmospheric pollutants and mercury in the Brazilian Western Amazon. This is a cross-sectional study of the relationship between demographic, genetic, and socioenvironmental factors and serum concentrations of redox imbalance biomarkers (thiol groups, malondialdehyde, and glutathione S-transferase [GST]) in children and adolescents living in the municipality of Porto Velho, Rond?nia. The investigated factors were hierarchically organized into groups of variables and their relationship with redox imbalance biomarkers was estimated by a multiple linear regression model. Children and adolescents with asthma, with C-reactive protein values, with the polymorphic variant GSTP1, and exposed to indoor air pollution presented lower thiol serum concentrations when compared to those categorized in their respective reference groups. GST activity and malondialdehyde serum concentrations were positively related to weekly fish consumption and exposure to PM2.5. This study showed that enzymatic GST activity and malondialdehyde serum concentrations are positively associated with environmental factors, especially air pollution (β = 8.64 U/L for GST and β = 0.244 μmol/L for MDA in high exposure group;p-value < 0.01);while serum thiol concentrations presented an inversely proportional relationship with markers of general health status, such asthma (median: 0.45 mmol/L vs. 0.48 mmol/L;p-value < 0.05), acute inflammation (β = -0.25 mmol/L;p-value < 0.01), and positively with genetic factor (β = 0.12 mmol/L for Val/Val;p-value < 0.05).展开更多
基金supported by the National Natural Science Foundation of China(No.22208230)Fundamental Research Program of Shanxi Province(No.202103021223281)。
文摘Metal-organic frameworks(MOFs)attract broad interests in mercury(Hg)ion adsorption field,while unreasonable distribution of active groups commonly restricts their utilization efficiency.In this work,we constructed a new MOF(TYUST-6)with dense thiol-rich traps in the 1D pore wall.This accessible channel and rational distribution of thiols allow the smooth diffusion of Hg ions and thereby result in a high Langmuir adsorption capacity of 1347.6 mg/g,almost reaching the theoretical maximum(1444.3 mg/g).Adsorption equilibrium needs 10 and 30 min at the initial concentrations of 10 and 100 mg/L,respectively.Common co-existing ions and solution pH show almost negligible interferences on the adsorption,and adsorbent regeneration can be well achieved.Combining experimental characterizations and theoretical calculations,the thiol groups in the pore wall are proved to be the dominant interaction sites.Thus,this work reports a novel high-capacity adsorbent for Hg^(2+),and proposes a feasible guideline for designing effective adsorbents.
文摘Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this study, we evaluate the relationship between genetic, demographic, social, environmental, and health factors and redox imbalance biomarkers in a group of children and adolescents environmentally exposed to atmospheric pollutants and mercury in the Brazilian Western Amazon. This is a cross-sectional study of the relationship between demographic, genetic, and socioenvironmental factors and serum concentrations of redox imbalance biomarkers (thiol groups, malondialdehyde, and glutathione S-transferase [GST]) in children and adolescents living in the municipality of Porto Velho, Rond?nia. The investigated factors were hierarchically organized into groups of variables and their relationship with redox imbalance biomarkers was estimated by a multiple linear regression model. Children and adolescents with asthma, with C-reactive protein values, with the polymorphic variant GSTP1, and exposed to indoor air pollution presented lower thiol serum concentrations when compared to those categorized in their respective reference groups. GST activity and malondialdehyde serum concentrations were positively related to weekly fish consumption and exposure to PM2.5. This study showed that enzymatic GST activity and malondialdehyde serum concentrations are positively associated with environmental factors, especially air pollution (β = 8.64 U/L for GST and β = 0.244 μmol/L for MDA in high exposure group;p-value < 0.01);while serum thiol concentrations presented an inversely proportional relationship with markers of general health status, such asthma (median: 0.45 mmol/L vs. 0.48 mmol/L;p-value < 0.05), acute inflammation (β = -0.25 mmol/L;p-value < 0.01), and positively with genetic factor (β = 0.12 mmol/L for Val/Val;p-value < 0.05).
